专利检索 ap:("Thomas BARA" OR "Sathesh Bhat" OR "Dipshika Biswas" OR "Linda Brockunier" OR "Duane Burnette" OR "Samuel Chackalamannil" OR "Mariappan Vasu Cheliah" OR "Austin Chen" OR "Martin Clasby" OR "Vince J. Colandrea" OR "Zhuyan Guo" OR "Yongxin Han" OR "Charles Jayne" OR "Hubert Josien" OR "Karen Marcantonio" OR "Shouwu Miao" OR "Santhosh Neelamkavil" OR "Patrick Pinto" OR "Murali Rajogopalan" OR "Unmesh Shah" OR "Francisco Velazquez" OR "Srikanth Venkatraman" OR "Yan Xia") AND inv:"Sathesh Bhat" 第 1 页

1.

发明申请
HCV NS3 PROTEASE INHIBITORS 有权
标题翻译： HCV NS3蛋白酶抑制剂

公开(公告)号：US20140057836A1

公开(公告)日：2014-02-27

申请号：US13960343

申请日：2013-08-06

申请人： Thomas BARA , Sathesh Bhat , Dipshika Biswas , Linda Brockunier , Duane Burnette , Samuel Chackalamannil , Mariappan Vasu Cheliah , Austin Chen , Martin Clasby , Vince J. Colandrea , Zhuyan Guo , Yongxin Han , Charles Jayne , Hubert Josien , Karen Marcantonio , Shouwu Miao , Santhosh Neelamkavil , Patrick Pinto , Murali Rajogopalan , Unmesh Shah , Francisco Velazquez , Srikanth Venkatraman , Yan Xia

发明人： Thomas BARA , Sathesh Bhat , Dipshika Biswas , Linda Brockunier , Duane Burnette , Samuel Chackalamannil , Mariappan Vasu Cheliah , Austin Chen , Martin Clasby , Vince J. Colandrea , Zhuyan Guo , Yongxin Han , Charles Jayne , Hubert Josien , Karen Marcantonio , Shouwu Miao , Santhosh Neelamkavil , Patrick Pinto , Murali Rajogopalan , Unmesh Shah , Francisco Velazquez , Srikanth Venkatraman , Yan Xia

IPC分类号： C07K5/08 , A61K45/06 , A61K38/06

CPC分类号： C07K5/08 , A61K38/06 , A61K45/06 , C07D419/00 , C07D491/22

摘要： The present invention relates to hepatitis C virus (HCV) NS3 protease inhibitors containing a spirocyclic moeity, uses of such compounds, and synthesis of such compounds.

摘要翻译： 本发明涉及含有螺环状的丙型肝炎病毒（HCV）NS3蛋白酶抑制剂，这些化合物的用途，以及这些化合物的合成。

2.

发明申请
NOVEL SUBSTITUTED HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE 审中-公开
标题翻译：新型替代异构化合物作为硬脂酸苄酯DE DELTA-9去饱和酶的抑制剂

公开(公告)号：US20110021532A1

公开(公告)日：2011-01-27

申请号：US12934100

申请日：2009-04-21

申请人： David Powell , Marie-Eve Lebrun , Sathesh Bhat , Yeeman K. Ramtohul

发明人： David Powell , Marie-Eve Lebrun , Sathesh Bhat , Yeeman K. Ramtohul

IPC分类号： A61K31/501 , C07D235/18 , A61K31/4184 , C07D401/02 , A61K31/4439 , C07D403/04 , A61K31/506 , C07D471/02 , A61K31/437 , A61P3/10 , A61P3/00 , A61P3/04 , A61P1/16 , A61P9/00 , A61P9/10

CPC分类号： C12N9/0083 , C07D235/18 , C07D401/04 , C07D401/10 , C07D403/04 , C07D405/10 , C07D409/10 , C07D471/04

摘要： Substituted heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis. Formula (I).

摘要翻译： 结构式I的取代的杂芳族化合物是硬脂酰辅酶A delta-9去饱和酶的抑制剂。本发明的化合物可用于预防和治疗与脂质合成和代谢异常有关的病症，包括心血管疾病，如动脉粥样硬化; 肥胖; 2型糖尿病; 胰岛素抵抗; 高血糖症代谢综合征; 神经系统疾病; 癌症; 和肝脂肪变性。式（I）。