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23 条记录 (耗时 0.043 秒)

    Drug for nerve regeneration
    1.
    发明申请
    Drug for nerve regeneration 审中-公开
    药物用于神经再生

    公开(公告)号：US20060217368A1

    公开(公告)日：2006-09-28

    申请号：US10552061

    申请日：2004-04-16

    申请人： Tsuyoshi Morishita ,  Kazuhiro Sakurada ,  Keiko Suzuki ,  Shun-ichi Ikeda

    发明人： Tsuyoshi Morishita ,  Kazuhiro Sakurada ,  Keiko Suzuki ,  Shun-ichi Ikeda

    IPC分类号： A61K31/55 ,  A61K31/404 ,  A61K33/00 ,  A61K31/407 ,  A61K31/405

    CPC分类号： A61K31/00 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/407 ,  A61K31/553

    摘要： An object of the present invention is to provide a nerve regenerating drug, an agent for the promotion of neuropoiesis of a neural stem cell, a neuron obtained by culturing a neural stem cell in the presence of the agent for the promotion of neuropoiesis, and a method of the manufacture of the neuron. In order to achieve the object, the invention provides a nerve regenerating drug comprising a substance that inhibits the activity of glycogen synthase kinase-3, as an active ingredient; an agent for the promotion of neuropoiesis of a neural stem cell comprising the substance as an active ingredient; a neuron obtained by culturing a neural stem cell in the presence of the agent for the promotion of neuropoiesis; and a method of the manufacture of the neuron. The medical drug according to the invention is useful as a therapeutic drug for neurological diseases such as Parkinson's disease, Alzheimer's disease, Down's disease, cerebrovascular disorder, cerebral stroke, spinal cord injury, Huntington's chorea, multiple sclerosis, amyotrophic lateral sclerosis, epilepsy, anxiety disorder, schizophrenia, depression and manic depressive psychosis.

    摘要翻译： 本发明的目的是提供一种神经再生药物，用于促进神经干细胞神经生成的药剂，通过在用于促进​​神经生成的药剂的存在下培养神经干细胞获得的神经元，以及 神经元的制造方法。 为了达到上述目的，本发明提供了包含抑制糖原合成酶激酶-3活性的物质作为活性成分的神经再生药物。 用于促进包含该物质作为活性成分的神经干细胞神经生成的药剂; 在用于促进​​神经生成的药剂存在下培养神经干细胞获得的神经元; 以及神经元的制造方法。 根据本发明的药物可用作神经疾病如帕金森病，阿尔茨海默氏病，唐氏病，脑血管病，脑卒中，脊髓损伤，亨廷顿舞蹈病，多发性硬化，肌萎缩性侧索硬化，癫痫，焦虑症的治疗药物 失调，精神分裂症，抑郁症和躁狂抑郁症精神病。

    METHODS AND PLATFORMS FOR DRUG DISCOVERY
    4.
    发明申请
    METHODS AND PLATFORMS FOR DRUG DISCOVERY 审中-公开
    药物发现的方法和平台

    公开(公告)号：US20100240090A1

    公开(公告)日：2010-09-23

    申请号：US12709379

    申请日：2010-02-19

    申请人： Kazuhiro Sakurada ,  Hideki Masaki ,  Tetsuya Ishikawa ,  Shunichi Takahashi

    发明人： Kazuhiro Sakurada ,  Hideki Masaki ,  Tetsuya Ishikawa ,  Shunichi Takahashi

    IPC分类号： C12Q1/02

    CPC分类号： C12N15/85 ,  C12N5/0696 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2510/00 ,  C12N2799/027

    摘要： The present invention involves methods for identifying an agent that corrects a phenotype associated with a health condition or a predisposition for a health condition. The invention also involves methods for identifying a diagnostic cellular phenotype, determining the risk of a health condition in a subject, methods for reducing the risk of drug toxicity in a human subject, and methods for identifying a candidate gene that contributes to a human disease. The invention also discloses human induced pluripotent stem cell lines.

