公开(公告)号：US09278119B2

公开(公告)日：2016-03-08

申请号：US14128064

申请日：2012-06-28

申请人： Tommy Andersson ,  Anders Bjartell

发明人： Tommy Andersson ,  Anders Bjartell

IPC分类号： A61K38/04 ,  C07K7/00 ,  A61P35/00 ,  A61K38/10 ,  C07K14/475 ,  G01N33/50 ,  G01N33/574 ,  A61K38/08

CPC分类号： A61K38/10 ,  A61K38/08 ,  C07K14/475 ,  G01N33/5088 ,  G01N33/57434 ,  G01N2800/52

摘要： The present invention relates to a Wnt5a protein or peptide thereof possessing Wnt5a signaling properties, such as Foxy5, for use in the treatment of prostate cancer, in particular in patients that have undergone or will undergo radical prosteatectomy. The invention also relates to a method for determining a prognosis for a patient having prostate cancer and a kit for performing said method. The method for determining a prognosis for a patient comprises the steps of: evaluating an amount of Wnt5a protein present in at least part of a sample earlier obtained from the patient and determining a sample value corresponding to the evaluated amount; comparing the sample value obtained in step a) with a reference value associated with a reference prognosis; and, if said sample value is higher than said reference value, concluding that the prognosis for said patient is better than said reference prognosis.

摘要翻译： 本发明涉及具有Wnt5a信号传导特性的Wnt5a蛋白或其肽，例如Foxy5，用于治疗前列腺癌，特别是在经历或将进行根治性前列腺切除术的患者中。 本发明还涉及一种用于确定具有前列腺癌的患者的预后的方法和用于执行所述方法的试剂盒。 用于确定患者预后的方法包括以下步骤：评估存在于患者早期获得的样品的至少部分中的Wnt5a蛋白质的量并确定与所述评估量相对应的样品值; 将步骤a）中获得的样品值与参考预后相关的参考值进行比较; 并且如果所述样品值高于所述参考值，则认为所述患者的预后优于所述参考预后。

公开(公告)号：US20120010151A1

公开(公告)日：2012-01-12

申请号：US13058036

申请日：2009-08-13

申请人： Tommy Andersson

发明人： Tommy Andersson

IPC分类号： A61K38/10 ,  A61P35/00 ,  A61K38/08 ,  C07K7/08 ,  C07K7/06

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention relates to a novel unbranched carbamate derivative, in particular N-butyloxycarbonyl derivative of certain Wnt5-α peptides and to their use in the treatment of melanoma or gastric cancer, as well as a method for treating melanoma as well as a pharmaceutical composition comprising the same derivative.

摘要翻译： 本发明涉及一种新型的无支链氨基甲酸酯衍生物，特别是某些Wnt5-α肽的N-丁氧基羰基衍生物及其在治疗黑素瘤或胃癌中的应用，以及治疗黑素瘤的方法以及药物组合物 包含相同的衍生物。

公开(公告)号：US20110308037A1

公开(公告)日：2011-12-22

申请号：US13140771

申请日：2009-11-05

申请人： Tommy Andersson ,  Magnus Wennerström ,  Henrik Nygren ,  Gunnar Lundmark

发明人： Tommy Andersson ,  Magnus Wennerström ,  Henrik Nygren ,  Gunnar Lundmark

IPC分类号： A47L9/10

CPC分类号： A47L9/0081 ,  B01D45/16

摘要： The present disclosure relates to a vacuum cleaner comprising an electric motor (3) and a blower (5), producing an air flow (9) through the vacuum cleaner. The electric motor and the blower are placed on a common vertical axis (17). A separator unit (13) is placed lateral with respect to the common axis of the motor and the blower. A bent conduit (19) connects the blower with the separator unit, and one end (21) of the conduit encloses the common vertical axis. In the prolongation of the common axis the conduit comprises a portion with a double wall forming a closed air pocket (23). This provides damping of noise emitted by the blower/motor and which propagates in the opposite direction of the air flow.

