公开(公告)号：US20130237511A1

公开(公告)日：2013-09-12

申请号：US13418235

申请日：2012-03-12

申请人： Thomas J. Manning ,  Ryenne Nicole Ogburn ,  Kaitlyn Victoria Ledwitch ,  Dennis Ray Phillips ,  Gregory Page Wylie

发明人： Thomas J. Manning ,  Ryenne Nicole Ogburn ,  Kaitlyn Victoria Ledwitch ,  Dennis Ray Phillips ,  Gregory Page Wylie

IPC分类号： A61K31/555 ,  A61P35/00

CPC分类号： A61K31/555 ,  A61K47/55 ,  Y02A50/411

摘要： Methods for utilizing copper ions to bind to and help transport medicinal agents that contain a nitrogen atom or atoms are disclosed. The copper ion or ions serve as a delivery platform for a known pharmaceutical agent. The copper ions may be used to impact the polarity of the medicinal agents so they perform more efficiently in a physiological environment. The copper ions may also improve the efficacy of the drug by impacting their stability.

摘要翻译： 公开了利用铜离子结合并有助于运输含有氮原子或原子的药剂的方法。 铜离子或离子用作已知药剂的递送平台。 铜离子可用于影响药剂的极性，使得它们在生理环境中更有效地进行。 铜离子还可以通过影响其稳定性来改善药物的功效。

公开(公告)号：US6022456A

公开(公告)日：2000-02-08

申请号：US26835

申请日：1998-02-20

申请人： Thomas J. Manning

发明人： Thomas J. Manning

IPC分类号： C01B13/10 ,  C01B13/11 ,  B01J19/08

CPC分类号： C01B13/10 ,  C01B13/11 ,  C01B2201/50 ,  C01B2201/60 ,  C01B2201/80

摘要： A recirculating loop method for producing and/or using ozone is disclosed. The method comprises the steps of: supplying a gas mixture comprising oxygen and a catalyst, generating ozone from the gas mixture, and recirculating the gas mixture. In a preferred method, the method comprises the additional steps of: reacting the ozone with a chemically reactive species and adding sufficient oxygen to the oxygen and noble gas mixture to maintain the specific oxygen to noble gas ratio. Preferably, the ozone is generated by electrical discharge from oxygen and noble gas mixtures of a volume ratio of not greater than 9 to 1 oxygen to catalyst gas. The closed loop apparatus for generating ozone gas comprises: an electrical discharge chamber, a means for supplying oxygen to said electrical discharge chamber, a means for supplying a catalyst to said electrical discharge chamber, an application chamber connected to said electrical chamber, a means for supplying a chemically reactive species to said application chamber, a means for removing said chemically reactive species from said application chamber, a means for returning oxygen and the catalyst to said electrical discharge chamber.

摘要翻译： 公开了一种用于生产和/或使用臭氧的循环回路方法。 该方法包括以下步骤：提供包含氧和催化剂的气体混合物，从气体混合物产生臭氧，并再循环气体混合物。 在优选的方法中，该方法包括以下附加步骤：使臭氧与化学反应性物质反应，并向氧气和惰性气体混合物中加入足够的氧以将特定氧气保持为惰性气体比。 优选地，通过从不大于9至1个氧气的体积比与氧气和催化剂气体的氧气和惰性气体混合物的放电产生臭氧。 用于产生臭氧气体的闭环装置包括：放电室，用于向所述放电室供氧的装置，用于向所述放电室供应催化剂的装置，连接到所述电室的施加室，用于 向所述施用室供应化学反应性物质，用于从所述施用室除去所述化学反应物质的装置，用于将氧气和催化剂返回到所述放电室的装置。

公开(公告)号：US5625414A

公开(公告)日：1997-04-29

申请号：US380486

申请日：1995-01-30

申请人： Thomas J. Manning

发明人： Thomas J. Manning

IPC分类号： H01L29/762 ,  H01L21/339 ,  H04N5/335 ,  H04N3/14

CPC分类号： H04N3/1575 ,  H04N5/335

摘要： A charge transfer imager useful for charge summing includes a photosensitive area for producing image charge, a floating diffusion for converting the image charge to a voltage, an output register for transferring the image charge to the floating diffusion, and an output circuit including the floating diffusion for producing an output signal that contains image information as a function of the difference between a predetermined reference level and an image level, both levels characterized by respective relatively constant pedestal regions. The imager is part of an imaging device that includes a clock generator for generating a reset signal of predetermined frequency that resets the voltage level of the floating diffusion, and for generating a transport signal that is applied to the output register for shifting the image charge to the floating diffusion at a multiple of the reset clock frequency. By modifying the symmetry of the transitions of the transport signal waveform that cause shifting of the image charge, an asymmetrical pattern of transition is obtained which accordingly affects charge transfer and widens the pedestal regions of the output signal, making them more suitable for subsequent sampling pulse placement.

