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    Percutaneous heart valve, system, and method
    1.
    发明申请
    Percutaneous heart valve, system, and method 审中-公开
    经皮心脏瓣膜，系统和方法

    公开(公告)号：US20090171456A1

    公开(公告)日：2009-07-02

    申请号：US12005881

    申请日：2007-12-28

    申请人： Graig L. Kveen ,  Mark L. Jenson ,  Joseph M. Thielen ,  William J. Drasler ,  Tracee E.J. Eidenschink

    发明人： Graig L. Kveen ,  Mark L. Jenson ,  Joseph M. Thielen ,  William J. Drasler ,  Tracee E.J. Eidenschink

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2230/0008 ,  A61F2230/0013 ,  A61F2230/0069 ,  A61F2230/008 ,  A61F2250/0004 ,  A61F2250/0029

    摘要： Devices, systems, and methods are provided to treat diseased cardiac valves. The device includes a percutaneous heart valve having an expandable valve frame including valve frame members, a valve leaflet coupled to the valve frame, and an expandable stent anchoring frame coupled to the valve frame including stent frame members defining a first portion and a second portion having greater flexibility than the first portion, where the first portion and the valve frame define a length, and where the stent frame members and the valve frame members along the length provide a contiguous surface over which a delivery device can repeatedly slide over the length in its entirety in two longitudinal directions when the first portion and the valve frame are in a partially expanded state during delivery from the delivery device.

    摘要翻译： 提供设备，系统和方法来治疗患病的心脏瓣膜。 该装置包括经皮心脏瓣膜，该经皮心脏瓣膜具有包括阀框架构件的可扩张瓣膜框架，联接到瓣膜框架的瓣膜单元和联接到瓣膜框架的可扩张支架锚固框架，其包括限定第一部分的支架框架构件和具有第 比第一部分具有更大的灵活性，其中第一部分和阀框架限定长度，并且其中支架框架构件和沿着长度的阀框架构件提供连续的表面，输送装置可以在该连续表面上反复滑过其中的长度 当从输送装置输送时，当第一部分和阀框处于部分膨胀状态时，它们在两个纵向方向上整体。

    PFO clip
    6.
    发明授权
    PFO clip 有权
    PFO剪辑

    公开(公告)号：US08894682B2

    公开(公告)日：2014-11-25

    申请号：US11518753

    申请日：2006-09-11

    申请人： Joseph M. Thielen ,  Mark L. Jenson ,  William J. Drasler

    发明人： Joseph M. Thielen ,  Mark L. Jenson ,  William J. Drasler

    IPC分类号： A61B17/08 ,  A61B17/00

    CPC分类号： A61B17/0057 ,  A61B17/083 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61B2017/00867 ,  A61B2017/00893

    摘要： Embodiments for a device, system and method for occluding an opening in a septum. Embodiments of the device can include a first control component, a first elongate member that extends from the first control component, a second elongate member, a connecting member that positions the first elongate member adjacent the second elongate member and a retraction member releasably coupled to the first control component. The retraction member can be used to change a relative position of the first elongate member and the second elongate member of the device.

    摘要翻译： 用于封闭隔膜中的开口的装置，系统和方法的实施例。 该装置的实施例可以包括第一控制部件，从第一控制部件延伸的第一细长部件，第二细长部件，将第一细长部件定位成邻近第二细长部件的连接部件和可释放地联接到 第一控制组件。 缩回构件可用于改变第一细长构件和装置的第二细长构件的相对位置。

    Thrombectomy apparatus and method
    7.
    发明授权
    Thrombectomy apparatus and method 有权
    血栓切除装置及方法

    公开(公告)号：US08430837B2

    公开(公告)日：2013-04-30

    申请号：US12026317

    申请日：2008-02-05

    申请人： Mark L. Jenson ,  William J. Drasler ,  Joseph M. Thielen

    发明人： Mark L. Jenson ,  William J. Drasler ,  Joseph M. Thielen

    IPC分类号： A61N1/30

    CPC分类号： A61B17/32037 ,  A61B17/221 ,  A61B2017/2212 ,  A61F2/013

    摘要： A thrombectomy system may include an elongate shaft that defines a high pressure lumen and a low pressure lumen. The high pressure lumen may terminate near an end of the low pressure lumen. An expandable capture basket may be disposed near the end of the low pressure lumen. A thrombectomy apparatus may include an elongate shaft, an evacuation lumen extending within the elongate shaft and a high pressure lumen extending within the elongate shaft. A capture apparatus may be disposed within a wire lumen that extends within the elongate shaft such that the capture apparatus extends distally from the wire lumen.

