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公开(公告)号：US08246929B2
公开(公告)日：2012-08-21
申请号：US11920380
申请日：2005-05-31
申请人： Tom Eriksson , Kenth Nilsson , Anna-Karin Johansson , Karin Ljungström , Koroush Lashgari , Annika Pohl , Gunnar Westin
发明人： Tom Eriksson , Kenth Nilsson , Anna-Karin Johansson , Karin Ljungström , Koroush Lashgari , Annika Pohl , Gunnar Westin
IPC分类号： C04B35/00
CPC分类号： C04B35/495 , A61N1/056 , A61N1/0565 , A61N1/36542 , A61N1/36564 , C01G33/00 , C01G33/006 , C01P2002/72 , C01P2002/77 , C01P2002/82 , C01P2002/88 , C01P2004/03 , C04B35/624 , C04B35/62645 , C04B35/62675 , C04B2235/3201 , C04B2235/3251 , C04B2235/3255 , C04B2235/441 , C04B2235/6562 , C04B2235/768 , C04B2235/80 , C23C18/1216 , C23C18/1225 , C23C18/1254 , C23C18/1283 , H01L41/1873 , H01L41/318
摘要： A method for producing a biocompatible material of the formula NaxKyNbO3, 0≦x≦0.8, 0.2≦y≦1, x+y=1 includes the steps of a) providing a Na-precursor and a K-precursor for NaxKyNbO3, b) mixing the precursors in solution wherein said precursors first react to form a sol and thereafter a gel, c) heat treating the gel to obtain an oxide of the material NaxKyNbO3, 0≦x≦0.8, 0.2≦y≦1, x+y=1. The material can be produced as a film, and the material or film can be provided on the exterior surface of a medical implant that will come into contact with body tissue and/or body fluids upon implantation thereof.
摘要翻译： 一种制备式NaxKyNbO3,0和nlE; x和nlE; 0.8,0.2＆nlE; y＆nlE; 1，x + y = 1的生物相容性材料的方法包括以下步骤：a）提供NaxKyNbO3的Na前体和K-前体，b 将前体混合在溶液中，其中所述前体首先反应形成溶胶，然后进行凝胶，c）热处理该凝胶以获得材料NaxKyNbO3,0和nlE; x和nlE; 0.8,0.2和nlE; y和nlE; 1，x + y = 1。 该材料可以作为膜制造，并且材料或膜可以设置在将在其植入时将与身体组织和/或体液接触的医用植入物的外表面上。
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公开(公告)号：US20120276279A1
公开(公告)日：2012-11-01
申请号：US13547841
申请日：2012-07-12
申请人： Tom Eriksson , Kenth Nilsson , Anna-Karin Johansson , Karin Lungstrom , Koroush Lashgari , Annika Pohl , Gunnar Westin
发明人： Tom Eriksson , Kenth Nilsson , Anna-Karin Johansson , Karin Lungstrom , Koroush Lashgari , Annika Pohl , Gunnar Westin
IPC分类号： H01L41/22
CPC分类号： C04B35/495 , A61N1/056 , A61N1/0565 , A61N1/36542 , A61N1/36564 , C01G33/00 , C01G33/006 , C01P2002/72 , C01P2002/77 , C01P2002/82 , C01P2002/88 , C01P2004/03 , C04B35/624 , C04B35/62645 , C04B35/62675 , C04B2235/3201 , C04B2235/3251 , C04B2235/3255 , C04B2235/441 , C04B2235/6562 , C04B2235/768 , C04B2235/80 , C23C18/1216 , C23C18/1225 , C23C18/1254 , C23C18/1283 , H01L41/1873 , H01L41/318
摘要： A method for producing a biocompatible material of the formula NaxKyNbO3, 0≦x≦0.8, 0.2≦y≦1, x+y=1 includes the steps of a) providing a Na-precursor and a K-precursor for NaxKyNbO3, b) mixing the precursors in solution wherein said precursors first react to form a sol and thereafter a gel, c) heat treating the gel to obtain an oxide of the material NaxKyNbO3, 0≦x≦0.8, 0.2≦y≦1, x+y=1. The material can be produced as a film, and the material or film can be provided on the exterior surface of a medical implant that will come into contact with body tissue and/or body fluids upon implantation thereof.
