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34 条记录 (耗时 0.028 秒)

    Therapeutic Agent for Sensory Abnormality
    1.
    发明申请
    Therapeutic Agent for Sensory Abnormality 审中-公开
    感觉异常的治疗剂

    公开(公告)号：US20090069442A1

    公开(公告)日：2009-03-12

    申请号：US11814008

    申请日：2006-01-18

    申请人： Hirohito Shiomi ,  Yutaka Tamura ,  Bang Luu ,  Masashi Yamada ,  Keizou Koyama ,  Hiroto Suzuki

    发明人： Hirohito Shiomi ,  Yutaka Tamura ,  Bang Luu ,  Masashi Yamada ,  Keizou Koyama ,  Hiroto Suzuki

    IPC分类号： A61K31/122 ,  C07C49/743 ,  A61P27/00

    CPC分类号： A61K31/122

    摘要： The present invention provides therapeutic agents for sensory disorders represented by the following formula (1): [wherein R1, R2, and R3 each represent a hydrogen atom or a methyl group, and X represents a linear or branched C10-C28 alkylene or alkenylene group].The cyclohexenone long chain alcohol of the present invention improves hyperalgesia or hypoalgesia, and thus is useful as therapeutic agents for sensory disorders. Sensory disorders that can be prevented or treated by the present invention include chronic intractable pain, neurogenic pain, reduction of pain threshold caused by nerve injuries, hypesthesia or hyperesthesia caused by diabetes and nerve injuries, and the like.

    摘要翻译： 本发明提供由下式（1）表示的感觉障碍治疗剂：其中R1，R2和R3各自表示氢原子或甲基，X表示直链或支链C 10 -C 28亚烷基或亚烯基 ]。 本发明的环己烯酮长链醇可以改善痛觉过敏或减轻痛觉过敏，因此可用作感觉障碍的治疗剂。 可以通过本发明预防或治疗的感觉障碍包括慢性顽固性疼痛，神经性疼痛，由神经损伤引起的疼痛阈值的降低，由糖尿病和神经损伤引起的感觉过敏或感觉异常等。

    (Meth)acryloyloxy substituted acetylsalicylates and polymers thereof
    3.
    发明授权
    (Meth)acryloyloxy substituted acetylsalicylates and polymers thereof 失效
    （甲基）丙烯酰氧取代的乙酰水杨酸酯及其聚合物

    公开(公告)号：US5693320A

    公开(公告)日：1997-12-02

    申请号：US614016

    申请日：1996-03-12

    申请人： Masamune Sakai ,  Hiroyuki Ikeda ,  Noriaki Kaneko ,  Yutaka Tamura

    发明人： Masamune Sakai ,  Hiroyuki Ikeda ,  Noriaki Kaneko ,  Yutaka Tamura

    IPC分类号： C07C233/55 ,  C08F20/30 ,  C08F20/58 ,  C07C229/00 ,  C08F20/18 ,  C08K5/01

    CPC分类号： C08F20/30 ,  C07C233/55 ,  C08F20/58

    摘要： Novel acetylsalicylic acid derivatives having general formula (I) are provided, in which R.sup.1 is hydrogen or methyl; R.sup.2 is --O-- or --NH--; and W is hydroxy, halogen, lower alkoxy, lower alkenyloxy, lower alkynyloxy, cycloalkyloxy, aryloxy, aralkyloxy, acyloxy, or --N(R.sup.3)(R.sup.4) wherein the lower alkoxy, the lower alkenyloxy, the lower alkynyloxy, the cycloalkyloxy, the aryloxy, the aralkyloxy, and the acyloxy are optionally substituted with hydroxy, carboxyl, lower alkoxy, lower alkyl, halogen, nitro, and amino. The invention also pertains to a polymer made from such derivatives and a medical equipment containing the polymer. The polymer is useful in the prevention of platelet aggregation thereon. ##STR1##