摘要翻译： 本发明涉及包括电动机（3）和鼓风机（5）的真空吸尘器，其通过真空吸尘器产生空气流（9）。 电动机和鼓风机被放置在共同的竖直轴线（17）上。 分离器单元（13）相对于电机和鼓风机的公共轴线横向放置。 弯曲的管道（19）将鼓风机与分离器单元连接，导管的一端（21）包围共同的垂直轴线。 在公共轴的延长期间，导管包括具有双壁的部分，形成封闭气囊（23）。 这提供了由鼓风机/马达发出的噪声并且在与空气流相反的方向传播的噪声。

公开(公告)号：US07389896B2

公开(公告)日：2008-06-24

申请号：US10495190

申请日：2002-11-05

申请人： Tommy Andersson ,  Johan Berg ,  Nils Fyhr ,  Johan Kronstedt ,  Kenth Nilsson

发明人： Tommy Andersson ,  Johan Berg ,  Nils Fyhr ,  Johan Kronstedt ,  Kenth Nilsson

IPC分类号： C22B1/00

CPC分类号： B05C11/1034 ,  B05C5/02

摘要： This invention relates to a device for jetting droplets of a particle filled viscous medium. The device has a nozzle, an eject mechanism connected to the nozzle, a medium feeding mechanism connected to the eject mechanism, a particle filled viscous medium container connected to the medium feeding mechanism, and a filter arranged between an outlet of the particle filled viscous medium container and the medium feeding mechanism.

摘要翻译： 本发明涉及一种用于喷射填充颗粒的粘性介质的液滴的装置。 该装置具有喷嘴，连接到喷嘴的排出机构，连接到排出机构的介质供给机构，连接到介质供给机构的填充颗粒的粘性介质容器，以及布置在填充颗粒的粘性介质的出口之间的过滤器 容器和介质送料机构。

公开(公告)号：US4531687A

公开(公告)日：1985-07-30

申请号：US549556

申请日：1983-11-07

申请人： Tommy Andersson

发明人： Tommy Andersson

IPC分类号： B60R22/405 ,  A62B35/02 ,  B65H75/48

CPC分类号： B60R22/405

摘要： A retractor reel for a vehicle safety belt comprising a shaft rotatably mounted on a support adapted automatically to wind a safety belt when the belt is not in use and incorporating means for locking the shaft to prevent the belt being withdrawn from the retractor reel under certain conditions, said locking means comprising stop abutment means on said support and at least one locking pin which extends through an aperture in the shaft, substantially diametrically across the shaft, substantially perpendicularly to the longitudinal axis of the shaft, the locking pin being axially movable between a retracted position and an extended locking position, the locking pin, when in the locking position, having an engagement end extending out of the shaft on one side thereof to cooperate with a stop abutment means provided on the support to prevent rotation of the shaft, the opposite end of the locking pin engaging the shaft on the other side of the axis of the shaft that is remote from the engagement end of the locking pin, there being a control disk rotatably mounted on the shaft for controlling movement of the locking pin.

摘要翻译： 一种用于车辆安全带的牵开器卷轴，包括可旋转地安装在支架上的轴，所述支撑件在带不使用时自动地卷绕安全带，并且包括用于锁定轴的装置，以防止在特定条件下将带从牵开器卷轴中拉出 所述锁定装置包括在所述支撑件上的止动抵接装置和至少一个锁定销，所述至少一个锁定销延伸穿过所述轴中的孔，基本上直径地穿过所述轴，大致垂直于所述轴的纵向轴线，所述锁定销可在 缩回位置和延伸的锁定位置，当处于锁定位置时，锁定销在其一侧具有从轴延伸出的接合端，以配合设置在支撑件上的止动抵接装置，以防止轴的旋转， 锁定销的相对端在轴远离接头的轴的另一侧上接合轴 锁定销的端部，存在可旋转地安装在轴上的控制盘，用于控制锁定销的移动。

公开(公告)号：US08601736B2

公开(公告)日：2013-12-10

申请号：US13127706

申请日：2009-11-04

申请人： Tommy Andersson

发明人： Tommy Andersson

IPC分类号： F41C23/14

CPC分类号： F41C23/12 ,  F41C23/20 ,  F41C27/22 ,  F41G3/12

摘要： A method for stabilizing a weapon, eg a rifle or a handgun, barrel movements when aiming by attenuating the influence of, primarily, unintentional barrel movements on the barrel orientation. The method is especially characterized in the steps of providing a hinge (3) between the barrel front part (1), which comprises the barrel (1′), and the weapon rear part (2), which comprises the weapon butt end (2′), for mutual movability between said parts; continuously detecting the barrel longitudinal direction movement in at least two planes; and controlling at least one angle between the butt end and the barrel longitudinal direction orientation, respectively, by means of a control system (4h, 4v, 5h, 5v, 6h,6v) so that changes in the barrel orientation are counteracted. The invention also relates to a device and a fire arm.

