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1.发明授权Methods and compositions using (−) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists 失效使用（ - ）诺西沙必利与质子泵抑制剂或H2受体拮抗剂组合的方法和组合物公开(公告)号：US06362202B1
公开(公告)日：2002-03-26
申请号：US09507951
申请日：2000-02-22
Applicant: Paul D. Rubin , Timothy J. Barberich
Inventor： Paul D. Rubin , Timothy J. Barberich
IPC: A61K31445
CPC classification number: A61K31/445 , A61K31/415 , A61K31/426 , A61K31/4439 , A61K31/4468 , A61K45/06 , A61K31/44 , A61K31/425 , A61K2300/00
Abstract: The invention relates to methods and compositions for the prevention, treatment, or management of gastrointestinal disorders or symptoms thereof, employing two or more agents or compounds to provide a triple site action on 5-HT3 receptors, 5-HT4 receptors, and at least one of H2 receptors and proton pumps.
Abstract translation: 本发明涉及用于预防，治疗或管理胃肠道疾病或其症状的方法和组合物，其采用两种或多种药剂或化合物来提供对5-HT 3受体，5-HT 4受体和至少一种 的H2受体和质子泵。
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公开(公告)号：US5919827A
公开(公告)日：1999-07-06
申请号：US992376
申请日：1997-12-17
Applicant: Timothy J. Barberich , James W. Young
Inventor： Timothy J. Barberich , James W. Young
IPC: A61K31/137 , A61K31/165 , A61K31/19 , A61K31/60 , A61K31/135
CPC classification number: A61K31/165 , A61K31/137 , A61K31/19 , A61K31/60
Abstract: The optically pure R(-) isomer of salmeterol, which is substantially free of the S(+) isomer, is a potent bronchodilator for relieving the symptoms associated with asthma in individuals. A method is disclosed utilizing the optically pure R(-) isomer of salmeterol for treating asthma while minimizing toxicity and other side effects associated with salmeterol.
Abstract translation: 基本上不含S（+）异构体的沙美特罗的光学纯的R（ - ）异构体是一种有效的支气管扩张剂，用于缓解个体与哮喘相关的症状。 公开了利用沙美特罗的光学纯的R（ - ）异构体治疗哮喘，同时最小化与沙美特罗相关的毒副作用的方法。
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3.发明授权Methods and compositions for treating hypertension, angina and other disorders using optically pure s(-) nitrendipine 失效使用光学纯的（ - ）尼群地平治疗高血压，心绞痛和其他疾病的方法和组合物
公开(公告)号：US5571827A
公开(公告)日：1996-11-05
申请号：US259930
申请日：1994-06-15
Applicant: Timothy J. Barberich , James W. Young
Inventor： Timothy J. Barberich , James W. Young
Abstract: Methods and compositions are disclosed utilizing the optically pure S(-) isomer of nitrendipine. This compound is a potent drug for the treatment of hypertension while avoiding the concomitant liability of adverse effects associated with the administration of the racemic mixture of nitrendipine. The S(-) isomer of nitrendipine is also useful for the treatment of angina and such other conditions as may be related to the activity of S(-) nitrendipine as a calcium channel antagonist without the concomitant liability of adverse effects associated with the racemic mixture of nitrendipine.