摘要翻译： 用于电荷求和的电荷转移成像器包括用于产生图像电荷的光敏区域，用于将图像电荷转换为电压的浮动扩散，用于将图像电荷转移到浮动扩散的输出寄存器，以及包括浮动扩散的输出电路 用于产生包含作为预定参考水平和图像水平之间的差的函数的图像信息的输出信号，两个水平由相应相对恒定的基座区域表征。 成像器是成像装置的一部分，其包括用于产生预定频率的复位信号的时钟发生器，其复位浮动扩散的电压电平，并且用于产生施加到输出寄存器以将图像电荷移位到 浮动扩散在复位时钟频率的倍数。 通过改变导致图像电荷偏移的传输信号波形的转变的对称性，获得了非对称的转变模式，这相应地影响电荷转移并且加宽了输出信号的基座区域，使得它们更适合于随后的采样脉冲 放置。

公开(公告)号：US5075691A

公开(公告)日：1991-12-24

申请号：US383473

申请日：1989-07-24

申请人： Oscar Garay ,  Quirino Balzano ,  Thomas J. Manning

发明人： Oscar Garay ,  Quirino Balzano ,  Thomas J. Manning

IPC分类号： H01Q1/38 ,  H01Q5/00 ,  H01Q5/01 ,  H01Q5/371 ,  H01Q9/04 ,  H01Q13/08 ,  H01Q21/30

CPC分类号： H01Q9/045 ,  H01Q5/371

摘要： A multi-resonant antenna is formed by a plurality of resonators which resonate at different frequencies. A feed member is coupled to the multi-resonant resonators. Disposed between and separating the resonators from the feed member is a dielectric substrate.

摘要翻译： 多谐振天线由以不同频率谐振的多个谐振器形成。 馈电元件耦合到多谐振谐振器。 将谐振器与馈电元件分开并将其分离的是电介质衬底。

公开(公告)号：US4968142A

公开(公告)日：1990-11-06

申请号：US360559

申请日：1989-06-02

申请人： Thomas J. Manning ,  Byron A. Palmer ,  Douglas E. Hof

发明人： Thomas J. Manning ,  Byron A. Palmer ,  Douglas E. Hof

IPC分类号： G01N21/73 ,  H05H1/46

CPC分类号： H05H1/46 ,  G01N21/73

摘要： A closed inductively coupled plasma cell generates a relatively high power, low noise plasma for use in spectroscopic studies. A variety of gases can be selected to form the plasma to minimize spectroscopic interference and to provide a electron density and temperature range for the sample to be analyzed. Grounded conductors are placed at the tube ends and axially displaced from the inductive coil, whereby the resulting electromagnetic field acts to elongate the plasma in the tube. Sample materials can be injected in the plasma to be excited for spectroscopy.

摘要翻译： 闭合的电感耦合等离子体单元产生用于光谱研究的较高功率的低噪声等离子体。 可以选择各种气体以形成等离子体以使分光干涉最小化，并为待分析的样品提供电子密度和温度范围。 接地导体放置在管端，并从感应线圈轴向移位，由此产生的电磁场用于延长管中的等离子体。 可以将样品材料注入等离子体以进行光谱激发。

公开(公告)号：US20160038422A1

公开(公告)日：2016-02-11

申请号：US14816377

申请日：2015-08-03

申请人： Thomas J. Manning ,  Sydney E. B. Plummer ,  Tess A. Baker

发明人： Thomas J. Manning ,  Sydney E. B. Plummer ,  Tess A. Baker

IPC分类号： A61K9/20 ,  A61K31/4409

CPC分类号： A61K9/2031 ,  A61K9/2009 ,  A61K9/2018 ,  A61K31/4409 ,  A61K31/496 ,  A61K31/555 ,  A61K31/7036 ,  A61K31/7135 ,  A61K31/77 ,  A61K38/12

摘要： Bacterial resistance to antibiotics is increasing worldwide creating a global threat. Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, is a bacterial infectious disease that results in over one million deaths annually. The discovery outlined here involves a tablet composition for patient administration and subsequently a new paradigm in drug delivery vehicles in vivo and in vitro and is applied to existing TB antibiotics in order to increase their efficacy. The drug delivery system is a three component complex that is administered with the TB antibiotic or a combination of TB antibiotics. The components are a saccharide or saccharides, a transition metal ion or a combination of metal ions that can bind a nitrogen and/or oxygen atom(s), and a water soluble polymer capable of aggregating and enclosing the other constituents. The three component molecular delivery approach has demonstrated ability to overcome M. tuberculosis bacterial resistance to an existing antibiotic.

