公开(公告)号：US20140107516A1

公开(公告)日：2014-04-17

申请号：US14111165

申请日：2012-04-13

Applicant: Karsten Heyne ,  Martin Stockmann ,  Tom Rubin

Inventor： Karsten Heyne ,  Martin Stockmann ,  Tom Rubin

IPC: A61B5/083 ,  A61B5/087 ,  G01J3/42 ,  A61B5/00 ,  G01T1/29 ,  G01R33/465 ,  A61B5/08 ,  A61B5/097 ,  H01J49/26

CPC classification number: A61B5/0836 ,  A61B5/0813 ,  A61B5/087 ,  A61B5/097 ,  A61B5/72 ,  G01J3/42 ,  G01R33/465 ,  G01T1/2985 ,  H01J49/26

Abstract: A method for determining the metabolic capacity of an enzyme includes time-resolved determination of the concentration of a product in exhaled air. The product is created by metabolism of a substrate, previously administered to an individual, by an enzyme of the individual. The product concentration is determined until the maximum product concentration in the exhaled air is reached. A model function is fitted to measured values of the product concentration, obtained by the time-resolved determination of the product concentration between start and end times. The metabolic capacity of the enzyme is determined based on parameters of the model function. Determining the metabolic capacity of the enzyme takes place based on at least two parameters of the model function, wherein the maximum value and time constant of the model function are not selected as parameters at the same time, and the start and/or end times are not selected as parameters.

Abstract translation: 用于测定酶的代谢能力的方法包括对呼出空气中产物浓度的时间分辨确定。 该产物通过个体的酶由先前施用于个体的底物的代谢产生。 确定产物浓度，直到达到呼出空气中的最大产物浓度。 模型函数适用于通过开始和结束时间之间的产物浓度的时间分辨确定获得的产物浓度的测量值。 基于模型函数的参数确定酶的代谢能力。 基于模型函数的至少两个参数确定酶的代谢能力，其中模型函数的最大值和时间常数不被同时选择为参数，并且开始和/或结束时间是 未选择作为参数。

公开(公告)号：US10365204B2

公开(公告)日：2019-07-30

申请号：US16077490

申请日：2017-02-09

Applicant: Tom Rubin

Inventor： Tom Rubin

IPC: G01N1/10 ,  G01N21/03 ,  G01N21/3504 ,  G02B17/00 ,  G02B5/09 ,  G02B5/10 ,  G02B7/182 ,  G01N21/31 ,  G02B6/42

Abstract: The invention relates to a long path cell (10), in particular a Herriott cell, with (a) a primary mirror (12) and (b) a secondary mirror (14). According to the invention, it is provided that the primary mirror (12) has a first primary mirror segment (42.1) and at least one second primary mirror segment (42.2), which radially surrounds the first primary mirror segment (42.1), whereby the primary mirror segments (42) differ in their curvatures (R42.1, 42.2) or focal lengths, the secondary mirror (14) has a first secondary mirror segment (44.1) and at least one second secondary mirror segment (44.2) which radially sur-rounds the first secondary mirror segment (44.1), whereby the secondary mirror segments (44) differ in their curvatures (R42.1, R42.2) or focal lengths, the first primary mirror segment (42.1) and the first secondary mirror segment (44.1) are arranged in relation to each other such that a light beam is reflected back and forth between the two, and that the second primary mirror segment (42.2) and the second secondary mirror segment (44.2) are arranged in relation to each other such that a light beam is reflected back and forth between the two.

公开(公告)号：US09560989B2

公开(公告)日：2017-02-07

申请号：US14111165

申请日：2012-04-13

Applicant: Karsten Heyne ,  Martin Stockmann ,  Tom Rubin

Inventor： Karsten Heyne ,  Martin Stockmann ,  Tom Rubin

IPC: A61B5/08 ,  A61B5/083 ,  A61B5/097 ,  A61B5/087 ,  A61B5/00 ,  G01J3/42 ,  G01R33/465 ,  G01T1/29 ,  H01J49/26

CPC classification number: A61B5/0836 ,  A61B5/0813 ,  A61B5/087 ,  A61B5/097 ,  A61B5/72 ,  G01J3/42 ,  G01R33/465 ,  G01T1/2985 ,  H01J49/26

Abstract: A method for determining the metabolic capacity of an enzyme includes time-resolved determination of the concentration of a product in exhaled air. The product is created by metabolism of a substrate, previously administered to an individual, by an enzyme of the individual. The product concentration is determined until the maximum product concentration in the exhaled air is reached. A model function is fitted to measured values of the product concentration, obtained by the time-resolved determination of the product concentration between start and end times. The metabolic capacity of the enzyme is determined based on parameters of the model function. Determining the metabolic capacity of the enzyme takes place based on at least two parameters of the model function, wherein the maximum value and time constant of the model function are not selected as parameters at the same time, and the start and/or end times are not selected as parameters.

