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公开(公告)号：US10093948B2
公开(公告)日：2018-10-09
申请号：US14904449
申请日：2014-07-10
摘要： A method of producing alcohol from cellulose-containing biomass includes steps (1) to (8): step (1): pretreating a cellulose-containing biomass; step (2): saccharifying the pretreated cellulose-containing biomass obtained in step (1) with a saccharification enzyme; step (3): removing a saccharification residual solid from a saccharification treated product obtained in step (2); step (4): culturing an alcohol fermentation microorganism with an aqueous sugar solution obtained in step (3) as a fermentation raw material; step (5): removing the alcohol fermentation microorganism from a culture liquid containing the alcohol fermentation microorganism obtained in step (4); step (6): distilling the alcohol fermentation liquid obtained in step (5) to recover alcohol; step (7): passing and filtering a distillation residual liquid obtained in step (6) through a reverse osmosis membrane; and step (8): performing treatment of discharging a retentate obtained in step (7).
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公开(公告)号：US09795923B2
公开(公告)日：2017-10-24
申请号：US14384994
申请日：2013-02-14
CPC分类号： B01D63/02 , B01D63/04 , B01D2313/02 , B01D2313/21 , B01D2313/44 , B01D2317/04
摘要： A cartridge type hollow fiber membrane module includes: a cartridge type hollow fiber membrane element including a hollow fiber membrane bundle, a distribution cylinder, and an adhesive resin portion; a module case including a module case main body portion which has at least one port corresponding to a supply outlet of filtrate or an undiluted solution on a side surface, and a header which has a port corresponding to a supply outlet of filtrate or an undiluted solution, and accommodating the cartridge type hollow fiber membrane element; a first sealing member disposed to come into contact with the distribution cylinder and the header on an external side of a boundary surface between the supporting portion and the adhesive resin portion; and a second sealing member disposed to come into contact with an outer circumference portion of the distribution cylinder and the module case main body portion.
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公开(公告)号：US20160168601A1
公开(公告)日：2016-06-16
申请号：US15051710
申请日：2016-02-24
发明人： Takashi Mimitsuka , Kentaro Ishii , Ken Morita , Masashi Higasa , Kenji Sawai , Hideki Sawai , Katsushige Yamada , Shinichi Minegishi
IPC分类号： C12P7/56
CPC分类号： C12P7/56 , C12M29/18 , C12M47/10 , C12N9/00 , C12P1/00 , C12P7/02 , C12P7/40 , C12P13/001 , C12P13/04 , C12P13/08 , C12P19/34 , C12P21/02
摘要： A method of producing a chemical product includes cultivating microorganisms or culture cells in a fermentation tank; transferring a culture liquid from the fermentation tank to a membrane separation tank to filter the culture liquid through a separation membrane; and collecting a fermentation product from a filtration liquid as the chemical product while refluxing an unfiltered culture liquid that has not been filtered to be joined to the culture liquid on an upstream side of the membrane separation tank, wherein one portion of the culture liquid to be transferred from the fermentation tank is allowed to bypass the membrane separation tank depending on a pressure at a culture liquid flow-in side of the membrane separation tank.
摘要翻译： 生产化学产品的方法包括在发酵罐中培养微生物或培养细胞; 将培养液从发酵罐转移到膜分离罐中，通过分离膜过滤培养液; 并从作为化学产品的过滤液中收集发酵产物，同时在膜分离罐的上游侧回流未过滤的待过滤培养液与培养液接合的培养液，其中一部分培养液为 从膜分离罐的培养液流入侧的压力，允许从发酵罐转移到膜分离槽旁路。
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公开(公告)号：US20200325097A1
公开(公告)日：2020-10-15
申请号：US15931772
申请日：2020-05-14
发明人： Kenji Sawai , Hideki Sawai , Takashi Mimitsuka , Masateru Ito , Katsushige Yamada , Kenji Kawamura , Shin-ichi Minegishi , Izumi Na kagawa , Tatsuya Nagano
摘要： Lactic acid is obtained by a method including (A) a step of continuous fermentation wherein a fermentation culture medium of a microorganism having an ability of lactic acid fermentation is filtered through a porous membrane having an average pore size of not less than 0.01 μm and less than 1 μm with a transmembrane pressure difference within the range of 0.1 to 20 kPa, and the permeate is collected, while retaining the non-permeated liquid in or returning the non-permeated liquid to the culture, and adding a fermentation feedstock to the culture; (B) a step of filtering the permeate obtained in Step (A) through a nanofiltration membrane; and (C) a step of distilling the permeate obtained in Step (B) under a pressure of not less than 1 Pa and not more than atmospheric pressure, at 25° C. to 200° C. to recover lactic acid.
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公开(公告)号：US20160160242A1
公开(公告)日：2016-06-09
申请号：US14904449
申请日：2014-07-10
摘要： A method of producing alcohol from cellulose-containing biomass includes steps (1) to (8): step (1): pretreating a cellulose-containing biomass; step (2): saccharifying the pretreated cellulose-containing biomass obtained in step (1) with a saccharification enzyme; step (3): removing a saccharification residual solid from a saccharification treated product obtained in step (2); step (4): culturing an alcohol fermentation microorganism with an aqueous sugar solution obtained in step (3) as a fermentation raw material; step (5): removing the alcohol fermentation microorganism from a culture liquid containing the alcohol fermentation microorganism obtained in step (4); step (6): distilling the alcohol fermentation liquid obtained in step (5) to recover alcohol; step (7): passing and filtering a distillation residual liquid obtained in step (6) through a reverse osmosis membrane; and step (8): performing treatment of discharging a retentate obtained in step (7).
