公开(公告)号：US20050095245A1

公开(公告)日：2005-05-05

申请号：US10944416

申请日：2004-09-20

申请人： Thomas Riley ,  R. Levinson ,  Robert Cuca ,  Elio Mariani

发明人： Thomas Riley ,  R. Levinson ,  Robert Cuca ,  Elio Mariani

IPC分类号： A61F6/06 ,  A61K9/00 ,  A61K31/56 ,  A61K39/395 ,  A61K48/00

CPC分类号： A61K9/0036 ,  A61K9/0034

摘要： A pharmaceutical formulation to treat vaginal conditions in a human patient comprises: at least one active agent; a modified release dosage form which provides extended release of the anti-infective agent upon vaginal administration to the patient; and wherein the formulation, when containing a total dose of the anti-infective agent of about 25 μg to about 500 mg based on the active agent will produce a plasma concentration versus time curve (ng/mL versus hours) having an area under the curve (AUC) of less than about 600 ng/mL.hr.

摘要翻译： 用于治疗人类患者的阴道病症的药物制剂包括：至少一种活性剂; 一种改良释放剂型，其在阴道给药时提供对抗感染药物的延长释放; 并且其中当基于活性剂含有约25至约500mg的总剂量的抗感染剂时，制剂将产生具有曲线下面积的血浆浓度对时间曲线（ng / mL对小时） （AUC）小于约600ng / mL.hr。

公开(公告)号：US5554379A

公开(公告)日：1996-09-10

申请号：US262254

申请日：1994-06-20

申请人： Robert Cuca ,  Keith Lienhop ,  Thomas Riley ,  Mitchell I. Kirschner ,  R. Saul Levinson

发明人： Robert Cuca ,  Keith Lienhop ,  Thomas Riley ,  Mitchell I. Kirschner ,  R. Saul Levinson

IPC分类号： A61K9/00 ,  A61K9/68 ,  A61K47/00

CPC分类号： A61K9/006 ,  A61K9/0056 ,  A61K9/0058

摘要： A bioadherent, orally ingestible system, which comprises: a water-in-oil system having at least two phases, one phase comprises from about 75% to about 99% by volume of an internal hydrophylic phase and the other phase comprises from about 25% to about l% by volume of an external hydrophobic phase, wherein the external hydrophobic phase comprises two components, one component being about 3% to about 97% by volume of the hydrophobic phase of a hydrophobic oil and the other being about 97% to about 3% of an emulsifier having a HLB value less than about 10.

摘要翻译： 一种生物相容的口服摄取系统，其包括：具有至少两相的油包水体系，一相包含约75％至约99％体积的内部亲水相，另一相包含约25％ 至约1体积％的外部疏水相，其中外部疏水相包含两种组分，一种组分为疏水相的疏水性油的约3％至约97体积％，另一种为约97％至约 3％的HLB值小于约10的乳化剂。

公开(公告)号：US20070036848A1

公开(公告)日：2007-02-15

申请号：US11502253

申请日：2006-08-10

申请人： Jonathan Bortz ,  Thomas Riley

发明人： Jonathan Bortz ,  Thomas Riley

IPC分类号： A61K31/56 ,  A61K9/127

CPC分类号： A61K9/0014 ,  A61K9/0034 ,  A61K31/56 ,  A61K31/565 ,  A61K31/566 ,  A61K31/567 ,  A61K47/14 ,  A61K47/24 ,  A61K47/26 ,  A61K47/44

摘要： A pharmaceutical composition comprises at least one estrogenic compound, the composition being adapted for application in a unit dose amount to a vulvovaginal surface and having at least one nonlipoidal internal phase and at least one lipoidal external phase that is bioadhesive to the vulvovaginal surface, wherein the at least one estrogenic compound is present in an amount of about 5 to about 1000 μg estradiol equivalent per unit dose of the composition, and upon application of the composition to the vulvovaginal surface the at least one estrogenic compound is released over a period of about 3 hours to about 30 days. The composition is useful for vulvovaginal administration to treat atrophic vaginitis or a disorder associated therewith, for example in a menopausal or postmenopausal woman. A method for treating a hypoestrogenism-related condition of the urogenital system of a female patient comprises intravaginal administration of at least one estrogenic compound according to a treatment regimen wherein a series of compositions releasing a progressively increasing daily amount of the at least one estrogenic compound is administered over a period of at least about 1 month.

