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1.
公开(公告)号:US20120196881A1
公开(公告)日:2012-08-02
申请号:US13311476
申请日:2011-12-05
IPC分类号: A61K31/357 , A61P9/04 , A61K31/506 , A61P9/12 , A61K31/433 , A61K31/423
CPC分类号: A61K31/7048 , A61K31/137 , A61K31/18 , A61K31/198 , A61K31/34 , A61K31/357 , A61K31/382 , A61K31/415 , A61K31/42 , A61K31/423 , A61K31/433 , A61K31/444 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/522 , A61K31/53 , A61K31/635 , A61K45/06 , A61K2300/00
摘要: This disclosure relates generally to methods and pharmaceutical compositions useful in treating pulmonary hypertension. In one embodiment, for example, the disclosure provides a method for treating pulmonary hypertension comprising administering a therapeutically effective dose of a carbonic anhydrase inhibitor to a patient in need of treatment. The disclosure finds utility in the fields of medicine and pharmacology.
摘要翻译: 本公开一般涉及可用于治疗肺动脉高压的方法和药物组合物。 在一个实施方案中,例如,本公开提供了治疗肺动脉高压的方法,包括向需要治疗的患者施用治疗有效剂量的碳酸酐酶抑制剂。 该公开内容在医学和药理学领域中具有实用价值。
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2.
公开(公告)号:US20080312163A1
公开(公告)日:2008-12-18
申请号:US11818306
申请日:2007-06-13
IPC分类号: A61K31/70 , A61K31/137 , A61K31/423 , A61P11/16 , A61K31/433 , A61K31/506
CPC分类号: A61K31/7048 , A61K31/137 , A61K31/18 , A61K31/198 , A61K31/34 , A61K31/357 , A61K31/382 , A61K31/415 , A61K31/42 , A61K31/423 , A61K31/433 , A61K31/444 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/522 , A61K31/53 , A61K31/635 , A61K45/06 , A61K2300/00
摘要: This disclosure relates generally to methods and pharmaceutical compositions useful in treating pulmonary hypertension. In one embodiment, for example, the disclosure provides a method for treating pulmonary hypertension comprising administering a therapeutically effective dose of a carbonic anhydrase inhibitor to a patient in need of treatment. The disclosure finds utility in the fields of medicine and pharmacology.
摘要翻译: 本公开一般涉及可用于治疗肺动脉高压的方法和药物组合物。 在一个实施方案中,例如,本公开提供了治疗肺动脉高压的方法,包括向需要治疗的患者施用治疗有效剂量的碳酸酐酶抑制剂。 该公开内容在医学和药理学领域中具有实用价值。
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3.
公开(公告)号:US08071557B2
公开(公告)日:2011-12-06
申请号:US11818306
申请日:2007-06-13
IPC分类号: A61K31/7024 , A61K31/4985 , A61K31/137
CPC分类号: A61K31/7048 , A61K31/137 , A61K31/18 , A61K31/198 , A61K31/34 , A61K31/357 , A61K31/382 , A61K31/415 , A61K31/42 , A61K31/423 , A61K31/433 , A61K31/444 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/522 , A61K31/53 , A61K31/635 , A61K45/06 , A61K2300/00
摘要: This disclosure relates generally to methods and pharmaceutical compositions useful in treating pulmonary hypertension. In one embodiment, for example, the disclosure provides a method for treating pulmonary hypertension comprising administering a therapeutically effective dose of a carbonic anhydrase inhibitor to a patient in need of treatment. The disclosure finds utility in the fields of medicine and pharmacology.
摘要翻译: 本公开一般涉及可用于治疗肺动脉高压的方法和药物组合物。 在一个实施方案中,例如,本公开提供了治疗肺动脉高压的方法,包括向需要治疗的患者施用治疗有效剂量的碳酸酐酶抑制剂。 该公开内容在医学和药理学领域中具有实用价值。
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4.
