公开(公告)号：US07040314B2

公开(公告)日：2006-05-09

申请号：US10653934

申请日：2003-09-04

申请人： Tung T. Nguyen ,  Christopher L. Irving ,  Kenneth A. Cox ,  Douglas D. McRae ,  Walter A. Nichols

发明人： Tung T. Nguyen ,  Christopher L. Irving ,  Kenneth A. Cox ,  Douglas D. McRae ,  Walter A. Nichols

IPC分类号： A61M16/00

CPC分类号： A61K9/0078 ,  A61M11/007 ,  A61M11/041 ,  A61M11/042 ,  A61M15/008 ,  A61M15/0081 ,  A61M15/0083 ,  A61M15/02 ,  A61M15/025 ,  A61M2016/0027 ,  A61M2205/8206 ,  A61M2205/8237

摘要： Liquid aerosol formulations for generating aerosols include at least one high volatility carrier and a second component. In some embodiments, the liquid aerosol formulation is propellant free. An aerosol generating device generates an aerosol by passing liquid aerosol formulation through a flow passage heated to convert the liquid into a vapor, which is mixed with air to form an aerosol. In some embodiments, particles of the aerosol consist essentially of the second component. The aerosol generator can be incorporated in a hand held inhaler. The aerosol can be delivered to a targeted portion of the lung using the inhaler.

摘要翻译： 用于产生气溶胶的液体气溶胶制剂包括至少一种高挥发性载体和第二组分。 在一些实施方案中，液体气溶胶制剂不含推进剂。 气溶胶发生装置通过使液体气溶胶制剂通过加热的流动通道将液体转化为蒸汽而产生气溶胶，该蒸汽与空气混合以形成气溶胶。 在一些实施方案中，气溶胶的颗粒基本上由第二组分组成。 气溶胶发生器可以并入手持式吸入器中。 气雾剂可以使用吸入器输送到肺的目标部分。

公开(公告)号：US20080268060A1

公开(公告)日：2008-10-30

申请号：US12149604

申请日：2008-05-05

申请人： Tung T. Nguyen ,  Nina Brown ,  Jui C. Lin ,  Stephen Pham ,  Kenneth A. Cox ,  Douglas D. McRae ,  Walter A. Nichols

发明人： Tung T. Nguyen ,  Nina Brown ,  Jui C. Lin ,  Stephen Pham ,  Kenneth A. Cox ,  Douglas D. McRae ,  Walter A. Nichols

IPC分类号： A61K9/14 ,  A61K31/58 ,  A61K31/137

CPC分类号： A61K31/137 ,  A61K9/0073 ,  A61K31/573 ,  A61K47/08 ,  A61K47/10 ,  A61M11/041 ,  A61M11/042 ,  A61M15/0025 ,  A61M15/025 ,  A61M2016/0021 ,  A61M2205/8206 ,  A61M2205/8237

摘要： Liquid nanoscale particle precursor materials for generating nanoscale particles include at least one high volatility carrier and a second component. A nanoscale particle generating device generates nanoscale particles by passing a liquid nanoscale particle precursor material through a flow passage heated to convert the carrier into a vapor and the second component into nanoscale particles. The nanoscale particles preferably consist essentially of the second component and can consist essentially of dry, solid particles. The particle generator can be incorporated in a hand held inhaler, and can be delivered to a targeted portion of the lung using the inhaler. Composite controlled release particles of micron or nanoscale size can be produced by flowing a solution of medicament, control release agent and carrier liquid through a capillary heater.