Abstract translation: 公开利用尼群地平的光学纯的S（ - ）异构体的方法和组合物。 该化合物是用于治疗高血压的有效药物，同时避免与施用尼群地平的外消旋混合物相关的副作用的伴随责任。 尼群地平的S（ - ）异构体也可用于治疗心绞痛和其他可能与作为钙通道拮抗剂的S（ - ）尼群地平的活性有关的其他病症，而与外消旋混合物有关的不良反应的伴随责任 尼群地平。
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公开(公告)号：US5362757A
公开(公告)日：1994-11-08
申请号：US976676
申请日：1992-11-16
Applicant: James W. Young , Timothy J. Barberich
Inventor： James W. Young , Timothy J. Barberich
IPC: A61K31/075 , A61K31/13 , A61K31/135 , A61K31/16 , A61K31/18 , A61K31/22 , A61K31/255 , A61K31/425 , A61K31/50 , A61K31/505 , A61K49/00 , A61P7/06 , A61P7/08 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , C07B53/00 , C07C19/08 , C07C35/48 , C07C43/10 , C07C43/12 , C07C43/164 , C07C69/63 , C07C69/708 , C07C205/40 , C07C211/15 , C07C213/04 , C07C215/12 , C07C217/08 , C07C217/32 , C07C233/05 , C07C233/36 , C07C235/08 , C07C291/02 , C07C309/65 , C07C309/66 , C07C309/68 , C07C309/73 , C07C309/75
CPC classification number: A61K31/425 , A61K31/135 , A61K31/50 , A61K31/505 , C07C205/40 , C07C233/36 , C07C235/08 , C07C309/65 , C07C309/66 , C07C309/73 , C07C43/10 , C07C43/164 , C07C69/63 , C07C69/708 , Y10S514/821 , Y10S514/929
Abstract: Optically pure (S) metoprolol, which is substantially free of the (R) enantiomer, is a potent beta-blocker for treating myocardial infarction and for relieving the symptoms of angina pectoris, cardiac arrhythmia and hypertension in individuals. A method is disclosed utilizing the optically pure (S) configurational enantiomer of metoprolol for treating cardiovascular disorders while reducing undesirable side effects associated with the administration of beta-blockers.
Abstract translation: 基本上不含（R）对映异构体的光学纯（S）美托洛尔是治疗心肌梗塞和缓解个体心绞痛，心律失常和高血压症状的有效β受体阻滞剂。 公开了利用美托洛尔的光学纯（S）构型对映异构体治疗心血管疾病同时减少与β-受体阻滞剂相关的不良副作用的方法。
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公开(公告)号：US5190962A
公开(公告)日：1993-03-02
申请号：US492647
申请日：1990-03-13
Applicant: Timothy J. Barberich , James W. Young
Inventor： Timothy J. Barberich , James W. Young
Abstract: The optically pure isomer of nitrendipine having anti-hypertensive activity, is a potent anti-hypertensive drug for reducing blood pressure in individuals without the undesirable side effects associated with administration of a racemic mixture of nitrendipine. A method is disclosed utilizing an optically pure isomer of nitrendipine for treating hypertension while reducing undesirable side effects associated with nitrendipine.
Abstract translation: 具有抗高血压活性的尼群地平的光学纯的异构体是用于降低个体血压的有效的抗高血压药物，而没有与施用尼群地平的外消旋混合物相关的不期望的副作用。 公开了利用尼群地平的光学纯异构体治疗高血压同时减少与尼群地平相关的不良副作用的方法。
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Patent Agency Ranking
6.发明授权Methods for treating irritable bowel syndrome using optically pure (-) norcisapride 失效使用光学纯（ - ）诺西沙必丁治疗肠易激综合征的方法公开(公告)号：US07064138B2
公开(公告)日：2006-06-20
申请号：US10372875
申请日：2003-02-26
Applicant: Paul D. Rubin , Timothy J. Barberich
Inventor： Paul D. Rubin , Timothy J. Barberich
IPC: A61K31/445
CPC classification number: A61K31/445 , A61K31/4468
Abstract: Methods for the prophylaxis, treatment, or management of irritable bowel syndrome using (−) norcisapride, or a pharmaceutically acceptable salt thereof, substantially free of its (+) stereoisomer are disclosed.