摘要翻译： 由含纤维素生物质生产醇的方法包括步骤（1）至（8）：步骤（1）：预处理含纤维素的生物质; 步骤（2）：用糖化酶对步骤（1）中获得的预处理含纤维素的生物质进行糖化; 步骤（3）：从步骤（2）中获得的糖化处理产物中除去糖化残留固体; 步骤（4）：用作为发酵原料的步骤（3）获得的糖水溶液培养醇发酵微生物; 步骤（5）：从含有步骤（4）获得的醇发酵微生物的培养液中除去醇发酵微生物; 步骤（6）：蒸馏步骤（5）中获得的醇发酵液以回收酒精; 步骤（7）：通过反渗透膜将步骤（6）中获得的蒸馏残余液体通过和过滤; 和步骤（8）：进行步骤（7）中得到的渗余物的排出处理。
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6.发明申请公开(公告)号：US20200017886A1
公开(公告)日：2020-01-16
申请号：US16483501
申请日：2018-02-06
发明人： Takashi Mimitsuka , Kazumi Suda , Masashi Higasa
摘要： A method produces an alcohol by continuous fermentation using a fermentation raw material, the method including: culturing a microorganism to obtain a fermented liquid, while supplying the fermentation raw material into a fermenter using a plurality of fermentation raw material supply systems; filtering the obtained fermented liquid through a separation membrane to obtain an alcohol-containing filtered liquid and an unfiltered liquid; and retaining or refluxing the obtained unfiltered liquid in the fermenter, in which the plurality of fermentation raw material supply systems each include a fermentation raw material tank for storing the fermentation raw material the same as each other, and a supply line connecting the fermentation raw material tank and the fermenter; and selecting a fermentation raw material supply system to be allowed to stop supplying the fermentation raw material in rotation from the plurality of fermentation raw material supply systems during the supply of the fermentation raw material.
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公开(公告)号：US11597694B2
公开(公告)日：2023-03-07
申请号：US15931772
申请日：2020-05-14
发明人： Kenji Sawai , Hideki Sawai , Takashi Mimitsuka , Masateru Ito , Katsushige Yamada , Kenji Kawamura , Shin-ichi Minegishi , Izumi Nakagawa , Tatsuya Nagano
摘要： Lactic acid is obtained by a method including (A) a step of continuous fermentation wherein a fermentation culture medium of a microorganism having an ability of lactic acid fermentation is filtered through a porous membrane having an average pore size of not less than 0.01 μm and less than 1 μm with a transmembrane pressure difference within the range of 0.1 to 20 kPa, and the permeate is collected, while retaining the non-permeated liquid in or returning the non-permeated liquid to the culture, and adding a fermentation feedstock to the culture; (B) a step of filtering the permeate obtained in Step (A) through a nanofiltration membrane; and (C) a step of distilling the permeate obtained in Step (B) under a pressure of not less than 1 Pa and not more than atmospheric pressure, at 25° C. to 200° C. to recover lactic acid.
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公开(公告)号：US10428358B2
公开(公告)日：2019-10-01
申请号：US15051710
申请日：2016-02-24
发明人： Takashi Mimitsuka , Kentaro Ishii , Ken Morita , Masashi Higasa , Kenji Sawai , Hideki Sawai , Katsushige Yamada , Shinichi Minegishi
IPC分类号： C12P7/56 , C12M1/00 , C12N9/00 , C12P1/00 , C12P7/02 , C12P7/40 , C12P13/00 , C12P13/04 , C12P13/08 , C12P19/34 , C12P21/02
摘要： A method of producing a chemical product includes cultivating microorganisms or culture cells in a fermentation tank; transferring a culture liquid from the fermentation tank to a membrane separation tank to filter the culture liquid through a separation membrane; and collecting a fermentation product from a filtration liquid as the chemical product while refluxing an unfiltered culture liquid that has not been filtered to be joined to the culture liquid on an upstream side of the membrane separation tank, wherein one portion of the culture liquid to be transferred from the fermentation tank is allowed to bypass the membrane separation tank depending on a pressure at a culture liquid flow-in side of the membrane separation tank.
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公开(公告)号：US10370633B2
公开(公告)日：2019-08-06
申请号：US14899624
申请日：2014-06-23
摘要： A continuous sterilizing apparatus circulates, through members constituting a flow channel, a sterilizing medium that sterilizes the members to sterilize the members, circulates a sterilizing liquid subjected to sterilization treatment through pipes, performs a series of pieces of treatment including heating treatment, holding treatment, and cooling treatment on the sterilizing liquid, controls a flow rate, a temperature, and a pressure to be preset conditions, and switches a liquid to be circulated through the flow channel from the sterilizing liquid to a liquid to be sterilized.
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公开(公告)号：US20190093132A1
公开(公告)日：2019-03-28
申请号：US16085919
申请日：2017-03-16
IPC分类号： C12P7/06
摘要： A method of producing a chemical product includes culturing a microorganism with a fermentation feedstock containing cane molasses as a main component; filtering the resulting culture liquid through a separation membrane to recover a filtrate which contains the chemical product and from which the microorganism has been separated; retaining or returning an unfiltered liquid containing the microorganism, in or to the culture liquid; and adding an additional fermentation feedstock to the culture liquid to carry out continuous fermentation; in which the microorganism cultured causes a centrifugal supernatant of the culture liquid to contain particles having an average particle diameter of 100 nm or more.
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