公开(公告)号：US07976721B2

公开(公告)日：2011-07-12

申请号：US12876799

申请日：2010-09-07

Applicant: Seijyuro Maiya ,  Osamu Nakagome ,  Hideyuki Suzuki ,  Yasuhisa Kotani ,  Toshifumi Hatanaka ,  Toshihiro Wada

Inventor： Seijyuro Maiya ,  Osamu Nakagome ,  Hideyuki Suzuki ,  Yasuhisa Kotani ,  Toshifumi Hatanaka ,  Toshihiro Wada

IPC: C09K5/04

CPC classification number: C09K5/041 ,  F25B9/006

Abstract: To provide a safe, nontoxic, and high-performance mixed refrigerant for hot water supply/heating system which is prepared by mixing dimethyl ether with carbon dioxide and which does not deplete the ozone layer, has a low global warming potential, and permits low-pressure operation.A refrigerant composition for hot water supply/heating comprising 1 to 10% by mole of dimethyl ether and 99 to 90% by mole of carbon dioxide on the basis of the total number of moles of dimethyl ether and carbon dioxide.

Abstract translation: 为了提供一种安全，无毒，高性能的混合制冷剂，用于通过将二甲醚与二氧化碳混合并且不耗尽臭氧层制备的热水供应/加热系统，具有低的全球变暖潜力， 压力操作。 基于二甲醚和二氧化碳的总摩尔数，用于热水供应/加热的制冷剂组合物包含1至10摩尔％的二甲醚和99至90摩尔％的二氧化碳。

公开(公告)号：US20110017940A1

公开(公告)日：2011-01-27

申请号：US12876799

申请日：2010-09-07

Applicant: Seijyuro Maiya ,  Osamu Nakagome ,  Hideyuki Suzuki ,  Yasuhisa Kotani ,  Toshifumi Hatanaka ,  Toshihiro Wada

Inventor： Seijyuro Maiya ,  Osamu Nakagome ,  Hideyuki Suzuki ,  Yasuhisa Kotani ,  Toshifumi Hatanaka ,  Toshihiro Wada

IPC: C09K5/04

CPC classification number: C09K5/041 ,  F25B9/006

Abstract: [Problems] To provide a safe, nontoxic, and high-performance mixed refrigerant for hot water supply/heating system which is prepared by mixing dimethyl ether with carbon dioxide and which does not deplete the ozone layer, has a low global warming potential, and permits low-pressure operation.[Means for Solving Problems] A refrigerant composition for hot water supply/heating comprising 1 to 10% by mole of dimethyl ether and 99 to 90% by mole of carbon dioxide on the basis of the total number of moles of dimethyl ether and carbon dioxide.

Abstract translation: [问题]为了提供通过将二甲醚与二氧化碳混合并且不耗尽臭氧层制备的热水供应/加热系统的安全，无毒，高性能的混合制冷剂具有低的全球变暖潜能，以及 允许低压操作。 用于解决问题的手段根据二甲醚和二氧化碳的总摩尔数，含有1〜10摩尔％的二甲醚和99〜90摩尔％的二氧化碳的热水供给/加热用制冷剂组合物 。

公开(公告)号：US07700611B2

公开(公告)日：2010-04-20

申请号：US11988780

申请日：2006-07-24

Applicant: Russell R. Ferlita ,  Yuji Haga ,  Makoto Ishikawa ,  Keisuke Kamei ,  Shinji Kato ,  Hisaki Kojima ,  Aaron Moment ,  Nobuaki Nonoyama ,  Nobuya Satake ,  Kazuki Shigemori ,  Toshihiro Wada ,  Yaling Wang ,  Steven A. Weissman ,  Robert M. Wenslow

Inventor： Russell R. Ferlita ,  Yuji Haga ,  Makoto Ishikawa ,  Keisuke Kamei ,  Shinji Kato ,  Hisaki Kojima ,  Aaron Moment ,  Nobuaki Nonoyama ,  Nobuya Satake ,  Kazuki Shigemori ,  Toshihiro Wada ,  Yaling Wang ,  Steven A. Weissman ,  Robert M. Wenslow

IPC: A61K31/4355 ,  C07D491/048

CPC classification number: C07D491/10

Abstract: The present invention relates to a process for producing crystalline trans-N-[1-(2-fluorophenyl)-S-pyrazoly]-3-ox-ospiro[6-azaisobenzofuran-1(3H),1′-cyclohexane]-4′-carboxamide and novel salts, hydrates and polymorphs thereof.

