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公开(公告)号：US07563768B2
公开(公告)日：2009-07-21
申请号：US10550505
申请日：2004-03-24
IPC分类号： A61K38/18
CPC分类号： A61K31/711 , A61K9/127 , A61K38/1833 , Y02A50/465
摘要： A preventive or therapeutic agent for asthma, comprising HGF or its salt as an active ingredient.
摘要翻译： 用于哮喘的预防或治疗剂，其包含HGF或其盐作为活性成分。
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公开(公告)号：US20070213261A1
公开(公告)日：2007-09-13
申请号：US10550505
申请日：2004-03-24
CPC分类号： A61K31/711 , A61K9/127 , A61K38/1833 , Y02A50/465
摘要： A preventive or therapeutic agent for asthma, comprising HGF or its salt as an active ingredient.
摘要翻译： 用于哮喘的预防或治疗剂，其包含HGF或其盐作为活性成分。
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3.发明申请SKIN ULCER PREVENTIVE CURATIVE AGENT CONTAINING HUMAN RECOMBINANT HGF 审中-公开含有人类重组蛋白HGF的皮肤ULCER预防性治疗剂公开(公告)号：US20100322998A1
公开(公告)日：2010-12-23
申请号：US12842349
申请日：2010-07-23
CPC分类号： A61L26/0047 , A61K38/1833
摘要： A neovascularization promoting composition, a granulation formation-promoting composition and a preventive or curative composition for skin ulcer, comprising a human recombinant HGF wherein five amino acid residues are deleted in the first Kringle domain thereof. The provided compositions of the present invention are useful as a drug capable of promoting granulation formation and neovascularization and being effective in tissue restoration, especially as a preventive and curative agent for skin ulcer.
摘要翻译： 新生血管促进组合物，造粒促进组合物和皮肤溃疡的预防或治疗组合物，其包含人重组HGF，其中在其第一Kringle结构域中缺失5个氨基酸残基。 本发明提供的组合物可用作能够促进造粒形成和新血管形成并且在组织恢复中有效的药物，特别是作为皮肤溃疡的预防和治疗剂。
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公开(公告)号：US20100137217A1
公开(公告)日：2010-06-03
申请号：US12695532
申请日：2010-01-28
CPC分类号： C07K14/4753 , A61K38/1833 , A61K48/00
摘要： A pharmaceutical preparation comprising a hepatocyte growth factor or a DNA molecule encoding the same and the like according to the present invention can suppress the fibrosis of a transplanted organ after organ transplantation. The present invention is useful in the fields of organ transplantation and regeneration therapy.
摘要翻译： 包含肝细胞生长因子或编码本发明的DNA分子的药物制剂能够抑制器官移植后的移植器官的纤维化。 本发明可用于器官移植和再生治疗领域。
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公开(公告)号：US20060293275A1
公开(公告)日：2006-12-28
申请号：US10565301
申请日：2005-03-28
IPC分类号： A61K31/727
CPC分类号： C08B37/0075 , A61K31/7016 , A61K31/702 , A61K31/715 , C07H11/00 , C08B37/0078 , C08L5/10 , C12P19/04
摘要： The present invention aims to provide an agent for promoting HGF production comprising, as an effective ingredient, a disaccharide comprised of an uronic acid residue (wherein an uronic acid means an iduronic acid or a glucuronic acid, and has the same meaning hereinafter) and a glucosamine residue that are connected by α1,4-glycosidic linkage or β1,4-glycosidic linkage, or an oligosaccharide of tri- to hexadeca-saccharides having a structure in which uronic acid residues and glucosamine residues are alternately and repeatedly connected by α1,4-glycosidic linkage or β1,4-glycosidic linkage, wherein at least one hydroxy group of the uronic acid residues and/or the glucosamine residues may be sulfated, alkylated, acylated or aminated, and/or the amino group at position 2 of at least one of the glucosamine residue(s) may be sulfated, alkylated or acylated, or a salt thereof. The agent of the present invention for promoting HGF production is useful to promote healing of damaged tissues or organs of a living body.
