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公开(公告)号：US20190091476A1
公开(公告)日：2019-03-28
申请号：US16076410
申请日：2017-02-13
申请人： UNIVERSITE DE RENNES 1 , INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , CNRS (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE) , CHU DE RENNES (CENTRE HOSPITALIER UNIVERSITAIRE DE RENNES)
发明人： Alfredo HERNANDEZ , Benoit MARTIN , Arnaud BIRABEN
摘要： A treatment system for stimulating the vagus nerves is described, comprising the following elements: -a detection and control unit (20); -at least one detection probe (10d, 10g) connected to the detection and control unit and intended to be applied to at least one of the two vagus nerves of a patient; -means (24) provided in the detection and control unit for detecting a phenomenon of mass discharge of action potentials in at least one vagus nerve using the detection probe or detection probes; -stimulation probes (10d, 10g) for stimulating vagus nerves, and -means (24) provided in the detection and control unit that are capable, in response to the detection of a mass discharge, of applying predefined asymmetric stimulation signals to said stimulation probes capable of causing a depolarization and/or hyperpolarization of the vagus nerves and of blocking the conduction of the action potentials at least in the efferent direction. The system is intended for preventing the risk of sudden death in the event of an epileptic seizure in epilepsy patients.
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公开(公告)号：US20230021272A1
公开(公告)日：2023-01-19
申请号：US17955725
申请日：2022-09-29
发明人： Alfredo HERNANDEZ
摘要： A vibrotactile stimulation device intended to be applied against a body medium (MC) to be stimulated, produced in the form of a functional unit, comprising a vibrating effector suitable for applying, to said medium, pulses of mechanical vibrational energy, and a controller for controlling the effector according to stimulation rules. The functional unit further houses a first electrode suitable for cooperating with at least one second electrode separated from the first electrode in order to supply signals representative of a cardiac activity and a muscular activity on the medium to be stimulated, said controller being sensitive to cardiac activity and muscular activity signals in order to influence the stimulation. The stimulation device may be used for body stimulation in combating sleep apnea, with improved detection.
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公开(公告)号：US20170326025A1
公开(公告)日：2017-11-16
申请号：US15529202
申请日：2015-11-24
发明人： Alfredo HERNANDEZ
IPC分类号： A61H23/02 , A61B5/0492 , A61B5/00 , A61B5/0408 , A61B5/087
CPC分类号： A61H23/0245 , A61B5/0402 , A61B5/0408 , A61B5/0488 , A61B5/0492 , A61B5/087 , A61B5/4818 , A61B5/4836 , A61B5/6833 , A61B5/68335 , A61H23/0236 , A61H2201/0188 , A61H2201/1604 , A61H2201/1619 , A61H2201/164 , A61H2201/165 , A61H2230/045 , A61H2230/405
摘要： A vibrotactile stimulation device intended to be applied against a body medium (MC) to be stimulated, produced in the form of a functional unit, comprising a vibrating effector suitable for applying, to said medium, pulses of mechanical vibrational energy, and a controller for controlling the effector according to stimulation rules. The functional unit further houses a first electrode suitable for cooperating with at least one second electrode separated from the first electrode in order to supply signals representative of a cardiac activity and a muscular activity on the medium to be stimulated, said controller being sensitive to cardiac activity and muscular activity signals in order to influence the stimulation. The stimulation device may be used for body stimulation in combating sleep apnea, with improved detection.
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公开(公告)号：US20170326024A1
公开(公告)日：2017-11-16
申请号：US15529190
申请日：2015-11-24
发明人： Alfredo HERNANDEZ
CPC分类号： A61H23/02 , A61B5/0051 , A61B5/442 , A61B5/4818 , A61B5/4836 , A61B5/6833 , A61B5/68335 , A61B5/6843 , A61B2562/0219 , A61H2201/0188 , A61H2201/1604 , A61H2201/1619 , A61H2201/164 , A61H2201/165
摘要： A vibrotactile stimulation device intended to be applied against a body environment (MC) to be stimulated and comprising a vibrating effector suitable for applying, to said environment, pulses of mechanical vibrational energy, and a controller controlling the effector according to stimulation rules. The device is remarkable in that it further comprises vibration detector suitable for being exposed to the body environment in order to receive a part of the vibrational energy transmitted to said means by said environment during the application of the pulses of vibrational energy, and determine a transmission characteristic of the vibrational energy between the effector and the environment to be stimulated, said vibration detector being linked to the controller. An application to improving the efficacy of body stimulation in combating sleep apnoea is also disclosed.
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5.发明申请SYSTEM FOR STIMULATION THERAPY OF THE VAGUS NERVE BY IMPLEMENTATION OF A STATE TRANSITION MODEL 审中-公开通过实施状态转换模型进行VAGUS神经刺激治疗的系统公开(公告)号：US20160375249A1
公开(公告)日：2016-12-29
申请号：US15195746
申请日：2016-06-28
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/36053 , A61N1/3606 , A61N1/36125 , G06F19/00 , G06F19/30
摘要： One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to rules on the physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.