摘要翻译： 对抗生素的细菌耐药性在全球日益增加，造成全球威胁。 由细菌结核分枝杆菌引起的结核病（TB）是一种细菌感染性疾病，每年导致超过一百万人死亡。 这里概述的发现涉及用于患者给药的片剂组合物，并且随后在体内和体外的药物递送载体中的新范例，并且被应用于现有的结核病抗生素以提高它们的功效。 药物递送系统是与TB抗生素或结核抗生素组合施用的三组分复合物。 组分是可以结合氮和/或氧原子的糖或糖，过渡金属离子或金属离子的组合，以及能够聚集和封闭其它组分的水溶性聚合物。 三组分分子传递方法已经证明克服结核分枝杆菌对现有抗生素的细菌耐药性的能力。

公开(公告)号：US20130004993A1

公开(公告)日：2013-01-03

申请号：US13170855

申请日：2011-06-28

申请人： Thomas J. Manning

发明人： Thomas J. Manning

IPC分类号： C12P21/00 ,  C12N1/26 ,  C12N1/14 ,  C12N1/12 ,  C07D305/14 ,  C12P17/18 ,  C07D515/22 ,  C07K1/14 ,  C07D493/22 ,  C12P17/02 ,  C12N1/20 ,  C12N1/22

CPC分类号： C07D305/14 ,  C07D493/22 ,  C07D515/22 ,  C12P17/02 ,  C12P19/62

摘要： Methods for producing and obtaining natural products from microbial amplification chambers are described. This approach utilizes the concept of green chemistry to synthesize and extract the marine and terrestrial natural products. The method describes techniques to colonize and grow the selected bacteria and to continuously harvest the pharmaceutical agent from the broth without using any commercial solvents.

摘要翻译： 描述了从微生物放大室生产和获得天然产物的方法。 这种方法利用绿色化学的概念来合成和提取海洋和陆地天然产物。 该方法描述了定殖和生长选定细菌的技术，并且不使用任何商业溶剂从肉汤中连续地收获药剂。

公开(公告)号：US20150230434A1

公开(公告)日：2015-08-20

申请号：US14181606

申请日：2014-02-14

申请人： Thomas J. Manning

发明人： Thomas J. Manning

IPC分类号： A01K61/00

CPC分类号： A01K61/30 ,  A01K61/70 ,  Y02A40/83

摘要： Artificial reefs serve a useful purpose to promote the growth of sessile marine organisms such as bacteria, algae, corals, and bryozoans as well as providing a habitat and food source for species such as fish, crabs, lobsters, and some marine invertebrates. This invention applies the United States Environmental Protection Agencies' Twelve Principles of Green Technology to provide a cellulose based surface that is coated in nutrients to promote the rapid growth of marine microbes, the base of the marine food chain. This rapid growth, which begins days after being submerged, starts the food chain. The mineral based substrate attached to the cellulose based material is denser than water to allow the entire structure to sink; both the cellulose and mineral based materials will degrade rapidly leaving behind nucleation sites for microbes, corals, invertebrate collections, and more. The reef is constructed entirely from biodegradable materials and production costs are economical.