Abstract translation: 用于测定酶的代谢能力的方法包括对呼出空气中产物浓度的时间分辨确定。 该产物通过个体的酶由先前施用于个体的底物的代谢产生。 确定产物浓度，直到达到呼出空气中的最大产物浓度。 模型函数适用于通过开始和结束时间之间的产物浓度的时间分辨确定获得的产物浓度的测量值。 基于模型函数的参数确定酶的代谢能力。 基于模型函数的至少两个参数确定酶的代谢能力，其中模型函数的最大值和时间常数不被同时选择为参数，并且开始和/或结束时间是 未选择作为参数。

公开(公告)号：US09541497B2

公开(公告)日：2017-01-10

申请号：US13143074

申请日：2010-12-21

Applicant: Karsten Heyne ,  Tom Rubin

Inventor： Karsten Heyne ,  Tom Rubin

IPC: A61B5/08 ,  G01N21/3504 ,  A61B5/083 ,  G01N21/39 ,  A61B5/087 ,  A61M16/12

CPC classification number: G01N21/3504 ,  A61B5/082 ,  A61B5/0836 ,  A61B5/087 ,  A61M16/12 ,  A61M2230/432 ,  G01N21/39 ,  G01N2800/085

Abstract: A measurement device and a method for analyzing a sample gas by infrared absorption spectroscopy are described. The measurement device comprises a narrowband laser having a line width of less than 0.2 cm−1 and being smaller than a width of an infrared absorption line to be measured of a sample gas. The measurement device is suited and can be arranged to measure the respiratory gas of a human or animal as sample gas, wherein the respiratory gas exchanges in the measurement chamber only by the respiration of the human or animal, and the respiratory resistance of the measurement device is less than 60 mbar.

Abstract translation: 描述了通过红外吸收光谱分析样品气体的测量装置和方法。 测量装置包括具有小于0.2cm -1的线宽并且小于待测样品的红外吸收线的宽度的窄带激光。 测量装置是适合的，并且可以被布置为测量作为样品气体的人或动物的呼吸气体，其中呼吸气体仅通过人或动物的呼吸和测量装置的呼吸阻力在测量室中交换 小于60毫巴。

公开(公告)号：US20190049364A1

公开(公告)日：2019-02-14

申请号：US16077490

申请日：2017-02-09

Applicant: Tom Rubin

Inventor： Tom Rubin

IPC: G01N21/03 ,  G02B17/00 ,  G02B5/10 ,  G02B7/182 ,  G02B5/09

CPC classification number: G01N21/031 ,  G01N21/31 ,  G01N21/3504 ,  G01N2021/0314 ,  G01N2201/066 ,  G01N2201/0668 ,  G02B5/09 ,  G02B5/10 ,  G02B6/42 ,  G02B7/182 ,  G02B17/004

Abstract: The invention relates to a long path cell (10), in particular a Herriott cell, with (a) a primary minor (12) and (b) a secondary mirror (14). According to the invention, it is provided that the primary mirror (12) has a first primary minor segment (42.1) and at least one second primary minor segment (42.2), which radially surrounds the first primary mirror segment (42.1), whereby the primary minor segments (42) differ in their curvatures (R42.1, 42.2) or focal lengths, the secondary minor (14) has a first secondary minor segment (44.1) and at least one second secondary mirror segment (44.2) which radially sur-rounds the first secondary minor segment (44.1), whereby the secondary minor segments (44) differ in their curvatures (R42.1, R42.2) or focal lengths, the first primary mirror segment (42.1) and the first secondary minor segment (44.1) are arranged in relation to each other such that a light beam is reflected back and forth between the two, and that the second primary mirror segment (42.2) and the second secondary minor segment (44.2) are arranged in relation to each other such that a light beam is reflected back and forth between the two.

