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    Readout apparatus for a ring laser angular rate sensor
    1.
    发明授权
    Readout apparatus for a ring laser angular rate sensor 失效
    环形激光角速度传感器读出装置

    公开(公告)号：US4533250A

    公开(公告)日：1985-08-06

    申请号：US484108

    申请日：1983-04-11

    Applicant: Timothy J. Callaghan ,  Robert M. Kay

    Inventor： Timothy J. Callaghan ,  Robert M. Kay

    IPC: G01C19/66 ,  G01C19/64

    CPC classification number: G01C19/662

    Abstract: In the present invention, a detector responsive to an interference pattern produces pulses which relate to the fringe change of the pattern. The pulses are timed by a running clock. The pulse times are fed to an interpolating means such as a computer for interpolating fringe change between the last pulse and a measurement command signal. The detector of the present invention is specifically applicable to ring laser angular rate sensor systems.

    Abstract translation: 在本发明中，响应于干涉图案的检测器产生与图案的边缘变化有关的脉冲。 脉冲由运行时钟定时。 脉冲时间被馈送到内插装置，例如计算机，用于内插最后脉冲和测量命令信号之间的条纹变化。 本发明的检测器特别适用于环形激光角速度传感器系统。

    Sinusoidal noise injection into the dither of a ring laser gyroscope
    5.
    发明授权
    Sinusoidal noise injection into the dither of a ring laser gyroscope 失效
    正弦噪声注入环形激光陀螺仪的抖动

    公开(公告)号：US5416584A

    公开(公告)日：1995-05-16

    申请号：US233162

    申请日：1994-04-25

    Applicant: Robert M. Kay

    Inventor： Robert M. Kay

    IPC: G01C19/68 ,  G01C19/70

    CPC classification number: G01C19/68

    Abstract: Method and apparatus for reducing the effects of lock-in in a ring laser gyroscope. A sinusoidal noise signal is generated having a peak amplitude which shifts as a function of a dither drive monitor signal to new, random, peak amplitude levels. In the preferred embodiment, the peak amplitude level changes at each zero crossing of the dither drive monitor signal. Each new peak amplitude level is determined as a function of a value provided by a passband filtered random or pseudo random noise source. A step noise signal representative of that passband filtered value is multiplied by the dither drive monitor signal and the resulting sinusoidal noise signal is summed into the dither drive monitor signal. The resulting signal is then used to introduce a frequency bias, electrically or mechanically in at least one of the RLG light beams.

    Abstract translation: 减少环形激光陀螺仪锁定效果的方法和装置。 产生正弦噪声信号，其具有作为抖动驱动监视信号的函数的峰值幅度移动到新的，随机的峰值振幅电平。 在优选实施例中，峰值振幅电平在抖动驱动监视信号的每个过零点处改变。 每个新的峰值振幅电平被确定为由通带滤波的随机噪声源或伪随机噪声源提供的值的函数。 表示通带滤波值的步进噪声信号乘以抖动驱动监视信号，并将所得到的正弦噪声信号求和到抖动驱动监视信号中。 然后，所得信号用于在至少一个RLG光束中电或机械地引入频率偏置。

    Targeting constructs for the functional disruption of avian immunoglobulin genes
    6.
    发明申请
    Targeting constructs for the functional disruption of avian immunoglobulin genes 审中-公开
    针对禽类免疫球蛋白基因功能性破坏的构建体

    公开(公告)号：US20090083871A1

    公开(公告)日：2009-03-26

    申请号：US11977538

    申请日：2007-10-24

    Applicant: Robert J. Etches ,  Robert M. Kay ,  Lei Zhu

    Inventor： Robert J. Etches ,  Robert M. Kay ,  Lei Zhu

    IPC: A01K67/027 ,  C12N15/00

    CPC classification number: C12N15/8509 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/075 ,  A01K2227/30 ,  A01K2267/01 ,  A01K2267/0381 ,  C07K16/00 ,  C07K2317/21 ,  C07K2317/23 ,  C12N2800/30

    Abstract: A transgenic chicken is disclosed having disrupted endogenous immunoglobulin production. In one embodiment, a targeting construct is stably integrated into the genome of the chicken by homologous recombination in embryonic stem cells, and injection of the engineered embryonic stem cells into recipient embryos, thereby knocking out the endogenous immunoglobulin gene locus in resulting animals. The targeted disruption of the locus in embryonic stem cells is particularly useful in combination with the insertion of genetic elements encoding exogenous immunoglobulin molecules. After these chickens are cross-bred, a line of chickens is produced that has a reduction of endogenous immunoglobulin molecule production.