摘要翻译： 用于产生纳米尺寸颗粒的液体纳米级颗粒前体材料包括至少一种高挥发性载体和第二组分。 纳米级粒子产生装置通过使液体纳米级粒子前体材料通过加热的流动通道将载体转化为蒸气并将第二组分转变为纳米级颗粒而产生纳米级颗粒。 纳米尺度颗粒优选基本上由第二组分组成，并且可以基本上由干燥的固体颗粒组成。 颗粒发生器可以并入手持式吸入器中，并且可以使用吸入器输送到肺的目标部分。 可以通过使药物，控制释放剂和载液的溶液流过毛细管加热器来生产微米或纳米尺寸的复合控制释放颗粒。

公开(公告)号：US07147170B2

公开(公告)日：2006-12-12

申请号：US10655017

申请日：2003-09-05

申请人： Tung T. Nguyen ,  Douglas D. McRae ,  Kenneth A. Cox ,  Walter A. Nichols ,  Ulysses Smith ,  Gary E. Grollimund ,  Donald L. Brookman

发明人： Tung T. Nguyen ,  Douglas D. McRae ,  Kenneth A. Cox ,  Walter A. Nichols ,  Ulysses Smith ,  Gary E. Grollimund ,  Donald L. Brookman

IPC分类号： B05B1/24 ,  A61M11/00

CPC分类号： B05B17/04 ,  A61M11/001 ,  A61M11/041 ,  A61M11/042 ,  A61M15/008 ,  A61M15/025 ,  A61M2205/50 ,  A61M2205/8206 ,  B05B1/24

摘要： An aerosol generating device generates an aerosol having a desired particle size by passing a liquid through a flow passage heated to convert the liquid into a vapor. The flow passage includes an outlet section that controls the exit velocity of the vapor and produces an aerosol with a desired particle size. The aerosol generator can be incorporated in a hand held inhaler, and the liquid can include a medicament, which is delivered to a targeted portion of the lung using the inhaler.

摘要翻译： 气溶胶发生装置通过使液体通过加热的流体将液体转化为蒸气而产生具有所需粒径的气溶胶。 流动通道包括一个出口部分，其控制蒸气的出口速度并产生具有所需粒径的气溶胶。 气溶胶发生器可以结合在手持式吸入器中，并且液体可以包括药物，其使用吸入器输送到肺的目标部分。

公开(公告)号：US07625548B2

公开(公告)日：2009-12-01

申请号：US12149604

申请日：2008-05-05

申请人： Tung T. Nguyen ,  Nina Brown ,  Jui C. Lin ,  Stephen Pham ,  Kenneth A. Cox ,  Douglas D. McRae ,  Walter A. Nichols

发明人： Tung T. Nguyen ,  Nina Brown ,  Jui C. Lin ,  Stephen Pham ,  Kenneth A. Cox ,  Douglas D. McRae ,  Walter A. Nichols

IPC分类号： A61K47/06

CPC分类号： A61K31/137 ,  A61K9/0073 ,  A61K31/573 ,  A61K47/08 ,  A61K47/10 ,  A61M11/041 ,  A61M11/042 ,  A61M15/0025 ,  A61M15/025 ,  A61M2016/0021 ,  A61M2205/8206 ,  A61M2205/8237

摘要： Liquid nanoscale particle precursor materials for generating nanoscale particles include at least one high volatility carrier and a second component. A nanoscale particle generating device generates nanoscale particles by passing a liquid nanoscale particle precursor material through a flow passage heated to convert the carrier into a vapor and the second component into nanoscale particles. The nanoscale particles preferably consist essentially of the second component and can consist essentially of dry, solid particles. The particle generator can be incorporated in a hand held inhaler, and can be delivered to a targeted portion of the lung using the inhaler. Composite controlled release particles of micron or nanoscale size can be produced by flowing a solution of medicament, control release agent and carrier liquid through a capillary heater.

摘要翻译： 用于产生纳米尺寸颗粒的液体纳米级颗粒前体材料包括至少一种高挥发性载体和第二组分。 纳米级粒子产生装置通过使液体纳米级粒子前体材料通过加热的流动通道将载体转化为蒸气并将第二组分转变为纳米级颗粒而产生纳米级颗粒。 纳米尺度颗粒优选基本上由第二组分组成，并且可以基本上由干燥的固体颗粒组成。 颗粒发生器可以并入手持式吸入器中，并且可以使用吸入器输送到肺的目标部分。 可以通过使药物，控制释放剂和载液的溶液流过毛细管加热器来生产微米或纳米尺寸的复合控制释放颗粒。

