公开(公告)号：US09324167B2

公开(公告)日：2016-04-26

申请号：US14117056

申请日：2012-05-22

申请人： Thomas Blaffert ,  Steffen Renisch ,  Bernd Schweizer ,  Zhiqiang Hu

发明人： Thomas Blaffert ,  Steffen Renisch ,  Bernd Schweizer ,  Zhiqiang Hu

IPC分类号： G06K9/00 ,  G06T11/00 ,  G01R33/48 ,  G06T7/00

CPC分类号： G06T11/005 ,  G01R33/481 ,  G06T7/11 ,  G06T7/155 ,  G06T7/174 ,  G06T7/181 ,  G06T2207/10084 ,  G06T2207/10088 ,  G06T2207/10104 ,  G06T2207/20152 ,  G06T2207/20221 ,  G06T2207/30004 ,  G06T2207/30008 ,  G06T2207/30061

摘要： The invention relates to an apparatus for generating an attenuation correction map. An image providing unit (5, 6) provides an image of an object comprising different element classes and a segmentation unit (11) applies a segmentation to the image for generating a segmented image comprising image regions corresponding to the element classes. The segmentation is based on at least one of a watershed segmentation and a body contour segmentation based on a contiguous skin and fat layers in the image. A feature determination unit (12) determines features of at least one of a) the image regions and b) boundaries between the image regions depending on image values of the image and an assigning unit (13) assigns attenuation values to the image regions based on the determined features for generating the attenuation correction map. The performed image processing steps can allow for producing a high quality attenuation correction map, even if the initial image does not comprise image values related to the attenuation of radiation like a CT image.

摘要翻译： 本发明涉及一种用于产生衰减校正图的装置。 图像提供单元（5,6）提供包括不同元素类别的对象的图像，并且分割单元（11）对图像应用分割以生成包括对应于元素类别的图像区域的分割图像。 分割基于基于图像中的连续皮肤和脂肪层的分水岭分割和身体轮廓分割中的至少一个。 特征确定单元（12）确定a）图像区域和b）图像区域之间的边界中的至少一个的特征，取决于图像的图像值，并且分配单元（13）基于图像区域向图像区域分配衰减值 确定的用于产生衰减校正图的特征。 执行的图像处理步骤可以允许产生高质量的衰减校正图，即使初始图像不包括像CT图像的辐射衰减相关的图像值。

公开(公告)号：US20140193054A1

公开(公告)日：2014-07-10

申请号：US14117056

申请日：2012-05-22

申请人： Thomas Blaffert ,  Steffen Renisch ,  Bernd Schweizer ,  Zhiqiang Hu

发明人： Thomas Blaffert ,  Steffen Renisch ,  Bernd Schweizer ,  Zhiqiang Hu

IPC分类号： G06T11/00

CPC分类号： G06T11/005 ,  G01R33/481 ,  G06T7/11 ,  G06T7/155 ,  G06T7/174 ,  G06T7/181 ,  G06T2207/10084 ,  G06T2207/10088 ,  G06T2207/10104 ,  G06T2207/20152 ,  G06T2207/20221 ,  G06T2207/30004 ,  G06T2207/30008 ,  G06T2207/30061

摘要： The invention relates to an apparatus for generating an attenuation correction map. An image providing unit (5, 6) provides an image of an object comprising different element classes and a segmentation unit (11) applies a segmentation to the image for generating a segmented image comprising image regions corresponding to the element classes. The segmentation is based on at least one of a watershed segmentation and a body contour segmentation based on a contiguous skin and fat layers in the image. A feature determination unit (12) determines features of at least one of a) the image regions and b) boundaries between the image regions depending on image values of the image and an assigning unit (13) assigns attenuation values to the image regions based on the determined features for generating the attenuation correction map. The performed image processing steps can allow for producing a high quality attenuation correction map, even if the initial image does not comprise image values related to the attenuation of radiation like a CT image.

摘要翻译： 本发明涉及一种用于产生衰减校正图的装置。 图像提供单元（5,6）提供包括不同元素类别的对象的图像，并且分割单元（11）对图像应用分割以生成包括对应于元素类别的图像区域的分割图像。 分割基于基于图像中的连续皮肤和脂肪层的分水岭分割和身体轮廓分割中的至少一个。 特征确定单元（12）确定a）图像区域和b）图像区域之间的边界中的至少一个的特征，取决于图像的图像值，并且分配单元（13）基于图像区域向图像区域分配衰减值 确定的用于产生衰减校正图的特征。 执行的图像处理步骤可以允许产生高质量的衰减校正图，即使初始图像不包括像CT图像的辐射衰减相关的图像值。

