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公开(公告)号：US5286837A
公开(公告)日：1994-02-15
申请号：US986665
申请日：1992-12-08
IPC分类号： A61L27/00 , A61L17/10 , A61L31/06 , C08G63/685 , C08G69/44 , C08G69/46 , C08G69/48 , C08J3/00 , C08L77/00 , C08L77/12 , C08G73/10 , C08G63/68
摘要： Process for treating poly(esteramides) to improve the heat and storage stability thereof. Polymer is optionally suspended in a liquid medium, treated with an amide group-containing solvent, and then separated from the solvent and liquid medium (if any). Also, poly(esteramides) treated in this process and devices and articles comprising such poly(esteramides).
摘要翻译： 用于处理聚（酯酰胺）以改进其热和储存稳定性的方法。 将聚合物任选地悬浮在液体介质中，用含酰胺基的溶剂处理，然后从溶剂和液体介质（如果有的话）中分离。 此外，在该方法中处理的聚（酯酰胺）和包含这种聚（酯酰胺）的装置和制品。
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公开(公告)号：US5502092A
公开(公告)日：1996-03-26
申请号：US198906
申请日：1994-02-18
CPC分类号： A61L27/56 , A61L27/18 , C08L67/04 , Y10S977/795
摘要： A process for forming biocompatible porous matrices of bioabsorbable materials comprising:a) providing a bioabsorbable polymer;b) dissolving the bioabsorbable polymer in a volumetric orientation aid to yield a molten solution;c) solidifying the molten solution to yield an orientation matrix comprising first and second phases, the first phase being the bioabsorbable polymer and the second phase being the volumetric orientation aid; andd) removing the volumetric orientation aid while the solution is solid; to yield a biocompatible matrix of bioabsorbable polymer. Also matrices formed by the process and devices made with such matrices.
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公开(公告)号：US5856367A
公开(公告)日：1999-01-05
申请号：US574679
申请日：1995-12-19
CPC分类号： A61L27/56 , A61L27/18 , C08L67/04 , Y10S977/795
摘要： A process for forming biocompatible porous matrices of bioabsorbable materials comprising:a) providing a bioabsorbable polymer;b) dissolving the bioabsorbable polymer in a volumetric orientation aid to yield a molten solution;c) solidifying the molten solution to yield an orientation matrix comprising first and second phases, the first phase being the bioabsorbable polymer and the second phase being the volumetric orientation aid; andd) removing the volumetric orientation aid while the solution is solid; to yield a biocompatible matrix of bioabsorbable polymer. Also matrices formed by the process and devices made with such matrices.
摘要翻译： 一种用于形成生物可吸收材料的生物相容多孔基质的方法，包括：a）提供生物可吸收聚合物; b）将生物可吸收聚合物溶解在体积取向助剂中以产生熔融溶液; c）固化熔融溶液以产生包含第一和第二相的取向基质，第一相为生物可吸收聚合物，第二相为体积取向助剂; 和d）当溶液是固体时，去除体积取向助剂; 以产生生物可吸收聚合物的生物相容性基质。 还由通过这些矩阵制造的工艺和器件形成的矩阵。
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公开(公告)号：USRE38158E1
公开(公告)日：2003-06-24
申请号：US09185732
申请日：1998-11-04
IPC分类号： A61K3800
CPC分类号： A61L24/043 , A61L24/046 , A61L24/10 , A61L24/106 , C09J189/00 , Y10S530/83 , C08L89/00
摘要： This invention is related to an adhesive composition which may be used to bond or seal tissue in vivo. The adhesive composition is readily formed from a two component mixture which includes a first part of a protein, preferably a serum albumin protein, in an aqueous buffer having a pH in the range of about 8.0-11.0 and a second part of a water-compatible or water-soluble bifunctional crosslinking agent. When the two parts of the mixture are combined, the mixture is initially a liquid which cures in vivo on the surface of tissue in less than about one minute to give a strong, flexible, pliant substantive composition which bonds to the tissue and is absorbed in about four to sixty days. The adhesive composition may be used either to bond tissue, to seal tissue or to prevent tissue adhesions caused by surgery.
摘要翻译： 本发明涉及可用于在体内粘合或密封组织的粘合剂组合物。 粘合剂组合物容易地由包含蛋白质的第一部分，优选血清白蛋白的双组分混合物形成，所述第一部分混合物在pH为约8.0-11.0的水性缓冲液中，第二部分为水相容性 或水溶性双功能交联剂。 当混合物的两部分组合时，混合物最初是在小于约1分钟内在组织表面上体内固化的液体，以产生结合到组织上并被吸收的强的，柔性的，柔韧的，完整的组合物 约四六十天。 粘合剂组合物可以用于粘合组织，以密封组织或防止由手术引起的组织粘连。
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公开(公告)号：USRE38827E1
公开(公告)日：2005-10-11
申请号：US10293989
申请日：2002-11-14
IPC分类号： A61L24/04 , C09J189/00 , A61K38/00 , A61K39/00 , C07K1/00
CPC分类号： C09J189/00 , A61L24/043 , A61L24/046 , C08L89/00
摘要： This invention is related to an adhesive composition which may be used to bond or seal tissue in vivo. The adhesive composition is readily formed from a two component mixture which includes a first part of a protein, preferably a serum albumin protein, in an aqueous buffer having a pH in the range of about 8.0-11.0 and a second part of a water-compatible or water-soluble bifunctional crosslinking agent. When the two parts of the mixture are combined, the mixture is initially a liquid which cures in vivo on the surface of tissue in less than about one minute to give a strong, flexible, pliant substantive composition which bonds to the tissue and is absorbed in about four to sixty days. The adhesive composition may be used either to bond tissue, to seal tissue or to prevent tissue adhesions caused by surgery.
