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    SAMPLE DETECTION METHOD BY THIN-LAYER CHROMATOGRAPHY, THIN-LAYER CHROMATOGRAPHY PLATE, AND METHOD FOR PRODUCING SAME
    2.
    发明申请
    SAMPLE DETECTION METHOD BY THIN-LAYER CHROMATOGRAPHY, THIN-LAYER CHROMATOGRAPHY PLATE, AND METHOD FOR PRODUCING SAME 有权
    薄层色谱法，薄层色谱板样品检测方法及其生产方法

    公开(公告)号：US20130067996A1

    公开(公告)日：2013-03-21

    申请号：US13700223

    申请日：2011-05-27

    申请人： Toshiharu Minoda ,  Isamu Ikeda ,  Satoru Nose ,  Noriaki Takeya ,  Ichiro Okamoto

    发明人： Toshiharu Minoda ,  Isamu Ikeda ,  Satoru Nose ,  Noriaki Takeya ,  Ichiro Okamoto

    IPC分类号： G01N30/90

    CPC分类号： G01N30/90 ,  B01D15/20 ,  B01D15/265 ,  B01J20/045 ,  B01J20/26 ,  B01J20/3042 ,  G01N30/92 ,  G01N30/93 ,  G01N30/94 ,  G01N2030/945

    摘要： The present invention provides a thin-layer chromatography plate and a thin-layer chromatography that can detect the separation of a component in a sample by a separating agent layer that does not permit the detection of the separation of the component in the sample by an optical response. For a sample that has an optical response to ultraviolet light or a coloring agent, the present invention uses a thin-layer chromatography plate that has a first separating agent layer, which has the same optical response as the sample, and a second separating agent layer, which is disposed adjacent thereto and has an optical response that is different from the aforementioned optical response; carries out development of the sample in the first separating agent layer; thereafter carries out further development of the spots from the first separating agent layer toward the second separating agent layer; and detects the spots in the second separating agent layer through exposure to ultraviolet radiation or a color-development treatment with a coloring agent. In addition, the development axis in the first separating agent layer is maintained approximately perpendicular, and spot broadening at the boundary surface is prevented by adjusting the binder blending ratio.

    摘要翻译： 本发明提供薄层色谱板和薄层色谱法，其可以通过分离剂层检测样品中组分的分离，所述分离剂层不允许通过光学检测样品中组分的分离 响应。 对于具有对紫外线或着色剂的光学响应的​​样品，本发明使用具有与样品相同的光学响应的​​第一分离剂层的薄层色谱板和第二分离剂层 ，其与其相邻布置并具有与上述光学响应不同的光学响应; 在第一分离剂层中进行样品的开发; 然后进一步开发从第一分离剂层朝向第二分离剂层的斑点; 并通过暴露于紫外线照射或着色剂的显色处理来检测第二分离剂层中的斑点。 此外，第一分离剂层中的显影轴保持大致垂直，并且通过调节粘合剂共混比来防止边界表面的斑点变宽。

    Malonic acid monomethyl derivatives and production process thereof
    3.
    发明授权
    Malonic acid monomethyl derivatives and production process thereof 失效
    丙二酸单甲基衍生物及其制备方法

    公开(公告)号：US07109369B2

    公开(公告)日：2006-09-19

    申请号：US10976966

    申请日：2004-11-01

    申请人： Satoru Nose ,  Kieko Sano ,  Takeshi Hamatani

    发明人： Satoru Nose ,  Kieko Sano ,  Takeshi Hamatani

    IPC分类号： C07C69/76

    CPC分类号： C07C69/65 ,  C07C67/30 ,  C07C67/343

    摘要： A novel monomethyl malonate derivative is represented by following Formula (I): wherein X is a halogen atom; and Me is methyl group. This compound can be prepared by the steps of (A) reacting a benzyl halide derivative represented by following Formula (II): wherein X and Y may be the same as or different from each other and are each a halogen atom, with dimethyl malonate in the presence of a base to yield a dimethyl malonate derivative represented by following Formula (III): wherein X and Me have the same meanings as defined above; and (B) hydrolyzing the dimethyl malonate derivative of Formula (III). The compound is useful in the production of an indanonecarboxylic acid ester having a halogen atom on the indanone ring.