Abstract translation: 本发明涉及一种制备结晶反式-N-〔1-（2-氟苯基）-S-吡唑基〕-3-氧 - 环螺[6-氮杂苯并呋喃-1（3H），1'-环己烷〕-4 ' - 甲酰胺及其新型盐，水合物及其多晶型物。

公开(公告)号：US20090124648A1

公开(公告)日：2009-05-14

申请号：US11988780

申请日：2006-07-24

Applicant: Russell R. Ferlita ,  Yuji Haga ,  Makoto Ishikawa ,  Keisuke Kamei ,  Shinji Kato ,  Hisaki Kojima ,  Aaron Moment ,  Nobuaki Nonoyama ,  Nobuya Satake ,  Kazuki Shigemori ,  Toshihiro Wada ,  Yaling Wang ,  Steven A. Weissman ,  Robert M. Wenslow

Inventor： Russell R. Ferlita ,  Yuji Haga ,  Makoto Ishikawa ,  Keisuke Kamei ,  Shinji Kato ,  Hisaki Kojima ,  Aaron Moment ,  Nobuaki Nonoyama ,  Nobuya Satake ,  Kazuki Shigemori ,  Toshihiro Wada ,  Yaling Wang ,  Steven A. Weissman ,  Robert M. Wenslow

IPC: A61K31/4355 ,  C07D491/048 ,  A61P3/04

CPC classification number: C07D491/10

Abstract: The present invention relates to a process for producing crystalline trans-N-[1-(2-fluorophenyl)-S-pyrazoly]-3-ox-ospiro[6-azaisobenzofuran-1(3H),1′-cyclohexane]-4′-carboxamide and novel salts, hydrates and polymorphs thereof.

Abstract translation: 本发明涉及一种制备结晶反式-N-〔1-（2-氟苯基）-S-吡唑基〕-3-氧 - 环螺[6-氮杂苯并呋喃-1（3H），1'-环己烷〕-4 ' - 甲酰胺及其新型盐，水合物及其多晶型物。

公开(公告)号：US09564768B2

公开(公告)日：2017-02-07

申请号：US14390057

申请日：2012-04-12

Applicant: Keita Hatanaka ,  Sho Shiraga ,  Toshihiro Wada ,  Shoji Yoshioka

Inventor： Keita Hatanaka ,  Sho Shiraga ,  Toshihiro Wada ,  Shoji Yoshioka

IPC: H02J7/00 ,  H01M10/44 ,  H01M10/48 ,  G01R31/36 ,  H01M10/42

CPC classification number: H02J7/007 ,  G01R31/3606 ,  H01M10/44 ,  H01M10/48 ,  H01M2010/4271 ,  H02J7/0016 ,  H02J7/0063 ,  H02J2007/005

Abstract: A battery-condition monitoring device that monitors a condition of the battery through discharge thereof includes a discharger and a discharge control device. The discharger includes a discharge circuit having a load resistor and a switching element connected in series between a positive electrode of the battery and a negative electrode thereof. The discharge control device controls an open/close operation of the switching element. The discharge control device adjusts the resistance value of the load resistor in the discharger, thereby enabling an adjustment of a discharge current.

