公开(公告)号：US20060153783A1

公开(公告)日：2006-07-13

申请号：US10542467

申请日：2004-01-13

申请人： Thomas Ehlis ,  Dietmar Huglin ,  Elek Borsos

发明人： Thomas Ehlis ,  Dietmar Huglin ,  Elek Borsos

IPC分类号： A61K8/49 ,  C07D251/18 ,  C07D403/02

CPC分类号： C07D251/18 ,  C07D251/20

摘要： The present invention relates to new compounds of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, and R8 independently from each other are hydrogen; C1-C18alkyl; C2-C18alkenyl; C5-C7, cycloalkyl; C1-C6alkylene-C5-C7, cycloalkyl; R9 is hydrogen; C1-C18alkyl; C2-C18alkenyl; C5-C7cycloalkyl; C1-C6alkylene-C5-C7cycloalkyl; C6-C10aryl; A is —S—; —O— or —NR10—, wherein R10 has the same meanings as R9; X is COOR11; CONR12R13; SO3, R14; or SO2NR15R16, wherein R11, R12, R13, R14, R15, and R16, have independently from each other the same meanings as R9; to their preparation and to their use as UV absorbers in cosmetic and pharmaceutical formulations.

摘要翻译： 本发明涉及新的式（I）化合物，其中R 1，R 2，R 3，R 4， R 5，R 6，R 7和R 8彼此独立地是氢 ; C 1 -C 18烷基; C 2 -C 18链烯基; C 5 -C 7环烷基，环烷基， C 1 -C 6亚烷基-C 5 -C 7亚烷基，环烷基; R 9是氢; C 1 -C 18烷基; C 2 -C 18链烯基; C 5 -C 7环烷基; C 1 -C 6亚烷基-C 5 -C 7环烷基; C 6 -C 10芳基; A是-S-; -O-或-NR 10 - ，其中R 10具有与R 9相同的含义; X是COOR 11; CONR 12 R 13; SO 3，R 14; 或其中R 11，R 12，R 12，R 12，R 12， R 13，R 14，R 15和R 16，彼此独立地具有与 R 9; 用于制备和用作化妆品和药物制剂中的UV吸收剂。

公开(公告)号：US20050129632A1

公开(公告)日：2005-06-16

申请号：US10507295

申请日：2003-03-04

申请人： Jurg Haase ,  Thomas Ehlis ,  Elek Borsos ,  Dietmar Huglin ,  Bernd Herzog

发明人： Jurg Haase ,  Thomas Ehlis ,  Elek Borsos ,  Dietmar Huglin ,  Bernd Herzog

IPC分类号： C07D249/20 ,  A61K8/00 ,  A61K8/35 ,  A61K8/49 ,  A61Q5/02 ,  A61Q17/04 ,  C07D251/16 ,  C09K3/00 ,  A61K7/42

CPC分类号： A61K8/4966 ,  A61Q17/04

摘要： UV absorber compositions are described, comprising (a) from 1 to 99% by weight of a hydroxyphenyltriazine compound of formula (I) wherein R1, R2 and R3 are each independently of the others C1-C18 alkyl; C2-C10,alkenyl; or phenyl-C1-C4 alkyl; R4 is hydrogen; or C1-C5alkyl; and (b) from 99 to 1% by weight of a further UV absorber selected from the group of (b) hydroxyphenyltriazines that are different from component (a), (b2) benzotriazoles, (b3) dibenzoylmethane derivatives and (b4) camphor derivatives. The compositions are suitable as UV filters in cosmetic compositions.

