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公开(公告)号：US20100022011A1
公开(公告)日：2010-01-28
申请号：US11581777
申请日：2006-10-16
CPC分类号： G01N21/643 , G01N33/22 , G01N2021/6432 , G01N2021/6441 , G01N2021/7786 , Y10T436/145555 , Y10T436/17 , Y10T436/200833
摘要： The present invention provides sensors and methods for determination of an analyte. The analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material upon exposure to an analyte. In some embodiments, the analyte and the emissive material may interact via a chemical reaction, or other chemical, biochemical or biological interaction (e.g., recognition), to form a new emissive species. In some cases, the present invention may be used for the detection of analytes such as explosives (e.g., RDX, PETN). Methods of the present invention may be advantageous in that the high sensitivity of luminescence (e.g., fluorescence) spectroscopy can allow for the reliable detection of small changes in luminescence intensity.
摘要翻译： 本发明提供用于测定分析物的传感器和方法。 分析物可以通过监测例如在暴露于分析物时发射材料的光学信号的变化来确定。 在一些实施方案中，分析物和发射材料可通过化学反应或其它化学，生物化学或生物相互作用（例如识别）相互作用以形成新的发射物质。 在某些情况下，本发明可用于检测分析物如爆炸物（例如RDX，PETN）。 本发明的方法的优点在于，发光（例如，荧光）光谱的高灵敏度可以允许可靠地检测发光强度的小变化。
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公开(公告)号：US20100303672A1
公开(公告)日：2010-12-02
申请号：US12693868
申请日：2010-01-26
IPC分类号： G01N21/00
CPC分类号： G01N21/643 , G01N33/22 , G01N2021/6432 , G01N2021/6441 , G01N2021/7786 , Y10T436/145555 , Y10T436/17 , Y10T436/200833
摘要： The present invention provides sensors and methods for determination of an analyte. The analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material upon exposure to an analyte. In some embodiments, the analyte and the emissive material may interact via a chemical reaction, or other chemical, biochemical or biological interaction (e.g., recognition), to form a new emissive species. In some cases, the present invention may be used for the detection of analytes such as explosives (e.g., RDX, PETN). Methods of the present invention may be advantageous in that the high sensitivity of luminescence (e.g., fluorescence) spectroscopy can allow for the reliable detection of small changes in luminescence intensity.
摘要翻译： 本发明提供用于测定分析物的传感器和方法。 分析物可以通过监测例如在暴露于分析物时发射材料的光学信号的变化来确定。 在一些实施方案中，分析物和发射材料可通过化学反应或其他化学，生物化学或生物相互作用（例如识别）相互作用以形成新的发射物质。 在某些情况下，本发明可用于检测分析物如爆炸物（例如RDX，PETN）。 本发明的方法的优点在于，发光（例如，荧光）光谱的高灵敏度可以允许可靠地检测发光强度的小变化。
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公开(公告)号：US07666684B2
公开(公告)日：2010-02-23
申请号：US11581777
申请日：2006-10-16
IPC分类号： G01N33/00
CPC分类号： G01N21/643 , G01N33/22 , G01N2021/6432 , G01N2021/6441 , G01N2021/7786 , Y10T436/145555 , Y10T436/17 , Y10T436/200833
摘要： The present invention provides sensors and methods for determination of an analyte. The analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material upon exposure to an analyte. In some embodiments, the analyte and the emissive material may interact via a chemical reaction, or other chemical, biochemical or biological interaction (e.g., recognition), to form a new emissive species. In some cases, the present invention may be used for the detection of analytes such as explosives (e.g., RDX, PETN). Methods of the present invention may be advantageous in that the high sensitivity of luminescence (e.g., fluorescence) spectroscopy can allow for the reliable detection of small changes in luminescence intensity.
摘要翻译： 本发明提供用于测定分析物的传感器和方法。 分析物可以通过监测例如在暴露于分析物时发射材料的光学信号的变化来确定。 在一些实施方案中，分析物和发射材料可通过化学反应或其他化学，生物化学或生物相互作用（例如识别）相互作用以形成新的发射物质。 在某些情况下，本发明可用于检测分析物如爆炸物（例如RDX，PETN）。 本发明的方法的优点在于，发光（例如，荧光）光谱的高灵敏度可以允许可靠地检测发光强度的小变化。
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公开(公告)号：US20090215189A1
公开(公告)日：2009-08-27
申请号：US11588881
申请日：2006-10-27
CPC分类号： G01N21/76 , C07F15/0086 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C09K2211/1092 , C09K2211/185 , G01N21/64 , G01N33/0057 , G01N33/20 , G01N2201/06113 , Y10T436/172307 , Y10T436/196666
摘要： The present invention generally relates to emissive materials, devices, and related methods. In some cases, the present invention provides sensors and methods for the determination of analytes, wherein the analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material upon exposure to an analyte. The analyte and the emissive material may interact via a chemical reaction, such as an oxidative addition reaction, or other chemical, biochemical or biological interaction (e.g., recognition), to form a new emissive species. In some cases, the present invention may be useful in the detection of a wide variety of analytes, such as toxins, chemical warfare agents, and explosives. The present invention also provides emissive compounds, and related methods, including metal complexes that are capable of interacting with an analyte to produce a change in the emission of the compound. Some advantages of the present invention include the determination of analytes with high specificity and sensitivity and the ability to fabricate simplified and highly portable devices.
