-
1.发明授权Analysis of cerebral white matter for prognosis and diagnosis of neurological disorders 有权脑白质分析用于预后和诊断神经系统疾病公开(公告)号：US06463315B1
公开(公告)日：2002-10-08
申请号：US09491986
申请日：2000-01-26
申请人： Torkel Klingberg , Maj Hedehus , John D. E. Gabrieli , Michael E. Moseley , Russell A. Poldrack
发明人： Torkel Klingberg , Maj Hedehus , John D. E. Gabrieli , Michael E. Moseley , Russell A. Poldrack
IPC分类号： A61B5055
CPC分类号： G01R33/56341 , A61B5/055 , G06F19/00
摘要： A method of detecting a neurological disorder such as dyslexia includes the steps of measuring microstructure of cerebral white matter, and correlating the microstructure to the presence of the neurological disorder. For dyslexia, the white matter is confined to temporo-parietal white matter. The microstructure is measured by determining cerebral white matter anisotropy using diffusion tensor magnetic resonance imaging (DTI).
摘要翻译： 检测诸如诵读困难之类的神经障碍的方法包括测量脑白质微结构并使微结构与神经障碍的存在相关联的步骤。 对于阅读障碍，白质仅限于颞顶白质。 通过使用扩散张量磁共振成像（DTI）确定脑白质各向异性来测量微结构。
-
公开(公告)号：US07048716B1
公开(公告)日：2006-05-23
申请号：US09448720
申请日：1999-11-24
CPC分类号： A61M25/0043 , A61M25/0108 , A61M25/0127 , G01R33/285
摘要： A catheter is used for medical treatments within an organism. The catheter comprises at least one lumen. Within the at least one lumen are at least two microcatheters, with at least one of the at least two microcatheters being connected to a source of liquid material to be delivered to the organism and another of the at least two microcatheters being connected to a system capable of effecting a medical treatment other than delivery of the liquid.
摘要翻译： 导管用于生物体内的医疗治疗。 导管包括至少一个内腔。 所述至少一个腔内至少有两个微导管，所述至少两个微导管中的至少一个微小导管连接到待传递给所述生物的液体材料源，并且所述至少两个微导管中的另一个连接到能够 除了输送液体之外进行医疗。
-
3.发明授权Correction of the effect of spatial gradient field distortions in diffusion-weighted imaging 有权校正扩散加权成像中空间梯度场失真的影响公开(公告)号：US06969991B2
公开(公告)日：2005-11-29
申请号：US10317516
申请日：2002-12-11
IPC分类号： G01R33/563 , G01R33/565 , G01V3/00
CPC分类号： G01R33/56341 , G01R33/56518
摘要： A general mathematical framework is formulated to characterize the contribution of gradient non-uniformities to diffusion tensor imaging in MRI. Based on a model expansion, the actual gradient field is approximated and employed, after elimination of geometric distortions, for predicting and correcting the errors in diffusion encoding. Prior to corrections, experiments clearly reveal marked deviations of the calculated diffusivity for fields of view generally used in diffusion experiments. These deviations are most significant with greater distance from the magnet's isocenter. For a FOV of 25 cm the resultant errors in absolute diffusivity can range from approximately −10 to +20 percent. Within the same field of view, the diffusion-encoding direction and the orientation of the calculated eigenvectors can be significantly altered if the perturbations by the gradient non-uniformities are not considered. With the proposed correction scheme most of the errors introduced by gradient non-uniformities can be removed.
摘要翻译： 制定了一般的数学框架来表征梯度不均匀性对MRI中扩散张量成像的贡献。 基于模型扩展，在消除几何失真之后，实际梯度场被近似和采用，用于预测和纠正扩散编码中的误差。 在更正之前，实验清楚地揭示了通常用于扩散实验的视野的计算的扩散系数的显着偏差。 这些偏差是最重要的，距离磁体的等角点更远。 对于25cm的FOV，绝对扩散率的所得误差可以在约-10至+ 20％的范围内。 在相同视野内，如果不考虑梯度不均匀性的扰动，则可以显着地改变计算的特征向量的扩散编码方向和取向。 利用提出的校正方案，可以消除由梯度不均匀性引入的大多数误差。
-
4.发明授权Imaging methods for early detection of brain tumors following embryonic stem cell implants 失效用于早期检测胚胎干细胞植入物后脑肿瘤的成像方法公开(公告)号：US08706187B2
公开(公告)日：2014-04-22
申请号：US11386394
申请日：2006-03-22
IPC分类号： A61B5/055
CPC分类号： A61B5/413 , A61B5/055 , A61B5/14532 , A61B5/4082 , G01R33/54
摘要： Non-invasive imaging methods and minimally invasive sensing methods are used for assessing the viability of cells implanted in the central nervous system for therapeutic purposes and for detecting the transformation of such cells, including embryonic stem cells, into brain tumors. In particular, the present invention provides an imaging means for differentiating normal cell proliferation and angiogenesis following a cell implant from abnormal tumor growth and neovascularization associated with teratoma-inducing implanted embryonic stem cells.