摘要翻译： 描述了UV吸收剂组合物，其包含（a）1至99重量％的式（I）的羟基苯基三嗪化合物，其中R 1，R 2和R 2 > 3 各自独立地为C 1 -C 12烷基; C 2 -C 10，烯基; 或苯基-C 1 -C 4烷基; R 4是氢; 或C 1 -C 5烷基; （b）99〜1重量％的另外的紫外线吸收剂，其选自（b）不同于组分（a），（b-2）苯并三唑的（b）羟基苯基三嗪，（b < （3/4）二苯甲酰甲烷衍生物和（b 4 S）樟脑衍生物。 该组合物适用于化妆品组合物中的UV过滤器。

公开(公告)号：US6111103A

公开(公告)日：2000-08-29

申请号：US287029

申请日：1999-04-06

申请人： Thomas Ehlis ,  Elek Borsos ,  Helmut Luther ,  Bernd Herzog

发明人： Thomas Ehlis ,  Elek Borsos ,  Helmut Luther ,  Bernd Herzog

IPC分类号： A61K8/00 ,  A61K8/49 ,  A61Q17/04 ,  C07D251/22 ,  C07D251/26 ,  C07D405/12 ,  C08K5/3492 ,  C09K3/00 ,  C09K15/30

CPC分类号： C07D405/12 ,  A61K8/4966 ,  A61Q17/04 ,  C07D251/22

摘要： The invention relates to diresorcinyl-alkoxy- and -aryloxy-triazines of the formula ##STR1## in which R.sub.1 is C.sub.2 -C.sub.30 alkyl; C.sub.2 -C.sub.30 alkenyl; unsubstituted or C.sub.1 -C.sub.5 alkyl-mono- or polysubstituted C.sub.5 -C.sub.12 cycloalkyl, C.sub.1 -C.sub.5 alkoxy-C.sub.1 -C.sub.12 alkyl; amino-C.sub.1 -C.sub.12 alkyl; C.sub.1 -C.sub.5 monoalkylamino-C.sub.1 -C.sub.12 alkyl; C.sub.1 -C.sub.5 dialkylamino-C.sub.1 -C.sub.12 alkyl; a radical of the formula ##STR2## R.sub.2, R.sub.3 and R.sub.4, independently of one another, are hydrogen, hydroxyl, C.sub.1 -C.sub.30 alkyl, C.sub.1 -C.sub.30 alkenyl,R.sub.5 is hydrogen; or C.sub.1 -C.sub.5 alkyl;m.sub.1 is 0 or 1; andn.sub.1 is 1 to 5.The novel compounds are suitable as cosmetic UV-A absorbers.

摘要翻译： 本发明涉及下式的二缩水甘油基 - 烷氧基 - 和 - 芳氧基 - 三嗪，其中R 1是C 2 -C 30烷基; C2-C30烯基; 未取代的或C 1 -C 5烷基 - 单取代或多取代的C 5 -C 12环烷基，C 1 -C 5烷氧基-C 1 -C 12烷基; 氨基-C 1 -C 12烷基; C 1 -C 5单烷基氨基-C 1 -C 12烷基; C 1 -C 5二烷基氨基-C 1 -C 12烷基; 式R2，R3和R4彼此独立的基团是氢，羟基，C 1 -C 30烷基，C 1 -C 30烯基，R 5是氢; 或C 1 -C 5烷基; m1为0或1; n1为1〜5。新化合物适合作为化妆品UV-A吸收剂。

公开(公告)号：US20090124576A1

公开(公告)日：2009-05-14

申请号：US12227042

申请日：2007-05-02

申请人： Thomas Ehlis ,  Elek Borsos

发明人： Thomas Ehlis ,  Elek Borsos

IPC分类号： A61K8/49 ,  C07D403/14 ,  C07D403/12 ,  A61K8/58

CPC分类号： C07D251/52 ,  C07D251/70

摘要： Disclosed are triazine derivatives of formula X1 is a bivalent radical of formula A and A′ independently from each other are unsubstituted or substituted, straight-chain or branched C1-C12alkylene, which is optionally interrupted by C5-C12cycloalkylene, N, O or S; C5-C12cycloalkylene; biphenylene; C6-C10arylene; or C5-C10arylene-(C1-C12alkylene); R1 is a radical of formula R2 and R3 independently from each other are hydrogen; C1-C12alkyl; OR7; NR7R8; C6-C10aryl; X2 is O, or NH; W1 is C1-C20alkyl; or a group Sp-Sil; Sp is a straight-chain or branched saturated or single or multiple unsaturated C3-C12 hydrocarbon; Sil is a silane; an oligosiloxane; or a polysiloxane moiety; and R4, R5 R6, R7, R8 and R9 independently from each other are hydrogen; C1-C12alkyl; or C3-C12cycloalkyl.