    摘要翻译： 新型单甲基丙二酸酯衍生物由下式（I）表示：其中X为卤素原子; 而我是甲基。 该化合物可以通过以下步骤制备：（A）使由下式（II）表示的苄基卤衍生物：其中X和Y可以彼此相同或不同，并且各自为卤素原子，与丙二酸二甲酯 碱的存在得到由下式（III）表示的丙二酸二甲酯衍生物：其中X和Me具有与上述相同的含义; 和（B）水解式（III）的丙二酸二甲酯衍生物。 该化合物可用于制备在茚酮环上具有卤素原子的茚满酮羧酸酯。

    Malonic acid monomethyl derivatives and production process thereof
    4.
    发明授权
    Malonic acid monomethyl derivatives and production process thereof 失效
    丙二酸单甲基衍生物及其制备方法

    公开(公告)号：US07208621B2

    公开(公告)日：2007-04-24

    申请号：US11486116

    申请日：2006-07-14

    申请人： Satoru Nose ,  Kieko Sano ,  Takeshi Hamatani

    发明人： Satoru Nose ,  Kieko Sano ,  Takeshi Hamatani

    IPC分类号： C07C69/76

    CPC分类号： C07C69/65 ,  C07C67/30 ,  C07C67/343

    摘要： A novel monomethyl malonate derivative is represented by following Formula (I): wherein X is a halogen atom; and Me is methyl group. This compound can be prepared by the steps of (A) reacting a benzyl halide derivative represented by following Formula (II): wherein X and Y may be the same as or different from each other and are each a halogen atom, with dimethyl malonate in the presence of a base to yield a dimethyl malonate derivative represented by following Formula (III): wherein X and Me have the same meanings as defined above; and (B) hydrolyzing the dimethyl malonate derivative of Formula (III). The compound is useful in the production of an indanonecarboxylic acid ester having a halogen atom on the indanone ring.

    摘要翻译： 新型单甲基丙二酸酯衍生物由下式（I）表示：其中X为卤素原子; 而我是甲基。 该化合物可以通过以下步骤制备：（A）使由下式（II）表示的苄基卤衍生物：其中X和Y可以彼此相同或不同，并且各自为卤素原子，与丙二酸二甲酯 碱的存在得到由下式（III）表示的丙二酸二甲酯衍生物：其中X和Me具有与上述相同的含义; 和（B）水解式（III）的丙二酸二甲酯衍生物。 该化合物可用于制备在茚酮环上具有卤素原子的茚满酮羧酸酯。

    Ester and process for producing the same
    5.
    发明授权
    Ester and process for producing the same 失效
    酯及其制备方法

    公开(公告)号：US06462223B2

    公开(公告)日：2002-10-08

    申请号：US09845207

    申请日：2001-05-01

    申请人： Mitsuru Ohno ,  Noritsugu Yamasaki ,  Satoru Nose

    发明人： Mitsuru Ohno ,  Noritsugu Yamasaki ,  Satoru Nose

    IPC分类号： C07C6703

    CPC分类号： C07D319/06

    摘要： 6-Alkoxycarbonylmethyl-4H-1,3-dioxin-4-one derivatives are produced by reacting a 6-halomethyl-4H-1,3-dioxin-4-one derivative with carbon monoxide and an alcohol or water, and 3-oxopentanedicarboxylic acid esters are further produced by reacting the above derivatives with an alcohol or water. Such a process can produce 3-oxopentanedicarboxylic acid esters in an easy and simple and efficient manner.

    摘要翻译： 6-烷氧基羰基甲基-4H-1,3-二恶英-4-酮衍生物是通过6-卤代甲基-4H-1,3-二恶英-4-酮衍生物与一氧化碳和醇或水反应制备的，3-氧代戊烷二羧酸 通过使上述衍生物与醇或水反应进一步制备酸酯。 这种方法可以容易且简单且有效地生产3-氧代戊二酸酯。

    Novel malonic acid monomethyl derivatives and production process thereof
    6.
    发明申请
    Novel malonic acid monomethyl derivatives and production process thereof 失效
    新型丙二酸单甲基衍生物及其制备方法

    公开(公告)号：US20060252957A1

    公开(公告)日：2006-11-09

    申请号：US11486116

    申请日：2006-07-14

    申请人： Satoru Nose ,  Kieko Sano ,  Takeshi Hamatani

    发明人： Satoru Nose ,  Kieko Sano ,  Takeshi Hamatani

    IPC分类号： C07C69/76

    CPC分类号： C07C69/65 ,  C07C67/30 ,  C07C67/343

    摘要： A novel monomethyl malonate derivative is represented by following Formula (I): wherein X is a halogen atom; and Me is methyl group. This compound can be prepared by the steps of (A) reacting a benzyl halide derivative represented by following Formula (II): wherein X and Y may be the same as or different from each other and are each a halogen atom, with dimethyl malonate in the presence of a base to yield a dimethyl malonate derivative represented by following Formula (III): wherein X and Me have the same meanings as defined above; and (B) hydrolyzing the dimethyl malonate derivative of Formula (III). The compound is useful in the production of an indanonecarboxylic acid ester having a halogen atom on the indanone ring.