公开(公告)号：US20120241622A1

公开(公告)日：2012-09-27

申请号：US13392377

申请日：2010-08-27

Applicant: Karsten Heyne ,  Jens Beckmann ,  Tom Rubin

Inventor： Karsten Heyne ,  Jens Beckmann ,  Tom Rubin

IPC: G01N21/39 ,  G01N21/35

CPC classification number: G01N21/3504 ,  G01N21/031 ,  G01N21/276 ,  G01N2201/0697 ,  G01N2201/1288

Abstract: A method for determining the 14C content of a gas mixture in which 14C isotopes are present as molecule constituents, is provided. The gas mixture is provided in a measuring space, wherein infrared laser radiation is supplied to the measuring space as measurement radiation. The laser radiation to be supplied to the measuring space is deflected such that it passes through the measuring space a plurality of times by interacting with the gas mixture, wherein the laser radiation is supplied to a detector, in order to determine the absorption of laser radiation by the gas mixture and therefrom determine the 14C content. For generating the laser radiation a pulsed laser is used, which as measurement radiation emits laser pulses with a pulse duration of less than 5 μs, which are supplied to the measuring space.

Abstract translation: 提供了一种确定其中14C同位素作为分子成分存在的气体混合物的14C含量的方法。 气体混合物设置在测量空间中，其中红外激光辐射作为测量辐射被提供给测量空间。 要供应到测量空间的激光辐射被偏转，使得其通过与气体混合物相互作用而多次通过测量空间，其中激光辐射被提供给检测器，以便确定激光辐射的吸收 由气体混合物确定14C含量。 为了产生激光辐射，使用脉冲激光，其作为测量辐射发射具有小于5μs的脉冲持续时间的激光脉冲，其被提供给测量空间。

公开(公告)号：US20110270113A1

公开(公告)日：2011-11-03

申请号：US13143074

申请日：2010-12-21

Applicant: Karsten Heyne ,  Tom Rubin

Inventor： Karsten Heyne ,  Tom Rubin

IPC: A61B5/083 ,  G01J5/02

CPC classification number: G01N21/3504 ,  A61B5/082 ,  A61B5/0836 ,  A61B5/087 ,  A61M16/12 ,  A61M2230/432 ,  G01N21/39 ,  G01N2800/085

Abstract: A measurement device and a method for analyzing a sample gas by infrared absorption spectroscopy are described. The measurement device comprises: a measurement chamber with the sample gas to be analyzed, a laser being arranged in relation to the measurement chamber such that light being emitted from the laser radiates through the measurement chamber, a detection device detecting the light being emitted from the laser and radiated through the measurement chamber, and an evaluation unit evaluating signals generated by the detection device regarding a light absorption occurred in the measurement chamber. Provision is made that the laser is a narrowband emitting laser, the line width of which is smaller or equal to the width of an infrared absorption line to be measured of the sample gas, the laser is designed and arranged such that the laser frequency is varied periodically within a defined spectral range, wherein the laser frequency and its variation are chosen such that at least one infrared absorption line to be measured of the sample gas lies in the defined spectral range, and the detection device is designed and arranged such that it detects the light being emitted from the laser and radiated through the measurement chamber in such a time-resolved manner that the light absorption can be determined frequency-resolved within the defined spectral range, wherein the detection device carries out a single absorption measurement within 10−5 s or faster. Furthermore, the measurement device is suited and can be arranged to measure the respiratory gas of a human or animal as sample gas, wherein the respiratory gas exchanges in the measurement chamber only by the respiration of the human or animal, and the respiratory resistance of the measurement device is less than 60 mbar.

Abstract translation: 描述了通过红外吸收光谱分析样品气体的测量装置和方法。 测量装置包括：具有待分析的样品气体的测量室，相对于测量室布置的激光，使得从激光发射的光辐射穿过测量室;检测装置，检测从 激光并通过测量室辐射，并且评估单元评估由检测装置产生的关于在测量室中发生的光吸收的信号。 规定，激光是窄带发射激光器，其线宽小于或等于待测样品气体的红外线吸收线的宽度，激光器的设计和布置使得激光频率变化 周期性地在限定的光谱范围内，其中激光频率及其变化被选择为使得要测量的样品气体的至少一个红外线吸收线位于限定的光谱范围内，并且检测装置被设计和布置成使得其检测 该光从激光器射出并以这样的时间分辨方式辐射通过测量室，使得光吸收可被确定为在规定的光谱范围内频率分辨，其中检测装置在10-5-5内进行单次吸收测量 s或更快。 此外，测量装置是适合的，并且可以被布置为测量作为样品气体的人或动物的呼吸气体，其中呼吸气体仅通过人或动物的呼吸而在测量室中交换，并且呼吸阻力 测量装置小于60毫巴。