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1.发明申请PULMONARY DELIVERY PARTICLES COMPRISING WATER INSOLUBLE OR CRYSTALLINE ACTIVE AGENTS 审中-公开包含水不溶性或结晶活性剂的脉冲递送颗粒公开(公告)号：US20100272823A1
公开(公告)日：2010-10-28
申请号：US12774540
申请日：2010-05-05
IPC分类号： A61K9/14 , A61K38/43 , A61K31/56 , A61K31/7088 , A61K31/713 , A61K38/00 , A61P11/00 , A61P31/00 , A61P37/08 , A61P29/00 , A61P23/00 , A61P9/00 , B29B9/12
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： A pulmonary delivery medicament comprises a plurality of particulates, the particulates comprising a structural matrix and a water insoluble and/or crystalline active agent. The particulates have a geometric diameter of 0.5 to 50 μm. The water insoluble active agent can be a fungicide, antibiotic, budesonide. A method of making the medicament comprises forming a liquid feedstock, and forming a feedstock suspension by suspending in the liquid feedstock, the active agent and an excipient capable of forming a structural matrix, such as a phospholipid. The feedstock suspension is spray dried to produce the particulates.
摘要翻译： 肺递送药物包括多个颗粒，所述颗粒包含结构基质和水不溶性和/或结晶活性剂。 颗粒的几何直径为0.5至50μm。 水不溶性活性剂可以是杀真菌剂，抗生素，布地奈德。 制备药物的方法包括形成液体原料，并通过悬浮在液体原料，活性剂和能够形成结构基质如磷脂的赋形剂中形成原料悬浮液。 将原料悬浮液喷雾干燥以产生颗粒。
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公开(公告)号：US09554993B2
公开(公告)日：2017-01-31
申请号：US12774540
申请日：2010-05-05
IPC分类号： A61K9/00 , A61K9/16 , A61K31/685
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： A pulmonary delivery medicament comprises a plurality of particulates, the particulates comprising a structural matrix and a water insoluble and/or crystalline active agent. The particulates have a geometric diameter of 0.5 to 50 μm. The water insoluble active agent can be a fungicide, antibiotic, budesonide. A method of making the medicament comprises forming a liquid feedstock, and forming a feedstock suspension by suspending in the liquid feedstock, the active agent and an excipient capable of forming a structural matrix, such as a phospholipid. The feedstock suspension is spray dried to produce the particulates.
摘要翻译： 肺递送药物包括多个颗粒，所述颗粒包含结构基质和水不溶性和/或结晶活性剂。 颗粒的几何直径为0.5至50μm。 水不溶性活性剂可以是杀真菌剂，抗生素，布地奈德。 制备药物的方法包括形成液体原料，并通过悬浮在液体原料，活性剂和能够形成结构基质如磷脂的赋形剂中形成原料悬浮液。 将原料悬浮液喷雾干燥以产生颗粒。
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公开(公告)号：US08168223B1
公开(公告)日：2012-05-01
申请号：US09886296
申请日：2001-06-21
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y02A50/41 , Y02A50/466 , Y02A50/472 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： Engineered particles are provided may be used for the delivery of a bioactive agent to the respiratory tract of a patient. The particles may be used in the form of dry powders or in the form of stabilized dispersions comprising a nonaqueous continuous phase. In particularly preferred embodiments the particles may be used in conjunction with an inhalation device such as a dry powder inhaler, metered dose inhaler or a nebulizer.
摘要翻译： 提供的工程颗粒可用于将生物活性剂递送到患者的呼吸道。 颗粒可以以干粉形式或以包含非水连续相的稳定分散体的形式使用。 在特别优选的实施方案中，颗粒可以与吸入装置如干粉吸入器，计量剂量吸入器或喷雾器结合使用。
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公开(公告)号：US07790145B2
公开(公告)日：2010-09-07
申请号：US12012827
申请日：2008-02-05
IPC分类号： A61K9/00 , A61K9/10 , A61K9/12 , A61K9/14 , A61K38/00 , A61K38/02 , A61K47/42 , A61K31/56 , A61K31/565 , A61K31/567 , A61K31/568 , A61K31/569 , A61K31/57 , A61K31/573 , A61K31/575
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： A respiratory dispersion is provided for the pulmonary delivery of at least two bioactive agents. The dispersion comprises a propellant suspension medium having dispersed therein a plurality of perforated microstructures, wherein the two bioactive agents are incorporated into individual perforated microstructures.