摘要翻译： 当通过减弱主要是无意的机筒运动对机筒方向的影响来瞄准时，用于稳定武器（例如步枪或手枪）的方法。 该方法的特征在于在包括枪管（1'）的枪管前部（1）和武器后部（2）之间提供铰链（3）的步骤，其包括武器对接端（2 '），用于所述部件之间的相互移动; 在至少两个平面中连续地检测筒纵向运动; 并且通过控制系统（4h，4v，5h，5v，6h，6v）分别控制对接端和筒体纵向取向之间的至少一个角度，从而抵消桶的取向的变化。 本发明还涉及一种装置和消防臂。

公开(公告)号：US20120030984A1

公开(公告)日：2012-02-09

申请号：US13127706

申请日：2009-11-04

申请人： Tommy Andersson

发明人： Tommy Andersson

IPC分类号： F41C23/14 ,  F41C27/00

CPC分类号： F41C23/12 ,  F41C23/20 ,  F41C27/22 ,  F41G3/12

摘要： A method for stabilizing a weapon, eg a rifle or a handgun, barrel movements when aiming by attenuating the influence of, primarily, unintentional barrel movements on the barrel orientation. The method is especially characterized in the steps of providing a hinge (3) between the barrel front part (1), which comprises the barrel (1′), and the weapon rear part (2), which comprises the weapon butt end (2′), for mutual movability between said parts; continuously detecting the barrel longitudinal direction movement in at least two planes; and controlling at least one angle between the butt end and the barrel longitudinal direction orientation, respectively, by means of a control system (4h, 4v, 5h, 5v, 6h,6v) so that changes in the barrel orientation are counteracted. The invention also relates to a device and a fire arm.

摘要翻译： 当通过减弱主要是无意的机筒运动对机筒方向的影响来瞄准时，用于稳定武器（例如步枪或手枪）的方法。 该方法的特征在于在包括枪管（1'）的枪管前部（1）和武器后部（2）之间提供铰链（3）的步骤，其包括武器对接端（2 '），用于所述部件之间的相互移动; 在至少两个平面中连续地检测筒纵向运动; 并且通过控制系统（4h，4v，5h，5v，6h，6v）分别控制对接端和筒体纵向取向之间的至少一个角度，从而抵消桶的取向的变化。 本发明还涉及一种装置和消防臂。

公开(公告)号：US20080207521A1

公开(公告)日：2008-08-28

申请号：US11946303

申请日：2007-11-28

申请人： Tommy Andersson

发明人： Tommy Andersson

IPC分类号： A61K38/10 ,  C07K7/08 ,  C07K7/06 ,  A61P35/00 ,  A61K38/08

CPC分类号： C07K14/475 ,  A61K38/00

摘要： Loss of Wnt-5a protein expression in breast carcinoma patients is associated with a shorter recurrence-free survival as well as increased motility in mammary cell lines. Based on sequence analysis of Wnt-5a 13 peptide fragments were identified and investigated for their ability to mimic effects of the Wnt-5a protein on mammary cell adhesion and motility. Two of these peptides significantly increased adhesion and impaired the motility of non-tumourigenic breast cancer cell lines, both low in endogenous Wnt-5a protein expression. To identify the shortest possible peptide that still had an anti-motile effect, sequential deletions of two Wnt-5a protein expression. To identify the shortest possible peptide that still had an anti-motile effect, sequential deletions of two amino acids from the N-terminal side of the shorter of these two peptides were performed. The effect on tumour cell adhesion was gradually lost, and when only 6 amino acids remained the effect was not detectable. However, formulation of the N—terminal methionine of this hexapeptide restored its effect on adhesion and reduced tumour cell motility. The novel formyl-Met-Asp-Gly-Cys-Glu-Leu peptide ligand can serve as a lead substance for anti-metastatic treatment in the 50% of human breast cancers where the endogenous expression of Wnt-5a is reduced.