摘要翻译： 药物组合物包含至少一种雌激素化合物，所述组合物适于以单位剂量施用于外阴阴道表面并且具有至少一个非脂性内相和至少一个与外阴阴道表面生物粘附的脂质外相，其中， 至少一种雌激素化合物以每单位剂量组合物约5至约1000兆克雌二醇当量的量存在，并且当将组合物施用于外阴阴道表面时，至少一种雌激素化合物在约3周期内释放 小时至约30天。 该组合物可用于外阴阴道给药以治疗萎缩性阴道炎或与其相关的病症，例如在绝经或绝经后的女性中。 用于治疗女性患者的泌尿生殖系统的与雌激素相关症状的方法包括根据治疗方案的阴道内施用至少一种雌激素化合物，其中释放逐渐增加的每日量的至少一种雌激素化合物的一系列组合物是 在至少约1个月的时间内进行管理。

公开(公告)号：US20130271210A1

公开(公告)日：2013-10-17

申请号：US13996572

申请日：2011-12-23

申请人： Thomas Riley

发明人： Thomas Riley

IPC分类号： H03H11/04 ,  H03H7/01

CPC分类号： H03H11/04 ,  H03H7/0138 ,  H03H19/002

摘要： An N-path filter with each path forming a different filter. A signal insertion block is provided at the start of the circuit and, in one embodiment, multiple memory capacitors are coupled to the signal insertion block. A bank of sequential rotating capacitors are provided along with a bank of switches. By activating selected switches, any of the memory capacitors can be coupled to selected rotating capacitors. A different filter subcircuit is formed by coupling each memory capacitor to different rotating capacitors as this creates a different signal path. By timing the switching of the rotating capacitors, signals from previous outputs can be inserted into the circuit. At the output end of the circuit, the output of the different filter subcircuits is put together into an output for the whole circuit.

摘要翻译： 每个路径形成不同过滤器的N路径过滤器。 在电路的起始处提供信号插入块，并且在一个实施例中，多个存储器电容器耦合到信号插入块。 一组顺序旋转电容器与一组开关一起提供。 通过激活所选择的开关，可以将任何存储电容器耦合到选定的旋转电容器。 通过将每个存储电容器耦合到不同的旋转电容器来形成不同的滤波器分支电路，因为这创建了不同的信号路径。 通过定时旋转电容器的切换，来自先前输出的信号可以插入电路。 在电路的输出端，将不同滤波器子电路的输出放在整个电路的输出端。

公开(公告)号：US06129067A

公开(公告)日：2000-10-10

申请号：US969352

申请日：1997-11-28

申请人： Thomas Riley

发明人： Thomas Riley

IPC分类号： F01C1/20 ,  F02B53/02 ,  F02B75/02 ,  F02B53/00

CPC分类号： F01C1/20 ,  F02B53/02 ,  F02B2075/027 ,  Y02T10/17

摘要： An improved rotary engine (12), wherein the improvement comprises a facility (58) for transferring any remaining exhaust gases from a first center well (16) in a housing (14) of the engine (12) into a cavity (34) of a second rotor (32) in a second well (18) in the housing (14) during the expansion cycle. An assembly (62) is for purging any remaining exhaust gases from the cavity (34) of the second rotor (32) in the second well (18) back into an air intake port (44) in the housing (14). An assembly (70) is for ejecting the compression of any fresh air and trapped exhaust gases into an exhaust port (48) in the housing (14) during the meshing of a piston (28) on a first rotor (26) in the first center well (16), with a cavity in a third rotor (38) in a third well (22) in the housing (14). A unit (78) is for drawing fresh air from the air intake port (44) into the cavity (40) in the third rotor (38), when the piston (28) of the first rotor (26) starts to exit from the cavity (40) in the third rotor (38).

摘要翻译： 一种改进的旋转发动机（12），其中改进包括用于将任何剩余废气从发动机（12）的壳体（14）中的第一中心井（16）传送到空腔（34）的设备（58） 在膨胀循环期间在壳体（14）中的第二井（18）中的第二转子（32）。 组件（62）用于将来自第二井（18）中的第二转子（32）的空腔（34）的任何剩余废气清除回到壳体（14）中的进气口（44）中。 在第一转子（26）内的活塞（28）啮合期间，组件（70）用于将任何新鲜空气和被捕获的废气的压缩排出到壳体（14）中的排气口（48） 中心井（16），在壳体（14）中的第三井（22）中的第三转子（38）中具有空腔。 当第一转子（26）的活塞（28）开始从第三转子（38）中的出口离开时，单元（78）用于将新鲜空气从进气口（44）吸入第三转子（38）中的空腔（40） 第三转子（38）中的空腔（40）。