公开(公告)号:US08536138B2
公开(公告)日:2013-09-17
申请号:US13311476
申请日:2011-12-05
IPC分类号: A61K31/53 , A61K31/407 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/7048 , A61P11/00 , A61K31/137
CPC分类号: A61K31/7048 , A61K31/137 , A61K31/18 , A61K31/198 , A61K31/34 , A61K31/357 , A61K31/382 , A61K31/415 , A61K31/42 , A61K31/423 , A61K31/433 , A61K31/444 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/522 , A61K31/53 , A61K31/635 , A61K45/06 , A61K2300/00
摘要: This disclosure relates generally to methods and pharmaceutical compositions useful in treating pulmonary hypertension. In one embodiment, for example, the disclosure provides a method for treating pulmonary hypertension comprising administering a therapeutically effective dose of a carbonic anhydrase inhibitor to a patient in need of treatment. The disclosure finds utility in the fields of medicine and pharmacology.
摘要翻译: 本公开一般涉及可用于治疗肺动脉高压的方法和药物组合物。 在一个实施方案中,例如,本公开提供了治疗肺动脉高压的方法,包括向需要治疗的患者施用治疗有效剂量的碳酸酐酶抑制剂。 该公开内容在医学和药理学领域中具有实用价值。
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公开(公告)号:US08735314B2
公开(公告)日:2014-05-27
申请号:US13248710
申请日:2011-09-29
申请人: Dick Nagaki , Craig Peterson , Mark Scates , Heiko Weiner , Josefina T. Chapman , Alexandra S. Locke
发明人: Dick Nagaki , Craig Peterson , Mark Scates , Heiko Weiner , Josefina T. Chapman , Alexandra S. Locke
CPC分类号: B01J35/1061 , B01J23/22 , B01J27/198 , B01J35/1014 , B01J37/03 , B01J37/031 , B01J37/08 , B01J2523/00 , C07C51/353 , B01J2523/47 , B01J2523/51 , B01J2523/55 , C07C57/04
摘要: In one embodiment, the invention is to a catalyst composition comprising vanadium and titanium. The catalyst composition further comprises ethylene glycol and citric acid. Preferably, the catalyst composition is substantially free of oxalic acid and lactic acid.
摘要翻译: 在一个实施方案中,本发明涉及包含钒和钛的催化剂组合物。 催化剂组合物还包含乙二醇和柠檬酸。 优选地,催化剂组合物基本上不含草酸和乳酸。
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公开(公告)号:US20130253224A1
公开(公告)日:2013-09-26
申请号:US13424779
申请日:2012-03-20
IPC分类号: C07C51/48
摘要: In one embodiment, the invention is to process for producing acrylics. The process includes the steps of contacting a crude product stream with an extraction agent mixture and diluting the crude product stream with at least one diluent.
摘要翻译: 在一个实施方案中,本发明是用于生产丙烯酸树脂的方法。 该方法包括使粗产物流与提取剂混合物接触并用至少一种稀释剂稀释粗产物流的步骤。
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公开(公告)号:US07731104B2
公开(公告)日:2010-06-08
申请号:US11411644
申请日:2006-04-26
IPC分类号: B05B15/06
CPC分类号: B05B7/1486 , B05B7/12 , B05B7/1413 , B05B7/2408 , B05B7/2416 , B05B7/2478
摘要: A hand-held apparatus for spraying texture material including a body, a pressurized air source mounted on the body, a texture material hopper mounted on the body, and a texture delivery nozzle for selectively spraying texture material from the hopper onto a surface to be coated by propelling the texture material using pressurized air from the pressurized air source wherein each of the air source and the hopper can be disconnected from the body without the use of tools.
