公开(公告)号：US06731981B1

公开(公告)日：2004-05-04

申请号：US09530384

申请日：2000-04-27

申请人： Tryggve Hemmingsson ,  Jakub Hirschberg

发明人： Tryggve Hemmingsson ,  Jakub Hirschberg

IPC分类号： A61N118

CPC分类号： A61N1/3962 ,  A61N1/395

摘要： A heart stimulator has a stimulation energy delivering assembly, including at least one lead adapted for implantation in contact with cardiac tissue, and an atrial arrhythmia detector, and a control unit connected to the stimulation energy delivering assembly and to the detector. The control unit controls the stimulation energy delivering assembly to deliver at least one atrial arrhythmia abolishing therapy and, if continued atrial arrhythmia is detected, to deliver antithrombus stimulation energy pulses of lower energy than a defibrillation shock, but with different timing and with sufficient energy for producing atrial contraction for increasing hemodynamic blood transportation away from the atrium and for preventing thrombi formation in the atrium. For a patient suffering from a chronic or paroxysmal non-curable atrial arrhythmia, the control unit controls the stimulation energy delivering assembly to deliver the antithrombus energy without any preceding arrhythmia abolishing therapy.

摘要翻译： 心脏刺激器具有刺激能量输送组件，包括至少一个适于植入与心脏组织接触的引线，以及心房心律失常检测器，以及连接到刺激能量输送组件和检测器的控制单元。 控制单元控制刺激能量递送组件以递送至少一种心房心律失常消除治疗，并且如果检测到持续的心律失常，则提供比除颤休克更低能量但具有不同时间和足够能量的抗凝血刺激能量脉冲 产生心房收缩以增加远离心房的血液动力学血液输送并防止心房中的血栓形成。 对于患有慢性或阵发性不可治愈心房心律失常的患者，控制单元控制刺激能量输送组件以递送抗凝血能量，而不会发生任何先前的心律失常消除治疗。

公开(公告)号：US5571164A

公开(公告)日：1996-11-05

申请号：US533250

申请日：1995-09-25

申请人： Christer Ekwall ,  Jakub Hirschberg ,  Kurt Hognelid

发明人： Christer Ekwall ,  Jakub Hirschberg ,  Kurt Hognelid

IPC分类号： A61B5/042 ,  A61N1/05 ,  A61N1/362

CPC分类号： A61B5/6852 ,  A61B5/0422 ,  A61N1/056 ,  A61B2562/0209 ,  A61B2562/043

摘要： An electrode device, for intracardiac stimulation and/or defibrillation of heart tissue and/or sensing heart signals in a patient, has a soft, flexible electrode cable with an outer coating of insulation containing at least one elongate conductor connected to an electrode arranged on the electrode cable. In order to attain an electrode device of this kind which is structurally very simple and in which all the electrodes on the electrode cable can be applied to the heart wall in a very simple manner so the entire electrode surface faces the wall and firmly presses against it, the electrode cable is at least partially ribbon-shaped.

摘要翻译： 用于心脏刺激和/或心脏组织除颤和/或感测患者心脏信号的电极装置具有软的柔性电极电缆，其具有外部涂层绝缘体，其包含至少一个连接到布置在所述电极上的电极的细长导体 电极电缆。 为了获得这样一种结构上非常简单的电极装置，其中电极电缆上的所有电极可以以非常简单的方式施加到心脏壁上，使得整个电极表面面向壁并且牢固地压靠在其上 电极电缆至少部分是带状的。

公开(公告)号：US5423873A

公开(公告)日：1995-06-13

申请号：US111198

申请日：1993-08-24

申请人： Heinz Neubauer ,  Jakub Hirschberg ,  Hans Strandberg

发明人： Heinz Neubauer ,  Jakub Hirschberg ,  Hans Strandberg

IPC分类号： A61N1/365 ,  A61N1/372 ,  A61N1/36

CPC分类号： A61N1/3686 ,  A61N1/36185 ,  A61N1/365 ,  A61N1/372

摘要： A device for stimulating heart tissue contains a stimulation unit connected via a switching device to an electrode system. The number of connecting lines between the stimulation unit and the switching device is minimized by emitting control signals and stimulation pulses from a common pulse signal output socket of the stimulation unit. The switching device contains a signal discriminator which separates the control signals from the stimulation pulses, the control signals then controlling the switching device such that the stimulation pulses are delivered to a specific part of the electrode system.