    摘要翻译： 新型单甲基丙二酸酯衍生物由下式（I）表示：其中X为卤素原子; 而我是甲基。 该化合物可以通过以下步骤制备：（A）使由下式（II）表示的苄基卤衍生物：其中X和Y可以彼此相同或不同，并且各自为卤素原子，与丙二酸二甲酯 碱的存在得到由下式（III）表示的丙二酸二甲酯衍生物：其中X和Me具有与上述相同的含义; 和（B）水解式（III）的丙二酸二甲酯衍生物。 该化合物可用于制备在茚酮环上具有卤素原子的茚满酮羧酸酯。

    Novel malonic acid monomethyl derivatives and production process thereof
    8.
    发明申请
    Novel malonic acid monomethyl derivatives and production process thereof 失效
    新型丙二酸单甲基衍生物及其制备方法

    公开(公告)号：US20050124825A1

    公开(公告)日：2005-06-09

    申请号：US10976966

    申请日：2004-11-01

    申请人： Satoru Nose ,  Kieko Sano ,  Takeshi Hamatani

    发明人： Satoru Nose ,  Kieko Sano ,  Takeshi Hamatani

    IPC分类号： C07C69/612 ,  C07C67/30 ,  C07C67/313 ,  C07C67/343 ,  C07C69/65 ,  C07C69/76

    CPC分类号： C07C69/65 ,  C07C67/30 ,  C07C67/343

    摘要： A novel monomethyl malonate derivative is represented by following Formula (I): wherein X is a halogen atom; and Me is methyl group. This compound can be prepared by the steps of (A) reacting a benzyl halide derivative represented by following Formula (II): wherein X and Y may be the same as or different from each other and are each a halogen atom, with dimethyl malonate in the presence of a base to yield a dimethyl malonate derivative represented by following Formula (III): wherein X and Me have the same meanings as defined above; and (B) hydrolyzing the dimethyl malonate derivative of Formula (III). The compound is useful in the production of an indanonecarboxylic acid ester having a halogen atom on the indanone ring.

    摘要翻译： 新型单甲基丙二酸酯衍生物由下式（I）表示：其中X为卤素原子; 而我是甲基。 该化合物可以通过以下步骤制备：（A）使由下式（II）表示的苄基卤衍生物：其中X和Y可以彼此相同或不同，并且各自为卤素原子，与丙二酸二甲酯 碱的存在得到由下式（III）表示的丙二酸二甲酯衍生物：其中X和Me具有与上述相同的含义; 和（B）水解式（III）的丙二酸二甲酯衍生物。 该化合物可用于制备在茚酮环上具有卤素原子的茚满酮羧酸酯。

    Ester and process for producing the same
    10.
    发明授权
    Ester and process for producing the same 失效
    酯及其制备方法

    公开(公告)号：US06297388B1

    公开(公告)日：2001-10-02

    申请号：US09704576

    申请日：2000-11-03

    申请人： Mitsuru Ohno ,  Noritsugu Yamasaki ,  Satoru Nose

    发明人： Mitsuru Ohno ,  Noritsugu Yamasaki ,  Satoru Nose

    IPC分类号： C07D31906

    CPC分类号： C07D319/06

    摘要： 6-Alkoxycarbonylmethyl-4H-1,3-dioxin-4-one derivatives are produced by reacting a 6-halomethyl-4H-1,3-dioxin-4-one derivative with carbon monoxide and an alcohol or water, and 3-oxopentanedicarboxylic acid esters are further produced by reacting the above derivatives with an alcohol or water. Such a process can produce 3-oxopentanedicarboxylic acid esters in an easy and simple and efficient manner.

    摘要翻译： 6-烷氧基羰基甲基-4H-1,3-二恶英-4-酮衍生物是通过6-卤代甲基-4H-1,3-二恶英-4-酮衍生物与一氧化碳和醇或水反应制备的，3-氧代戊烷二羧酸 通过使上述衍生物与醇或水反应进一步制备酸酯。 这种方法可以容易且简单且有效地生产3-氧代戊二酸酯。