摘要翻译： 非侵入性成像方法和微创感测方法用于评估植入中枢神经系统中用于治疗目的的细胞的存活力，并用于检测这些细胞（包括胚胎干细胞）转化入脑肿瘤。 特别地，本发明提供了一种用于区分正常细胞增殖和细胞植入之后的异常肿瘤生长和与引起畸胎瘤的植入胚胎干细胞相关的新生血管形成的成像装置。
-
5.发明授权Magnetic resonance apparatus for use with active electrode and drug deliver catheter 有权用于活性电极和药物输送导管的磁共振装置公开(公告)号：US07505807B1
公开(公告)日：2009-03-17
申请号：US09566798
申请日：2000-05-08
IPC分类号： A61B5/055
CPC分类号： A61M31/005 , A61B5/14525 , A61B17/3421 , A61B90/11 , A61B2034/2051 , A61B2090/3954 , A61B2090/3958 , A61B2562/17 , A61M2025/0057 , A61M2025/0073 , A61M2210/06 , A61M2210/0693 , G01R33/281 , G01R33/285 , G01R33/286 , G01R33/287 , G01R33/5601 , G01R33/563 , G01R33/56341
摘要： The invention is an apparatus and method for treatments and targeted drug delivery into a living patient, particularly but not exclusively using magnetic resonance (MR) imaging. The apparatus and method are useful in delivery to all types of living tissue and uses MR Imaging to track the location of drug delivery and estimating the rate of drug delivery. An MR-visible drug delivery device positioned at a target site (e.g., intracranial delivery) delivers a diagnostic or therapeutic drug solution into the tissue (e.g., the brain). The spinal distribution kinetics of the injected or infused drug agent are monitored quantitatively and non-invasively using water proton directional diffusion MR imaging to establish the efficacy of drug delivery at a targeted location.
摘要翻译： 本发明是一种用于治疗和靶向药物递送到生命患者中的装置和方法，特别但不排他地使用磁共振（MR）成像。 该装置和方法在递送到所有类型的活组织中是有用的，并且使用MR成像来跟踪药物递送的位置并估计药物递送速率。 定位在靶位点（例如，颅内递送）的MR-可见药物递送装置将诊断或治疗药物溶液递送到组织（例如，脑）中。 使用水质子定向扩散MR成像定量和非侵入性地监测注射或输注的药物的脊髓分布动力学，以确定靶向位置的药物递送的功效。
-
公开(公告)号：US6061587A
公开(公告)日：2000-05-09
申请号：US856894
申请日：1997-05-15
CPC分类号： G01R33/5601 , A61M31/005 , A61B2034/2051 , A61B2090/365 , A61B2090/3958 , A61B90/11 , A61M2025/0057 , A61M2025/0073 , A61M2210/0693 , G01R33/563
摘要： The invention is an apparatus and method for targeted drug delivery into a living patient using magnetic resonance (MR) imaging. The apparatus and method are useful in delivery to all types of living tissue and uses MR Imaging to track the location of drug delivery and estimating the rate of drug delivery. An MR-visible drug delivery device positioned at an target site (e.g., intracranial delivery) delivers a diagnostic or therapeutic drug solution into the tissue (e.g., the brain). The spatial distribution kinetics of the injected or infused drug agent are monitored quantitatively and non-invasively using water proton directional diffusion MR imaging to establish the efficacy of drug delivery at a targeted location.
-
公开(公告)号：US6026316A
公开(公告)日：2000-02-15
申请号：US857043
申请日：1997-05-15
IPC分类号： A61M25/00 , A61M31/00 , G01R33/28 , G01R33/563 , A61B5/055
CPC分类号： G01R33/5601 , A61M31/005 , A61M2025/0036 , A61M2025/004 , A61M2025/0057 , A61M2025/0073 , G01R33/563
摘要： The invention is an apparatus and method for targeted drug delivery into a living patient using magnetic resonance (MR) imaging. The apparatus and method are useful in delivery to all types of living tissue and uses MR Imaging to track the location of drug delivery and estimating the rate of drug delivery. An MR-visible drug delivery device positioned at an target site (e.g., intracranial delivery) delivers a diagnostic or therapeutic drug solution into the tissue (e.g., the brain). The spatial distribution kinetics of the injected or infused drug agent are monitored quantitatively and non-invasively using water proton directional diffusion MR imaging to establish the efficacy of drug delivery at a targeted location.