公开(公告)号：US06923179B2

公开(公告)日：2005-08-02

申请号：US10654980

申请日：2003-09-05

申请人： Rajiv Gupta ,  Douglas D. McRae ,  Kenneth A. Cox ,  Walter A. Nichols

发明人： Rajiv Gupta ,  Douglas D. McRae ,  Kenneth A. Cox ,  Walter A. Nichols

IPC分类号： A61M11/00 ,  A61M11/04 ,  A61M15/00 ,  B05B1/24 ,  B05B7/00 ,  A61M16/00 ,  H05B3/00

CPC分类号： B05B1/24 ,  A61M11/002 ,  A61M11/041 ,  A61M11/042 ,  A61M15/00 ,  A61M2205/50 ,  B05B7/0012

摘要： An aerosol generating device includes a housing, a heater and an optional mouthpiece. The heater volatilizes liquid within a flow passage and forms an aerosol in the mouthpiece. An aerosol confinement sleeve is disposed to control the size distribution of the aerosol.

公开(公告)号：US07743766B2

公开(公告)日：2010-06-29

申请号：US11140984

申请日：2005-06-01

申请人： Rajiv Gupta ,  Douglas D. McRae ,  Kenneth A. Cox ,  Walter A. Nichols

发明人： Rajiv Gupta ,  Douglas D. McRae ,  Kenneth A. Cox ,  Walter A. Nichols

IPC分类号： F24F3/14 ,  F23D11/00 ,  H05B3/00 ,  A61M15/00

CPC分类号： B05B1/24 ,  A61M11/002 ,  A61M11/041 ,  A61M11/042 ,  A61M15/00 ,  A61M2205/50 ,  B05B7/0012

摘要： An aerosol generating device includes a housing, a heater and an optional mouthpiece. The heater volatilizes liquid within a flow passage and forms an aerosol in the mouthpiece. An aerosol confinement sleeve is disposed to control the size distribution of the aerosol.

摘要翻译： 烟雾发生装置包括壳体，加热器和可选的接口。 加热器在流动通道内挥发液体并在接口管中形成气溶胶。 设置气溶胶限制套管以控制气溶胶的尺寸分布。

公开(公告)号：US07173222B2

公开(公告)日：2007-02-06

申请号：US10279035

申请日：2002-10-24

申请人： Kenneth A. Cox ,  Walter A. Nichols ,  F. Murphy Sprinkel, Jr. ,  Douglas D. McRae ,  William R. Sweeney

发明人： Kenneth A. Cox ,  Walter A. Nichols ,  F. Murphy Sprinkel, Jr. ,  Douglas D. McRae ,  William R. Sweeney

IPC分类号： A05B1/02

CPC分类号： A61M11/041 ,  A61M11/007 ,  A61M11/042 ,  A61M15/025 ,  A61M2205/3372

摘要： A temperature and flow rate controlled capillary aerosol generator includes two heating zones optionally separated by a region in which a pressure drop is induced. Power is metered or applied to the downstream, second zone to achieve a target resistance, and therefore a target temperature, while power is metered or applied to the upstream, first zone to achieve a target mass flow rate exiting the second zone. A target temperature is achieved in the second zone to generate an aerosol from the liquid flowing through the generator at the desired mass flow rate.

摘要翻译： 温度和流速控制的毛细管气溶胶发生器包括两个加热区，任选地由诱导压降的区域分开。 将功率计量或施加到下游的第二区域以实现目标电阻，并因此实现目标温度，同时计量或施加功率到上游第一区域以实现离开第二区域的目标质量流量。 在第二区域中实现目标温度，以期望的质量流率从流过发生器的液体产生气溶胶。

公开(公告)号：US06501052B2

公开(公告)日：2002-12-31

申请号：US09742322

申请日：2000-12-22

申请人： Kenneth A. Cox ,  Walter A. Nichols ,  F. Murphy Sprinkel, Jr. ,  Douglas D. McRae ,  William R. Sweeney

发明人： Kenneth A. Cox ,  Walter A. Nichols ,  F. Murphy Sprinkel, Jr. ,  Douglas D. McRae ,  William R. Sweeney

IPC分类号： H05B102

CPC分类号： A61M11/041 ,  A61M11/007 ,  A61M11/042 ,  A61M15/025 ,  A61M2205/3372

摘要： A temperature and flow rate controlled capillary aerosol generator includes two heating zones optionally separated by a region in which a pressure drop is induced. Power is metered or applied to the downstream, second zone to achieve a target resistance, and therefore a target temperature, while power is metered or applied to the upstream, first zone to achieve a target mass flow rate exiting the second zone. A target temperature is achieved in the second zone to generate an aerosol from the liquid flowing through the generator at the desired mass flow rate.