Abstract translation: 通过放电监视电池的状态的电池状态监视装置包括放电器和放电控制装置。 放电器包括具有负载电阻器和串联连接在电池的正极和负电极之间的开关元件的放电电路。 放电控制装置控制开关元件的打开/关闭操作。 放电控制装置调节放电器中的负载电阻器的电阻值，从而能够调节放电电流。

公开(公告)号：US08138206B2

公开(公告)日：2012-03-20

申请号：US11921435

申请日：2006-05-29

Applicant: Shiho Ishikawa ,  Tsuyoshi Nagase ,  Nagaaki Sato ,  Hidekazu Takahashi ,  Shigeru Tokita ,  Toshihiro Wada

Inventor： Shiho Ishikawa ,  Tsuyoshi Nagase ,  Nagaaki Sato ,  Hidekazu Takahashi ,  Shigeru Tokita ,  Toshihiro Wada

IPC: A61K31/445 ,  A61K31/44 ,  A61K31/535 ,  C07D211/10 ,  C07D401/00 ,  C07D491/00 ,  C07D491/10 ,  C07D405/00 ,  C07D413/00

CPC classification number: C07D519/00 ,  C07D401/12 ,  C07D471/10 ,  C07D491/107 ,  C07D491/20 ,  C07D498/10

Abstract: Disclosed is a substance having an antagonistic effect on the binding of histamine to a histamine H3 receptor or an inhibitory effect on the activity which a histamine H3 receptor constantly exhibits. A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof; (I) wherein R1 represents a phenyl group which may be substituted or the like and R2 represents a cyano group which may be substituted or the like, or R1 and R2 together form an aliphatic heterocylic ring which may be substituted; R3 represents a group represented by the formula (II-1) below; and all of X1 to X4 represent a carbon atom or the like: (II-1) where R4 and R5 represent a lower alkyl group or the like; and m1 represents an integer of 2 to 4.

Abstract translation: 公开了对组胺H3受体的结合具有拮抗作用的物质或对组胺H3受体不断显示的活性的抑制作用。 由式（I）表示的化合物或其药学上可接受的盐; （I）其中R 1表示可被取代的苯基等，R 2表示可被取代的氰基等，或者R 1和R 2一起形成可被取代的脂肪族杂环; R3表示由下式（II-1）表示的基团; 并且X1至X4全部表示碳原子等：（II-1）其中R4和R5代表低级烷基等; m1表示2〜4的整数。

公开(公告)号：US20110017941A1

公开(公告)日：2011-01-27

申请号：US12878548

申请日：2010-09-09

Applicant: Seijyuro Maiya ,  Osamu Nakagome ,  Hideyuki Suzuki ,  Yasuhisa Kotani ,  Toshifumi Hatanaka ,  Toshihiro Wada

Inventor： Seijyuro Maiya ,  Osamu Nakagome ,  Hideyuki Suzuki ,  Yasuhisa Kotani ,  Toshifumi Hatanaka ,  Toshihiro Wada

IPC: C09K5/04

CPC classification number: C09K5/041 ,  C09K2205/106 ,  C09K2205/11

Abstract: The present invention is directed to using a composition comprising carbon dioxide and dimethyl ether as a refrigerant. In particular, the refrigerant composition comprises 3-6% by mole dimethyl ether and 97-94% by mole of carbon dioxide on the basis of a total number of moles of dimethyl ether and carbon dioxide. Advantageously, the refrigerant composition does not cause ozonosphere depletion, has a low global warming potential, and is safe and nontoxic.

Abstract translation: 本发明涉及使用包含二氧化碳和二甲醚作为制冷剂的组合物。 特别地，基于二甲醚和二氧化碳的总摩尔数，制冷剂组合物包含3-6摩尔％的二甲醚和97-94摩尔％的二氧化碳。 有利地，制冷剂组合物不会引起臭氧层消耗，全球变暖潜能低，安全无毒。

公开(公告)号：US07482449B2

公开(公告)日：2009-01-27

申请号：US12077419

申请日：2008-03-19

Applicant: Ralph P. Volante ,  David M. Tschaen ,  Steven A. Weissman ,  Matthew Heileman ,  Toshiaki Mase ,  Takehiko Iida ,  Kenji Maeda ,  Toshihiro Wada ,  Hiroki Sato ,  Kenichi Asakawa