摘要翻译： 人造珊瑚礁有助于促进固体海洋生物如细菌，藻类，珊瑚和苔藓植物的生长，并为鱼类，螃蟹，龙虾和一些海洋无脊椎动物等物种提供栖息地和食物来源。 本发明适用美国环保署“十二项绿色科技原则”，提供涂层营养成分的纤维素基表面，促进海洋食物链基地海洋微生物的快速生长。 这种快速增长，从淹没的日子开始，开始了食物链。 附着在纤维素基材料上的矿物基底层比水更致密，以使整个结构下沉; 纤维素和矿物基材料都将快速降解，留下微生物，珊瑚，无脊椎动物收藏品等等的成核位点。 珊瑚礁完全由生物降解材料构成，生产成本经济。

公开(公告)号：US4803625A

公开(公告)日：1989-02-07

申请号：US879900

申请日：1986-06-30

申请人： Ping W. Fu ,  Thomas J. Manning

发明人： Ping W. Fu ,  Thomas J. Manning

IPC分类号： G06Q50/00 ,  G06F19/00 ,  G06F15/42

CPC分类号： G06F19/3456 ,  G06F19/3418 ,  G06F19/322 ,  G06F19/3406 ,  G06F19/3412 ,  G06F19/345 ,  G06F19/3487 ,  G06F19/363 ,  Y10S128/906 ,  Y10S128/908 ,  Y10S128/92

摘要： A personal health monitor includes sensors for measuring patient weight, temperature, blood pressure, and ECG waveform. The monitor is coupled to a central unit via modems and includes a computer which is programmed to prompt a patient to take prescribed medication at prescribed times, to use the sensors to measure prescribed health parameters, and to supply answers to selected questions. Medication compliance information, test results, and patient answers are compiled in a composite log which is automatically transmitted to the central unit. The computer is also programmed automatically to disconnect the monitor from an alternating current power source and to rely on internal battery power during certain periods of patient-monitor interaction, such as during use of the ECG module. In this way, danger to the patient and complexity of the ECG module are minimized. The computer is also programmed to compare measured test information with predetermined expected values, and in the event of a discrepancy, to collect additional information from the patient to assist trained personnel at the central unit in interpreting the composite log. The computer is also programmed to alert the central unit promptly in the event one or more measured parameters falls outside of a prescribed normal range. The normal range for a given parameter is made to vary in accordance with the measured value of one or more other parameters in order to reduce the incidence of false alarms.

摘要翻译： 个人健康监测器包括用于测量患者体重，温度，血压和ECG波形的传感器。 监视器通过调制解调器耦合到中央单元，并且包括计算机，其被编程为提示患者在规定时间采取处方药，以使用传感器来测量规定的健康参数，并提供对所选问题的答案。 药物合规信息，测试结果和患者答案编译在自动传输到中央单元的复合日志中。 计算机也被自动编程以将显示器与交流电源断开连接，并且在患者监视器交互的某些时段（例如在ECG模块的使用期间）依赖于内部电池电力。 以这种方式，对患者的危害和ECG模块的复杂性被最小化。 计算机还被编程为将测量的测试信息与预定的预期值进行比较，并且在出现差异的情况下，从患者收集附加信息，以协助在中央单元的训练有素的人员解释复合日志。 如果一个或多个测量参数超出了规定的正常范围，计算机也被编程为立即警告中央单元。 给定参数的正常范围根据一个或多个其他参数的测量值而变化，以便减少误报警的发生。

公开(公告)号：US4800392A

公开(公告)日：1989-01-24

申请号：US001284

申请日：1987-01-08

申请人： Oscar M. Garay ,  Quirino Balzano ,  Thomas J. Manning

发明人： Oscar M. Garay ,  Quirino Balzano ,  Thomas J. Manning

IPC分类号： H01Q1/24 ,  H01Q5/00 ,  H01Q5/40 ,  H01Q9/04 ,  H01Q1/38

CPC分类号： H01Q21/30 ,  H01Q1/243 ,  H01Q5/40 ,  H01Q9/0407

摘要： A laminar antenna includes a conductive ground plane (102), a first dielectric lamina (106), a conductive exciter lamina (108), a second dielectric lamina (114), and a conductive radiator lamina (116). The radiator partially overlaps the exciter and the amount of overlap determines the input impedance of the antenna. The laminar antenna can be positioned within the wall of a plastic radio housing (302). Multi-radiator wideband and duplex embodiments of the antenna are also described. In another embodiment, the ground plane extends above the radio housing while the radiator and dielectric laminae wrap around the extended portion of the ground plane.

摘要翻译： 层状天线包括导电接地平面（102），第一电介质层（106），导电激励器层（108），第二介电层（114）和导电辐射体层（116）。 辐射器与激励器部分重叠，重叠量决定了天线的输入阻抗。 层状天线可以定位在塑料无线电外壳（302）的壁内。 还描述了天线的多辐射体宽带和双工实施例。 在另一个实施例中，接地平面在无线电外壳的上方延伸，同时散热器和电介质层环绕接地平面的延伸部分。