摘要翻译： 温度和流速控制的毛细管气溶胶发生器包括两个加热区，任选地由诱导压降的区域分开。 将功率计量或施加到下游的第二区域以实现目标电阻，并因此实现目标温度，同时计量或施加功率到上游第一区域以实现离开第二区域的目标质量流量。 在第二区域中实现目标温度，以期望的质量流率从流过发生器的液体产生气溶胶。

公开(公告)号：US06640050B2

公开(公告)日：2003-10-28

申请号：US09957026

申请日：2001-09-21

申请人： Walter A. Nichols ,  Kenneth A. Cox ,  Douglas D. McRae ,  Tung Tien Nguyen

发明人： Walter A. Nichols ,  Kenneth A. Cox ,  Douglas D. McRae ,  Tung Tien Nguyen

IPC分类号： F24F600

CPC分类号： A61M11/041 ,  A61M11/001 ,  A61M11/007 ,  A61M11/042 ,  A61M15/025 ,  A61M2016/0021 ,  A61M2205/8206

摘要： A fluid vaporizing device useful for vaporizing fluid into an aerosol includes a capillary tube made from an electrically conductive material, an upstream electrode connected to the tube, and a downstream electrode connected to the tube and provided with an electrical resistivity sufficient to cause heating of the downstream electrode during operation to approximately the same temperature as the tube at the point of connection. The upstream and downstream electrodes connected to the capillary tube divide the tube into an initial feed section, a heated section, and a tip. A source of material to be volatilized is provided to the tube at the feed section, passes downstream into the heated section, is vaporized, and then exits from the tube through the tip. The temperature profile of the tube along the heated section is controlled by varying parameters to substantially eliminate any effect of the downstream electrode as a heat sink. These parameters may include the electrical resistivity of the downstream electrode, its cross-sectional area, and its length.

公开(公告)号：US07400940B2

公开(公告)日：2008-07-15

申请号：US10871536

申请日：2004-06-21

申请人： Douglas D. McRae ,  John L. Felter ,  Clinton E. Blake ,  Mark T. Capps ,  Kenneth A. Cox ,  David H. Keeler ,  Rajiv Gupta

发明人： Douglas D. McRae ,  John L. Felter ,  Clinton E. Blake ,  Mark T. Capps ,  Kenneth A. Cox ,  David H. Keeler ,  Rajiv Gupta

IPC分类号： G05B21/00 ,  A61M11/00

CPC分类号： A61M11/041 ,  A61M11/007 ,  A61M11/042 ,  A61M15/025 ,  A61M16/0093 ,  A61M16/1065 ,  A61M16/202 ,  A61M2205/3317 ,  A61M2205/3368 ,  A61M2209/02 ,  B05B9/002

摘要： A programmable aerosol generator forms a volatilized liquid by supplying a material in liquid form to a flow passage and heating the flow passage, such that the material volatilizes and expands out of an outlet of the channel. The volatilized material, if desired, mixes with ambient air such that volatilized material condenses to form the aerosol. An apparatus and method for generating such a volatilized liquid, as well as the control and methods of heating, are disclosed as an analytical tool useful for experimental use, a tool useful for production of commercial products or an inhaler device.

摘要翻译： 可编程气溶胶发生器通过将液体形式的材料供应到流动通道并加热流路而形成挥发液体，使得材料从通道的出口挥发和膨胀。 如果需要，挥发的物质与环境空气混合，使得挥发的物质冷凝形成气溶胶。 公开了用于产生这种挥发性液体的装置和方法以及加热控制和方法，作为可用于实验用途的分析工具，可用于生产商业产品或吸入器装置的工具。