Inventor： Ralph P. Volante ,  David M. Tschaen ,  Steven A. Weissman ,  Matthew Heileman ,  Toshiaki Mase ,  Takehiko Iida ,  Kenji Maeda ,  Toshihiro Wada ,  Hiroki Sato ,  Kenichi Asakawa

IPC: C07D405/12 ,  C07D405/14 ,  C07D307/94 ,  C07D491/107

CPC classification number: C07D493/10

Abstract: This invention relates to a process for making spirolactone compounds analogous to formula I.

Abstract translation: 本发明涉及类似于式I的制备螺内酯化合物的方法。

公开(公告)号：US06946559B2

公开(公告)日：2005-09-20

申请号：US10182622

申请日：2001-01-24

Applicant: Takehiko Iida ,  Toshihiro Wada ,  Toshiaki Mase

Inventor： Takehiko Iida ,  Toshihiro Wada ,  Toshiaki Mase

IPC: C07C45/00 ,  C07C45/45 ,  C07D213/61 ,  C07D213/84 ,  C07D277/32 ,  C07D333/28 ,  C07F3/02 ,  C07F7/08 ,  C07D213/74 ,  C07C47/55

CPC classification number: C07D213/84 ,  C07C45/004 ,  C07C45/45 ,  C07D213/61 ,  C07D333/28 ,  C07F3/02 ,  C07F7/0827 ,  C07C47/55

Abstract: A method by which a halogen atom of a halogen compound can be efficiently replaced with an electrophilic group.Also provided are: a reagent for converting a functional group through a halogen-metal exchange reaction, characterized by comprising either a mixture of a magnesium compound represented by the formula R1—Mg—X (I) (wherein R1 represents a halogen atom or an optionally substituted hydrocarbon residue; and X1 represents a halogen atom) and an organolithium compound represented by the formula R2—Li (II) (wherein R2 represents an optionally substituted hydrocarbon residue) or a product of the reaction of the magnesium compound with the organolithium compound; and a process for producing with the reagent a compound in which a halogen atom of a halogen compound has been replaced with an electrophilic group.

Abstract translation: 可以用亲电子基团有效地代替卤素化合物的卤素原子的方法。 还提供：用于通过卤素 - 金属交换反应转化官能团的试剂，其特征在于包含由式R 1 -Mg-X（I）表示的镁化合物的混合物（ 其中R 1表示卤素原子或任选取代的烃残基; X 1表示卤素原子）和由式R 2表示的有机锂化合物， （II）（其中R 2表示任选取代的烃残基）或镁化合物与有机锂化合物的反应的产物; 以及用该试剂制备其中卤素化合物的卤素原子已被亲电子基团取代的化合物的方法。

公开(公告)号：US5680999A

公开(公告)日：1997-10-28

申请号：US562779

申请日：1995-11-27

Applicant: Toshihiro Wada

Inventor： Toshihiro Wada

IPC: B02C18/14 ,  B02C18/18

CPC classification number: B02C18/142 ,  B02C18/184 ,  Y10T83/9331 ,  Y10T83/9374

Abstract: A shredder comprising a frame, at least two rotatable shafts supported in parallel by the frame, a plurality of cutting blades, each of the blades including a mount which is fixed to one of the shafts and has an outer peripheral side, and a number of tip pieces, each tip piece being fixed to the peripheral side of the mount, and a plurality of spacers mounted on each of the shafts alternately with the blades such that the spacers on each of the shafts are radially aligned with the blades on the other shaft.

Abstract translation: 一种粉碎机，包括框架，由所述框架平行支撑的至少两个可旋转轴，多个切割刀片，每个所述叶片包括固定到所述轴中的一个并具有外周侧的安装件，以及多个 每个尖端件固定到安装座的周边，并且多个间隔件与叶片交替地安装在每个轴上，使得每个轴上的间隔件与另一轴上的叶片径向对准 。