公开(公告)号：US20050093710A1

公开(公告)日：2005-05-05

申请号：US10698165

申请日：2003-10-31

申请人： Manuel Soto ,  Adam Bergman ,  Guillermo Padula ,  Thomas Riley ,  Jackie Cooper ,  Ricci Cerasini ,  Israel Alexander

发明人： Manuel Soto ,  Adam Bergman ,  Guillermo Padula ,  Thomas Riley ,  Jackie Cooper ,  Ricci Cerasini ,  Israel Alexander

IPC分类号： G08B13/14 ,  G08B13/24 ,  G08B29/04 ,  G08B21/00

CPC分类号： G08B13/2402 ,  G08B13/1445 ,  G08B29/046

摘要： A method and apparatus to prevent unauthorized removal of a pedestal from a base are described.

摘要翻译： 描述了一种防止从基座未经授权地移除基座的方法和装置。

公开(公告)号：US06785346B1

公开(公告)日：2004-08-31

申请号：US09676233

申请日：2000-09-29

申请人： Neil Birkett ,  Norm Filiol ,  Thomas Riley

发明人： Neil Birkett ,  Norm Filiol ,  Thomas Riley

IPC分类号： H03D318

CPC分类号： H04L27/3836 ,  H03D3/245

摘要： A digital demodulator which coherently demodulates a low-IF or zero-IF complex signal using a complex-valued phase-locked loop (CPPL). The CPPL includes a numerical controlled oscillator, four multipliers and two combiners to provide independent phase/frequency and amplitude outputs. The CPLL exhibits in first order PLL dynamics without a loop filter in the feedback loop to the NCO. However a filter with one or more poles may be included in the feedback circuit to exhibit 2nd or higher order PLL dynamics. The CPLL allows coherent demodulation of extremely low FM modulation indexes whereby the incoming frequency drift may be larger than the frequency deviation. It can also be used to coherently demodulate signals which have combined amplitude and phase characteristics.

摘要翻译： 数字解调器，其使用复值锁相环（CPPL）相干地解调低中频或零中频复信号。 CPPL包括数控振荡器，四个乘法器和两个组合器，以提供独立的相位/频率和幅度输出。 CPLL在没有环路滤波器的一阶PLL动态中展现了到NCO的反馈环路。 然而，具有一个或多个极点的滤波器可以包括在反馈电路中以呈现2阶或更高阶PLL动力学。 CPLL允许相干解调极低的FM调制指数，从而输入频率漂移可能大于频率偏差。 它也可以用于相干解调具有组合幅度和相位特性的信号。

公开(公告)号：US07079598B2

公开(公告)日：2006-07-18

申请号：US10891586

申请日：2004-07-15

申请人： Neil Birkett ,  Norm Filiol ,  Thomas Riley

发明人： Neil Birkett ,  Norm Filiol ,  Thomas Riley

IPC分类号： H04B17/00

CPC分类号： H04L27/3836 ,  H03D3/245

摘要： A digital demodulator which coherently demodulates a low-IF or zero-IF complex signal using a complex-valued phase-locked loop (CPPL). The CPPL includes a numerical controlled oscillator, four multipliers and two combiners to provide independent phase/frequency and amplitude outputs. The CPLL exhibits in first order PLL dynamics without a loop filter in the feedback loop to the NCO. However a filter with one or more poles may be included in the feedback circuit to exhibit 2nd or higher order PLL dynamics. The CPLL allows coherent demodulation of extremely low FM modulation indexes whereby the incoming frequency drift may be larger than the frequency deviation. It can also be used to coherently demodulate signals which have combined amplitude and phase characteristics.

摘要翻译： 数字解调器，其使用复值锁相环（CPPL）相干地解调低中频或零中频复信号。 CPPL包括数控振荡器，四个乘法器和两个组合器，以提供独立的相位/频率和幅度输出。 CPLL在没有环路滤波器的一阶PLL动态中展现了到NCO的反馈环路。 然而，具有一个或多个极点的滤波器可以包括在反馈电路中以呈现第二和第二或更高阶PLL动态。 CPLL允许相干解调极低的FM调制指数，从而输入频率漂移可能大于频率偏差。 它也可以用于相干解调具有组合幅度和相位特性的信号。