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1.发明授权Method for separation of electrolytes, and method for ion exchange of electrolytes with counter-ions 失效电解质分离方法，以及用离子交换电解质的方法
公开(公告)号：US5015386A
公开(公告)日：1991-05-14
申请号：US220597
申请日：1988-07-18
IPC分类号： B01D61/02 , C07C227/40 , C07C229/26
CPC分类号： B01D61/025 , C07C227/40 , C07C229/26
摘要： A method for separating electrolytes which have different charges of the same sign or of carrying out ion exchange of electrolytes with counterions, which comprises causing the electrolytes (anion or cation) to pass through a positively or negatively charged loose reverse-osmotic membrane, in an aqueous solution.
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公开(公告)号：US06329548B1
公开(公告)日：2001-12-11
申请号：US09518094
申请日：2000-03-03
申请人： Kazuhiro Hasegawa , Toshiya Tanabe , Keita Minami
发明人： Kazuhiro Hasegawa , Toshiya Tanabe , Keita Minami
IPC分类号： C07C22900
CPC分类号： C07C229/26 , A23K20/142
摘要： Herein is disclosed an aqueous stable lysine solution containing an acid radical in such amount that the solubility of lysine therein has been increased than in the corresponding aqueous lysine base solution, whereby during storage of lysine in the form of a free-lysine solution (liquid composition), the precipitation of lysine base crystals due to the drop in temperature is prevented thereby improving the handling thereof during transportation (transfer) etc.
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公开(公告)号：US06800185B2
公开(公告)日：2004-10-05
申请号：US10097752
申请日：2002-03-15
IPC分类号： B01D6144
摘要： Herein are disclosed a method for producing a basic amino acid solution which comprises subjecting a solution of a basic amino acid salt to electrodialysis with the use of an electrodialyser equipped with cation exchange membranes and anion exchange membranes in combination, wherein an alkali aqueous solution is added to the solution of a basic amino acid salt during the electrodialysis, whereby not only desalting is caused but also the counter anions of the basic amino acid are removed to such degree that the said counter anions remain in an amount of 40 mol % or smaller based on the basic amino acid, as well as a method for producing a basic amino acid solution which comprises subjecting a solution of a basic amino acid salt to electrodialysis with the use of an electrodialyser equipped with anion exchange membrane alone, wherein an alkali aqueous solution is added to the solution of a basic amino acid salt to adjust the pH of the solution to 7 to 10 during the electrodialysis, whereby the counter anions are removed. According to these methods, a basic amino acid solution having a high concentration within the concentration range in which crystals of a basic amino acid salt are not deposited, can be easily provided, by removing the counter anions from a solution of a basic amino acid salt efficiently by use of electrodialysis.
摘要翻译： 本发明公开了碱性氨基酸溶液的制造方法，其特征在于，使用配有阳离子交换膜和阴离子交换膜的电渗析器对碱性氨基酸盐的溶液进行电渗析，其中添加碱水溶液 在电渗析中与碱性氨基酸盐的溶液接触，由此不仅可以除去脱盐，而且去除碱性氨基酸的反阴离子，使得所述抗衡阴离子的残留量为40摩尔％以下 碱性氨基酸的制造方法以及碱性氨基酸溶液的制造方法，其特征在于，使用仅含有阴离子交换膜的电渗析器对碱性氨基酸盐的溶液进行电渗析，其中碱性水溶液为 加入到碱性氨基酸盐的溶液中，以在电渗析期间将溶液的pH调节至7至10，其中 通过这些方法，可以容易地提供在碱性氨基酸盐的晶体不沉积的浓度范围内具有高浓度的碱性氨基酸溶液，通过从 通过电渗析有效地溶解碱性氨基酸盐。
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公开(公告)号：US4962193A
公开(公告)日：1990-10-09
申请号：US291155
申请日：1988-12-28
申请人： Kenzo Yokozeki , Hideyuki Shirae , Hiroshi Shiragami , Yasuo Irie , Naohiko Yasuda , Masaru Otani , Toshiya Tanabe
发明人： Kenzo Yokozeki , Hideyuki Shirae , Hiroshi Shiragami , Yasuo Irie , Naohiko Yasuda , Masaru Otani , Toshiya Tanabe
CPC分类号： C12P19/02 , C12P19/38 , Y10S435/822
摘要： A biological process for producing a 2',3'-dideoxynucleoside from 2',3'-dideoxyuridine is disclosed. the 2',3'-dideoxynucleoside can be purified readily using a porous nonpolar resin adsorbent.
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公开(公告)号：US07553367B2
公开(公告)日：2009-06-30
申请号：US11423969
申请日：2006-06-14
申请人： Takeshi Kushiku , Dave Steckelberg , Toshiya Tanabe , Jirou Haga , Shinya Fujiki , Kisho Suzuki
发明人： Takeshi Kushiku , Dave Steckelberg , Toshiya Tanabe , Jirou Haga , Shinya Fujiki , Kisho Suzuki
IPC分类号： C30B7/08
CPC分类号： C07C229/26 , C07C227/42
摘要： A diL-lysine monosulfate trihydrate crystal which has a large tabular form and is more easily separable from the mother liquor is described. The crystal is obtained by a novel process wherein crystallization is conducted at a lower temperature.
