公开(公告)号：US20060108287A1

公开(公告)日：2006-05-25

申请号：US11231670

申请日：2005-09-21

申请人： Todd Arnold ,  Keith Solomon ,  Zhijun He ,  Peter Meier ,  Keith Wesner ,  Mark Meyering ,  Aaron Spearin

发明人： Todd Arnold ,  Keith Solomon ,  Zhijun He ,  Peter Meier ,  Keith Wesner ,  Mark Meyering ,  Aaron Spearin

IPC分类号： B01D65/00

CPC分类号： B01D65/102 ,  B01D63/08 ,  B01D63/081 ,  B01D63/088 ,  B01D65/003 ,  B01D71/56 ,  B01L3/508 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2300/069 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/165

摘要： The present disclosure relates to processes and methods for producing a hydrophobic zone boundary that surrounds a hydrophilic porous material layer mounted on a substrate, the hydrophilic porous material layer containing tortuous channels and pores such that the fluid contained within one hydrophilic layer region does not cross the hydrophobic zone boundary and the articles formed thereby and, more particularly, to processes and methods for producing a hydrophobic zone boundary that separates adjacent regions of a hydrophilic porous material layer mounted on a substrate, the hydrophilic porous material layer containing tortuous channels and pores mounted on a substrate such that a uniform hydrophobic zone boundary layer in the z-direction is formed in the hydrophilic porous material or the removal of the hydrophilic porous material layer from the substrate to form a hydrophilic porous material zone on the substrate, the so formed hydrophilic porous material zone having a predetermined geometric shape such that the combination produced thereby is useful in microarray applications and other applications. Methods of making and using discrete zoned microporous nylon coated glass plateforms for use with microwell plates are also disclosed.

摘要翻译： 本公开涉及用于生产围绕安装在基底上的亲水性多孔材料层的疏水区域边界的方法和方法，所述亲水性多孔材料层含有曲折通道和孔，使得包含在一个亲水层区域内的流体不会穿过 疏水区边界和由此形成的制品，更具体地，涉及用于制造分离安装在基板上的亲水性多孔材料层的相邻区域的疏水区边界的方法和方法，所述亲水性多孔材料层包含曲折通道和安装在 使得在亲水性多孔材料中形成z方向上的均匀疏水区域边界层或者从基底去除亲水性多孔材料层以在基底上形成亲水性多孔材料区域的基底，所形成的亲水性多孔体 材料区域具有预定的 几何形状使得由此产生的组合在微阵列应用和其它应用中是有用的。 还公开了制造和使用用于微孔板的分散的带微孔尼龙涂层玻璃板的方法。

公开(公告)号：US20050227917A1

公开(公告)日：2005-10-13

申请号：US10779543

申请日：2004-02-12

申请人： Lewis Williams ,  Jaime Escobedo ,  Michael Innis ,  Pablo Garcia ,  Julie Sudduth-Klinger ,  Christoph Reinhard ,  Klaus Giese ,  Filippo Randazzo ,  Giulia Kennedy ,  David Pot ,  Altaf Kassam ,  George Lamson ,  Zhijun He ,  Elizabeth Scott ,  Guozhong Zhang ,  Theresa May ,  Doreen Sakamoto ,  Radoje Drmanac ,  Radomir Crkvenjakov ,  Mark Dickson ,  Snezana Drmanac ,  Ivan Labat ,  Dena Leshkowitz ,  David Kita ,  Veronica Garcia ,  Lee Jones ,  Birgit Stache-Crain

发明人： Lewis Williams ,  Jaime Escobedo ,  Michael Innis ,  Pablo Garcia ,  Julie Sudduth-Klinger ,  Christoph Reinhard ,  Klaus Giese ,  Filippo Randazzo ,  Giulia Kennedy ,  David Pot ,  Altaf Kassam ,  George Lamson ,  Zhijun He ,  Elizabeth Scott ,  Guozhong Zhang ,  Theresa May ,  Doreen Sakamoto ,  Radoje Drmanac ,  Radomir Crkvenjakov ,  Mark Dickson ,  Snezana Drmanac ,  Ivan Labat ,  Dena Leshkowitz ,  David Kita ,  Veronica Garcia ,  Lee Jones ,  Birgit Stache-Crain

IPC分类号： A61K38/17 ,  C07H21/04 ,  C07K14/47 ,  C12Q1/68 ,  G01N33/574

CPC分类号： A61K38/1709 ,  C07K14/47 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/574

摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.

摘要翻译： 本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。 这些多核苷酸可用于各种诊断和治疗方法。 本发明还提供减少癌细胞生长的方法。 这些方法可用于治疗癌症。