摘要翻译： 用于刺激心脏组织的装置包含经由开关装置连接到电极系统的刺激单元。 通过从刺激单元的公共脉冲信号输出插座发出控制信号和刺激脉冲来最小化刺激单元和开关装置之间的连接线的数量。 开关装置包含信号鉴别器，其将控制信号与刺激脉冲分离，然后控制信号控制开关装置，使得刺激脉冲被传送到电极系统的特定部分。

公开(公告)号：US5066278A

公开(公告)日：1991-11-19

申请号：US562696

申请日：1990-08-06

申请人： Jakub Hirschberg ,  Bengt Svensson

发明人： Jakub Hirschberg ,  Bengt Svensson

IPC分类号： A61M5/142 ,  A61M25/00

CPC分类号： A61M5/14276 ,  A61M25/0045 ,  A61M25/007

摘要： An implantable injection body for the time-dependent dosable, long-term injection of a medication into a living being, the medication being stored in an implanted medication dosing device and being supplied by the latter to the injection body via a programmable pump arrangement. The injection body has a plurality of medication discharge openings, at least some of which are initially sealed, by a selectively openable seal, preferably by a dissolvable tissue-compatible, plastic material that dissolves at different times, so that, after closure of the initially unsealed discharge opening caused by overgrowth of connective tissue, agglomeration of matter, and/or the like, the initially sealed discharge openings can be selectively unsealed, preferably in serial fashion, to permit continued medication flow-through. Alternatively, the openable seals can comprise rupturable membranes of varying strengths.

摘要翻译： 一种可植入注射体，用于将药物长时间注射到生活中，将药物储存在植入的药物计量装置中并由后者通过可编程泵装置供给注射体。 注射体具有多个药物排出口，其中至少一些最初被密封，通过选择性可打开的密封，优选地通过在不同时间溶解的可溶解的组织相容的塑料材料，使得在最初 最初密封的排出口可以选择性地开封，优选地以串联方式，以允许持续的药物流通，这是因为结缔组织的过度生长，物质的聚集等引起的非密封排放口。 或者，可打开的密封件可以包括具有不同强度的可破裂膜。

公开(公告)号：US4932409A

公开(公告)日：1990-06-12

申请号：US341477

申请日：1989-04-21

申请人： Jakub Hirschberg

发明人： Jakub Hirschberg

IPC分类号： A61N1/375 ,  B65D51/00 ,  H01R4/36

CPC分类号： B65D51/00 ,  A61N1/3752 ,  H01R4/36

摘要： A seal element for an opening in an implantable medical apparatus, which can be penetrated by a tool and which maintains a hermetic seal after removal of the tool, is in the form of a ring of resilient material, initially having a ring opening with the wall thickness of the ring being larger than the radius of the ring opening. The ring can be turned inside-out, whereby the ring opening is closed. The placement of the seal element in the opening in the implantable medical apparatus maintains the opening closed to form a seal, but permits insertion of a tool therethrough.