    摘要翻译： 提供了具有通式（I）的新型乙酰水杨酸衍生物，其中R 1是氢或甲基; R2是-O-或-NH-; 并且W是羟基，卤素，低级烷氧基，低级链烯氧基，低级炔氧基，环烷氧基，芳氧基，芳烷氧基，酰氧基或-N（R3）（R4），其中低级烷氧基，低级烯氧基，低级炔氧基，环烷氧基， 芳氧基，芳烷氧基和酰氧基任选被羟基，羧基，低级烷氧基，低级烷基，卤素，硝基和氨基取代。 本发明还涉及由这样的衍生物制成的聚合物和含有聚合物的医疗设备。 聚合物可用于预防血小板聚集。

    Embedded type speaker with over lying grill
    6.
    发明授权
    Embedded type speaker with over lying grill 失效
    嵌入式扬声器与躺卧格栅

    公开(公告)号：US3952834A

    公开(公告)日：1976-04-27

    申请号：US515954

    申请日：1974-10-18

    申请人： Hiroshi Soma ,  Yutaka Tamura ,  Kenzo Miyazawa

    发明人： Hiroshi Soma ,  Yutaka Tamura ,  Kenzo Miyazawa

    IPC分类号： H04R1/02 ,  H05K5/00

    CPC分类号： H04R1/025 ,  H04R1/023

    摘要： An embedded type speaker has the speaker body mounted on a wall by inserting the speaker within a mounting opening within the wall. A grill is detachably mounted in overlying fashion in front of the speaker body with the grill consisting of an annular grill frame having circumferentially spaced sound communicating holes at the peripheral portion and a large central opening therein. A support strip extends transversely across the central opening of the grill frame from one side of the frame to the other. A grill sheet overlies the grill frame to close off the central opening and has the same appearance and is preferably formed of the same material as that overlying the wall surface, facing in the same direction as the speaker. A packing is provided between the peripheral portion of the grill sheet and the periphery of the grill frame and a connecting member couples the center of the grill sheet to the center of the support strip.

    摘要翻译： 嵌入式扬声器通过将扬声器插入壁内的安装开口中而将扬声器主体安装在壁上。 格栅可以以上述方式可拆卸地安装在扬声器主体的前面，格栅由环形格栅架构成，该环形格栅架在周边部分具有周向隔开的声音连通孔，在其中具有大的中心开口。 支撑条从框架的一侧横向穿过格栅框架的中心开口延伸到另一侧。 格栅片覆盖在格栅架上，以封闭中心开口并且具有相同的外观，并且优选地由与面向与扬声器相同的方向的壁面相同的材料形成。 在格栅板的周边部分和格栅框架的周边之间设有一个填料，连接件将格栅板的中心连接到支撑条的中心。

    Antibody Drug
    7.
    发明申请
    Antibody Drug 审中-公开
    抗体药物

    公开(公告)号：US20090111146A1

    公开(公告)日：2009-04-30

    申请号：US10570143

    申请日：2004-09-02

    申请人： Eiko Ohtsuka ,  Yutaka Tamura

    发明人： Eiko Ohtsuka ,  Yutaka Tamura

    IPC分类号： C12P21/04 ,  C12N15/00 ,  C07K16/18 ,  C12N15/11 ,  C12N5/06

    CPC分类号： C07K14/7155 ,  C07K2319/30

    摘要： Means for effectively performing therapies at a low cost is provided in which an antibody drug including a fusion protein fusing an extracellular region of IL-10 receptor 1 with a human antibody is used. A gene encoding a fusion protein fusing an extracellular region of IL-10 receptor 1 with a constant region of human IgG1 is incorporated into an expression vector to provide an expression vector for gene therapies and vaccines.

