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公开(公告)号：US20080268060A1
公开(公告)日：2008-10-30
申请号：US12149604
申请日：2008-05-05
申请人： Tung T. Nguyen , Nina Brown , Jui C. Lin , Stephen Pham , Kenneth A. Cox , Douglas D. McRae , Walter A. Nichols
发明人： Tung T. Nguyen , Nina Brown , Jui C. Lin , Stephen Pham , Kenneth A. Cox , Douglas D. McRae , Walter A. Nichols
IPC分类号： A61K9/14 , A61K31/58 , A61K31/137
CPC分类号： A61K31/137 , A61K9/0073 , A61K31/573 , A61K47/08 , A61K47/10 , A61M11/041 , A61M11/042 , A61M15/0025 , A61M15/025 , A61M2016/0021 , A61M2205/8206 , A61M2205/8237
摘要： Liquid nanoscale particle precursor materials for generating nanoscale particles include at least one high volatility carrier and a second component. A nanoscale particle generating device generates nanoscale particles by passing a liquid nanoscale particle precursor material through a flow passage heated to convert the carrier into a vapor and the second component into nanoscale particles. The nanoscale particles preferably consist essentially of the second component and can consist essentially of dry, solid particles. The particle generator can be incorporated in a hand held inhaler, and can be delivered to a targeted portion of the lung using the inhaler. Composite controlled release particles of micron or nanoscale size can be produced by flowing a solution of medicament, control release agent and carrier liquid through a capillary heater.
摘要翻译： 用于产生纳米尺寸颗粒的液体纳米级颗粒前体材料包括至少一种高挥发性载体和第二组分。 纳米级粒子产生装置通过使液体纳米级粒子前体材料通过加热的流动通道将载体转化为蒸气并将第二组分转变为纳米级颗粒而产生纳米级颗粒。 纳米尺度颗粒优选基本上由第二组分组成，并且可以基本上由干燥的固体颗粒组成。 颗粒发生器可以并入手持式吸入器中，并且可以使用吸入器输送到肺的目标部分。 可以通过使药物，控制释放剂和载液的溶液流过毛细管加热器来生产微米或纳米尺寸的复合控制释放颗粒。
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公开(公告)号：US07625548B2
公开(公告)日：2009-12-01
申请号：US12149604
申请日：2008-05-05
申请人： Tung T. Nguyen , Nina Brown , Jui C. Lin , Stephen Pham , Kenneth A. Cox , Douglas D. McRae , Walter A. Nichols
发明人： Tung T. Nguyen , Nina Brown , Jui C. Lin , Stephen Pham , Kenneth A. Cox , Douglas D. McRae , Walter A. Nichols
IPC分类号： A61K47/06
CPC分类号： A61K31/137 , A61K9/0073 , A61K31/573 , A61K47/08 , A61K47/10 , A61M11/041 , A61M11/042 , A61M15/0025 , A61M15/025 , A61M2016/0021 , A61M2205/8206 , A61M2205/8237
摘要： Liquid nanoscale particle precursor materials for generating nanoscale particles include at least one high volatility carrier and a second component. A nanoscale particle generating device generates nanoscale particles by passing a liquid nanoscale particle precursor material through a flow passage heated to convert the carrier into a vapor and the second component into nanoscale particles. The nanoscale particles preferably consist essentially of the second component and can consist essentially of dry, solid particles. The particle generator can be incorporated in a hand held inhaler, and can be delivered to a targeted portion of the lung using the inhaler. Composite controlled release particles of micron or nanoscale size can be produced by flowing a solution of medicament, control release agent and carrier liquid through a capillary heater.
摘要翻译： 用于产生纳米尺寸颗粒的液体纳米级颗粒前体材料包括至少一种高挥发性载体和第二组分。 纳米级粒子产生装置通过使液体纳米级粒子前体材料通过加热的流动通道将载体转化为蒸气并将第二组分转变为纳米级颗粒而产生纳米级颗粒。 纳米尺度颗粒优选基本上由第二组分组成，并且可以基本上由干燥的固体颗粒组成。 颗粒发生器可以并入手持式吸入器中，并且可以使用吸入器输送到肺的目标部分。 可以通过使药物，控制释放剂和载液的溶液流过毛细管加热器来生产微米或纳米尺寸的复合控制释放颗粒。
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公开(公告)号：US07147170B2
公开(公告)日：2006-12-12
申请号：US10655017
申请日：2003-09-05
申请人： Tung T. Nguyen , Douglas D. McRae , Kenneth A. Cox , Walter A. Nichols , Ulysses Smith , Gary E. Grollimund , Donald L. Brookman
发明人： Tung T. Nguyen , Douglas D. McRae , Kenneth A. Cox , Walter A. Nichols , Ulysses Smith , Gary E. Grollimund , Donald L. Brookman
CPC分类号： B05B17/04 , A61M11/001 , A61M11/041 , A61M11/042 , A61M15/008 , A61M15/025 , A61M2205/50 , A61M2205/8206 , B05B1/24
摘要： An aerosol generating device generates an aerosol having a desired particle size by passing a liquid through a flow passage heated to convert the liquid into a vapor. The flow passage includes an outlet section that controls the exit velocity of the vapor and produces an aerosol with a desired particle size. The aerosol generator can be incorporated in a hand held inhaler, and the liquid can include a medicament, which is delivered to a targeted portion of the lung using the inhaler.