摘要翻译： 一种制备式NaxKyNbO3,0和nlE; x和nlE; 0.8,0.2＆nlE; y＆nlE; 1，x + y = 1的生物相容性材料的方法包括以下步骤：a）提供NaxKyNbO3的Na前体和K-前体，b 将前体混合在溶液中，其中所述前体首先反应形成溶胶，然后进行凝胶，c）热处理该凝胶以获得材料NaxKyNbO3,0和nlE; x和nlE; 0.8,0.2和nlE; y和nlE; 1，x + y = 1。 该材料可以作为膜制造，并且材料或膜可以设置在将在其植入时将与身体组织和/或体液接触的医用植入物的外表面上。
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公开(公告)号：US08372469B2
公开(公告)日：2013-02-12
申请号：US13547841
申请日：2012-07-12
申请人： Tom Eriksson , Kenth Nilsson , Anna-Karin Johansson , Karin Lungstrom , Koroush Lashgari , Annika Pohl , Gunnar Westin
发明人： Tom Eriksson , Kenth Nilsson , Anna-Karin Johansson , Karin Lungstrom , Koroush Lashgari , Annika Pohl , Gunnar Westin
IPC分类号： B32B17/00
CPC分类号： C04B35/495 , A61N1/056 , A61N1/0565 , A61N1/36542 , A61N1/36564 , C01G33/00 , C01G33/006 , C01P2002/72 , C01P2002/77 , C01P2002/82 , C01P2002/88 , C01P2004/03 , C04B35/624 , C04B35/62645 , C04B35/62675 , C04B2235/3201 , C04B2235/3251 , C04B2235/3255 , C04B2235/441 , C04B2235/6562 , C04B2235/768 , C04B2235/80 , C23C18/1216 , C23C18/1225 , C23C18/1254 , C23C18/1283 , H01L41/1873 , H01L41/318
摘要： A method for producing a biocompatible material of the formula NaxKyNbO3, 0≦x≦0.8, 0.2≦y≦1, x+y=1 includes the steps of a) providing a Na-precursor and a K-precursor for NaxKyNbO3, b) mixing the precursors in solution wherein said precursors first react to form a sol and thereafter a gel, c) heat treating the gel to obtain an oxide of the material NaxKyNbO3, 0≦x≦0.8, 0.2≦y≦1, x+y=1. The material can be produced as a film, and the material or film can be provided on the exterior surface of a medical implant that will come into contact with body tissue and/or body fluids upon implantation thereof.
摘要翻译： 一种制备式NaxKyNbO3,0和nlE; x和nlE; 0.8,0.2＆nlE; y＆nlE; 1，x + y = 1的生物相容性材料的方法包括以下步骤：a）提供NaxKyNbO3的Na前体和K-前体，b 将前体混合在溶液中，其中所述前体首先反应形成溶胶，然后进行凝胶，c）热处理该凝胶以获得材料NaxKyNbO3,0和nlE; x和nlE; 0.8,0.2和nlE; y和nlE; 1，x + y = 1。 该材料可以作为膜制造，并且材料或膜可以设置在将在其植入时将与身体组织和/或体液接触的医用植入物的外表面上。
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公开(公告)号：US20090177049A1
公开(公告)日：2009-07-09
申请号：US11920380
申请日：2005-05-31
申请人： Tom Eriksson , Kenth Nilsson , Anna-Karin Johansson , Karin Ljungstrom , Koroush Lashgari , Annika Pohl , Gunnar Westin
发明人： Tom Eriksson , Kenth Nilsson , Anna-Karin Johansson , Karin Ljungstrom , Koroush Lashgari , Annika Pohl , Gunnar Westin
IPC分类号： A61B5/00 , C04B35/495 , B05D3/02 , B32B9/00
CPC分类号： C04B35/495 , A61N1/056 , A61N1/0565 , A61N1/36542 , A61N1/36564 , C01G33/00 , C01G33/006 , C01P2002/72 , C01P2002/77 , C01P2002/82 , C01P2002/88 , C01P2004/03 , C04B35/624 , C04B35/62645 , C04B35/62675 , C04B2235/3201 , C04B2235/3251 , C04B2235/3255 , C04B2235/441 , C04B2235/6562 , C04B2235/768 , C04B2235/80 , C23C18/1216 , C23C18/1225 , C23C18/1254 , C23C18/1283 , H01L41/1873 , H01L41/318
摘要： A method for producing a biocompatible material of the formula NaxKyNbO3, 0≦x≦0.8, 0.2≦y≦1, x+y=1 includes the steps of a) providing a Na-precursor and a K-precursor for NaxKyNbO3, b) mixing the precursors in solution wherein said precursors first react to form a sol and thereafter a gel, c) heat treating the gel to obtain an oxide of the material NaxKyNbO3, 0≦x≦0.8, 0.2≦y≦1, x+y=1. The material can be produced as a film, and the material or film can be provided on the exterior surface of a medical implant that will come into contact with body tissue and/or body fluids upon implantation thereof.
