公开(公告)号：US07270634B2

公开(公告)日：2007-09-18

申请号：US10780443

申请日：2004-02-17

申请人： Steven Scampini ,  Michael Peszynski ,  Ivan Salgo ,  Bernard Savord

发明人： Steven Scampini ,  Michael Peszynski ,  Ivan Salgo ,  Bernard Savord

IPC分类号： A61B8/00

CPC分类号： G01S7/52074 ,  A61B5/061 ,  A61B5/062 ,  A61B5/063 ,  A61B5/065 ,  A61B5/068 ,  A61B8/00 ,  A61B8/0833 ,  A61B8/0841 ,  A61B8/483 ,  G01S7/52073 ,  G01S7/52085 ,  G01S7/52095 ,  G01S15/8993 ,  Y10S128/916

摘要： A three dimensional ultrasonic diagnostic imaging system is operated to guide or observe the operation of an invasive medical device (30) in three dimensions. The appearance of the invasive device (30) in the three dimensional ultrasonic image is enhanced to be more readily observable by a clinician. The enhancement is produced by transmitting a greater ultrasonic beam density in a subvolumetric region including the invasive device (30) than in the surrounding portion of the volumetric region (120). The beam density may be uniformly high in the subvolumetric region and uniformly low in the surrounding region, or may taper from a relatively high beam density around the invasive device (30) to a minimum beam density at distances removed from the invasive device (30).

摘要翻译： 操作三维超声诊断成像系统以引导或观察三维的侵入性医疗装置（30）的操作。 三维超声图像中的侵入性装置（30）的外观被增强以便由临床医生更容易观察到。 通过在包括侵入性装置（30）的子体积区域中比在体积区域（120）的周围部分中传输更大的超声波束密度来产生增强。 光束密度可以在子体积区域中均匀地高，并且在周围区域中均匀地低，或者可以从入侵设备（30）周围的相对较高的光束密度逐渐减小到从侵入性设备（30）移除的距离处的最小光束密度， 。

公开(公告)号：US20070173737A1

公开(公告)日：2007-07-26

申请号：US11725846

申请日：2007-03-20

申请人： Steven Scampini

发明人： Steven Scampini

IPC分类号： A61B10/00

CPC分类号： A61B10/0045 ,  A61B10/0291 ,  A61B2010/0074

摘要： This invention relates generally to medical devices, and more particularly, an apparatus and method for collecting cells or tissue samples from the cervix of a patient for medical testing.

摘要翻译： 本发明一般涉及医疗装置，更具体地说，涉及用于从用于医学测试的患者子宫颈收集细胞或组织样本的装置和方法。

公开(公告)号：US08137642B2

公开(公告)日：2012-03-20

申请号：US12482731

申请日：2009-06-11

申请人： Timothy Hutchins ,  Steven Scampini ,  Eric Baur

发明人： Timothy Hutchins ,  Steven Scampini ,  Eric Baur

IPC分类号： G01D18/00

CPC分类号： G01N1/36

摘要： A bubble point of a combination of a filter and a liquid is calibrated by applying an initial back pressure through the filter toward the liquid; taking a first plurality of measurements of the level of the liquid in the container; calculating a first variance of the first plurality of measurements; and comparing the first calculated variance with a known threshold variance. Then a second plurality of measurements of the level of the liquid in the container is taken; a second variance of the second plurality of measurements is calculated; and the second calculated variance is compared with a known threshold variance. The above described steps are repeated at incrementally increased back pressures until the first and second calculated variances are each greater than or equal to the known threshold variance, which is about 0.01. The bubble point is determined to be the back pressure at that point. If the determined bubble point is less than or equal to the known threshold bubble point, which is about 0.8 pounds per square inch, the filter is identified as unsuitable for use in cell block formation.

摘要翻译： 过滤器和液体的组合的起泡点通过将初始的背压通过过滤器朝向液体进行校准; 对容器中液体的水平进行第一次多次测量; 计算所述第一多个测量的第一方差; 以及将第一计算的方差与已知的阈值方差进行比较。 然后取出容器中的液体水平的第二多个测量值; 计算第二多个测量的第二方差; 并将第二计算方差与已知的阈值方差进行比较。 上述步骤以逐渐增加的背压重复，直到第一和第二计算的方差各自大于或等于已知阈值方差，其为约0.01。 泡点确定为此时的背压。 如果确定的气泡点小于或等于已知的阈值气泡点（约0.8磅/平方英寸），则过滤器被识别为不适合用于细胞块形成。

公开(公告)号：US20070142746A1

公开(公告)日：2007-06-21

申请号：US11314754

申请日：2005-12-21

申请人： Steven Scampini

发明人： Steven Scampini

IPC分类号： A61B10/00

CPC分类号： A61B10/0045 ,  A61B10/0291 ,  A61B2010/0074

摘要： This invention relates generally to medical devices, and more particularly, an apparatus and method for collecting cells or tissue samples from the cervix of a patient for medical testing.