摘要翻译： 公开了式X1的三嗪衍生物是式A的二价基团，A'彼此独立地是未取代或取代的直链或支链C 1 -C 12亚烷基，其任选被C 5 -C 12亚环烷基，N，O或S中断; C5-C12环亚烷基; 联苯; C6-C10亚芳基 或C 5 -C 10亚芳基 - （C 1 -C 12亚烷基）; R1是式R2和R3的基团彼此独立地是氢; C 1 -C 12烷基; OR7; NR7R8; C6-C10芳基; X2是O或NH; W1是C1-C20烷基; 或一组Sp-Sil; Sp是直链或支链饱和或单或多不饱和C 3 -C 12烃; 硅是硅烷; 低聚硅氧烷; 或聚硅氧烷部分; R 4，R 5，R 6，R 7，R 8和R 9彼此独立地为氢; C 1 -C 12烷基; 或C 3 -C 12环烷基。

公开(公告)号：US07344706B2

公开(公告)日：2008-03-18

申请号：US10507295

申请日：2003-03-04

申请人： Jürg Haase ,  Thomas Ehlis ,  Elek Borsos ,  Dietmar Hüglin ,  Bernd Herzog

发明人： Jürg Haase ,  Thomas Ehlis ,  Elek Borsos ,  Dietmar Hüglin ,  Bernd Herzog

IPC分类号： A61Q17/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61K8/02 ,  A61K31/53

CPC分类号： A61K8/4966 ,  A61Q17/04

摘要： UV absorber compositions are described, comprising (a) from 1 to 99% by weight of a hydroxyphenyltriazine compound of formula (I) wherein R1, R2 and R3 are each independently of the others C1-C18alkyl; C2-C10,alkenyl; or phenyl-C1-C4 alkyl; R4 is hydrogen; or C1-C5alkyl; and (b) from 99 to 1% by weight of a further UV absorber selected from the group of (b) hydroxyphenyltriazines that are different from component (a), (b2) benzotriazoles, (b3) dibenzoylmethane derivatives and (b4) camphor derivatives. The compositions are suitable as UV filters in cosmetic compositions

摘要翻译： 描述了UV吸收剂组合物，其包含（a）1至99重量％的式（I）的羟基苯基三嗪化合物，其中R 1，R 2和R 2 > 3 各自独立地为C 1 -C 12烷基; C 2 -C 10，烯基; 或苯基-C 1 -C 4烷基; R 4是氢; 或C 1 -C 5烷基; （b）99〜1重量％的另外的紫外线吸收剂，其选自（b）不同于组分（a），（b-2）苯并三唑的（b）羟基苯基三嗪，（b < （3/4）二苯甲酰甲烷衍生物和（b 4 S）樟脑衍生物。 该组合物适用于化妆品组合物中的UV过滤器

公开(公告)号：US20060018846A1

公开(公告)日：2006-01-26

申请号：US10537940

申请日：2003-12-03

申请人： Jurg Haase ,  Thomas Ehlis ,  Elek Borsos ,  Stefan Muller

发明人： Jurg Haase ,  Thomas Ehlis ,  Elek Borsos ,  Stefan Muller

IPC分类号： C07D417/02 ,  C07D405/02 ,  A61K8/49

CPC分类号： C07D295/192 ,  A61K8/42 ,  A61K8/44 ,  A61K8/49 ,  A61K8/4973 ,  A61Q17/04 ,  C07C229/52 ,  C07C237/32 ,  C07C237/34 ,  C07C237/40 ,  C07C237/42 ,  C07D277/46 ,  C07D277/66 ,  C07D313/12

