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公开(公告)号：US08466104B2
公开(公告)日：2013-06-18
申请号：US12064923
申请日：2005-08-26
CPC分类号： C07K7/08 , C07K14/685 , C07K2319/31
摘要： The invention describes peptide analogues of a-melanocyte-stimulating hormone (a-MSH), which posses an increased efficacy compared to the native α-MSH peptide. The α-MSH analogues exhibit increased anti-inflammatory effects and increased capability to prevent ischemic conditions compared to α-MSH. The invention further discloses use of the peptides for the manufacture of pharmaceutical compositions for the treatment or prophylaxis of a condition in the tissue of one or more organs of a mammal, and moreover pharmaceutical compositions.
摘要翻译： 本发明描述了与天然α-MSH肽相比具有增加的功效的α-黑素细胞刺激激素（a-MSH）的肽类似物。 与α-MSH相比，α-MSH类似物表现出增加的抗炎作用和增强的预防缺血状况的能力。 本发明进一步公开了该肽用于制备用于治疗或预防哺乳动物的一种或多种器官的组织中的病症的药物组合物的用途，以及药物组合物。
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公开(公告)号：US20090069242A1
公开(公告)日：2009-03-12
申请号：US12064923
申请日：2005-08-26
CPC分类号： C07K7/08 , C07K14/685 , C07K2319/31
摘要： The invention describes peptide analogues of a-melanocyte-stimulating hormone (a-MSH), which posses an increased efficacy compared to the native α-MSH peptide. The α-MSH analogues exhibit increased anti-inflammatory effects and increased capability to prevent ischemic conditions compared to α-MSH. The invention further discloses use of the peptides for the manufacture of pharmaceutical compositions for the treatment or prophylaxis of a condition in the tissue of one or more organs of a mammal, and moreover pharmaceutical compositions.
摘要翻译： 本发明描述了与天然α-MSH肽相比具有增加的功效的α-黑素细胞刺激激素（a-MSH）的肽类似物。 与α-MSH相比，α-MSH类似物表现出增加的抗炎作用和增强的预防缺血状况的能力。 本发明进一步公开了该肽用于制备用于治疗或预防哺乳动物的一种或多种器官的组织中的病症的药物组合物的用途，以及药物组合物。
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公开(公告)号：US20060063705A1
公开(公告)日：2006-03-23
申请号：US11262921
申请日：2005-11-01
CPC分类号： A61K38/1816 , A61K38/34 , A61K2300/00
摘要： Alpha-melanocyte stimulating hormone (α-MSH) or an equivalent is used, in conjunction with erythropoietin (EPO) or equivalent, to prevent or treat ischemic conditions.
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4.发明申请公开(公告)号：US20050158860A1
公开(公告)日：2005-07-21
申请号：US10470062
申请日：2002-01-25
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/10 , C12P21/02 , C12R1/66 , C12R1/865 , C12N15/74 , C12N1/18
CPC分类号： C12N15/1027 , C12N15/1051 , C12N15/1079 , C12N15/1086
摘要： The present invention relates to evolution of a cell or a composition of cells having a desired property or functionally. The principle behind the evolution of cells according to the invention is to produce a great diversity of genes in each cell subjected to evolution and a great diversity of genes among the cells in a composition according to the invention and to exchange the genes between the cells from time to time. In preferred embodiments the genes are arranged in expression cassettes in concatemers in the cells, as well as in artificial chromosomes. Said methods comprising the steps of a) obtaining a composition of cells, at least one cell of said composition comprising a1) at least two expressible nucleotide sequences, at least one of said sequences being incorporated into an artificial chromosome in the cell and/or a2) at least two expression cassettes of the following formula: [rs2-SP-PR-X-TR-SP-rs11 wherein rs1 and rs2 together denotes a restriction site, SP individually denotes a spacer, PR denotes a promoter, capable of functionning in the first cell, X denotes an expressible nucleotide sequence, TR denotes a terminator, and/or a3) at least two expressible nucleotide sequences, said sequences being heterologous to the cell, determining at least one screening functionality. The genes are preferably co-ordinately controllable for increasing diversity. The desired property of functionality is preferably a compound, or a series of compounds synergistically acting to each other.