    摘要翻译： 提供了以低成本有效进行治疗的方法，其中使用包含融合IL-10受体1的细胞外区域的融合蛋白的抗体药物与人抗体。 将编码融合蛋白质的融合蛋白质融合到表达载体中以提供IL-10受体1的细胞外区域与人IgG1的恒定区域以提供用于基因治疗和疫苗的表达载体。

    Silver halide photographic material
    9.
    发明授权
    Silver halide photographic material 失效
    卤化银照相材料

    公开(公告)号：US5302501A

    公开(公告)日：1994-04-12

    申请号：US966383

    申请日：1992-10-26

    申请人： Yutaka Tamura ,  Yasuyuki Takagi ,  Junichi Yamanouchi

    发明人： Yutaka Tamura ,  Yasuyuki Takagi ,  Junichi Yamanouchi

    IPC分类号： G03C1/005 ,  G03C1/053 ,  G03C1/76

    CPC分类号： G03C1/7614 ,  G03C1/0051 ,  G03C1/053 ,  Y10S430/164

    摘要： A silver halide photographic material comprising a support having thereon at least one silver halide emulsion layer, wherein the swelling ratio of the entire hydrophilic colloid layers on the acid polymer-containing layer side of the support of the silver halide photographic material having a hydrophilic colloid layer containing at least one acid polymer (having a carboxyl group-containing monomer unit content of at least 15 mol % or an acid value of at least 1.5 meq/g) on at least one silver halide emulsion layer-coated side thereof is at least 200% in distilled water, said acid polymer being dissolved in water and added to said hydrophilic colloid layer, and the swollen thickness of the above entire hydrophilic colloid layers at the time of the completion of the rinsing stage is not more than 8 .mu.m when said silver halide photographic material is processed (the swelling ratio in distilled water is a value obtained by incubating the photographic material at 40.degree. C. and 60% RH (percent relative humidity) for 16 hours, immersing it in distilled water at 21.degree. C. for 3 minutes and measuring the change of the thickness thereof).

    摘要翻译： 一种卤化银照相材料，包括其上具有至少一个卤化银乳剂层的载体，其中具有亲水胶体层的卤化银照相材料的载体的含酸性聚合物层层上的整个亲水胶体层的溶胀比 含有至少一种酸性聚合物（具有含羧基的单体单元含量为至少15mol％或酸值至少为1.5meq / g）在至少一个卤化银乳剂层涂覆侧上为至少200 在蒸馏水中，所述酸性聚合物溶于水中并加入到所述亲水胶体层中，并且在漂洗阶段完成时上述整个亲水胶体层的溶胀厚度不大于8（m） 当所述卤化银照相材料被处理时（蒸馏水中的溶胀比是通过将照相材料在40℃和60％RH下温育获得的值 （相对湿度百分比）16小时，将其浸入21℃的蒸馏水中3分钟并测量其厚度变化）。

    Optical resin obtained from diethylenically unsaturated monomer
    10.
    发明授权
    Optical resin obtained from diethylenically unsaturated monomer 失效
    由烯属不饱和单体得到的光学树脂

    公开(公告)号：US5225508A

    公开(公告)日：1993-07-06

    申请号：US710447

    申请日：1991-06-05

    申请人： Yutaka Tamura ,  Fumie Watari

    发明人： Yutaka Tamura ,  Fumie Watari

    IPC分类号： C07C321/20 ,  C07C321/28 ,  C08F12/34 ,  G02B1/04

    CPC分类号： C08F12/34 ,  C07C321/20 ,  C07C321/28 ,  G02B1/04

    摘要： Disclosed are a diethylenicallyunsaturated monomer represented by the following formula [Ia]: ##STR1## wherein n is an integer of from 1 to 10, and a and b each represent 0 or an integer of from 1 to 4,and an optical resin which is substantially insoluble and infusible and has a refractive index .eta..sub.D of at least 1.62, and which is obtained by polymerizing a monomer comprising 50 to 100% by weight of this diethylenically unsaturated monomer.

    摘要翻译： 公开了由下式[Ia]表示的二烯类不饱和单体：其中n为1〜10的整数，a和b各自表示0或1〜4的整数， 树脂，其基本上不溶和不熔，折射率ηD至少为1.62，其通过聚合包含50-100重量％的该烯键式不饱和单体的单体而获得。