摘要： Described are amino substituted hydroxyphenyl benzophenone derivatives of formula (I), wherein R1, and R2 independently from each other are; C1-C20alkyl; C2-C20-alkenyl; C3-C10cycloalkyl; C3-C10cycloalkenyl; or R1, and R2 together with the linking nitrogen atom form a 5- or 6-membered heterocyclic ring; n1 is a number from 1 to 4; when n1=1, R3 is a saturated or unsaturated heterocyclic radical; hydroxy-C1-C5alkyl; cyclohexyl optionally substituted with one or more C1-C5alkyl; phenyl optionally substituted with a heterocyclic radical, aminocarbonyl or C1-C5alkylcarboxy; when n1 is 2, R3 is an alkylene-, cycloalkylene- or alkenylene radical which is optionally substituted by a carbonyl- or carboxy group; o R3 together with A forms a bivalent radical of the formula (Ia), wherein n2 is a number from 1 to 3; when n1 is 3, R3 is an alkanetriyl radical; when n1 is 4, R3 is an alkanetetrayl radical; A is —O—; or —N(R5)—; and R5 is hydrogen; C1-C5alkyl; or hydroxy-C1-C5alkyl. The compounds are useful as UV filters in sunscreen applications.

摘要翻译： 描述了式（I）的氨基取代的羟基苯基二苯甲酮衍生物，其中R 1和R 2彼此独立地为： C 1 -C 20烷基; C 1 -C 20烷基; C 2 -C 20 - 烯基; C 3 -C 10环烷基; C 3 -C 10环烯基; 或R 1和R 2与连接氮原子一起形成5-或6-元杂环; n 1是1至4的数; 当n 1 = 1时，R 3 3是饱和或不饱和杂环基; 羟基-C 1 -C 5烷基; 任选被一个或多个C 1 -C 5烷基取代的环己基; 任选被杂环基取代的苯基，氨基羰基或C 1 -C 5烷基羧基; 当n 1是2时，R 3是任选被羰基或羧基取代的亚烷基 - 亚环烷基 - 或亚烯基; R 3与A一起形成式（Ia）的二价基团，其中n 2是1至3的数; 当n 1为3时，R 3为烷三基; 当n 1为4时，R 3为烷基乙酰基; A为-O- 或-N（R 5） - ; 并且R 5是氢; C 1 -C 5烷基; 或羟基-C 1 -C 5烷基。 这些化合物可用作防晒霜中的紫外线过滤器。

公开(公告)号：US08444879B2

公开(公告)日：2013-05-21

申请号：US12227042

申请日：2007-05-02

申请人： Thomas Ehlis ,  Elek Borsos

发明人： Thomas Ehlis ,  Elek Borsos

IPC分类号： C07D251/52 ,  C07D251/70 ,  C07D403/12 ,  C07D403/14 ,  A61Q17/04 ,  A61K8/49

CPC分类号： C07D251/52 ,  C07D251/70

摘要： Disclosed are triazine derivatives of formula wherein X1 is a bivalent radical of formula A and A′ independently from each other are unsubstituted or substituted, straight-chain or branched C1-C12alkylene, which is optionally interrupted by C5-C12cycloalkylene, N, O or S; C5-C12cycloalkylene; biphenylene; C6-C10arylene; or C5-C10arylene-(C1-C12alkylene); R1 is a radical of formula R2 and R3 independently from each other are hydrogen; C1-C12alkyl; OR7; NR7R8; C6-C10aryl; X2 is O, or NH; W1 is C1-C20alkyl; or a group Sp-Sil; Sp is a straight-chain or branched saturated or single or multiple unsaturated C3-C12 hydrocarbon; Sil is a silane; an oligosiloxane; or a polysiloxane moiety; and R4, R5 R6, R7, R8 and R9 independently from each other are hydrogen; C1-C12alkyl; or C3-C12cycloalkyl.