    摘要翻译： 本发明涉及用于鉴定校正与健康状况或健康状况的倾向相关联的表型的药剂的方法。 本发明还涉及用于鉴定诊断性细胞表型，确定受试者健康状况风险的方法，降低人类受试者中药物毒性风险的方法，以及用于鉴定对人类疾病有贡献的候选基因的方法。 本发明还公开了人诱导的多能干细胞系。

    Pluripotent Cells Distributed Ubiquitously In Animal Tissue, Which Proliferate Selectively In Lower-Serum Culture
    9.
    发明申请
    Pluripotent Cells Distributed Ubiquitously In Animal Tissue, Which Proliferate Selectively In Lower-Serum Culture 审中-公开
    多能细胞分布在动物组织中，其选择性地在低血清培养物中增殖

    公开(公告)号：US20070202592A1

    公开(公告)日：2007-08-30

    申请号：US11631818

    申请日：2005-07-08

    申请人： Yasuo Kitagawa ,  Shuhei Torii ,  Kazuhiro Sakurada ,  Masato Kobori ,  Yuzuru Kamei ,  Hirotake Yamaguchi ,  Kazuhiro Toriyama ,  Toru Takada

    发明人： Yasuo Kitagawa ,  Shuhei Torii ,  Kazuhiro Sakurada ,  Masato Kobori ,  Yuzuru Kamei ,  Hirotake Yamaguchi ,  Kazuhiro Toriyama ,  Toru Takada

    IPC分类号： C12N5/06 ,  C12N5/08

    CPC分类号： C12N5/0667

    摘要： It is intended to provide a pluripotent cell having the following properties: (1) being contained in a mixed-cell type population obtained by enzymatic treatment of the tissue collected from an animal; (2) being contained in a sedimented cell population obtained by centrifugating the mixed-cell type population of the property (1); (3) selectively proliferating by culturing in a medium containing 2% (v/v) or lower serum and 1 to 100 ng/ml of fibroblast growth factor-2; and (4) being differentiated into cells having the characteristics of adipocytes, osteoblasts, chondrocytes, tendon cells, myocardial cells, myoblasts, neurocytes or vascular endothelial cells by adjusting the culture condition; cells having differentiated from the above cell; and a method of conveniently obtaining the pluripotent cell in a large amount.

    摘要翻译： 旨在提供具有以下性质的多能细胞：（1）包含在通过酶处理从动物收集的组织获得的混合细胞型群体中; （2）包含在通过离心所述性质的混合细胞型群体（1）获得的沉降细胞群体中; （3）通过在含有2％（v / v）或更低血清和1至100ng / ml成纤维细胞生长因子-2的培养基中培养而选择性增殖; （4）通过调节培养条件将细胞分化为具有脂肪细胞，成骨细胞，软骨细胞，肌腱细胞，心肌细胞，成肌细胞，神经细胞或血管内皮细胞特征的细胞; 与上述细胞有区别的细胞; 以及大量方便地获得多能细胞的方法。

    Biological information processing method and device, recording medium and program
    10.
    发明授权
    Biological information processing method and device, recording medium and program 有权

    公开(公告)号：US10303845B2

    公开(公告)日：2019-05-28

    申请号：US13704940

    申请日：2011-06-28

    申请人： Kazuhiro Sakurada

    发明人： Kazuhiro Sakurada

    IPC分类号： G01N33/48 ,  G01N33/50 ,  G06F19/10 ,  A61B5/145 ,  A61B5/00 ,  G06F19/24 ,  G06F19/18

    摘要： Provided is a biological information processing method and a device, a recording medium and a program that are able to predict and control changes in the state of an organism. The expression level of molecules in an organism is measured over a specific time interval; the measured time-series data is divided into a periodic component, an environmental stimulus response component and a baseline component; constant regions of the time-series data are identified from variations in the baseline component or from the amplitude or periodic variations of the periodic component; and causal relation between the identified constant regions is identified. The relation between the external environment and variations in the internal environment is identified and from the identified causal relation between the constant regions, changes in the state of the organism are inferred.