摘要翻译： 本发明的目的在于提供一种促进HGF生产的试剂，其包含由糖醛酸残基（其中糖醛酸表示艾杜糖醛酸或葡糖醛酸，并且具有下述相同含义）的二糖作为有效成分，和 通过α1,4-糖苷键或β1,4-糖苷键连接的葡糖胺残基或具有其中糖醛酸残基和葡糖胺残基被α1,44交替并重复连接的结构的三十六碳糖的寡糖 - 糖苷键或β1,4-糖苷键，其中所述糖醛酸残基和/或所述葡糖胺残基的至少一个羟基可以被硫酸化，烷基化，酰化或胺化，和/或至少在第2位的氨基 一种或多种葡糖胺残基可被硫酸化，烷基化或酰化，或其盐。 用于促进HGF产生的本发明的药剂可用于促进活体损伤的组织或器官的愈合。
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公开(公告)号：US20050221441A1
公开(公告)日：2005-10-06
申请号：US11041363
申请日：2005-01-25
IPC分类号： A61K38/00 , C07K14/475 , C07H21/04 , C12N15/09
CPC分类号： C07K14/4753
摘要： The present invention provides a segment of glycosylation-deficient HGF having mutation(s) introduced into an amino acid sequence so as to prevent glycosylation at least one glycosylation site of a hepatocyte growth factor (HGF), and a method of producing the same. The segment of glycosylation-deficient HGF of the present invention has the same activity as that of a segment of glycosylated HGF, therefore, it is useful as an alternate for a segment of glycosylated HGF.
摘要翻译： 本发明提供具有引入氨基酸序列的突变的糖基化缺陷型HGF片段，以防止肝细胞生长因子（HGF）的至少一个糖基化位点的糖基化及其制备方法。 本发明的糖基化缺陷型HGF片段具有与糖基化HGF片段相同的活性，因此，作为糖基化HGF片段的替代物是有用的。
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公开(公告)号：US08420350B2
公开(公告)日：2013-04-16
申请号：US12722823
申请日：2010-03-12
CPC分类号： C07K14/4753 , A61K48/00
摘要： The invention provides a modified glycosylation-deficient HGF and a production method thereof. The glycosylation-deficient HGF is produced by introducing amino acid mutation(s) so that no glycosylation take place at at least one glycosylation site of hepatocyte growth factor.
摘要翻译： 本发明提供了修饰的糖基化缺陷型HGF及其制备方法。 通过引入氨基酸突变来产生糖基化缺陷型HGF，使得在肝细胞生长因子的至少一个糖基化位点处不发生糖基化。
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公开(公告)号：US20120149642A1
公开(公告)日：2012-06-14
申请号：US13288392
申请日：2011-11-03
CPC分类号： C07K14/4753 , A61K38/1833 , A61K48/00
摘要： A pharmaceutical preparation comprising a hepatocyte growth factor or a DNA molecule encoding the same and the like according to the present invention can suppress the fibrosis of a transplanted organ after organ transplantation. The present invention is useful in the fields of organ transplantation and regeneration therapy.
摘要翻译： 包含肝细胞生长因子或编码本发明的DNA分子的药物制剂能够抑制器官移植后的移植器官的纤维化。 本发明可用于器官移植和再生治疗领域。
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公开(公告)号：US07807177B2
公开(公告)日：2010-10-05
申请号：US10926088
申请日：2004-08-26
IPC分类号： C07K14/575 , A61K38/22 , C12N15/00
CPC分类号： C07K14/4753
摘要： The present invention provides a segment of glycosylation-deficient HGF having mutation(s) introduced into an amino acid sequence so as to prevent glycosylation at at least one glycosylation site of a hepatocyte growth factor (HGF), and a method of producing the same. The segment of glycosylation-deficient HGF of the present invention has the same activity as that of a segment of glycosylated HGF, therefore, it is useful as an alternate for a segment of glycosylated HGF.
摘要翻译： 本发明提供了具有引入氨基酸序列的突变以防止肝细胞生长因子（HGF）的至少一个糖基化位点处的糖基化的糖基化缺陷型HGF的片段及其制备方法。 本发明的糖基化缺陷型HGF片段具有与糖基化HGF片段相同的活性，因此，作为糖基化HGF片段的替代物是有用的。
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公开(公告)号：US07741452B2
公开(公告)日：2010-06-22
申请号：US10582973
申请日：2004-12-15
IPC分类号： C07K14/175
CPC分类号： C07K14/4753 , A61K48/00
摘要： The invention provides a modified glycosylation-deficient HGF and a production method thereof. The glycosylation-deficient HGF is produced by introducing amino acid mutation(s) so that no glycosylation take place at at least one glycosylation site of hepatocyte growth factor.
摘要翻译： 本发明提供了修饰的糖基化缺陷型HGF及其制备方法。 通过引入氨基酸突变来产生糖基化缺陷型HGF，使得在肝细胞生长因子的至少一个糖基化位点处不发生糖基化。
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