摘要翻译： 公开了下式的三嗪衍生物其中X1是式A的二价基团，A'彼此独立地是未取代或取代的直链或支链C 1 -C 12亚烷基，其任选地被C 5 -C 12亚环烷基，N，O或S ; C5-C12环亚烷基; 联苯; C6-C10亚芳基 或C 5 -C 10亚芳基 - （C 1 -C 12亚烷基）; R1是式R2和R3的基团彼此独立地是氢; C 1 -C 12烷基; OR7; NR7R8; C6-C10芳基; X2是O或NH; W1是C1-C20烷基; 或一组Sp-Sil; Sp是直链或支链饱和或单或多不饱和C 3 -C 12烃; 硅是硅烷; 低聚硅氧烷 或聚硅氧烷部分; R 4，R 5，R 6，R 7，R 8和R 9彼此独立地为氢; C 1 -C 12烷基; 或C 3 -C 12环烷基。

公开(公告)号：US07374749B2

公开(公告)日：2008-05-20

申请号：US10537940

申请日：2003-12-03

申请人： Jürg Haase ,  Thomas Ehlis ,  Elek Borsos ,  Stefan Müller

发明人： Jürg Haase ,  Thomas Ehlis ,  Elek Borsos ,  Stefan Müller

IPC分类号： A61K8/44 ,  A61K8/49 ,  C07D277/66 ,  C07D313/12 ,  C07C233/73 ,  C07C233/69 ,  C07C233/78 ,  C07C229/52

CPC分类号： C07D295/192 ,  A61K8/42 ,  A61K8/44 ,  A61K8/49 ,  A61K8/4973 ,  A61Q17/04 ,  C07C229/52 ,  C07C237/32 ,  C07C237/34 ,  C07C237/40 ,  C07C237/42 ,  C07D277/46 ,  C07D277/66 ,  C07D313/12

摘要： Described are amino substituted hydroxyphenyl benzophenone derivatives of formula (I), wherein R1, and R2 independently from each other are; C1-C20alkyl; C2-C20-alkenyl; C3-C10cycloalkyl; C3-C10cycloalkenyl; or R1, and R2 together with the linking nitrogen atom form a 5- or 6-membered heterocyclic ring; n1 is a number from 1 to 4; when n1=1, R3 is a saturated or unsaturated heterocyclic radical; hydroxy-C1-C5alkyl; cyclohexyl optionally substituted with one or more C1-C5alkyl; phenyl optionally substituted with a heterocyclic radical, aminocarbonyl or C1-C5alkylcarboxy; when n1 is 2, R3 is an alkylene-, cycloalkylene- or alkenylene radical which is optionally substituted by a carbonyl- or carboxy group; o R3 together with A forms a bivalent radical of the formula (Ia), wherein n2 is a number from 1 to 3; when n1 is 3, R3 is an alkanetriyl radical; when n1 is 4, R3 is an alkanetetrayl radical; A is —O—; or —N(R5)—; and R5 is hydrogen; C1-C5alkyl; or hydroxy-C1-C5alkyl. The compounds are useful as UV filters in sunscreen applications.

摘要翻译： 描述了式（I）的氨基取代的羟基苯基二苯甲酮衍生物，其中R 1和R 2彼此独立地是; C 1 -C 20烷基; C 1 -C 20烷基; C 2 -C 20 - 烯基; C 3 -C 10环烷基; C 3 -C 10环烯基; 或R 1和R 2与连接氮原子一起形成5-或6-元杂环; n 1是1至4的数; 当n 1 = 1时，R 3 3是饱和或不饱和杂环基; 羟基-C 1 -C 5烷基; 任选被一个或多个C 1 -C 5烷基取代的环己基; 任选被杂环基取代的苯基，氨基羰基或C 1 -C 5烷基羧基; 当n 1是2时，R 3是任选被羰基或羧基取代的亚烷基 - 亚环烷基 - 或亚烯基; R 3与A一起形成式（Ia）的二价基团，其中n 2是1至3的数; 当n 1为3时，R 3为烷三基; 当n 1为4时，R 3为烷基乙酰基; A为-O- 或-N（R 5） - ; 并且R 5是氢; C 1 -C 5烷基; 或羟基-C 1 -C 5烷基。 这些化合物可用作防晒霜中的紫外线过滤器。