摘要翻译： 一个系统包括诸如迷走神经刺激引线的刺激装置，以及根据一组刺激参数来控制刺激装置的控制器。 刺激装置的存储器包含状态转换模型，并且对于每个状态，在用参数应用刺激期间定义一组刺激参数和至少一个预期响应。 基于测量的生理水平与目标水平，矩阵确定状态之间的过渡规则。 状态转移控制单元以有组织的及时方式确定根据响应于当前状态的刺激参数的实现而获得的关于生理水平的规则的状态之间的可能转换以及从当前状态到新状态的转变 导致用于刺激的参数集的相应变化。
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6.发明申请SYSTEM FOR STIMULATION THERAPY OF THE VAGUS NERVE BY IMPLEMENTATION OF A SELF-ADAPTIVE STATE TRANSITION MODEL BASED ON PHYSICAL OR PHYSIOLOGICAL LEVELS 审中-公开通过实施基于物理或生理水平的自适应状态过渡模型进行VAGUS神经刺激治疗的系统公开(公告)号：US20160375250A1
公开(公告)日：2016-12-29
申请号：US15195753
申请日：2016-06-28
CPC分类号： A61N1/36139 , A61B5/0205 , A61B5/4836 , A61B5/686 , A61N1/0551 , A61N1/36053 , A61N1/36114 , A61N1/36125 , A61N1/36146 , A61N1/36157 , A61N1/36175 , A61N1/36178 , A61N1/365 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/36585 , A61N1/36592 , A61N1/37235 , A61N1/37247 , G06F19/00 , G16H50/20 , G16H50/50
摘要： One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.
摘要翻译： 一个系统包括诸如迷走神经刺激引线的刺激装置，以及根据一组刺激参数来控制刺激装置的控制器。 刺激装置的存储器包含状态转换模型，并且对于每个状态，在用参数应用刺激期间定义一组刺激参数和至少一个预期响应。 基于测量的生理水平与目标水平，矩阵确定状态之间的过渡规则。 状态转移控制单元以有组织的及时方式确定根据响应于当前状态的刺激参数的实现而获得的关于生理水平的规则的状态之间的可能转换以及从当前状态到新状态的转变 导致用于刺激的参数集的相应变化。
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7.发明申请SYSTEM FOR STIMULATION THERAPY OF THE VAGUS NERVE BY IMPLEMENTATION OF A STATE TRANSITION MODEL OPERATING AT MULTIPLE TEMPORAL OR SPATIAL RESOLUTIONS 审中-公开通过在多个时间或空间决议中实施状态转换模型进行VAGUS神经刺激治疗的系统公开(公告)号：US20160375252A1
公开(公告)日：2016-12-29
申请号：US15195786
申请日：2016-06-28
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/36053 , A61N1/36125 , A61N1/37235
摘要： One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.
摘要翻译： 一个系统包括诸如迷走神经刺激引线的刺激装置，以及根据一组刺激参数来控制刺激装置的控制器。 刺激装置的存储器包含状态转换模型，并且对于每个状态，在用参数应用刺激期间定义一组刺激参数和至少一个预期响应。 基于测量的生理水平与目标水平，矩阵确定状态之间的过渡规则。 状态转移控制单元以有组织的及时方式确定根据响应于当前状态的刺激参数的实现而获得的关于生理水平的规则的状态之间的可能转换以及从当前状态到新状态的转变 导致用于刺激的参数集的相应变化。
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8.发明申请SYSTEM FOR STIMULATION THERAPY OF THE VAGUS NERVE BY IMPLEMENTATION OF A STATE TRANSITION MODEL WITH A LEARNING PHASE 有权通过实施具有学习阶段的状态过渡模型进行VAGUS神经刺激治疗的系统公开(公告)号：US20160375251A1
公开(公告)日：2016-12-29
申请号：US15195767
申请日：2016-06-28
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/36053 , A61N1/3606 , A61N1/36125 , A61N1/37235 , G06F19/00 , G06F19/30 , G16H50/20
摘要： One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.
摘要翻译： 一个系统包括诸如迷走神经刺激引线的刺激装置，以及根据一组刺激参数来控制刺激装置的控制器。 刺激装置的存储器包含状态转换模型，并且对于每个状态，在用参数应用刺激期间定义一组刺激参数和至少一个预期响应。 基于测量的生理水平与目标水平，矩阵确定状态之间的过渡规则。 状态转移控制单元以有组织的及时方式确定根据响应于当前状态的刺激参数的实现而获得的关于生理水平的规则的状态之间的可能转换以及从当前状态到新状态的转变 导致用于刺激的参数集的相应变化。
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