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公开(公告)号:US20120095217A1
公开(公告)日:2012-04-19
申请号:US13143705
申请日:2010-01-08
申请人: Tobias Ritter , Laura Brass , Curtis Keith , Alan Watson , David J. Greenblatt
发明人: Tobias Ritter , Laura Brass , Curtis Keith , Alan Watson , David J. Greenblatt
IPC分类号: C07D413/04 , C07D471/08 , C07C217/62 , C07C211/42 , C07D471/04 , C07C211/29 , C07D223/28 , C07D403/06 , C07C211/32 , C07C211/31 , C07D313/12 , C07D333/20 , C07D471/14
CPC分类号: C07D471/04 , C07B59/00 , C07B2200/05 , C07C59/72 , C07C63/72 , C07C69/63 , C07C69/736 , C07C69/76 , C07C211/27 , C07C211/29 , C07C211/31 , C07C211/32 , C07C211/40 , C07C211/42 , C07C215/42 , C07C217/10 , C07C217/18 , C07C217/20 , C07C217/48 , C07C217/74 , C07C225/16 , C07C225/20 , C07C229/34 , C07C229/36 , C07C233/15 , C07C237/04 , C07C237/10 , C07C243/18 , C07C243/34 , C07C255/41 , C07C271/44 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/10 , C07C2603/32 , C07C2603/88 , C07D223/28 , C07D249/12 , C07D267/20 , C07D313/12 , C07D333/20 , C07D471/08 , C07D471/14 , C07F9/6506
摘要: Fluorinated compounds and methods of making fluorinated compounds are described herein.
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公开(公告)号:US20120149900A1
公开(公告)日:2012-06-14
申请号:US13143694
申请日:2010-01-08
申请人: Tobias Ritter , Laura Brass , Curtis Keith , Alan Watson , David J. Greenblatt
发明人: Tobias Ritter , Laura Brass , Curtis Keith , Alan Watson , David J. Greenblatt
IPC分类号: C07D489/00 , C07C69/157 , C07C225/16 , C07D413/06 , C07D221/22 , C07D223/04 , C07D233/22 , C07D233/50 , C07C211/42 , C07D211/64 , C07D489/12 , C07D211/14
CPC分类号: C07D489/00 , C07D221/22 , C07D489/12
摘要: Fluorinated compounds and methods of making fluorinated compounds are described herein.
摘要翻译: 氟化化合物和制备氟化化合物的方法在本文中描述。
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公开(公告)号:US20060193845A1
公开(公告)日:2006-08-31
申请号:US11227696
申请日:2005-09-14
申请人: Alan Watson , Laura Brass , Bard Geesman , Vaughn Kailian
发明人: Alan Watson , Laura Brass , Bard Geesman , Vaughn Kailian
IPC分类号: A61K38/47 , A61K31/7034 , A61K31/695
CPC分类号: A61K31/7034 , A61K31/695 , A61K38/47 , A61K45/06 , A61K2300/00
摘要: Carbohydrate usage in the gastro-intestinal tract of a subject can be modulated by administering, to a subject, a first agent that inhibits carbohydrate degradation in combination with a second agent that decreases formation or severity of intestinal gas.
摘要翻译: 可以通过向受试者施用抑制碳水化合物降解的第一药剂与减少肠气体的形成或严重性的第二药剂组合来调节受试者在胃肠道中的碳水化合物用量。
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4.
公开(公告)号:US07109149B2
公开(公告)日:2006-09-19
申请号:US10177717
申请日:2002-06-21
摘要: The invention provides methods for the alteration of fertility in plants through modulation of floral GABA levels. The techniques of the invention may find use in plant breeding techniques. Also provided by the invention are assays for the screening of candidate modulators of GABA metabolism or GABA analogs through the identification of affects on fertility following application of the candidate modulator to a plant. The technique provides an alternative to animal testing and is amenable to large scale application.
摘要翻译: 本发明提供了通过调节花生GABA水平来改变植物生育力的方法。 本发明的技术可用于植物育种技术。 本发明还提供了通过鉴定将候选调节剂施用于植物后对生育力的影响来筛选GABA代谢或GABA类似物的候选调节剂的测定法。 该技术提供动物测试的替代方案,适合大规模应用。
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公开(公告)号:US20070105109A1
公开(公告)日:2007-05-10
申请号:US10562389
申请日:2004-07-01
申请人: Bard Geesaman , Laura Brass
发明人: Bard Geesaman , Laura Brass
CPC分类号: C12Q1/6883 , C12Q2600/156 , G01N33/6896 , G01N2800/2821 , G16B20/00
摘要: Alzheimer's Disease (AD) is genetically linked to a locus that includes the SIRT1 gene. This disclosure includes methods and compositions for evaluating genetic variances, e.g., within this locus, and for the association of these variances with AD. The disclosure also includes methods and compositions for modulating SIRT1 expression and/or activity. These methods and compositions can be used in the prevention or treatment of AD.
摘要翻译: 阿尔茨海默病(AD)与包括SIRT1基因的基因座遗传连锁。 本公开包括用于评价遗传变异的方法和组合物,例如在该基因座内,以及这些方差与AD的关联。 本公开还包括用于调节SIRT1表达和/或活性的方法和组合物。 这些方法和组合物可用于预防或治疗AD。
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