摘要翻译： 乳腺癌患者Wnt-5a蛋白表达的丧失与乳腺细胞系的无复发生存期以及运动能力增加有关。 基于Wnt-5a的序列分析，13个肽片段被鉴定并研究其模拟Wnt-5a蛋白对乳腺细胞粘附和运动性的影响的能力。 这些肽中的两种显着增加粘附性并且损害非致瘤性乳腺癌细胞系的动力，两者内源性Wnt-5a蛋白表达低。 为了鉴定仍然具有抗运动作用的最短可能的肽，可以连续删除两种Wnt-5a蛋白的表达。 为了鉴定仍然具有抗运动作用的最短可能的肽，进行了两个氨基酸从这两个较短的肽的N末端侧的连续缺失。 对肿瘤细胞粘附的影响逐渐丧失，只有6个氨基酸仍然没有检测到。 然而，该六肽的N-末端甲硫氨酸的配方恢复了其对粘附的作用和降低的肿瘤细胞运动性。 新型甲酰基-Mly-Asp-Gly-Cys-Glu-Leu肽配体可以作为在人类乳腺癌的50％中进行抗转移治疗的铅物质，其中Wnt-5a的内源性表达降低。

公开(公告)号：US5991043A

公开(公告)日：1999-11-23

申请号：US101273

申请日：1998-08-12

申请人： Tommy Andersson ,  Hans Ahlen

发明人： Tommy Andersson ,  Hans Ahlen

IPC分类号： F41G3/26 ,  G01B11/00

CPC分类号： F41G3/2611

摘要： An impact position marker for ordinary or simulated shooting from a fire-arm (1) towards a moving target comprises a sensor part (2) with an evaluation unit for the actual position of the target in relation to the fire-arm and a firing detector. The evaluation unit comprises an image taking device (10) with its optical axis directed in parallel with the sighting line of the fire-arm (1), a unit (11) which measures the rotation of the sighting line of the image taking device in at least two planes at an angle to each other and comprises one and the same line coinciding or parallel with the sighting line of the fire-arm. The output signals from the image taking device (10), the rotation-measuring unit (11) and the firing detector (12) are inputted to an evaluation unit (13) which calculates the distance to the target and the position of the point of impact in relation to the target at the calculated impact moment. The result of the measuring is presented on a presentation unit (4) and/or controls an acoustic feed-back signal which assists the shooter during aiming and firing.

摘要翻译： PCT No.PCT / SE96 / 01757 Sec。 371日期1998年8月12日 102（e）1998年8月12日PCT PCT 1996年12月27日PCT公布。 公开号WO97 / 25583 日期1997年7月17日从消防臂（1）朝向移动目标的普通或模拟射击的冲击位置标记包括传感器部分（2），其具有用于目标的实际位置相对于火焰 - 手臂和点火检测器。 评估单元包括其光轴与消防臂（1）的瞄准线平行的摄像装置（10），测量摄像装置的瞄准线的旋转的单元（11） 至少两个彼此成角度的平面，并且包括与火臂的瞄准线重合或平行的同一条线。 来自图像摄取装置（10），旋转测量单元（11）和点火检测器（12）的输出信号被输入到计算到目标的距离和点的位置的评估单元（13） 在计算冲击时刻对目标的影响。 测量的结果呈现在呈现单元（4）上和/或控制在瞄准和射击期间辅助射手的声反馈信号。

公开(公告)号：US4763853A

公开(公告)日：1988-08-16

申请号：US900431

申请日：1986-08-26

申请人： Tommy Andersson

发明人： Tommy Andersson

IPC分类号： B60R22/36 ,  B60R22/405 ,  B60R22/41 ,  B60R22/38 ,  B60R22/40

CPC分类号： B60R22/405 ,  B60R22/41

摘要： A retractor reel for a vehicle safety belt has a sensor responsive to the speed or acceleration of belt withdrawal to actuate a reel locking mechanism and also has a sensor responsive to vehicle acceleration or deceleration to actuate the locking mechanism. A solenoid actuated device is provided to retain both the sensors in the inoperative position. The reel can thus safely be used in an automatic seat belt arrangement of the type in which a carriage moves withdrawing belt from the reel to locate the belt in the operative position.

摘要翻译： 用于车辆安全带的牵开器卷轴具有响应于皮带取出的速度或加速度以致致动卷轴锁定机构的传感器，并且还具有响应于车辆加速或减速以致动锁定机构的传感器。 提供电磁致动装置以将两个传感器保持在不工作位置。 因此，卷轴可以安全地用于自动安全带装置，其中托架将抽出带从卷轴移开，以将带定位在操作位置。