摘要翻译： 气溶胶发生装置通过使液体通过加热的流体将液体转化为蒸气而产生具有所需粒径的气溶胶。 流动通道包括一个出口部分，其控制蒸气的出口速度并产生具有所需粒径的气溶胶。 气溶胶发生器可以结合在手持式吸入器中，并且液体可以包括药物，其使用吸入器输送到肺的目标部分。
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4.发明授权Aerosol generating devices and methods for generating aerosols suitable for forming propellant-free aerosols 有权用于产生适于形成不含无推进剂的气溶胶的气溶胶的气溶胶产生装置和方法公开(公告)号：US07040314B2
公开(公告)日：2006-05-09
申请号：US10653934
申请日：2003-09-04
IPC分类号： A61M16/00
CPC分类号： A61K9/0078 , A61M11/007 , A61M11/041 , A61M11/042 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M15/02 , A61M15/025 , A61M2016/0027 , A61M2205/8206 , A61M2205/8237
摘要： Liquid aerosol formulations for generating aerosols include at least one high volatility carrier and a second component. In some embodiments, the liquid aerosol formulation is propellant free. An aerosol generating device generates an aerosol by passing liquid aerosol formulation through a flow passage heated to convert the liquid into a vapor, which is mixed with air to form an aerosol. In some embodiments, particles of the aerosol consist essentially of the second component. The aerosol generator can be incorporated in a hand held inhaler. The aerosol can be delivered to a targeted portion of the lung using the inhaler.
摘要翻译： 用于产生气溶胶的液体气溶胶制剂包括至少一种高挥发性载体和第二组分。 在一些实施方案中，液体气溶胶制剂不含推进剂。 气溶胶发生装置通过使液体气溶胶制剂通过加热的流动通道将液体转化为蒸汽而产生气溶胶，该蒸汽与空气混合以形成气溶胶。 在一些实施方案中，气溶胶的颗粒基本上由第二组分组成。 气溶胶发生器可以并入手持式吸入器中。 气雾剂可以使用吸入器输送到肺的目标部分。
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5.发明授权公开(公告)号：US06923179B2
公开(公告)日：2005-08-02
申请号：US10654980
申请日：2003-09-05
CPC分类号： B05B1/24 , A61M11/002 , A61M11/041 , A61M11/042 , A61M15/00 , A61M2205/50 , B05B7/0012
摘要： An aerosol generating device includes a housing, a heater and an optional mouthpiece. The heater volatilizes liquid within a flow passage and forms an aerosol in the mouthpiece. An aerosol confinement sleeve is disposed to control the size distribution of the aerosol.
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6.发明授权Aerosol generating devices and methods for generating aerosols having controlled particle sizes 有权气溶胶产生装置和用于产生具有受控粒度的气溶胶的方法公开(公告)号：US07743766B2
公开(公告)日：2010-06-29
申请号：US11140984
申请日：2005-06-01
CPC分类号： B05B1/24 , A61M11/002 , A61M11/041 , A61M11/042 , A61M15/00 , A61M2205/50 , B05B7/0012
摘要： An aerosol generating device includes a housing, a heater and an optional mouthpiece. The heater volatilizes liquid within a flow passage and forms an aerosol in the mouthpiece. An aerosol confinement sleeve is disposed to control the size distribution of the aerosol.
摘要翻译： 烟雾发生装置包括壳体，加热器和可选的接口。 加热器在流动通道内挥发液体并在接口管中形成气溶胶。 设置气溶胶限制套管以控制气溶胶的尺寸分布。
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7.发明授权Aerosol generator having temperature controlled heating zone and method of use thereof 有权具有温度控制加热区的气溶胶发生器及其使用方法公开(公告)号：US07173222B2
公开(公告)日：2007-02-06
申请号：US10279035
申请日：2002-10-24
申请人： Kenneth A. Cox , Walter A. Nichols , F. Murphy Sprinkel, Jr. , Douglas D. McRae , William R. Sweeney
发明人： Kenneth A. Cox , Walter A. Nichols , F. Murphy Sprinkel, Jr. , Douglas D. McRae , William R. Sweeney
IPC分类号： A05B1/02
CPC分类号： A61M11/041 , A61M11/007 , A61M11/042 , A61M15/025 , A61M2205/3372
摘要： A temperature and flow rate controlled capillary aerosol generator includes two heating zones optionally separated by a region in which a pressure drop is induced. Power is metered or applied to the downstream, second zone to achieve a target resistance, and therefore a target temperature, while power is metered or applied to the upstream, first zone to achieve a target mass flow rate exiting the second zone. A target temperature is achieved in the second zone to generate an aerosol from the liquid flowing through the generator at the desired mass flow rate.