公开(公告)号：US08187575B2

公开(公告)日：2012-05-29

申请号：US10542467

申请日：2004-01-13

申请人： Thomas Ehlis ,  Dietmar Hüglin ,  Elek Borsos

发明人： Thomas Ehlis ,  Dietmar Hüglin ,  Elek Borsos

IPC分类号： A61K8/49 ,  C07D403/02 ,  C07D251/18

CPC分类号： C07D251/18 ,  C07D251/20

摘要： The present invention relates to new compounds of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, and R8 independently from each other are hydrogen; C1-C18alkyl; C2-C18alkenyl; C5-C7, cycloalkyl; C1-C6alkylene-C5-C7, cycloalkyl; R9 is hydrogen; C1-C18alkyl; C2-C18alkenyl; C5-C7cycloalkyl; C1-C6alkylene-C5-C7cycloalkyl; C6-C10aryl; A is —S—; —O— or —NR10—, wherein R10 has the same meanings as R9; X is COOR11; CONR12R13; SO3, R14; or SO2NR15R16, wherein R11, R12, R13, R14, R15, and R16, have independently from each other the same meanings as R9; to their preparation and to their use as UV absorbers in cosmetic and pharmaceutical formulations.

摘要翻译： 本发明涉及新的式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8彼此独立地是氢; C1-C18烷基; C 2 -C 18烯基; C5-C7，环烷基; C 1 -C 6亚烷基-C 5 -C 7，环烷基; R9是氢; C1-C18烷基; C 2 -C 18烯基; C5-C7环烷基; C 1 -C 6亚烷基-C 5 -C 7环烷基; C6-C10芳基; A是-S-; -O-或-NR 10 - ，其中R 10具有与R 9相同的含义; X为COOR11; CONR12R13; SO3，R14; 或SO 2 NR 15 R 16，其中R 11，R 12，R 13，R 14，R 15和R 16彼此独立地为与R 9相同的含义; 用于制备和用作化妆品和药物制剂中的UV吸收剂。

公开(公告)号：US20050214233A1

公开(公告)日：2005-09-29

申请号：US11133532

申请日：2005-05-20

申请人： Dietmar Huglin ,  Thomas Ehlis ,  Erich Kramer ,  Joseph Lupia ,  Oliver Reich

发明人： Dietmar Huglin ,  Thomas Ehlis ,  Erich Kramer ,  Joseph Lupia ,  Oliver Reich

IPC分类号： A61K8/49 ,  A61Q1/02 ,  A61Q1/06 ,  A61Q1/08 ,  A61Q1/10 ,  A61Q3/02 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q9/02 ,  A61Q13/00 ,  A61Q15/00 ,  C11D3/28 ,  C11D3/42 ,  A61K7/42

CPC分类号： C11D3/28 ,  A61K8/496 ,  A61K8/4966 ,  A61K2800/52 ,  A61Q1/02 ,  A61Q1/06 ,  A61Q1/08 ,  A61Q1/10 ,  A61Q3/02 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q9/02 ,  A61Q13/00 ,  A61Q15/00

摘要： A description is given of the use of light stabilizers of formulae (1) and/or (2) for protecting body-care and household products from photolytic degradation.

摘要翻译： 给出了使用式（1）和/或（2）的光稳定剂用于保护身体护理和家用产品免受光解降解的描述。