摘要翻译： 一种制备式NaxKyNbO3,0 <= x <= 0.8,0.2 <= y <= 1，x + y = 1的生物相容性材料的方法包括以下步骤：a）提供Na-前体和K-前体， NaxKyNbO3，b）在溶液中混合前体，其中所述前体首先反应形成溶胶，然后凝胶，c）热处理该凝胶以获得材料NaxKyNbO3的氧化物，0≤x≤0.8,0.2≤y <= 1，x + y = 1。 该材料可以作为膜制造，并且材料或膜可以设置在将在其植入时将与身体组织和/或体液接触的医用植入物的外表面上。
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公开(公告)号：US09295833B2
公开(公告)日：2016-03-29
申请号：US11914050
申请日：2005-05-31
CPC分类号： A61N1/056 , A61N1/36564
摘要： An implantable lead for sensing mechanical activity of a human heart has an insulating polymeric tube extending from a proximal end to a distal end of the lead, an electrical conductor provided in the lumen of the polymeric tube, and a sensor connected to the conductor at the distal end thereof. The polymeric tube is provided with a conductive surface layer along the inner face between the polymeric tube and the electrical conductor, the conductive surface layer being in electrical contact with this conductor. Accumulation of electrical charges between the electric conductor and the polymeric tube is thereby prevented.
摘要翻译： 用于感测人心脏的机械活动的可植入引线具有从引线的近端延伸到远端的绝缘聚合物管，设置在聚合物管的内腔中的电导体，以及连接到导体的传感器 其远端。 聚合物管沿着聚合物管和电导体之间的内表面设置有导电表面层，导电表面层与该导体电接触。 从而防止了电导体和聚合物管之间的电荷积聚。
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公开(公告)号：US20090125090A1
公开(公告)日：2009-05-14
申请号：US11914050
申请日：2005-05-31
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/36564
摘要： An implantable lead for sensing mechanical activity of a human heart has an insulating polymeric tube extending from a proximal end to a distal end of the lead, an electrical conductor provided in the lumen of the polymeric tube, and a sensor connected to the conductor at the distal end thereof. The polymeric tube is provided with a conductive surface layer along the inner face between the polymeric tube and the electrical conductor, the conductive surface layer being in electrical contact with this conductor. Accumulation of electrical charges between the electric conductor and the polymeric tube is thereby prevented.
摘要翻译： 用于感测人心脏的机械活动的可植入引线具有从引线的近端延伸到远端的绝缘聚合物管，设置在聚合物管的内腔中的电导体，以及连接到导体的传感器 其远端。 聚合物管沿着聚合物管和电导体之间的内表面设置有导电表面层，导电表面层与该导体电接触。 从而防止了电导体和聚合物管之间的电荷积聚。
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7.发明申请DEVICE AND METHOD OF A MEDICAL IMPLANT FOR MONITORING PROGRESSION OF HEART FAILURE IN A HUMAN HEART 审中-公开用于监测人心脏心脏衰竭进展的医用植入物的装置和方法公开(公告)号：US20100185252A1
公开(公告)日：2010-07-22
申请号：US12528496
申请日：2007-09-27
申请人： Anders Björling , Malin Öhlander , Tom Eriksson , Johan Eckerdal , Urban Lönn , Kenth Nilsson , Cecilia Tuvstedt , Johan Svahn , Anna-Karin Johansson , Kjell Norén , Michael Broomé
发明人： Anders Björling , Malin Öhlander , Tom Eriksson , Johan Eckerdal , Urban Lönn , Kenth Nilsson , Cecilia Tuvstedt , Johan Svahn , Anna-Karin Johansson , Kjell Norén , Michael Broomé
IPC分类号： A61N1/365 , A61B5/1455 , A61B5/1468 , A61B5/103
CPC分类号： A61B5/14542 , A61B5/0031 , A61B5/076 , A61B5/1459 , A61B2562/0219 , A61N1/3627 , A61N1/36542 , A61N1/36557 , A61N1/36585
摘要： In a device and method for a medical implant for monitoring progression of heart failure in a human heart, an activity sensor provides information related to the activity level of a patient and an oxygen sensor provides information related to the level of oxygen content in venous blood. A determined level of venous oxygen content at a determined activity level is obtained, and that level of venous oxygen content is compared to stored values at a corresponding activity level. The result of the comparison is used as a basis for determining a degree of heart failure.