摘要翻译： 用于可植入医疗设备中的开口的密封元件可以由工具穿透并且在移除工具之后保持气密密封件是弹性材料环的形式，其最初具有与壁的开口 环的厚度大于环形开口的半径。 环可以向内转出，从而环形开口关闭。 密封元件在可植入医疗设备的开口中的放置保持开口闭合以形成密封，但允许工具插入其中。

公开(公告)号：US4447053A

公开(公告)日：1984-05-08

申请号：US345242

申请日：1982-02-03

申请人： Mats Wager ,  Jakub Hirschberg

发明人： Mats Wager ,  Jakub Hirschberg

IPC分类号： B65H3/28 ,  G03B42/04 ,  B65H3/32

CPC分类号： B65H83/02 ,  B65H3/28 ,  G03B42/045 ,  B65H2404/663

摘要： A device for separating film sheets in a stack, particularly useful in X-ray installations, includes a threaded rotary screw member disposed within a magazine containing the stack of sheets for raising and lowering the sheet stack within the magazine and individually handling the uppermost sheet in the stack for transport to or from the magazine.

摘要翻译： 一种用于分离堆叠中的薄片的装置，在X射线装置中特别有用的装置包括：螺旋旋转螺杆，其设置在包含用于升高和降低弹匣内的薄片堆叠的薄片堆叠的料盒内，并单独处理最上面的薄片 用于运送到或从杂志运输的堆栈。

公开(公告)号：US06085118A

公开(公告)日：2000-07-04

申请号：US214997

申请日：1999-05-17

申请人： Jakub Hirschberg ,  Hans Strandberg

发明人： Jakub Hirschberg ,  Hans Strandberg

IPC分类号： A61N1/37 ,  A61N1/372 ,  A61N1/36

CPC分类号： A61N1/3706 ,  A61N1/37211

摘要： An implantable cardiac stimulator has a connector with at least two terminals, each terminal being connectible to an implantable electrode for delivering stimulation pulses to a heart and/or for sensing cardiac activity signals. The stimulator also has a switch and a control unit which operates the switch, so that one or both terminals are connectible to the pulse generator and/or to an input stage. The control unit identifies a position status for at least one of the electrodes in response to a signal received by the input stage at the time of implantation of the stimulator. The control unit also can select a terminal to be connected to the pulse generator, dependent on the established position status.

摘要翻译： PCT No.PCT / SE97 / 01238 Sec。 371日期1999年5月17日 102（e）日期1999年5月17日PCT提交1997年7月4日PCT公布。 公开号WO98 / 03223 日期1998年1月29日可植入心脏刺激器具有至少两个端子的连接器，每个端子可连接到可植入电极，用于将刺激脉冲输送到心脏和/或用于感测心脏活动信号。 刺激器还具有操作开关的开关和控制单元，使得一个或两个端子可连接到脉冲发生器和/或可连接到输入级。 控制单元响应于在植入刺激器时由输入级接收的信号来识别至少一个电极的位置状态。 控制单元还可以根据建立的位置状态选择要连接到脉冲发生器的端子。

公开(公告)号：US5423865A

公开(公告)日：1995-06-13

申请号：US161408

申请日：1993-12-06

申请人： Staffan Bowald ,  Jakub Hirschberg ,  Jens Wolf

发明人： Staffan Bowald ,  Jakub Hirschberg ,  Jens Wolf

IPC分类号： A61N1/05 ,  A61N1/39

CPC分类号： A61N1/0563 ,  A61N1/3918 ,  A61N2001/0585

摘要： An electrode system for a defibrillator avoids the use of a ventricular electrode, and provides efficient utilization of the energy stored in the defibrillator with a beneficial distribution of current in the heart. The electrode system includes three electrodes, at least two of which are intravascular electrodes. One of these intravascular electrodes is placed in the inferior vena cava and the other is placed in the coronary sinus, including its continuation (the great cardiac vein) along the base of the heart. The third electrode can be either an extravascular patch electrode, located in the region of the left ventricle, or an additional intravascular electrode located in the superior vena cava. The intravascular electrodes are devised so that they do not impede the flow of blood in the vein in which they are located.