公开(公告)号：US09336613B2

公开(公告)日：2016-05-10

申请号：US14117698

申请日：2012-05-23

申请人： Thomas Blaffert ,  Steffen Renisch ,  Bernd Schweizer ,  Zhiqiang Hu

发明人： Thomas Blaffert ,  Steffen Renisch ,  Bernd Schweizer ,  Zhiqiang Hu

IPC分类号： G06K9/00 ,  G06T11/00 ,  G06T7/00

CPC分类号： G06T11/008 ,  G06T7/0012 ,  G06T7/11 ,  G06T7/155 ,  G06T7/174 ,  G06T2207/10088 ,  G06T2207/10104 ,  G06T2207/20152 ,  G06T2207/20221 ,  G06T2207/30004 ,  G06T2207/30061

摘要： An apparatus for generating assignments between image regions of an image of an object and element classes includes an assigning unit (13) for assigning element classes to image regions of an element image of the object, which is indicative of a distribution of the element classes, depending on region and/or boundary features, which are determined depending on image values of a provided object image and provided first preliminary assignments. Thus, the resulting element image with the assignments to the element classes is not necessarily based on the provided object image only, but can also be based on the provided preliminary assignments. If the quality of the assignments defined by the element image would be restricted due to restrictions of the provided object image, these restrictions of the provided image can therefore be compensated by the preliminary assignments such that the quality of the resulting element image can be improved.

摘要翻译： 一种用于在对象的图像和元素类的图像区域之间生成分配的装置包括：分配单元（13），用于将元素类分配给对象的元素图像的图像区域，其指示元素类别的分布， 取决于根据所提供的对象图像的图像值确定的区域和/或边界特征，并且提供第一初步分配。 因此，具有对元素类的赋值的结果元素图像不一定仅基于所提供的对象图像，而是还可以基于所提供的初步分配。 如果由于所提供的对象图像的限制而限制由元素图像定义的分配的质量，则可以通过初步分配来补偿所提供的图像的这些限制，使得可以提高所得到的元素图像的质量。

公开(公告)号：US20140133728A1

公开(公告)日：2014-05-15

申请号：US14117698

申请日：2012-05-23

申请人： Thomas Blaffert ,  Steffen Renisch ,  Bernd Schweizer ,  Zhiqiang Hu

发明人： Thomas Blaffert ,  Steffen Renisch ,  Bernd Schweizer ,  Zhiqiang Hu

IPC分类号： G06T11/00 ,  G06T7/00

CPC分类号： G06T11/008 ,  G06T7/0012 ,  G06T7/11 ,  G06T7/155 ,  G06T7/174 ,  G06T2207/10088 ,  G06T2207/10104 ,  G06T2207/20152 ,  G06T2207/20221 ,  G06T2207/30004 ,  G06T2207/30061

摘要： The invention relates to an apparatus for generating assignments between image regions of an image of an object and element classes. The apparatus (1) comprises an assigning unit (13) for assigning element classes to image regions of an element image of the object, which is indicative of a distribution of the element classes, depending on region and/or boundary features, which are determined depending on image values of a provided object image and provided first preliminary assignments. Thus, the resulting element image with the assignments to the element classes is not necessarily based on the provided object image only, but can also be based on the provided preliminary assignments. If the quality of the assignments defined by the element image would be restricted due to restrictions of the provided object image, these restrictions of the provided image can therefore be compensated by the preliminary assignments such that the quality of the resulting element image can be improved.

摘要翻译： 本发明涉及一种用于在对象和元素类的图像的图像区域之间生成分配的装置。 所述装置（1）包括分配单元（13），用于根据所确定的区域和/或边界特征将元素类别分配给所述对象的元素图像的图像区域，所述图像区域指示所述元素类别的分布 取决于提供的对象图像的图像值并提供第一初步分配。 因此，具有对元素类的赋值的结果元素图像不一定仅基于所提供的对象图像，而是还可以基于所提供的初步分配。 如果由于所提供的对象图像的限制而限制由元素图像定义的分配的质量，则可以通过初步分配来补偿所提供的图像的这些限制，使得可以提高所得到的元素图像的质量。

公开(公告)号：US07711090B2

公开(公告)日：2010-05-04

申请号：US12296309

申请日：2007-03-28

申请人： Bernd Schweizer ,  Michael Overdick

发明人： Bernd Schweizer ,  Michael Overdick

IPC分类号： H05G1/64

CPC分类号： G21K1/025

摘要： The invention relates to a method, to an X-ray apparatus for performing the method and to a detector arrangement intended for the latter, for producing X-ray images containing a reduced proportion of scattered radiation. The X-ray radiation is detected in this case by a detector arrangement comprising two X-ray detectors, there being provided in the first X-ray detector openings through which the second X-ray detector is able to detect scattered radiation and primary radiation by separate detector elements. The signals given by the second X-ray detector are used to determine the proportion of scattered radiation that is contained in the image produced by the first X-ray detector and to largely free the first image of the proportion of scattered radiation.