摘要翻译： 本发明涉及具有所需性质或功能的细胞的细胞或组成的进化。 根据本发明的细胞进化背后的原理是在根据本发明的组合物中经历进化和每个细胞中基因的多样性的每个细胞中产生大量的基因，并且将细胞之间的基因交换 时不时 在优选的实施方案中，将基因排列在细胞中以及人造染色体中的并列的表达盒中。 所述方法包括以下步骤：a）获得细胞组合物，所述组合物的至少一个细胞包含a1）至少两个可表达的核苷酸序列，所述序列中的至少一个被并入细胞和/或a2中的人造染色体 ）至少两个下式的表达盒：[rs2-SP-PR-X-TR-SP-rs11其中rs1和rs2一起表示限制性位点，SP分别表示间隔基，PR表示能够在 第一个细胞，X表示可表达的核苷酸序列，TR表示终止子，和/或a3）至少两个可表达的核苷酸序列，所述序列与细胞异源，确定至少一个筛选功能。 这些基因优选可协同控制以增加多样性。 功能性所需的性质优选是化合物或一系列协同作用的化合物。
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公开(公告)号：US20080257064A1
公开(公告)日：2008-10-23
申请号：US11886093
申请日：2005-03-14
申请人： Soren Nielsen
发明人： Soren Nielsen
IPC分类号： G01F1/58
摘要： There is described a tubular insert for a magnetically inductive flowmeter, a production method for said type of tubular insert and a flowmeter. The tubular insert is made of, essentially, an electrically-insulating material, in particular, rubber, which is reinforced by a tubular moulding part made of a dimensionally stable plastic which is based on polymers, at least in a measuring section. The tubular moulding part is embedded in the electrically-insulating rubber material by a press or casting method such that the electrically-insulating, rubber material essentially covers the inner surfaces of the tubular moulding part. An economical to produce, robust, tubular insert is thus achieved.
摘要翻译： 描述了用于磁感应流量计的管状插入件，所述类型的管状插入件的制造方法和流量计。 管状插入件基本上由绝缘材料制成，特别是橡胶，其由至少在测量部分中基于聚合物的尺寸稳定的塑料制成的管状模制部件加强。 管状成型部件通过压制或铸造方法嵌入电绝缘橡胶材料中，使得绝缘橡胶材料基本上覆盖管状模制部件的内表面。 因此实现了经济的生产，坚固的管状插入物。
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公开(公告)号：US20050177133A1
公开(公告)日：2005-08-11
申请号：US10520817
申请日：2003-07-03
申请人： Henrik Nielsen , Soren Nielsen
发明人： Henrik Nielsen , Soren Nielsen
CPC分类号： A61L29/141 , A61F5/453 , A61L29/06 , C08L77/12 , C08L75/04
摘要： The external urinary catheter for use as an external catheter comprises a tip portion (3) and a sheath portion (1). The external urinary catheter is manufactured by thermoplastic processing of a material comprising at least one transparent and/or thermoplastic elastomer and at least one plasticizer.
摘要翻译： 用作外部导管的外部导尿管包括尖端部分（3）和鞘部分（1）。 外部导尿管通过热塑性加工制造，该材料包括至少一种透明和/或热塑性弹性体和至少一种增塑剂。
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公开(公告)号：US20080196510A1
公开(公告)日：2008-08-21
申请号：US11667333
申请日：2004-11-10
申请人： Soren Nielsen
发明人： Soren Nielsen
IPC分类号： G01F1/58
摘要： There is described a tubular insert for a magnetic inductive flowmeter, a production method for such a tubular insert and a flowmeter. The tubular insert essentially comprises an electrically-insulating material, in particular, rubber, reinforced with a metal mesh, at least in a measuring section. The tubular metal mesh comprises one or more mesh sections, pre-prepared from sheet mesh by stamping, bending and welding butt edges running essentially parallel to the tube axis such as to form an essentially tubular metal mesh. The tubular metal grid is embedded in the electrically-insulating material passing therethrough and the electrically-insulating material essentially covers the inner and out surfaces of the tubular material. A robust, tubular insert is thus achieved, with a corresponding cheap production cost.