摘要翻译： 本发明一般涉及发射材料，器件和相关方法。 在一些情况下，本发明提供用于测定分析物的传感器和方法，其中分析物可以通过例如在暴露于分析物时监测发光材料的光学信号的变化来确定。 分析物和发射材料可通过诸如氧化加成反应或其他化学，生物化学或生物相互作用（例如识别）的化学反应相互作用以形成新的发射物质。 在一些情况下，本发明可用于检测各种分析物，例如毒素，化学战剂和爆炸物。 本发明还提供发射化合物和相关方法，包括能够与分析物相互作用以产生化合物的发射变化的金属络合物。 本发明的一些优点包括具有高特异性和灵敏度的分析物的测定以及制造简化和高度便携式装置的能力。
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公开(公告)号：US08377710B2
公开(公告)日：2013-02-19
申请号：US12425121
申请日：2009-04-16
申请人： George M. Whitesides , Scott T. Phillips , Andres W. Martinez , Manish J. Butte , Amy Wong , Samuel W. Thomas , Hayat Sindi , Sarah J. Vella , Emanuel Carrilho , Katherine A. Mirica , Yanyan Liu
发明人： George M. Whitesides , Scott T. Phillips , Andres W. Martinez , Manish J. Butte , Amy Wong , Samuel W. Thomas , Hayat Sindi , Sarah J. Vella , Emanuel Carrilho , Katherine A. Mirica , Yanyan Liu
IPC分类号： G01N21/77
CPC分类号： G01N33/558 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L2200/12 , B01L2300/06 , B01L2300/0848 , B01L2300/0887 , B01L2300/126 , B01L2300/161 , C12Q1/48 , G01N21/77 , G01N33/523 , G01N33/526 , G01N33/54386 , G06F3/005
摘要： Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.
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6.发明申请公开(公告)号：US20090240040A1
公开(公告)日：2009-09-24
申请号：US12303089
申请日：2007-06-01
申请人： Vijay M. Krishnamurthy , Lara A. Estroff , Vincent Semetey , Samuel W. Thomas , George K. Kaufman , Zihni Basar Bilgicer , George M. Whitesides
发明人： Vijay M. Krishnamurthy , Lara A. Estroff , Vincent Semetey , Samuel W. Thomas , George K. Kaufman , Zihni Basar Bilgicer , George M. Whitesides
IPC分类号： C07K1/00
CPC分类号： C07K16/065 , C07K16/468 , C07K2317/31 , C07K2317/54 , Y10S436/822
摘要： The present invention discloses a method of purifying bivalent antibodies or antibody fragments that are active at both Fab sites from a source of antibodies or antibody fragments using a non-chromatographic method that includes inducing the formation of cyclic immunoglobulin aggregates by addition of multivalent hapten to a salt solution of soluble antibodies or antibody fragments, wherein the multivalent hapten possesses a linker between the two haptens effective to prevent the binding of both haptens of the ligand to the same antibody or antibody fragment.
摘要翻译： 本发明公开了一种纯化二价抗体或抗体片段的方法，所述二价抗体或抗体片段在使用非色谱法的抗体或抗体片段来源的两个Fab位点都是活性的，其包括通过将多价半抗原加入到 可溶性抗体或抗体片段的盐溶液，其中多价半抗原具有两个半抗原之间的接头，其有效地防止配体的半抗原与相同的抗体或抗体片段的结合。
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7.发明授权公开(公告)号：US08124743B2
公开(公告)日：2012-02-28
申请号：US12303089
申请日：2007-06-01
申请人： Vijay M. Krishnamurthy , Lara A. Estroff , Vincent Semetey , Samuel W. Thomas , George K. Kaufman , Zihni Basar Bilgicer , George M. Whitesides
发明人： Vijay M. Krishnamurthy , Lara A. Estroff , Vincent Semetey , Samuel W. Thomas , George K. Kaufman , Zihni Basar Bilgicer , George M. Whitesides
CPC分类号： C07K16/065 , C07K16/468 , C07K2317/31 , C07K2317/54 , Y10S436/822
摘要： The present invention discloses a method of purifying bivalent antibodies or antibody fragments that are active at both Fab sites from a source of antibodies or antibody fragments using a non-chromatographic method that includes inducing the formation of cyclic immunoglobulin aggregates by addition of multivalent hapten to a salt solution of soluble antibodies or antibody fragments, wherein the multivalent hapten possesses a linker between the two haptens effective to prevent the binding of both haptens of the ligand to the same antibody or antibody fragment.
摘要翻译： 本发明公开了一种纯化二价抗体或抗体片段的方法，所述二价抗体或抗体片段在使用非色谱法的抗体或抗体片段来源的两个Fab位点都是活性的，其包括通过将多价半抗原加入到 可溶性抗体或抗体片段的盐溶液，其中多价半抗原具有两个半抗原之间的接头，其有效地防止配体的半抗原与相同的抗体或抗体片段的结合。
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