    摘要翻译： 血栓切除系统可以包括限定高压腔和低压腔的细长轴。 高压腔可以在低压腔的端部附近终止。 可扩张的捕获篮可以设置在低压腔的端部附近。 血栓切除装置可以包括细长轴，在细长轴内延伸的抽空腔和在细长轴内延伸的高压腔。 捕获装置可以设置在细长轴内延伸的线腔内，使得捕获装置从线腔向远侧延伸。

    Vascular Sealing Device and Method Using Clot Enhancing Balloon and Electric Field Generation
    8.
    发明申请
    Vascular Sealing Device and Method Using Clot Enhancing Balloon and Electric Field Generation 审中-公开
    血管密封装置和使用凝块增强气球和电场的方法

    公开(公告)号：US20080312645A1

    公开(公告)日：2008-12-18

    申请号：US12026067

    申请日：2008-02-05

    申请人： William J. Drasler ,  Tracee Eidenschink ,  Joseph M. Thielen ,  Mark L. Jenson ,  Anu Sadasiva

    发明人： William J. Drasler ,  Tracee Eidenschink ,  Joseph M. Thielen ,  Mark L. Jenson ,  Anu Sadasiva

    IPC分类号： A61B18/14 ,  A61M29/02

    CPC分类号： A61B18/14 ,  A61B17/0057 ,  A61B2017/00654 ,  A61N1/18 ,  A61N1/32

    摘要： An apparatus and method for closing an opening in a blood vessel wall is disclosed. The apparatus includes at least one member which is extended through a tissue tract formed through the epidermis and subcutaneous layer of skin and through the opening in the blood vessel. The member includes a proximal end and a distal end with the distal end being positionable proximate to the opening in the blood vessel wall. A positive electrode is positioned next to the distal end with a negative electrode being positioned next to the proximal end When the electrodes are energized an electric field is created therebetween, blood cells are attracted to the positive electrode, and a thrombus is formed at the opening in the blood vessel wall. The member may include a balloon at the distal end to temporarily occlude blood flow from the blood vessel to the tissue tract to facilitate formation of the thrombus. In addition, the shape of the balloon may be tailored to facilitate the formation of the thrombus including, but not limited to, the creation of pockets and self-supporting balloons

    摘要翻译： 公开了一种用于封闭血管壁中的开口的装置和方法。 该装置包括至少一个构件，其延伸穿过通过表皮和皮下皮肤层形成的组织通道并且穿过血管中的开口。 该构件包括近端和远端，远端可靠近血管壁中的开口定位。 正电极位于远端附近，负极位于近端的旁边。当电极通电时，电极之间产生电场，血细胞被吸引到正电极，并且在开口处形成血栓 在血管壁。 该构件可以包括在远端处的气囊，以暂时阻断从血管到组织道的血流，以促进血栓的形成。 此外，气囊的形状可以被调整以促进血栓的形成，包括但不限于创建口袋和自支撑气球

    Intravascular folded tubular endoprosthesis
    9.
    发明申请
    Intravascular folded tubular endoprosthesis 审中-公开
    血管内折叠管状假体

    公开(公告)号：US20080132996A1

    公开(公告)日：2008-06-05

    申请号：US12001393

    申请日：2007-12-11

    申请人： William J. Drasler ,  Joseph M. Thielen

    发明人： William J. Drasler ,  Joseph M. Thielen

    IPC分类号： A61F2/82

    CPC分类号： A61F2/07 ,  A61F2/844 ,  A61F2/89 ,  A61F2002/065 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2002/8483 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2250/0007