摘要翻译： 描述了用于磁感应流量计的管状插入件，这种管状插入件和流量计的制造方法。 管状插入件至少在测量部分中基本上包括用绝缘材料，特别是用金属网加强的橡胶。 管状金属网包括一个或多个网状部分，其通过冲压，弯曲和焊接基本上平行于管轴线的对接边缘预先制备，从而形成基本上管状的金属网。 管状金属网格嵌入通过其的电绝缘材料中，并且电绝缘材料基本上覆盖管状材料的内表面和外表面。 因此实现了坚固的管状插入件，具有相应的廉价生产成本。
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公开(公告)号：US20060252156A1
公开(公告)日：2006-11-09
申请号：US10523007
申请日：2003-08-01
CPC分类号： C12N15/1093 , C12N15/02 , C12N15/1027
摘要： The present invention relates to methods of mixing large numbers of heterologous genes, which are located on artificial chromsomes. The methods of the present invention are useful for evolution of cells and whole genomes to acquire new functionality(ies), such as the ability to synthesise novel secondary metabolites and/or the evolution of novel metabolic pathways. In particular the methods may involve mating or fusing two populations of cells, each population comprising different combinations of heterologous genes. Subsequently, desirable cells may be selected. In embodiments of the invention the heterologous genes are comprised within expression cassettes. The expression cassette can be in the form of a concatermer, and can be cut out using a restriction enzyme in order to make new combinations of expression cassettes.
摘要翻译： 本发明涉及混合大量位于人造染色体上的异源基因的方法。 本发明的方法可用于细胞和整个基因组的进化以获得新的功能性，例如合成新的次级代谢物的能力和/或新型代谢途径的进化。 特别地，所述方法可涉及交配或融合两个细胞群，每个群体包含异源基因的不同组合。 随后，可以选择期望的细胞。 在本发明的实施方案中，异源基因包含在表达盒内。 表达盒可以是连接体的形式，并且可以使用限制性内切酶切割以形成表达盒的新组合。
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公开(公告)号：US20070163359A1
公开(公告)日：2007-07-19
申请号：US10550228
申请日：2004-03-22
申请人： Soren Nielsen
发明人： Soren Nielsen
IPC分类号： G01F1/58
CPC分类号： G01F1/584
摘要： The invention relates to a magnetic inductive flowmeter comprising: a measuring distance that is surrounded by a wall; a magnetic field generating device, and; an electrode device, which has at least one electrode on the inside of the wall and an electrode connection on the outside of the wall. The aim of the invention is to simplify the assembly of the inventive flowmeter. To this end, the electrode connection is connected to the electrode by means of a plug-type connection, and the electrode connection fixes the electrode to the wall.
摘要翻译： 磁感应式流量计本发明涉及一种磁感应流量计，其包括：测量距离，被墙壁围绕; 磁场产生装置，和 电极装置，其在壁的内侧具有至少一个电极，在壁的外侧具有电极连接。 本发明的目的是简化本发明的流量计的组装。 为此，电极连接通过插塞式连接与电极连接，电极连接将电极固定在墙壁上。
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公开(公告)号：US20060281746A1
公开(公告)日：2006-12-14
申请号：US10568483
申请日：2004-08-13
申请人： Jan Kehler , Tore Hansen , Anders Poulsen , Berith Bjornholm , Thomas Ruhland , Morten Norgaard , Soren Nielsen
发明人： Jan Kehler , Tore Hansen , Anders Poulsen , Berith Bjornholm , Thomas Ruhland , Morten Norgaard , Soren Nielsen
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/495 , A61K31/4747 , A61K31/454 , C07D491/10 , C07D413/02 , C07D487/10
CPC分类号： C07D211/34 , C07D211/14 , C07D211/32 , C07D211/52 , C07D211/58 , C07D211/64 , C07D295/155 , C07D401/06 , C07D471/10
摘要： The present invention relates to cyclopropyl derivatives of formula (I) and salt thereof. These compounds are NK3 receptor antagonists and may therefore be useful for treatment of diseases where the NK3 receptor is implicated, e.g. psychotic disorders.
摘要翻译： 本发明涉及式（I）的环丙基衍生物及其盐。 这些化合物是NK3受体拮抗剂，因此可用于治疗涉及NK3受体的疾病，例如， 精神障碍
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