摘要翻译： 本发明是使用磁共振（MR）成像将靶向药物递送至生活患者的装置和方法。 该装置和方法在递送到所有类型的活组织中是有用的，并且使用MR成像来跟踪药物递送的位置并估计药物递送速率。 定位在靶位点（例如颅内递送）的MR-可见药物递送装置将诊断或治疗药物溶液递送到组织（例如，脑）中。 使用水质子定向扩散MR成像定量和非侵入性地监测注射或输注的药剂的空间分布动力学，以确定靶向位置的药物递送的功效。
-
8.发明授权Methods for detecting blood perfusion variations by magnetic resonance imaging 失效通过磁共振成像检测血液膨胀变化的方法
公开(公告)号：US5190744A
公开(公告)日：1993-03-02
申请号：US490859
申请日：1990-03-09
IPC分类号： A61B5/055 , A61K49/00 , A61K49/06 , G01R33/28 , G01R33/465 , G01R33/561 , G01R33/563
CPC分类号： G01R33/5601 , A61K49/06 , G01R33/465 , G01R33/563 , G01R33/56308 , Y10S514/836 , Y10T436/24
摘要： The invention provides a method of detecting blood flow abnormality or variation in a human or non-human body, said method comprising administering into the cardiovascular system of a said body a contrast enhancing amount of an intravascular paramagnetic metal containing magnetic resonance imaging contrast agent, subject said body to a magnetic resonance imaging procedure capable of generating from magnetic resonance signals from said body a series of temporally spaced images of at least a part of said body into which said agent passes, and detecting temporal variations in said signals or images whereby to identify regions of abnormal or modified blood flow in said body and to indicate the degree of blood flow abnormality or modification therein.
摘要翻译： 本发明提供一种检测人体或非人体血流异常或变异的方法，所述方法包括向所述体内的心血管系统施用对比度增加量的含有血管内顺磁性金属的磁共振成像造影剂，对象 所述身体到磁共振成像程序，其能够从所述身体的磁共振信号产生所述身体的至少一部分的一系列时间间隔的图像，所述代理人通过该图像，并且检测所述信号或图像中的时间变化，从而识别 所述身体中异常或改变的血流的区域，并指示其中的血流异常或改变的程度。
-
公开(公告)号：US5833947A
公开(公告)日：1998-11-10
申请号：US604778
申请日：1996-02-23
IPC分类号： A61K49/06 , G01R33/28 , G01R33/465 , G01R33/561 , G01R33/563 , A61B5/055
CPC分类号： G01R33/5601 , A61K49/06 , G01R33/465 , G01R33/563 , G01R33/56308 , Y10S514/836 , Y10T436/24
摘要： The invention provides a method of monitoring the vasodilatory or vasoconstrictive effects of a physiologically active substance administered to a human or non-human animal body, said method comprising the steps of: administering said substance into said body; administering into the systemic vasculature of said body a contrast enhancing amount of an intravascular paramagnetic metal containing magnetic resonance imaging contrast agent; subjecting said body to a magnetic resonance imaging procedure capable of generating from magnetic resonance signals from said body a series of temporally spaced images of at least a part of said body into which said agent passes, said procedure being a fast imaging procedure having an image acquisition time of less than five seconds; and detecting temporal variations in said signals or images whereby to monitor the vasoconstriction or vasodilation induced by said substance.
摘要翻译： 本发明提供了监测施用于人或非人动物体的生理活性物质的血管扩张或血管收缩作用的方法，所述方法包括以下步骤：将所述物质施用于所述体内; 对所述体内的系统性脉管系统施用对比度增加量的含血管内顺磁性金属的磁共振成像造影剂; 对所述身体进行磁共振成像程序，所述磁共振成像程序能够从所述身体的磁共振信号产生所述身体的至少一部分的一系列时间间隔的图像，所述过程是具有图像采集的快速成像过程 时间少于5秒; 以及检测所述信号或图像中的时间变化，从而监测由所述物质引起的血管收缩或血管舒张。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.026 秒)