摘要翻译： 描述了具有大片状并且更容易与母液分离的二L-赖氨酸单硫酸盐三水合物晶体。 通过其中在较低温度下进行结晶的新方法获得晶体。
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公开(公告)号：US20060281945A1
公开(公告)日：2006-12-14
申请号：US11423969
申请日：2006-06-14
申请人： Takeshi Kushiku , Dave Steckelberg , Toshiya Tanabe , Jirou Haga , Shinya Fujiki , Kisho Suzuki
发明人： Takeshi Kushiku , Dave Steckelberg , Toshiya Tanabe , Jirou Haga , Shinya Fujiki , Kisho Suzuki
IPC分类号： C07C227/38
CPC分类号： C07C229/26 , C07C227/42
摘要： A diL-lysine monosulfate trihydrate crystal which has a large tabular form and is more easily separable from the mother liquor is described. The crystal is obtained by a novel process wherein crystallization is conducted at a lower temperature.
摘要翻译： 描述了具有大片状并且更容易与母液分离的二L-赖氨酸单硫酸盐三水合物晶体。 通过其中在较低温度下进行结晶的新方法获得晶体。
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公开(公告)号：US20050132947A1
公开(公告)日：2005-06-23
申请号：US10736511
申请日：2003-12-17
申请人： Takeshi Kushiku , Dave Steckelberg , Toshiya Tanabe , Jirou Haga
发明人： Takeshi Kushiku , Dave Steckelberg , Toshiya Tanabe , Jirou Haga
IPC分类号： C07C227/42 , C07C229/26 , C30B1/00
CPC分类号： C07C229/26 , C07C227/42
摘要： A diL-lysine monosulfate trihydrate crystal which has a large tabular form and is more easily separable from the mother liquor. The crystal is obtained by a novel process of conducting crystallization at a lower temperature.
摘要翻译： 具有大片状形式并且更容易与母液分离的二L-赖氨酸单硫酸盐三水合物晶体。 通过在较低温度下进行结晶的新方法获得晶体。
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公开(公告)号：US5194625A
公开(公告)日：1993-03-16
申请号：US450089
申请日：1989-12-13
IPC分类号： A61K31/195 , A61K31/415 , A61P1/16 , A61P13/02 , A61P15/00 , C07C59/185 , C07C59/19 , C07C59/84 , C07C69/66 , C07C227/42 , C07C229/00 , C07C229/26 , C07D233/54 , C07D233/64
CPC分类号： C07D233/64 , C07C229/26 , C07C59/185 , C07C59/19 , C07C59/84
摘要： A compound of the formula:AN/xSwherein A represents an amino acid, N represents an .alpha.-keto acid, S represents a lower alcohol or acetone; and x ranges from 0.1 to 3.
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9.发明授权Process for producing and purifying 2',3'-dideoxynucleosides, and process for producing 2',3'-dideoxy-2',3'-didehydronucleosides 失效2'，3'-二脱氧核苷的生产和纯化方法，以及产生2'，3'-二脱氧-2'，3'-二脱氢核苷的方法
公开(公告)号：US4835104A
公开(公告)日：1989-05-30
申请号：US191370
申请日：1988-05-09
申请人： Kenzo Yokozeki , Hideyuki Shirae , Hiroshi Shiragami , Yasuo Irie , Naohiko Yasuda , Masaru Otani , Toshiya Tanabe
发明人： Kenzo Yokozeki , Hideyuki Shirae , Hiroshi Shiragami , Yasuo Irie , Naohiko Yasuda , Masaru Otani , Toshiya Tanabe
CPC分类号： C12P19/02 , C12P19/38 , Y10S435/822
摘要： A biological process for producing a 2',3'-dideoxyncleoside from 2',3'-dideoxyuridine is disclosed. The 2',3'-dideoxynucleoside can be purified readily using a porous nonpolar resin adsorbent.
摘要翻译： 公开了一种从2'，3'-二脱氧尿苷生产2'，3'-二脱氧核苷的生物工艺。 可以使用多孔非极性树脂吸附剂容易地纯化2'，3'-二脱氧核苷。
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公开(公告)号：US07161029B2
公开(公告)日：2007-01-09
申请号：US10736511
申请日：2003-12-17
申请人： Takeshi Kushiku , Dave Steckelberg , Toshiya Tanabe , Jirou Haga
发明人： Takeshi Kushiku , Dave Steckelberg , Toshiya Tanabe , Jirou Haga
IPC分类号： C30B29/54
CPC分类号： C07C229/26 , C07C227/42
摘要： A diL-lysine monosulfate trihydrate crystal which has a large tabular form and is more easily separable from the mother liquor. The crystal is obtained by a novel process of conducting crystallization at a lower temperature.
摘要翻译： 具有大片状形式并且更容易与母液分离的二L-赖氨酸单硫酸盐三水合物晶体。 通过在较低温度下进行结晶的新方法获得晶体。
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