摘要翻译: 一种用于喷涂纹理材料的手持设备,包括主体,安装在主体上的加压空气源,安装在主体上的纹理材料料斗和用于选择性地将料斗中的材料从料斗喷射到待涂覆的表面上的纹理输送喷嘴 通过使用来自加压空气源的加压空气推进纹理材料,其中空气源和料斗中的每一个可以在不使用工具的情况下与主体分离。
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公开(公告)号:US08658823B2
公开(公告)日:2014-02-25
申请号:US13251623
申请日:2011-10-03
申请人: Craig Peterson , Josefina Chapman , Ilias Kotsianis , Sean Mueller , Dick Nagaki , Tianshu Pan
发明人: Craig Peterson , Josefina Chapman , Ilias Kotsianis , Sean Mueller , Dick Nagaki , Tianshu Pan
IPC分类号: C07C51/42 , C07C51/353
CPC分类号: C07C51/44 , C07C51/353 , C07C51/377 , C07C51/42 , C07C51/46 , C07C51/48 , Y02P20/582 , C07C57/04
摘要: In one embodiment, the invention is to a process for producing an acrylate product. The process comprises the step of providing a crude product stream comprising the acrylate product and an alkylenating agent. The process further comprises the step of separating at least a portion of the crude product stream to form an alkylenating agent stream and an intermediate product stream. The alkylenating agent stream comprises at least 1 wt % alkylenating agent and the intermediate product stream comprises acrylate product.
摘要翻译: 在一个实施方案中,本发明涉及一种生产丙烯酸酯产物的方法。 该方法包括提供包含丙烯酸酯产物和亚烷基化试剂的粗产物流的步骤。 该方法还包括分离至少一部分粗产物流以形成亚烷基化剂流和中间产物流的步骤。 亚烷基化剂流包含至少1重量%的亚烷基化剂,中间产物流包含丙烯酸酯产物。
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公开(公告)号:US20130085296A1
公开(公告)日:2013-04-04
申请号:US13428065
申请日:2012-03-23
申请人: Sean Mueller , Josefina Chapman , Craig Peterson , Dick Nagaki
发明人: Sean Mueller , Josefina Chapman , Craig Peterson , Dick Nagaki
IPC分类号: C07C51/347
CPC分类号: C07C51/353 , Y02P20/582 , C07C57/04
摘要: In one embodiment, the invention is to a process for producing an acrylate product. The process comprises the step of reacting a reaction mixture comprising an alkanoic acid, an alkylenating agent, and oxygen over a catalyst and under conditions effective to form a crude acrylate product. Preferably, the reaction mixture comprises from 0.5 wt % to 10 wt % oxygen. The crude acrylate product comprises acrylate product and alkylenating agent. The process further comprises the step of separating at least a portion of the crude product to form at least one alkylenating agent stream and at least one purified acrylate product stream. The purified acrylate product stream comprises acrylate product.
摘要翻译: 在一个实施方案中,本发明涉及一种生产丙烯酸酯产物的方法。 该方法包括通过催化剂和有效形成粗制丙烯酸酯产物的条件使包含链烷酸,亚烷基化试剂和氧的反应混合物反应的步骤。 优选地,反应混合物包含0.5重量%至10重量%的氧气。 丙烯酸粗产物包含丙烯酸酯产物和亚烷基化剂。 该方法还包括分离至少一部分粗产物以形成至少一种亚烷基化剂流和至少一种纯化的丙烯酸酯产物流的步骤。 纯化的丙烯酸酯产物流包含丙烯酸酯产物。
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公开(公告)号:US20070292197A1
公开(公告)日:2007-12-20
申请号:US11425264
申请日:2006-06-20
CPC分类号: A46B11/0041 , A46B5/0095 , A46B11/0062 , A46B11/0079 , A46B2200/202 , B44D3/12
摘要: A manually operated internally fed paint brush having a resilient handle forming a refillable paint reservoir and a brush head with a fluid delivery path connecting the reservoir to the brush head via a siphon tube having an inlet positioned at a lowermost region of the reservoir when the paint brush is generally horizontal. A combined valve and O-ring seals an outlet of the siphon tube and selectively opens in response to compression of the reservoir. A latching mechanism retains the brush head to the handle. A trough having a spout is provided for filling the paint brush.
摘要翻译: 一种手动内部输送的油漆刷,其具有形成可重新填充的油漆储存器的弹性手柄和具有流体输送路径的刷头,刷头具有通过虹吸管将储存器连接到刷头,该虹吸管具有位于储存器最低位置的入口, 刷子一般是水平的。 组合阀和O形环密封虹吸管的出口并且响应于储存器的压缩而选择性地打开。 闩锁机构将刷头保持在手柄上。 提供具有喷口的槽以填充油漆刷。
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