摘要翻译： 温度和流速控制的毛细管气溶胶发生器包括两个加热区，任选地由诱导压降的区域分开。 将功率计量或施加到下游的第二区域以实现目标电阻，并因此实现目标温度，同时计量或施加功率到上游第一区域以实现离开第二区域的目标质量流量。 在第二区域中实现目标温度，以期望的质量流率从流过发生器的液体产生气溶胶。
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8.发明授权公开(公告)号：US06501052B2
公开(公告)日：2002-12-31
申请号：US09742322
申请日：2000-12-22
申请人： Kenneth A. Cox , Walter A. Nichols , F. Murphy Sprinkel, Jr. , Douglas D. McRae , William R. Sweeney
发明人： Kenneth A. Cox , Walter A. Nichols , F. Murphy Sprinkel, Jr. , Douglas D. McRae , William R. Sweeney
IPC分类号： H05B102
CPC分类号： A61M11/041 , A61M11/007 , A61M11/042 , A61M15/025 , A61M2205/3372
摘要： A temperature and flow rate controlled capillary aerosol generator includes two heating zones optionally separated by a region in which a pressure drop is induced. Power is metered or applied to the downstream, second zone to achieve a target resistance, and therefore a target temperature, while power is metered or applied to the upstream, first zone to achieve a target mass flow rate exiting the second zone. A target temperature is achieved in the second zone to generate an aerosol from the liquid flowing through the generator at the desired mass flow rate.
摘要翻译： 温度和流速控制的毛细管气溶胶发生器包括两个加热区，任选地由诱导压降的区域分开。 将功率计量或施加到下游的第二区域以实现目标电阻，并因此实现目标温度，同时计量或施加功率到上游第一区域以实现离开第二区域的目标质量流量。 在第二区域中实现目标温度，以期望的质量流率从流过发生器的液体产生气溶胶。
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公开(公告)号：US06640050B2
公开(公告)日：2003-10-28
申请号：US09957026
申请日：2001-09-21
IPC分类号： F24F600
CPC分类号： A61M11/041 , A61M11/001 , A61M11/007 , A61M11/042 , A61M15/025 , A61M2016/0021 , A61M2205/8206
摘要： A fluid vaporizing device useful for vaporizing fluid into an aerosol includes a capillary tube made from an electrically conductive material, an upstream electrode connected to the tube, and a downstream electrode connected to the tube and provided with an electrical resistivity sufficient to cause heating of the downstream electrode during operation to approximately the same temperature as the tube at the point of connection. The upstream and downstream electrodes connected to the capillary tube divide the tube into an initial feed section, a heated section, and a tip. A source of material to be volatilized is provided to the tube at the feed section, passes downstream into the heated section, is vaporized, and then exits from the tube through the tip. The temperature profile of the tube along the heated section is controlled by varying parameters to substantially eliminate any effect of the downstream electrode as a heat sink. These parameters may include the electrical resistivity of the downstream electrode, its cross-sectional area, and its length.
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10.发明授权Fluid vaporizing device having controlled temperature profile heater/capillary tube 有权具有受控温度曲线加热器/毛细管的流体蒸发装置公开(公告)号：US07367334B2
公开(公告)日：2008-05-06
申请号：US10648282
申请日：2003-08-27
IPC分类号： A61M11/00
CPC分类号： A61M11/041 , A61M11/007 , A61M11/042 , A61M15/025
摘要： A fluid vaporizing device useful for vaporizing fluid into an aerosol includes a capillary tube made from an electrically conductive material, an upstream electrode connected to the capillary tube, and a downstream electrode connected to the tube and provided with an electrical resistivity sufficient to cause heating of the downstream electrode during operation. According to various manufacturing techniques (a) the downstream electrode can be made of a material having a resistivity that is approximately constant over a desired temperature range, (b) the ratio of the resistance of the downstream electrode to the resistance of the capillary tube can be selected as a function of a preset liquid flow rate through the capillary tube, (c) the tuning range over which a desired quality aerosol can be produced can be selected to compensate for dimensional tolerances during mass production, and (d) the total hot resistance of the downstream electrode and capillary tube can be adjusted to control the location of a meniscus of a liquid vaporized in the capillary tube to produce a desired quality aerosol.
摘要翻译： 用于将流体蒸发成气溶胶的流体蒸发装置包括由导电材料制成的毛细管，连接到毛细管的上游电极和连接到管的下游电极，并且具有足以引起 操作期间的下游电极。 根据各种制造技术（a），下游电极可以由在所需温度范围内电阻率近似恒定的材料制成，（b）下游电极的电阻与毛细管的电阻的比率可以 作为通过毛细管的预设液体流速的函数来选择，（c）可以选择可以产生期望质量气溶胶的调谐范围以补偿大量生产期间的尺寸公差，以及（d）总热量 可以调节下游电极和毛细管的电阻以控制在毛细管中蒸发的液体的弯液面的位置以产生期望的质量气溶胶。
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