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1.发明授权公开(公告)号：US08267905B2
公开(公告)日：2012-09-18
申请号：US11414543
申请日：2006-05-01
CPC分类号： A61M5/14276 , A61M5/165 , A61M39/0208 , A61M39/04 , A61M39/10 , A61M39/105 , A61M2005/14513 , A61M2039/0211 , A61M2039/0241 , A61M2205/054 , A61M2205/3331 , A61M2205/3382 , A61M2205/7518 , A61M2210/0662 , A61M2210/0687 , A61N1/0529 , A61N1/0541
摘要： Implantable drug delivery systems target delivery of small volumes of drugs to specific tissues. In some cases, a drug delivery system includes an implantable osmotic pump connected to a drug-containing housing, with that housing connected to a needle, cochlear implant or other type of component for ultimate delivery to the target tissue. In some implementations, a subcutaneous port receives a fluid from an external pump. The port is connected to a needle or other component for delivery of one or more drugs to the target tissue. Both solid and liquid drug formulations can be used. In embodiments using solid drugs, a separate drug vehicle (such as saline) can be used to dissolve a portion of the solid drug, with the drug-loaded vehicle then delivered to the target tissue.
摘要翻译： 可植入药物递送系统将小量药物递送到特定组织。 在一些情况下，药物递送系统包括连接到含药物的壳体的可植入渗透泵，其中该壳体连接到针，人工耳蜗植入物或其它类型的组件以最终输送到靶组织。 在一些实施方案中，皮下端口从外部泵接收流体。 端口连接到针或其他部件，用于将一种或多种药物递送至靶组织。 可以使用固体和液体药物制剂。 在使用固体药物的实施方案中，可以使用单独的药物载体（例如盐水）来溶解一部分固体药物，然后将药物载体递送至靶组织。
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公开(公告)号：US08298176B2
公开(公告)日：2012-10-30
申请号：US12839003
申请日：2010-07-19
CPC分类号： A61M5/1409 , A61M5/14276 , A61M39/0208 , A61M39/04
摘要： Drug solutions (or other combinations of vehicle with entrained drug) are prepared by removing drug from one or more masses of a solid form of the drug. The solid form of the drug may be sparingly soluble or insoluble in water. Examples of devices for holding solid drug and facilitating delivery of such drug to targeted regions are also described.
摘要翻译： 通过从一种或多种固体形式的药物中除去药物来制备药物溶液（或其他携带药物的组合）。 药物的固体形式可能是微溶或不溶于水。 还描述了用于保持固体药物并便于将药物递送至目标区域的装置的实例。
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公开(公告)号：US20110071493A1
公开(公告)日：2011-03-24
申请号：US12839003
申请日：2010-07-19
IPC分类号： A61M5/00
CPC分类号： A61M5/1409 , A61M5/14276 , A61M39/0208 , A61M39/04
摘要： Drug solutions (or other combinations of vehicle with entrained drug) are prepared by removing drug from one or more masses of a solid form of the drug. The solid form of the drug may be sparingly soluble or insoluble in water. Examples of devices for holding solid drug and facilitating delivery of such drug to targeted regions are also described.
摘要翻译： 通过从一种或多种固体形式的药物中除去药物来制备药物溶液（或其他携带药物的组合）。 药物的固体形式可能是微溶或不溶于水。 还描述了用于保持固体药物并便于将药物递送至目标区域的装置的实例。
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公开(公告)号：US20070287984A1
公开(公告)日：2007-12-13
申请号：US11759387
申请日：2007-06-07
IPC分类号： A61B19/00
CPC分类号： A61M5/1409 , A61M5/14276 , A61M39/0208 , A61M39/04
摘要： Drug solutions (or other combinations of vehicle with entrained drug) are prepared by removing drug from one or more masses of a solid form of the drug. The solid form of the drug may be sparingly soluble or insoluble in water. Examples of devices for holding solid drug and facilitating delivery of such drug to targeted regions are also described.
摘要翻译： 通过从一种或多种固体形式的药物中除去药物来制备药物溶液（或其他携带药物的组合）。 药物的固体形式可能是微溶或不溶于水。 还描述了用于保持固体药物并便于将药物递送至目标区域的装置的实例。
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公开(公告)号：US07803148B2
公开(公告)日：2010-09-28
申请号：US11759387
申请日：2007-06-07
CPC分类号： A61M5/1409 , A61M5/14276 , A61M39/0208 , A61M39/04
摘要： Drug solutions (or other combinations of vehicle with entrained drug) are prepared by removing drug from one or more masses of a solid form of the drug. The solid form of the drug may be sparingly soluble or insoluble in water. Examples of devices for holding solid drug and facilitating delivery of such drug to targeted regions are also described.
