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公开(公告)号：US20100233232A1
公开(公告)日：2010-09-16
申请号：US12401243
申请日：2009-03-10
申请人： Thomas M. SWANICK , Joseph FERRARO , Lisa ROGERS , Paul MARTAKOS
发明人： Thomas M. SWANICK , Joseph FERRARO , Lisa ROGERS , Paul MARTAKOS
IPC分类号： A61K9/00 , C07C57/00 , A61K47/06 , A61K31/4353 , A61K31/4545 , A61K38/13 , A61K31/496 , A61K31/7028 , A61K9/14 , A61K31/20 , A61P29/00
CPC分类号： A61K31/20 , A61K9/10 , A61K9/145 , A61K9/16 , A61K9/7007 , A61K31/00 , A61K31/4353 , A61K31/436 , A61K31/445 , A61K31/4545 , A61K31/496 , A61K31/7028 , A61K31/7036 , A61K35/60 , A61K38/13 , A61L27/28 , A61L27/54 , A61L31/08 , A61L31/16 , A61L2300/606
摘要： The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed. The particles can be used for a variety of therapeutic applications.
摘要翻译： 本发明涉及脂肪酸类颗粒，以及制造这种颗粒的方法。 颗粒可以与另外的治疗剂相关联。 本文还提供了形成脂肪酸颗粒的方法，其包括将交联的脂肪酸衍生的生物材料与低温液体缔合; 并使生物材料/低温液体组合物分裂，从而形成脂肪酸颗粒。 该颗粒可用于各种治疗应用。
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公开(公告)号：US20100183697A1
公开(公告)日：2010-07-22
申请号：US12581582
申请日：2009-10-19
申请人： Thomas M. SWANICK , Joe BIENKIEWICZ , Joseph FERRARO , Paul MARTAKOS , Keith M. FAUCHER , Alicia DALE
发明人： Thomas M. SWANICK , Joe BIENKIEWICZ , Joseph FERRARO , Paul MARTAKOS , Keith M. FAUCHER , Alicia DALE
CPC分类号： A61L31/148 , A61F2/06 , A61F2250/0067 , A61L31/00 , A61L31/10 , A61L31/145 , A61L2420/02
摘要： Exemplary embodiments of the present invention provide adhesion barriers having anti-adhesion and tissue fixating properties. The adhesion barriers are formed of fatty acid based films. The fatty acid-based films may be formed from fatty acid-derived biomaterials. The films may be coated with, or may include, tissue fixating materials to create the adhesion barrier. The adhesion barriers are well tolerated by the body, have anti-inflammation properties, fixate, well to tissue, and have a residence time sufficient to prevent post-surgical adhesions.
摘要翻译： 本发明的示例性实施方案提供了具有抗粘连和组织固定性质的粘合屏障。 粘合屏障由脂肪酸基膜形成。 脂肪酸基膜可以由脂肪酸衍生的生物材料形成。 膜可以涂覆或可以包括组织固定材料以产生粘合屏障。 粘附屏障由身体良好耐受，具有抗炎特性，固定到组织上，并具有足以防止手术后粘连的停留时间。
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公开(公告)号：US20150024018A1
公开(公告)日：2015-01-22
申请号：US14281682
申请日：2014-05-19
摘要： A material including a plurality of fatty acid chains cross-linked together and a silver fatty acid salt formed with the fatty acid chains within the material. Methods for forming a material are also included. The silver-containing materials can be utilized alone or in combination with a medical device for the release and local delivery of one or more anti-infective agents.
摘要翻译： 包括交联在一起的多个脂肪酸链和与材料内的脂肪酸链形成的银脂肪酸盐的材料。 还包括形成材料的方法。 含银材料可以单独使用或与医疗装置组合使用以释放和局部递送一种或多种抗感染剂。
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公开(公告)号：US20110038910A1
公开(公告)日：2011-02-17
申请号：US12539282
申请日：2009-08-11
摘要： Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of loading them with silver compounds are described. The silver-containing biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more anti-infective agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
摘要翻译： 描述了脂肪酸衍生的生物材料，制备生物材料的方法以及用银化合物加载它们的方法。 含银生物材料可以单独使用或与医疗装置组合使用以释放和局部递送一种或多种抗感染剂。 还提供了形成和调整所述生物材料的性质的方法以及使用所述生物材料治疗哺乳动物的损伤的方法。
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5.发明申请REDUCING TEMPLATE WITH COATING RECEPTACLE CONTAINING A MEDICAL DEVICE TO BE COATED 审中-公开用包含待涂敷的医疗装置的涂敷装置减少模板公开(公告)号：US20090011116A1
公开(公告)日：2009-01-08
申请号：US12182165
申请日：2008-07-30
申请人： Steve A. HERWECK , Theodore KARWOSKI , Paul MARTAKOS , Scott E. CORBEIL , Roger LABRECQUE , Suzanne CONROY , Brian SUNTER , Edward BROMANDER
发明人： Steve A. HERWECK , Theodore KARWOSKI , Paul MARTAKOS , Scott E. CORBEIL , Roger LABRECQUE , Suzanne CONROY , Brian SUNTER , Edward BROMANDER
CPC分类号： A61M25/0009 , A61F2/86 , A61F2/958 , A61F2250/0036 , A61F2250/0067 , A61M25/0045
摘要： An apparatus and a method for applying a coating to a medical device such as a stent, balloon, or catheter, shortly before insertion or implantation are described. The apparatus and method produce uniform consistent coverage of the medical device in a predictable, repeatable and controllable manner and reduce the need for preservative components in the coating or for excessive curing or hardening of the coating.