    摘要： A bifurcated or straight intravascular folded tubular member is deliverable percutaneously or by small cutdown to the site of a vascular lesion. Its inserted state has a smaller nondeployed diameter and a shorter nondeployed length. The intravascular tubular member has a folded tubular section that is unfolded following insertion into the blood vessel. The length of the intravascular folded tubular member is sized in situ to the length of the vessel lesion without error associated with diagnostic estimation of lesion length. The folded tubular member is self-expandable or balloon-expandable to a larger deployed diameter following delivery to the lesion site. An attachment anchor can be positioned at the inlet or outlet ends of the intravascular folded tubular member to prevent leakage between the tubular member and the native vessel lumen and to prevent migration of the tubular member. The attachment anchor has a short axial length to provide a more focal line of attachment to the vessel wall. Such attachment is valuable in attaching to a short aortic neck in the treatment of abdominal aortic aneurysm. The attachment anchor can have barbs which are held in a protected conformation during insertion of the tubular member and are released upon deployment of the attachment anchor. The intravascular tubular member can be formed of woven multifilament polymeric strands with metallic strands interwoven along with them. Double weaving is incorporated to prevent leakage at crossover points.

    摘要翻译： 分叉或直的血管内折叠的管状构件可经皮肤递送或通过小切口传送至血管病变部位。 其插入状态具有较小的非部署直径和较短的非部署长度。 血管内管状构件具有折叠的管状部分，其在插入血管之后被展开。 血管内折叠的管状构件的长度在原位尺寸与血管损伤的长度无关，与病变长度的诊断估计相关。 折叠的管状构件在递送到病变部位之后是自膨胀的或球囊扩张的，以扩大到更大的部署直径。 附着锚可以位于血管内折叠的管状构件的入口端或出口端，以防止管状构件和天然血管腔之间的泄漏并且防止管状构件的移动。 附接锚具有短的轴向长度以提供与血管壁的更紧密的连接线。 这种附着在腹主动脉瘤治疗中附着于短主动脉颈颈是有价值的。 附接锚固件可以具有倒钩，其在管状构件的插入期间保持在受保护的构象中，并且在展开附接锚固件时释放。 血管内管状构件可以由具有与它们交织的金属线的编织多丝聚合物线形成。 并入双编以防止交叉点的泄漏。

    Thrombectomy method
    10.
    发明授权
    Thrombectomy method 失效
    血栓切除术

    公开(公告)号：US06558366B1

    公开(公告)日：2003-05-06

    申请号：US08349665

    申请日：1994-12-05

    申请人： William J. Drasler ,  Robert G. Dutcher ,  Mark L. Jenson ,  Joseph M. Thielen ,  Emmanuil I. Protonotarios

    发明人： William J. Drasler ,  Robert G. Dutcher ,  Mark L. Jenson ,  Joseph M. Thielen ,  Emmanuil I. Protonotarios

    IPC分类号： A61M3100

    CPC分类号： A61B17/32037 ,  A61B17/3203

    摘要： A method of and apparatus for removing a thrombus deposit from the cardiovascular system of a patient without the need to surgically access the location of the thrombus deposit via a cut-down or other surgical procedure. A catheter is inserted percutaneously into the patient at a convenient location either directly or over a previously positioned guide wire. The distal end of the catheter is advanced under fluoroscopy to the site of the thrombus deposit. A balloon is inflated to stabilize the position of the distal end of the catheter within the center of the vessel lumen. A flexible metal tube conveys an extremely high pressure stream of sterile saline solution to at least one jet at the distal end of the catheter. At least one jet positions the thrombus deposit for emulsification by at least one other jet. By directing the jets toward the orifice of the large evacuation lumen of the catheter, a stagnation pressure is induced which propels the emulsion proximally for disposal. The rate of proximal flow of effluent is metered to correspond with the distal flow of saline solution to ensure minimal local impact on the vasculature at the site of the thrombus deposit.

    摘要翻译： 一种用于从患者的心血管系统中去除血栓沉积物的方法和装置，而不需要通过切割或其它外科手术手术地进入血栓沉积物的位置。 在方便的位置，将导管经皮插入患者中，直接或超过预先定位的导丝。 导管的远端在荧光透视下前进到血栓沉积部位。 气囊膨胀以将导管的远端的位置稳定在血管内腔的中心内。 柔性金属管将非常高压的无菌盐水溶液流传送到导管远端处的至少一个射流。 至少一个喷射器通过至少一个其它喷射器将血栓沉积物定位成乳化。 通过将射流引导到导管的大抽空腔的孔口，引起停滞压力，其推动乳剂向近端处理。 流出物的近端流量计量以与盐溶液的远端流动相对应，以确保对血栓沉积部位的脉管系统的局部影响最小。