摘要翻译： 通过从一种或多种固体形式的药物中除去药物来制备药物溶液（或其他携带药物的组合）。 药物的固体形式可能是微溶或不溶于水。 还描述了用于保持固体药物并便于将药物递送至目标区域的装置的实例。
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公开(公告)号：US20080152694A1
公开(公告)日：2008-06-26
申请号：US11780853
申请日：2007-07-20
IPC分类号： A61K9/00 , A61K9/14 , A61K31/4523 , A61P27/02
CPC分类号： A61F9/0017 , A61K9/0051 , A61M5/14276 , A61M5/385 , A61M25/0029 , A61M2005/14513 , A61M2025/0034 , A61M2025/0037 , A61M2205/7518 , A61N1/36046
摘要： Devices, systems and techniques for delivering drugs to an ocular tissue are described. In at least some embodiments, a terminal component (e.g., a needle or open end of a catheter) is implanted in an ocular tissue and used to deliver one or more drugs. The delivered drugs may come from a source which is also implanted, or may be introduced from an external source (e.g., via a port). Both solid and liquid drug formulations can be used. Ocular implants can alternatively include a thin film coating that releases a drug into an ocular tissue.
摘要翻译： 描述了将药物递送到眼组织的装置，系统和技术。 在至少一些实施例中，终端组件（例如，导管的针或开放端）植入眼组织中并用于递送一种或多种药物。 所递送的药物可以来自也植入或可以从外部来源（例如经由端口）引入的源。 可以使用固体和液体药物制剂。 眼部植入物可以替代地包括将药物释放到眼组织中的薄膜包衣。
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公开(公告)号：US20080145439A1
公开(公告)日：2008-06-19
申请号：US11831230
申请日：2007-07-31
IPC分类号： A61K9/51 , A61K31/4535 , B01F11/00
CPC分类号： A61K9/10 , A61K9/5153 , A61K9/5192
摘要： A suspension of nanoparticles in a liquid medium provides a mechanism for delivery of gacyclidine base or other drug that is substantially insoluble in the liquid medium.
摘要翻译： 纳米颗粒在液体介质中的悬浮液提供用于递送基本上不溶于液体培养基的格列替丁碱或其它药物的机制。
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公开(公告)号：US20080065002A1
公开(公告)日：2008-03-13
申请号：US11850156
申请日：2007-09-05
IPC分类号： A61N1/30
CPC分类号： A61M25/0068 , A61M25/003 , A61M25/007 , A61M25/0074 , A61M25/008 , A61M25/0082 , A61M2025/0037 , A61M2025/004 , A61M2025/0073 , A61M2025/0085 , A61N1/30 , A61N1/36036
摘要： A drug-compatible, biocompatible, drug-delivery catheter can include multi-lumen tubing attached to an end fitting, with the end fitting having an internal fluid chamber and a fluid exit region. The catheter can also include multi-lumen tubing having one or more needles attached at a distal end.
摘要翻译： 药物相容的，生物相容的药物递送导管可以包括连接到端部配件的多腔管，其中端部配件具有内部流体室和流体出口区域。 导管还可以包括具有连接在远端的一个或多个针的多腔管。
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公开(公告)号：US20140235717A1
公开(公告)日：2014-08-21
申请号：US14184046
申请日：2014-02-19
申请人： John V. Schloss
发明人： John V. Schloss
IPC分类号： A61K31/197 , A23L1/305 , A23C9/152
CPC分类号： A61K31/197 , A23C9/1526 , A23C19/054 , A23G9/38 , A23L13/428 , A23L33/175 , A23L33/19 , A23V2002/00 , A23V2250/0632 , A23V2250/0616
摘要： A method is provided for the supplementation of milk, dairy products, meat products, and other food substances generally considered to be a major part of the Western diet, with substances capable of balancing the ratio of methionine and cysteine. Drug therapy with various carbamoyl thioesters or glutamate receptor antagonists can also be used, alone or in combination with dietary supplements and vitamins, to prevent or treat the pathology resulting from a Western diet.
摘要翻译： 提供了一种补充牛奶，乳制品，肉制品和通常被认为是西方饮食主要部分的其他食物的方法，能够平衡甲硫氨酸和半胱氨酸的比例的物质。 也可以单独或与膳食补充剂和维生素组合使用各种氨基甲酰硫酯或谷氨酸受体拮抗剂的药物治疗，以预防或治疗西方饮食引起的病理。
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公开(公告)号：US20130102624A1
公开(公告)日：2013-04-25
申请号：US13475260
申请日：2012-05-18
申请人： John V. Schloss
发明人： John V. Schloss
IPC分类号： H01J49/00
CPC分类号： H01J49/0027 , G01N33/82 , H01J49/004 , G01N2030/8813 , G01N30/7233
摘要： A method is provided for determining the thiamine status of a human or animal based on the relative levels of thiamine and its metabolites. Certain embodiments of the present invention also provide methods for determining the effectiveness of a thiamine deficiency treatment.
摘要翻译： 提供了一种基于硫胺素及其代谢物的相对水平来测定人或动物的硫胺素状态的方法。 本发明的某些实施方案还提供了确定硫胺素缺乏症治疗的有效性的方法。
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