    Abstract translation: 公开了转基因鸡，其破坏了内源性免疫球蛋白产生。 在一个实施方案中，靶向构建体通过胚胎干细胞中的同源重组稳定整合到鸡的基因组中，并将工程化的胚胎干细胞注射到受体胚胎中，从而敲出所得动物中的内源性免疫球蛋白基因座。 胚胎干细胞中的位点的靶向破坏与编码外源性免疫球蛋白分子的遗传元件的插入特别有用。 在这些鸡交叉繁殖后，产生一系列内源性免疫球蛋白分子产生的鸡。

    Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
    7.
    发明授权
    Transgenic non-human animals capable of producing heterologous antibodies of various isotypes 失效
    能够产生各种同种型的异源抗体的转基因非人动物

    公开(公告)号：US5661016A

    公开(公告)日：1997-08-26

    申请号：US53131

    申请日：1993-04-26

    Applicant: Nils Lonberg ,  Robert M. Kay

    Inventor： Nils Lonberg ,  Robert M. Kay

    IPC: A01K67/027 ,  C07K16/00 ,  C07K16/28 ,  C07K16/30 ,  C07K16/44 ,  C12N15/85 ,  C12N15/90 ,  C12N15/00 ,  A61K39/00 ,  C12P19/34

    CPC classification number: C12N15/90 ,  A01K67/0278 ,  C07K16/00 ,  C07K16/2812 ,  C07K16/3007 ,  C07K16/44 ,  C12N15/8509 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/0381 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/56

    Abstract: The invention relates to transgenic non-human animals capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin genes. In one aspect of the invention, endogenous immunoglobulin genes are suppressed by antisense polynucleotides and/or by antiserum directed against endogenous immunoglobulins. Heterologous antibodies are encoded by immunoglobulin genes not normally found in the genome of that species of non-human animal. In one aspect of the invention, one or more transgenes containing sequences of unrearranged heterologous human immunoglobulin heavy chains are introduced into a non-human animal thereby forming a transgenic animal capable of functionally rearranging transgenic immunoglobulin sequences and producing a repertoire of antibodies of various isotypes encoded by human immunoglobulin genes. Such heterologous human antibodies are produced in B-cells which are thereafter immortalized, e.g., by fusing with an immortalizing cell line such as a myeloma or by manipulating such B-cells by other techniques to perpetuate a cell line capable of producing a monoclonal heterologous antibody. The invention also relates to heavy and light chain immunoglobulin transgenes for making such transgenic non-human animals as well as methods and vectors for disrupting endogenous immunoglobulin loci in the transgenic animal.

    Abstract translation: 本发明涉及能够产生具有失活的内源免疫球蛋白基因的异源抗体和转基因非人动物的转基因非人动物。 在本发明的一个方面，内源性免疫球蛋白基因被反义多核苷酸和/或针对内源性免疫球蛋白的抗血清抑制。 异源抗体由非人动物种类的基因组中通常不存在的免疫球蛋白基因编码。 在本发明的一个方面，将含有未经排列的异源人免疫球蛋白重链序列的一个或多个转基因引入非人动物中，从而形成能够功能重排转基因免疫球蛋白序列并产生编码的各种同种型抗体的所有组成的转基因动物 通过人免疫球蛋白基因。 这样的异源人抗体是在B细胞中产生的，其后被永生化，例如通过与永生化细胞系如骨髓瘤融合，或者通过其它技术操纵这样的B细胞，使能够产生单克隆异源抗体的细胞系 。 本发明还涉及用于制备这种转基因非人动物的重链和轻链免疫球蛋白转基因以及用于破坏转基因动物内源性免疫球蛋白基因座的方法和载体。

    Power supply for a ring laser
    9.
    发明授权
    Power supply for a ring laser 失效
    环形激光器的电源

    公开(公告)号：US4575658A

    公开(公告)日：1986-03-11

    申请号：US564802

    申请日：1983-12-23

    Applicant: Robert M. Kay

    Inventor： Robert M. Kay

    IPC: H01S3/097 ,  H01J7/24

    CPC classification number: H01S3/097 ,  G01C19/661

    Abstract: A power supply circuit is disclosed for a ring laser having a cathode and having first and second anodes so that the ionization current between the cathode and each of the anodes are substantially equal. According to the invention, a Zener diode is electrically connected in the path of one of the ionization currents. The Zener voltage magnitude of the Zener diode is selected so as to equalize the ionization currents.

    Abstract translation: 公开了一种用于具有阴极并具有第一和第二阳极的环形激光器的电源电路，使得阴极和每个阳极之间的电离电流基本相等。 根据本发明，在一个电离电流的路径中电连接齐纳二极管。 选择齐纳二极管的齐纳电压幅值以均衡电离电流。

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