Abstract translation: 公开了使用（ - ）诺西沙必利或其药学上可接受的盐基本上不含其（+）立体异构体来预防，治疗或治疗肠易激综合征的方法。
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7.发明授权Methods of treating gastro-esophogeal reflux disease using (-) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists 失效（ - ）诺西沙必利联合质子泵抑制剂或H2受体拮抗剂治疗胃肠病反流病的方法公开(公告)号：US06548518B2
公开(公告)日：2003-04-15
申请号：US10041486
申请日：2002-01-10
Applicant: Paul D. Rubin , Timothy J. Barberich
Inventor： Paul D. Rubin , Timothy J. Barberich
IPC: A61K31445
CPC classification number: A61K31/445 , A61K31/415 , A61K31/426 , A61K31/4439 , A61K31/4468 , A61K45/06 , A61K31/44 , A61K31/425 , A61K2300/00
Abstract: The invention relates to methods and compositions for the prevention, treatment, or management of gastrointestinal disorders or symptoms thereof, employing two or more agents or compounds to provide a triple site action on 5-HT3 receptors, 5-HT4 receptors, and at least one of H2 receptors and protons pumps.
Abstract translation: 本发明涉及用于预防，治疗或管理胃肠道疾病或其症状的方法和组合物，其采用两种或多种药剂或化合物来提供对5-HT 3受体，5-HT 4受体和至少一种 的H2受体和质子泵。
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公开(公告)号：US06548082B1
公开(公告)日：2003-04-15
申请号：US09515407
申请日：2000-02-29
Applicant: Paul D. Rubin , Timothy J. Barberich
Inventor： Paul D. Rubin , Timothy J. Barberich
IPC: A61K920
CPC classification number: A61K31/415 , A61K31/4178 , A61K31/00 , A61K2300/00
Abstract: Methods for the treatment, management, or prevention of apnea and apnea disorders, or symptoms thereof, using a therapeutically effective amount of substantially optically pure R(+) ondansetron, or a pharmaceutically acceptable salt thereof, substantially free of its S(−) stereoisomer.
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公开(公告)号：US5760090A
公开(公告)日：1998-06-02
申请号：US691604
申请日：1996-08-15
Applicant: Timothy J. Barberich , James W. Young
Inventor： Timothy J. Barberich , James W. Young
IPC: A61K31/135 , A61K31/137
CPC classification number: A61K31/137 , A61K31/135 , Y10S514/826
Abstract: The optically pure R(-) isomer of albuterol, which is substantially free of the S(+) isomer, is a potent bronchodilator for relieving the symptoms associated with asthma in individuals. A method is disclosed utilizing the optically pure R(-) isomer of albuterol for treating asthma while minimizing the side effects associated with albuterol.
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10.发明授权Methods for treating depression and other disorders using optically pure R (-) fluoxetine and monoamine oxidase inhibitor 失效使用光学纯的R（ - ）氟西汀和单胺氧化酶抑制剂治疗抑郁症和其他疾病的方法
公开(公告)号：US5648396A
公开(公告)日：1997-07-15
申请号：US486056
申请日：1995-06-07
Applicant: James W. Young , Timothy J. Barberich , Martin H. Teicher
Inventor： James W. Young , Timothy J. Barberich , Martin H. Teicher
IPC: A61K31/138 , A61K31/135 , A61K31/13
CPC classification number: A61K31/138
Abstract: A method and composition are utilizing the pure R(-) isomer of fluoxetine which is a potent antidepressant and appetite suppressant substantially free of adverse effects. In addition, a method and composition are disclosed utilizing the pure R(-) isomer of fluoxetine which is useful to treat migraine headaches, pain, in particular chronic pain, psychoactive substance abuse disorders and obsessive compulsive disorders.
Abstract translation: 一种方法和组合物正在利用氟西汀的纯R（ - ）异构体，其是有效的抗抑郁药和食欲抑制剂，其基本上没有不利影响。 另外，公开了使用氟西汀的纯R（ - ）异构体的方法和组合物，其可用于治疗偏头痛，疼痛，特别是慢性疼痛，精神活性物质滥用障碍和强迫症。
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