公开(公告)号：US20070133085A1

公开(公告)日：2007-06-14

申请号：US11298953

申请日：2005-12-09

申请人： Steven Scampini

发明人： Steven Scampini

IPC分类号： G02B21/00

CPC分类号： G02B21/24

摘要： A microscope control device comprises a coarse focus control, a manual navigation control, and a fine focus control. The microscope control device also includes a clutch configured to alternatively activate one of the coarse focus control and manual navigation control. The fine focus control, coarse focus control, manual navigation control, and clutch are configured and arranged for manual manipulation by a single hand of an operator without changing a general position of the hand.

摘要翻译： 显微镜控制装置包括粗焦控制，手动导航控制和精细对焦控制。 显微镜控制装置还包括配置成交替地激活粗焦控制和手动导航控制之一的离合器。 精细对焦控制，粗焦点控制，手动导航控制和离合器被配置和布置成用于操作者的单手的手动操作而不改变手的一般位置。

公开(公告)号：US07829021B2

公开(公告)日：2010-11-09

申请号：US11839531

申请日：2007-08-15

申请人： Timothy Hutchins ,  Hal Watts ,  Steven Scampini ,  Eric Grimes ,  Andrew H. Fischer

发明人： Timothy Hutchins ,  Hal Watts ,  Steven Scampini ,  Eric Grimes ,  Andrew H. Fischer

IPC分类号： G01N21/00

CPC分类号： C12M47/00 ,  G01N1/36 ,  Y10T436/25 ,  Y10T436/2575

摘要： A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well. The processing station includes an automated fluid delivery system operable to dispense a fluid into the collection well, and a controller operatively coupled to the fluid delivery system, wherein the controller causes the fluid delivery system to selectively dispense fluids into the collection well based at least in part on a flow rate across the filter determined at least in part based on changes in the monitored fluid level in the collection well.

摘要翻译： 用于制造单元块的系统包括单元块盒和处理站，所述盒包括具有形成在其中的收集孔的主体和可移除地附接到主体的过滤器组件，所述过滤器组件限定与 收集孔，并且具有穿过收集阱的底表面定位的过滤器，所述过滤器被配置为保持携带在被分配到收集井中并流过过滤器的流体中的细胞物质。 细胞块处理器具有可移除地安置细胞块盒的盒式接口，以及定位或定位以便检测和监测收集阱中的液面的传感器。 处理站包括可操作以将流体分配到收集井中的自动化流体输送系统，以及可操作地耦合到流体输送系统的控制器，其中控制器使得流体输送系统选择性地将流体分配到收集井中， 至少部分地基于收集井中监测的液体水平的变化确定穿过过滤器的流速的部分。

公开(公告)号：US20090165940A1

公开(公告)日：2009-07-02

申请号：US12268298

申请日：2008-11-10

申请人： Eric Baur ,  Steven Scampini

发明人： Eric Baur ,  Steven Scampini

IPC分类号： B32B37/04

CPC分类号： G01N1/36

摘要： Methods and apparatus for bonding block of paraffin having cellular material embedded at one end thereof with an additional amount of paraffin are disclosed, including a method comprising placing the paraffin block in a well of a mold with the paraffin-embedded cellular material positioned on a support structure that elevates the cellular matter from a bottom surface of the well; heating the mold to thereby soften and at least partially melt and blend together the embedding paraffin and additional paraffin located in the well, the support structure sized such that some of the additional paraffin flows on the bottom surface of the well at least partially surrounding the support structure; and cooling the mold to thereby bond the additional paraffin to the embedding paraffin and re-solidify the paraffin block, wherein the retained cellular matter is spaced apart from an end of the re-solidified paraffin block defined by the bottom surface of the well.