摘要翻译： 描述了在插入或植入之前不久将涂层施加到诸如支架，球囊或导管的医疗装置上的装置和方法。 该装置和方法以可预测，可重复和可控的方式产生医疗装置的均匀一致的覆盖，并且减少了涂层中防腐剂组分的需要或涂层的过度固化或硬化。
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公开(公告)号：US20090208552A1
公开(公告)日：2009-08-20
申请号：US12364763
申请日：2009-02-03
申请人： Keith M. FAUCHER , Hui TANG , Paul MARTAKOS , Steve A. HERWECK , Theodore KARWOSKI , Allison SULLIVAN , Greg MELVILLE , Scott E. CORBEIL
发明人： Keith M. FAUCHER , Hui TANG , Paul MARTAKOS , Steve A. HERWECK , Theodore KARWOSKI , Allison SULLIVAN , Greg MELVILLE , Scott E. CORBEIL
IPC分类号： A61K9/00 , A61K47/44 , C07C53/00 , C07D307/02 , A61K38/13 , A61K31/4353 , B05D3/00 , A61P37/00
CPC分类号： A61L31/08 , A61F2/82 , A61F2250/0067 , A61K31/4353 , A61L31/148 , A61L31/16 , A61L2300/404 , A61L2300/606 , A61L2420/06 , A61L2430/00
摘要： Fatty acid-based, pre-cure-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
摘要翻译： 描述了基于脂肪酸的预固化衍生的生物材料，制备生物材料的方法以及将其用作药物递送载体的方法。 脂肪酸衍生的生物材料可以单独使用或与医疗装置组合使用以释放和局部递送一种或多种治疗剂。 还提供了形成和调整所述生物材料的性质的方法以及使用所述生物材料治疗哺乳动物的损伤的方法。
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7.发明申请公开(公告)号：US20100233231A1
公开(公告)日：2010-09-16
申请号：US12401228
申请日：2009-03-10
IPC分类号： A61F2/00 , A61K31/436 , A61K31/355 , A61K31/70 , A61K31/337 , A61K9/14 , A61K38/13
CPC分类号： A61K9/19 , A61K9/10 , A61K31/337 , A61K31/343 , A61K31/436 , A61K31/445 , A61K47/22 , A61K47/44
摘要： The present invention related to substantially-thickened therapeutic formulation comprising an oil-based composition and a therapeutic agent, wherein the therapeutic agent is of a reduced particle size.
摘要翻译： 本发明涉及包含油基组合物和治疗剂的基本上增稠的治疗制剂，其中治疗剂具有减小的粒度。
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8.发明申请公开(公告)号：US20090047414A1
公开(公告)日：2009-02-19
申请号：US12182261
申请日：2008-07-30
申请人： Scott E. CORBEIL , Roger LABRECQUE , Paul MARTAKOS , Theodore KARWOSKI , Steve A. HERWECK , Suzanne CONROY , Brian SUNTER , Edward BROMANDER , Georgette HENRICH
发明人： Scott E. CORBEIL , Roger LABRECQUE , Paul MARTAKOS , Theodore KARWOSKI , Steve A. HERWECK , Suzanne CONROY , Brian SUNTER , Edward BROMANDER , Georgette HENRICH
CPC分类号： A61M25/0009 , A61F2/86 , A61F2240/001 , A61F2250/0067 , A61M25/0045
摘要： A method, a kit, and an apparatus provide a coating on an implantable medical device. The apparatus includes housing, a sealed reservoir chamber disposed in the housing, a reducing template, and a reservoir access port. The sealed reservoir contains the coating material. The reducing template is sized to receive a medical device therethrough for application of the coating material. A seal breaching mechanism can be provided and adapted to breach the sealed reservoir upon activation of the apparatus. The reservoir access port, which is disposed in the housing, is adapted to fluidly couple the reducing template with the reservoir chamber upon activation of the apparatus for coating the medical device.
摘要翻译： 方法，试剂盒和装置在可植入医疗装置上提供涂层。 该装置包括壳体，设置在壳体中的密封储存室，还原模板和储存器进入端口。 密封的容器包含涂料。 还原模板的尺寸适于接收穿过其中的医疗装置以施加涂层材料。 可以提供密封破裂机构并适于在启动装置时破坏密封储存器。 设置在壳体中的储存器进入端口适于在激活用于涂覆医疗装置的装置时将还原模板与储存室流体联接。
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