摘要翻译： 用于除颤器的电极系统避免使用心室电极，并且有效地利用存储在除颤器中的能量，并且有效地分配心脏中的电流。 电极系统包括三个电极，其中至少两个电极是血管内电极。 这些血管内电极之一被放置在下腔静脉中，另一个置于冠状窦中，包括其沿着心脏底部的延续（大心静脉）。 第三电极可以是位于左心室区域的血管外贴片电极，或位于上腔静脉中的另外的血管内电极。 设计血管内电极，使得它们不妨碍它们所在的静脉中的血液流动。

公开(公告)号：US5411546A

公开(公告)日：1995-05-02

申请号：US161412

申请日：1993-12-06

申请人： Staffan Bowald ,  Jakub Hirschberg

发明人： Staffan Bowald ,  Jakub Hirschberg

IPC分类号： A61N1/39 ,  A61N1/04 ,  A61N1/05

CPC分类号： A61N1/057 ,  A61N1/0563 ,  A61N2001/0578

摘要： A defibrillation electrode, especially for implantation at an intravascular site in a patient, has a flexible electrode cable containing at least one elongate, electrically insulated conductor with an electrode head disposed at a distal end of the electrode cable, and having at least one defibrillation surface for delivering defibrillation pulses to the patient's heart. The electrode head is constructed so as to be radially expandable and, in an expanded position, defines the contours (surface configuration) of a hollow body so as to provide a defibrillation electrode which is affixable to the vessel in which it is sited, and which has a minimal impact on the flow of blood in that blood vessel.

摘要翻译： 特别是用于植入患者血管内位置的除颤电极具有柔性电极电缆，其包含至少一个细长的电绝缘导体，电极头设置在电极电缆的远端，并且具有至少一个除颤表面 用于将除颤脉冲输送到患者的心脏。 电极头被构造成可径向扩张，并且在扩展位置中限定中空体的轮廓（表面构造），以便提供除颤电极，该除颤电极可固定在其所在的容器上，以及哪个 对该血管中血液的流动影响最小。

公开(公告)号：US5342413A

公开(公告)日：1994-08-30

申请号：US63555

申请日：1993-05-19

申请人： Jakub Hirschberg ,  Heinz Neubauer ,  Nina Gilljam ,  Staffan Bowald ,  Ulf Lindegren

发明人： Jakub Hirschberg ,  Heinz Neubauer ,  Nina Gilljam ,  Staffan Bowald ,  Ulf Lindegren

IPC分类号： A61B5/0408 ,  A61B5/0478 ,  A61B5/0492 ,  A61N1/04 ,  A61N1/05

CPC分类号： A61N1/056 ,  A61N1/0565

摘要： An electrode arrangement for in vivo stimulation of tissue with electrical energy has a catheter containing an electrical lead, the lead and the catheter being electrically and mechanically connected to further electrical conductors, arranged in a configuration forming a broad, flat, thin and flexible electrode. The conductors in the electrode are partially exposed and define an electrode surface for delivering electrical energy to adjacent tissue. The electrode arrangement further includes a fixing device, for attaching the electrode to tissue surrounding the tissue to be stimulated. The fixing device includes a fixing element which is mounted on the electrode so as to be movable independently of the electrode, and a stylet which controls movement of the fixing element, the stylet extending through the catheter. The fixing element can be controlled so as to be advanced from a retracted position to a position extending beyond the electrode surface in which the fixing element penetrates the tissue.

摘要翻译： 用于用电能体内刺激组织的电极装置具有含有电引线的导管，引线和导管电连接和机械地连接到形成宽，平，薄和柔性电极的构造中的另外的电导体。 电极中的导体部分地暴露并且限定用于将电能传递到相邻组织的电极表面。 电极装置还包括固定装置，用于将电极附接到要刺激的组织周围的组织。 定影装置包括固定元件，该固定元件安装在电极上以能够独立于电极移动;以及探针，该探针控制固定元件的移动，探针延伸穿过导管。 可以控制固定元件从缩回位置前进到延伸超过固定元件穿透组织的电极表面的位置。