摘要翻译： 为肺部递送至少两种生物活性剂提供呼吸分散体。 分散体包括其中分散有多个穿孔微结构的推进剂悬浮介质，其中两种生物活性剂并入单独的穿孔微结构中。
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公开(公告)号：US06309623B1
公开(公告)日：2001-10-30
申请号：US09218212
申请日：1998-12-22
IPC分类号： A61K912
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： Stabilized dispersions are provided for the delivery of a bioactive agent to the respiratory tract of a patient. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a hydrofluoroalkane propellant. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as, by settling or flocculation. In particularly preferred embodiments, the stabilized dispersions may be administered to the lung of a patient using a metered dose inhaler.
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公开(公告)号：US07393544B2
公开(公告)日：2008-07-01
申请号：US11675073
申请日：2007-02-14
IPC分类号： A61K9/127
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： Stabilized dispersions are provided for the delivery of a bioactive agent. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a liquid fluorochemical. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as by settling or flocculation. In particularly preferred embodiments the stabilized dispersions may be directly administered to the lung of a patient using an endotracheal tube or bronchoscope.
摘要翻译： 提供稳定的分散体用于递送生物活性剂。 分散体优选包括分散在通常包含液体含氟化合物的悬浮介质中的多个穿孔微结构。 随着悬浮颗粒和悬浮介质之间的密度变化被最小化，微结构之间的吸引力减弱，所公开的分散体特别地耐降解，例如通过沉降或絮凝。 在特别优选的实施方案中，稳定的分散体可以使用气管内导管或支气管镜直接施用于患者的肺。
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公开(公告)号：US06946117B1
公开(公告)日：2005-09-20
申请号：US09218213
申请日：1998-12-22
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/008 , Y02A50/41 , Y02A50/466 , Y02A50/472
摘要： Stabilized dispersions are provided for the delivery of a bioactive agent to the respiratory tract of a patient. The dispersions preferably comprise a stabilized colloidal system which may comprise a fluorochemical component. In particularly preferred embodiments, the stabilized dispersions comprise perforated microstructures dispersed in a fluorochemical suspension medium. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as by settling or flocculation. In particularly preferred embodiments, the stabilized dispersions may be administered to the lung of a patient using a nebulizer.
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公开(公告)号：US06565885B1
公开(公告)日：2003-05-20
申请号：US09219736
申请日：1998-12-22
IPC分类号： A61K914
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y02A50/41 , Y02A50/466 , Y02A50/472 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： Spray drying methods for forming powder compositions for pharmaceutical applications are disclosed. According to one aspect of the invention, the spray drying feed stock comprises a bioactive agent, surfactant, and a blowing agent. Another aspect of the invention is directed to spray drying a feed stock comprising a phospholipid and calcium chloride.
摘要翻译： 公开了用于形成药物应用的粉末组合物的喷雾干燥方法。 根据本发明的一个方面，喷雾干燥原料包含生物活性剂，表面活性剂和发泡剂。 本发明的另一方面涉及喷雾干燥包含磷脂和氯化钙的原料。
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公开(公告)号：US06433040B1
公开(公告)日：2002-08-13
申请号：US09218209
申请日：1998-12-22
IPC分类号： A61K950
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： Stabilized dispersions are provided for the delivery of a bioactive agent. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a liquid fluorochemical. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as by settling or flocculation. In particularly preferred embodiments the stabilized dispersions may be directly administered to the lung of a patient using an endotracheal tube or bronchoscope.
摘要翻译： 提供稳定的分散体用于递送生物活性剂。 分散体优选包括分散在通常包含液体含氟化合物的悬浮介质中的多个穿孔微结构。 随着悬浮颗粒和悬浮介质之间的密度变化被最小化，微结构之间的吸引力减弱，所公开的分散体特别地耐降解，例如通过沉降或絮凝。 在特别优选的实施方案中，稳定的分散体可以使用气管内导管或支气管镜直接施用于患者的肺。
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10.发明授权Respiratory dispersion for metered dose inhalers comprising perforated microstructures 有权包含穿孔微结构的计量吸入器的呼吸分散体公开(公告)号：US08246934B2
公开(公告)日：2012-08-21
申请号：US12875966
申请日：2010-09-03
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： A respiratory dispersion for pulmonary delivery comprises one or more bioactive agents, a suspension medium, and a plurality of perforated microstructures having a mean aerodynamic diameter of less than 5 μm. The suspension medium comprises at least one propellant and permeates the perforated microstructures.
摘要翻译： 用于肺部递送的呼吸分散体包含平均空气动力学直径小于5μm的一种或多种生物活性剂，悬浮介质和多个穿孔微结构。 悬浮介质包括至少一种推进剂并渗透穿孔微结构。
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