摘要翻译： 本发明涉及一种用于执行该方法的X射线设备和用于后者的检测器装置的方法，用于产生包含减少的散射辐射比例的X射线图像。 在这种情况下，通过包括两个X射线检测器的检测器装置检测X射线辐射，其中设置在第一X射线检测器开口中，第二X射线检测器通过该开口检测散射的辐射和主辐射， 分离的检测器元件。 由第二X射线检测器给出的信号用于确定由第一X射线检测器产生的图像中包含的散射辐射的比例，并且大部分地消除第一图像的散射辐射的比例。

公开(公告)号：US20090292481A1

公开(公告)日：2009-11-26

申请号：US12446989

申请日：2007-11-06

申请人： Heinrich Von Busch ,  Bernd Schweizer ,  Jens Christoph Georgi

发明人： Heinrich Von Busch ,  Bernd Schweizer ,  Jens Christoph Georgi

IPC分类号： G06F19/00

CPC分类号： G06F19/3481 ,  G06F19/00

摘要： An apparatus, method, system, computer-readable medium and use for individual patient therapy planning of diseases such as cancer for different therapy modalities, such as radiation therapy and chemotherapy is provided. A new aspect of the invention is that the degree of bone marrow depression of the patient is related to the count of immature blood platelets, which are measured before each treatment. Some embodiments of the invention provide an advantage allowing reducing the level of uncertainty in the prediction of the risk of bone marrow depression, and thus enabling to safely improve the therapy effect by an increase of the radiation dosage and/or chemical dosage to the individual patient while the risk for bone marrow depression is minimized.

摘要翻译： 提供了一种装置，方法，系统，计算机可读介质以及用于各种患者治疗计划疾病如癌症的不同治疗方式（如放射治疗和化疗）的用途。 本发明的新方面是患者的骨髓抑制程度与每次治疗前测量的未成熟血小板计数有关。 本发明的一些实施方案提供了一种优点，可以降低预测骨髓抑制风险的不确定性水平，从而能够通过增加单个患者的辐射剂量和/或化学剂量来安全地改善治疗效果 而骨髓抑制的风险最小化。

公开(公告)号：US08897518B2

公开(公告)日：2014-11-25

申请号：US13202840

申请日：2010-02-09

申请人： Torsten Solf ,  Bernd Schweizer ,  Martin Weibrecht ,  Carolina Ribbing

发明人： Torsten Solf ,  Bernd Schweizer ,  Martin Weibrecht ,  Carolina Ribbing

IPC分类号： G06K9/00 ,  A61B6/00 ,  A61B6/03 ,  A61B8/00 ,  G06F19/00 ,  A61B5/00 ,  A61B5/055 ,  A61B8/08

CPC分类号： A61B6/00 ,  A61B5/055 ,  A61B5/743 ,  A61B6/037 ,  A61B6/463 ,  A61B6/545 ,  A61B8/463 ,  A61B8/481 ,  A61B8/585 ,  G06F19/00 ,  G06F19/321 ,  G16H15/00

摘要： A method includes obtaining an image of a region of interest of a subject, wherein the image is generated with image data produced by an imaging system used to scan the subject, obtaining a signal indicative of a physiological state of the subject before the scan, and displaying both the image and data indicative of the physiological state. In another aspect, a method includes correcting, via a processor, a tracer uptake value for a target region of interest based on a tracer uptake correction factor.

摘要翻译： 一种方法包括获得对象感兴趣区域的图像，其中使用由用于扫描对象的成像系统产生的图像数据来生成图像，获得指示扫描之前对象的生理状态的信号，以及 显示指示生理状态的图像和数据。 在另一方面，一种方法包括：通过处理器，基于示踪剂吸收校正因子来校正目标感兴趣区域的示踪剂吸收值。

公开(公告)号：US20100133440A1

公开(公告)日：2010-06-03

申请号：US12513551

申请日：2007-11-12

申请人： Jens-Christoph Georgi ,  Bernd Schweizer ,  Heinrich Von Busch

发明人： Jens-Christoph Georgi ,  Bernd Schweizer ,  Heinrich Von Busch

IPC分类号： G01T1/02 ,  G01T1/161 ,  G01T1/24

CPC分类号： G01T1/161 ,  A61B6/4258

摘要： This invention relates to a system for determining a biodistribution of radioactive agents in a subject. According to the invention, a detector system comprising two or more detectors arranged to be attached to the subject at localized areas is used for detecting the radiation emitted from the imaging agents at localized tissues within the subject. The measuring results in separate radiation data sets associated to the tissues. The detectors are further being arranged to adapt the measuring rate to the pharmacokinetic behavior of the tissues in order to capture all relevant data points. A processor then uses the data sets for determining the radioactivity within each respective tissue and based thereon the biodistribution within the subject.

