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公开(公告)号：US06180352B2
公开(公告)日：2001-01-30
申请号：US09459191
申请日：1999-12-10
IPC分类号： C12Q168
CPC分类号： C07H21/00 , C07H23/00 , C12Q1/6818 , C12Q1/6825 , Y02A50/52 , C12Q2565/607 , C12Q2565/401 , C12Q2563/137 , C12Q2563/113 , C12Q2565/101 , C12Q2565/1015
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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公开(公告)号：US06277576B1
公开(公告)日：2001-08-21
申请号：US09306768
申请日：1999-05-07
IPC分类号： C12Q168
CPC分类号： C07H21/00 , C07H23/00 , C12Q1/6818 , C12Q1/6825 , Y02A50/52 , C12Q2565/607 , C12Q2565/401 , C12Q2563/137 , C12Q2563/113 , C12Q2565/101 , C12Q2565/1015
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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公开(公告)号：US06268150B1
公开(公告)日：2001-07-31
申请号：US09459751
申请日：1999-12-10
IPC分类号： C12Q168
CPC分类号： C07H21/00 , C07H23/00 , C12Q1/6818 , C12Q1/6825 , Y02A50/52 , C12Q2565/607 , C12Q2565/401 , C12Q2563/137 , C12Q2563/113 , C12Q2565/101 , C12Q2565/1015
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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公开(公告)号：US06238870B1
公开(公告)日：2001-05-29
申请号：US09458187
申请日：1999-12-08
IPC分类号： C12Q168
CPC分类号： C07H21/00 , C07H23/00 , C12Q1/6818 , C12Q1/6825 , Y02A50/52 , C12Q2565/607 , C12Q2565/401 , C12Q2563/137 , C12Q2563/113 , C12Q2565/101 , C12Q2565/1015
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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公开(公告)号：US06232295B1
公开(公告)日：2001-05-15
申请号：US08321552
申请日：1994-10-12
IPC分类号： A61K4800
CPC分类号： A61K49/146 , A61K47/645 , A61K49/085 , Y10S977/808 , Y10S977/927 , Y10S977/93
摘要： A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a polymeric molecule having a net positive charge complexed with another polymeric molecule having a net negative charge. Cell targeting moieties and MRI contrast agents are attached to one or both of the polymeric molecules. In one embodiment, the polymeric molecule having a net negative charge is a nucleic acid. Thus, the delivery vehicles can be used in clinical protocols in which nucleic acids for gene therapy and agents for MRI contrast are co-transported to specific cells allowing medical imaging monitoring of nucleic acid delivery.
摘要翻译： 描述了能够特异性结合并进入目标细胞的递送载体，为细胞的磁共振成像（MRI）递送许多顺磁离子。 递送载体包含具有与具有净负电荷的另一个聚合物分子络合的净正电荷的聚合物分子。 细胞靶向部分和MRI造影剂连接到一个或两个聚合物分子。 在一个实施方案中，具有净负电荷的聚合物分子是核酸。 因此，递送载体可以用于其中用于基因治疗的核酸和用于MRI对比的药剂共同转运到特定细胞的临床方案，允许对核酸递送进行医学成像监测。
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公开(公告)号：US5780234A
公开(公告)日：1998-07-14
申请号：US709263
申请日：1996-09-06
IPC分类号： C12N15/09 , C07H21/00 , C07H23/00 , C12Q1/68 , G01N33/566 , C07H21/02 , C07H21/04 , C12Q1/70
CPC分类号： C07H23/00 , C07H21/00 , C12Q1/6818 , C12Q1/6825 , C12Q1/6827
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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公开(公告)号：US20100069624A1
公开(公告)日：2010-03-18
申请号：US12260933
申请日：2008-10-29
IPC分类号： C07H19/04
CPC分类号： C07H21/00 , C07H23/00 , C12Q1/6818 , C12Q1/6825 , Y02A50/52 , C12Q2565/607 , C12Q2565/401 , C12Q2563/137 , C12Q2563/113 , C12Q2565/101 , C12Q2565/1015
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
摘要翻译： 本发明提供了用氧化还原活性部分如过渡金属配合物选择性共价修饰核酸。 电子供体和电子受体部分在预定位置与核酸的核糖 - 磷酸骨架共价结合。 所得的复合物表示一系列新的衍生物，其是能够以非常快的速率在非常大的距离上转移电子的双分子模板。 这些复合物具有独特的结构特征，可以使用全新的生物传感器和光敏探针。
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公开(公告)号：US06200761B1
公开(公告)日：2001-03-13
申请号：US09454497
申请日：1999-12-06
IPC分类号： C12Q168
CPC分类号： C07H21/00 , C07H23/00 , C12Q1/6818 , C12Q1/6825 , Y02A50/52 , C12Q2565/607 , C12Q2565/401 , C12Q2563/137 , C12Q2563/113 , C12Q2565/101 , C12Q2565/1015
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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公开(公告)号：US5952172A
公开(公告)日：1999-09-14
申请号：US873598
申请日：1997-06-12
CPC分类号： C07H21/00 , C07H23/00 , C12Q1/6818 , C12Q1/6825
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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公开(公告)号：US06258545B1
公开(公告)日：2001-07-10
申请号：US09545227
申请日：2000-04-07
IPC分类号： C12Q168
CPC分类号： C12Q1/6825 , C07H21/00 , C07H23/00 , C12Q1/6818 , C12Q2563/113 , C12Q2565/101
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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