摘要翻译： 本发明涉及可用于在体内粘合或密封组织的粘合剂组合物。 粘合剂组合物容易地由包含蛋白质的第一部分，优选血清白蛋白的双组分混合物形成，所述第一部分混合物在pH为约8.0-11.0的水性缓冲液中，第二部分为水相容性 或水溶性双功能交联剂。 当混合物的两部分组合时，混合物最初是在小于约1分钟内在组织表面上体内固化的液体，以产生结合到组织上并被吸收的强的，柔性的，柔韧的，完整的组合物 约四六十天。 粘合剂组合物可以用于粘合组织，以密封组织或防止由手术引起的组织粘连。
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公开(公告)号：US5583114A
公开(公告)日：1996-12-10
申请号：US281473
申请日：1994-07-27
CPC分类号： A61L24/043 , A61L24/046 , A61L24/10 , A61L24/106 , C09J189/00 , Y10S530/83
摘要： This invention is related to an adhesive composition which may be used to bond or seal tissue in vivo. The adhesive composition is readily formed from a two component mixture which includes a first part of a protein, preferably a serum albumin protein, in an aqueous buffer having a pH in the range of about 8.0-11.0 and a second part of a water-compatible or water-soluble bifunctional crosslinking agent. When the two parts of the mixture are combined, the mixture is initially a liquid which cures in vivo on the surface of tissue in less than about one minute to give a strong, flexible, pliant substantive composition which bonds to the tissue and is absorbed in about four to sixty days. The adhesive composition may be used either to bond tissue, to seal tissue or to prevent tissue adhesions caused by surgery.
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公开(公告)号：US08124096B2
公开(公告)日：2012-02-28
申请号：US12309778
申请日：2007-07-13
CPC分类号： A61L2/0011 , A61K31/4375 , A61K31/4745 , Y02A50/409
摘要： A pharmaceutical composition comprising 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine that is stable to sterilization and suitable for topical application directly to tissue sites where the dermis has been breached, and has been sterilized, packaged compositions that have been sterilized, and methods of sterilizing these compositions are disclosed.
摘要翻译： 一种药物组合物，其包含对灭菌稳定并适于直接局部施用真皮已被破坏的组织部位的1-（2-甲基丙基）-1H-咪唑并[4,5-c]喹啉-4-胺，并具有 已经灭菌，已经灭菌的包装组合物和这些组合物灭菌的方法。
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8.发明授权Delivery systems using preformed biodegradable polymer compositions and methods 有权使用预制的生物可降解聚合物组合物和方法的递送系统公开(公告)号：US06576263B2
公开(公告)日：2003-06-10
申请号：US09784934
申请日：2001-02-16
申请人： Myhanh T. Truong , Kaveh Pournoor , Hye-ok Choi , David J. Velasquez , Richard H. Ferber , Stephanie F. Bernatchez
发明人： Myhanh T. Truong , Kaveh Pournoor , Hye-ok Choi , David J. Velasquez , Richard H. Ferber , Stephanie F. Bernatchez
IPC分类号： A61K914
CPC分类号： C08G65/329 , A61K9/1658 , A61K9/2063 , A61K47/643 , A61K47/65
摘要： A preformed object for delivering an active agent for a subject, the preformed object including crosslinked protein, and methods of making and using.
摘要翻译： 用于递送受试者的活性剂的预成型物体，所述预成型物体包括交联的蛋白质，以及制备和使用方法。
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公开(公告)号：US08304454B2
公开(公告)日：2012-11-06
申请号：US12329947
申请日：2008-12-08
申请人： Myhanh T. Truong
发明人： Myhanh T. Truong
IPC分类号： A61K31/155
摘要： Biguanide bonded within a cellulose sponge inhibits or prevents the growth of microorganisms such as bacteria, mold, and fungus within the cellulose sponge over the useful life of the cellulose sponge.
摘要翻译： 粘合在纤维素海绵中的双胍在纤维素海绵的使用寿命内抑制或阻止纤维素海绵内微生物如细菌，霉菌和真菌的生长。
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公开(公告)号：USD641527S1
公开(公告)日：2011-07-12
申请号：US29361294
申请日：2010-05-10
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