摘要翻译： 本发明涉及用于确定受试者中放射性试剂生物分布的系统。 根据本发明，包括两个或更多个检测器的检测器系统被布置成在局部区域处附接到受试者，用于检测在受试者内的局部组织处从成像剂发射的辐射。 测量结果与组织相关联的单独辐射数据集。 检测器还被布置成使测量速率适应组织的药代动力学行为，以捕获所有相关的数据点。 然后，处理器使用数据集来确定每个相应组织内的放射性，并且基于该对象内的生物分布。

公开(公告)号：US07656996B2

公开(公告)日：2010-02-02

申请号：US10598003

申请日：2005-02-11

申请人： Geoffrey Harding ,  Gerhard Martens ,  Hans Barschdorf ,  Bernd Schweizer

发明人： Geoffrey Harding ,  Gerhard Martens ,  Hans Barschdorf ,  Bernd Schweizer

IPC分类号： G01T1/36

CPC分类号： G01N23/223 ,  G01N2223/076 ,  G01N2223/0766

摘要： The invention relates to a method and a device for determining the distribution of an X-ray fluorescence (XRF) marker (16) in a body volume (14). The body volume (14) is irradiated with a beam of rays (12) from an X-ray source (10) with a first ray component with a quantum energy just above and a second ray component with a quantum energy just below the K-edge of the XRF marker (16). Secondary radiation emitted from the body volume (14) is detected in a location-resolved way by a detector (30). To separate the X-ray fluorescence components in the secondary radiation from background radiation, the body volume is irradiated for a second time with a beam of rays from which the first ray component has been substantially removed by a filter (22) made from the material of the XRF marker.

摘要翻译： 本发明涉及一种用于确定身体体积（14）中的X射线荧光（XRF）标记物（16）的分布的方法和装置。 用来自X射线源（10）的射线束（12）照射具有刚好在上面的量子能的第一射线分量的体积（14），并且具有刚好低于K值的量子能量的第二射线分量， 边缘的XRF标记（16）。 通过检测器（30）以位置分辨的方式检测从体积（14）发射的次级辐射。 为了将二次辐射中的X射线荧光成分从背景辐射中分离出来，用第一射线成分基本上被该材料制成的过滤器（22）除去的射线束照射体积第二次 的XRF标记。

公开(公告)号：US07626174B2

公开(公告)日：2009-12-01

申请号：US11570900

申请日：2005-06-24

申请人： Bernd Schweizer ,  Gereon Vogtmeier ,  Klaus Engel

发明人： Bernd Schweizer ,  Gereon Vogtmeier ,  Klaus Engel

IPC分类号： H01L27/146

CPC分类号： G01T1/1648

摘要： The invention refers to X-ray devices, an X-ray detector and a method of correcting intensity signals. An X-ray detector then comprises for determining the intensity of X-rays, which comprise a proportion of primary radiation having an irradiation direction and a proportion of scattered radiation, at least a first sensor elements, which are each provided for converting the X-rays into first and second intensity signals, and a filter element, which is provided for decreasing the proportion of scattered radiation in the intensity of the X-rays, wherein the second sensor elements are arranged in irradiation direction behind the filter element and wherein the first sensor element fastened to the filter element is provided for determining the intensity of the X-rays before leaving the filter element. The proportion of the scattered radiation calculated from the measuring data of the first and second sensor elements is provided for correcting the second intensity signals for the following image generation.

摘要翻译： 本发明涉及X射线装置，X射线检测器和校正强度信号的方法。 然后，X射线检测器包括用于确定包括具有照射方向和散射辐射的比例的一次辐射的比例的X射线的强度，至少第一传感器元件，其被设置用于转换X射线， 射线成为第一和第二强度信号;以及滤波器元件，其设置用于减小X射线强度中的散射辐射的比例，其中第二传感器元件沿着过滤元件后面的照射方向排列，并且其中第一 固定在过滤元件上的传感器元件用于确定离开过滤元件之前的X射线的强度。 提供从第一和第二传感器元件的测量数据计算的散射辐射的比例，用于校正用于后续图像生成的第二强度信号。