摘要翻译： 公开了用于将其一端嵌入细胞材料的石蜡块与另外的石蜡粘合的方法和装置，包括将石蜡块放置在模具的孔中，将石蜡包埋的细胞材料置于载体上 从井下表面升高细胞物质的结构; 加热模具从而软化并且至少部分地熔化并将包埋石蜡和位于孔中的另外的链烷烃混合在一起，所述支撑结构的尺寸使得一些额外的石蜡在井的底部表面上至少部分地围绕支撑件 结构体; 并冷却模具，从而将另外的石蜡粘合到包埋石蜡上并重新固化石蜡块，其中保留的细胞物质与由井的底部表面限定的再固化石蜡块的端部间隔开。

公开(公告)号：US20080055572A1

公开(公告)日：2008-03-06

申请号：US11933889

申请日：2007-11-01

申请人： Steven Scampini

发明人： Steven Scampini

IPC分类号： G01B11/00

CPC分类号： G01N35/00029 ,  G01N2035/00089 ,  G01N2035/00138 ,  G02B21/34

摘要： A system and method for determining whether one or more slides are loaded properly within a cassette. Each slide includes one or more transparent regions and one or more non-transparent regions. The slides are between a light source and a sensor. The light source generates light that is directed towards the sensor through the slides. If the sensor is able to detect light from the light source, then the slides are properly loaded in the cassette. Slides are not properly loaded if the light is blocked by a non-transparent region before reaching the sensor. The sensor or a separate controller can generate a signal or data to provide an indication to a user or to processing equipment that the slides are or are not properly loaded. For example, a speaker or an indicator light can be used to provide an indication to the user. The signal or data can also be used for other functions, such as displaying a message on a screen indicating whether the slides are properly loaded.

摘要翻译： 一种用于确定一个或多个幻灯片是否正确加载在盒内的系统和方法。 每个幻灯片包括一个或多个透明区域和一个或多个不透明区域。 幻灯片在光源和传感器之间。 光源通过幻灯片产生指向传感器的光。 如果传感器能够检测来自光源的光，则将幻灯片正确地装载到暗盒中。 如果在到达传感器之前光被非透明区域阻挡，则幻灯片未正确加载。 传感器或单独的控制器可以生成信号或数据，以向用户或处理设备提供指示或未正确加载幻灯片的指示。 例如，扬声器或指示灯可以用于向用户提供指示。 信号或数据也可用于其他功能，例如在屏幕上显示指示幻灯片是否正确加载的消息。

公开(公告)号：US20070140915A1

公开(公告)日：2007-06-21

申请号：US11530300

申请日：2006-09-08

申请人： Robert Sakal ,  Hal Watts ,  Steven Scampini

发明人： Robert Sakal ,  Hal Watts ,  Steven Scampini

IPC分类号： B01L3/02

CPC分类号： B01L3/0272 ,  B01L3/50825 ,  B01L2300/047 ,  B01L2300/049 ,  B01L2300/0832 ,  B01L2400/0633 ,  G01N35/0099 ,  G01N2035/00524

摘要： An instrument for automated processing of sample vials are provided. The instrument causes an aliquot chamber within the vial to be filled with the fluid contained within the vial.

摘要翻译： 提供了一种用于样品瓶自动处理的仪器。 该仪器使小瓶内的等分试样室充满容纳在小瓶内的流体。

公开(公告)号：US20060182320A1

公开(公告)日：2006-08-17

申请号：US10550210

申请日：2004-03-04

申请人： Michael Peszynski ,  Ivan Salgo ,  Bernard Savord ,  Steven Scampini

发明人： Michael Peszynski ,  Ivan Salgo ,  Bernard Savord ,  Steven Scampini

IPC分类号： G06K9/00

CPC分类号： A61B8/483 ,  A61B8/0833 ,  A61B8/0841 ,  A61B8/0883 ,  A61B8/463 ,  A61B34/20 ,  A61B2034/105 ,  A61B2034/2051 ,  A61B2090/378 ,  A61B2090/3782 ,  G01S7/52073 ,  G01S7/52074 ,  G01S7/52085 ,  G01S7/52095 ,  G01S15/8993

摘要： A three dimensional ultrasonic diagnostic imaging system is operated to guide or observe the operation of an invasive medical device (30) in three dimensions. The invasive medical device (30) is shown in a detailed ultrasonic image and the balance of the volumetric region (120) in which the device is located is shown in a wide field of view. The detailed and wide fields of view may be displayed separately or overlapping in spatial alignment on an image display (18). The wide field of view may be shown in two or three dimensions. A quantified display may be shown together with the wide and detailed anatomical displays. The detailed view may also be shown in an enlarged or zoomed format.

摘要翻译： 操作三维超声诊断成像系统以引导或观察三维的侵入性医疗装置（30）的操作。 该侵入性医疗装置（30）以详细的超声波图像示出，并且在宽视场中示出了装置所在的体积区域（120）的平衡。 详细和广泛的视野可以在图像显示器（18）上分开显示或以空间对准重叠。 宽视野可以以二维或三维来显示。 量化显示可以与广泛和详细的解剖显示一起显示。 详细视图也可以放大或缩小的格式显示。