摘要翻译： 在用于监测人类心脏心脏衰竭进展的医用植入物的装置和方法中，活动传感器提供与患者的活动水平相关的信息，氧传感器提供与静脉血中氧含量水平相关的信息。 在确定的活性水平获得确定水平的静脉氧含量，并将该水平的静脉氧含量与在相应活动水平的储存值进行比较。 将比较结果用作确定心力衰竭程度的基础。
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8.发明申请公开(公告)号：US20080091239A1
公开(公告)日：2008-04-17
申请号：US11582211
申请日：2006-10-16
申请人： Anna-Karin Johansson , Kenth Nilsson , Cecilia Tuvstedt , Kjell Noren , Anders Bjorling , Andreas Blomqvist , Berit Larsson , Sven-Erik Hedberg , Karin Jarverud , Nils Holmstrom
发明人： Anna-Karin Johansson , Kenth Nilsson , Cecilia Tuvstedt , Kjell Noren , Anders Bjorling , Andreas Blomqvist , Berit Larsson , Sven-Erik Hedberg , Karin Jarverud , Nils Holmstrom
CPC分类号： A61N1/36514 , A61N1/3956
摘要： In a cardiac assist device and method, a microphone is placed in contact with the epicardium of the heart of a patient, and heart and lung sounds are simultaneously detected at the placement location of the microphone. The heart and lung sounds are automatically analyzed to set an appropriate cardiac therapy for the patient.
摘要翻译： 在心脏辅助装置和方法中，将麦克风放置成与患者心脏的心外膜接触，并且在麦克风的放置位置同时检测心脏和肺部的声音。 自动分析心脏和肺部声音，为患者设定适当的心脏治疗。
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9.发明授权Implantable cardiac stimulator, device and system for monitoring the status of a cardiac lead 有权可植入心脏刺激器，用于监测心脏导联状态的装置和系统公开(公告)号：US08224421B2
公开(公告)日：2012-07-17
申请号：US12160970
申请日：2006-01-31
CPC分类号： G01K13/002 , A61B2562/245 , A61N1/3706 , A61N2001/083 , G01K7/32
摘要： A cardiac stimulator has an implantable cardiac lead that carries a temperature sensitive element with a surface thereof in contact with biological matter. The temperature sensitive element emits a temperature signal corresponding to the temperature of biological matter, such as blood, in contact with the surface of the temperature sensitive element. Processing circuitry receives the temperature signal and determines a variability thereof within a selected time interval. A status signal is emitted dependent on this variability.
摘要翻译： 心脏刺激器具有植入式心脏引线，其携带温度敏感元件，其表面与生物物质接触。 温度敏感元件发出与温度敏感元件的表面接触的生物物质（例如血液）的温度对应的温度信号。 处理电路接收温度信号并在选定的时间间隔内确定其变化性。 取决于这种可变性发出状态信号。
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10.发明申请IMPLANTABLE CARDIAC STIMULATOR, DEVICE AND SYSTEM FOR MONITORING THE STATUS OF A CARDIAC LEAD 有权可注射的心脏刺激器，用于监测心脏病领域状态的装置和系统公开(公告)号：US20090306735A1
公开(公告)日：2009-12-10
申请号：US12160970
申请日：2006-01-31
IPC分类号： A61N1/37
CPC分类号： G01K13/002 , A61B2562/245 , A61N1/3706 , A61N2001/083 , G01K7/32
摘要： A cardiac stimulator has an implantable cardiac lead that carries a temperature sensitive element with a surface thereof in contact with biological matter. The temperature sensitive element emits a temperature signal corresponding to the temperature of biological matter, such as blood, in contact with the surface of the temperature sensitive element. Processing circuitry receives the temperature signal and determines a variability thereof within a selected time interval. A status signal is emitted dependent on this variability.
摘要翻译： 心脏刺激器具有植入式心脏引线，其携带温度敏感元件，其表面与生物物质接触。 温度敏感元件发出与温度敏感元件的表面接触的生物物质（例如血液）的温度对应的温度信号。 处理电路接收温度信号并在选定的时间间隔内确定其变化性。 取决于这种可变性发出状态信号。
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