公开(公告)号：US11654212B2

公开(公告)日：2023-05-23

申请号：US15558787

申请日：2016-03-17

申请人： UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Nadine Nassif ,  Francisco Miguel Moreira Martins Fernandes ,  Cedric Boissiere ,  Clement Sanchez ,  Marie-Madeleine Giraud-Guille

IPC分类号： A61L27/24 ,  A61L27/50 ,  A61L27/54 ,  A61L27/52 ,  A61K8/02 ,  A61K8/14 ,  A61K38/39 ,  A61K8/65 ,  A61Q19/08 ,  A61K8/60 ,  C08J3/12

CPC分类号： A61L27/24 ,  A61K8/022 ,  A61K8/025 ,  A61K8/14 ,  A61K8/606 ,  A61K8/65 ,  A61K38/39 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61Q19/08 ,  C08J3/122 ,  A61K2800/412 ,  A61K2800/654 ,  A61K2800/91 ,  A61L2300/232 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/402 ,  A61L2300/428 ,  A61L2400/06 ,  A61L2430/06 ,  A61L2430/34 ,  A61L2430/38 ,  C08J2389/00

摘要： Disclosed is the preparation of injectable collagen suspensions, to the method for preparing the suspensions, and to the uses thereof, particularly for forming dense collagen matrices.

公开(公告)号：US09884139B2

公开(公告)日：2018-02-06

申请号：US14482443

申请日：2014-09-10

申请人： UNIVERSITE PIERRE ET MARIE CURIE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  ECOLE PRATIQUE DES HAUTES ETUDES

发明人： Nadine Nassif ,  Frederic Gobeaux ,  Marie-Madeleine Giraud-Guille ,  Gervaise Mosser

IPC分类号： A61L27/46 ,  A61L27/24

CPC分类号： A61L27/46 ,  A61L2430/02 ,  C08L89/06

摘要： A method for preparing a synthetic material having an organic phase and a mineral phase which consists in preparing an initial acidic aqueous solution of collagen which is a precursor for the organic phase (I), and at least one aqueous solution of precursors for the mineral phase (II), and in precipitating the collagen by increasing the pH to a value of at least 7. The method includes the concentration of collagen in the acidic aqueous solution is at least 75 mg/ml and remains constant during said increase in pH. The mineral phase precursors have at least one calcium salt and at least one phosphate salt. The precipitation of the mineral phase (II) is carried out by bringing the mineral phase precursor solution into contact with the organic phase (I), the bringing into contact being carried out before or after the precipitation of the organic phase (I).

公开(公告)号：US20160361469A1

公开(公告)日：2016-12-15

申请号：US14482443

申请日：2014-09-10

申请人： UNIVERSITE PIERRE ET MARIE CURIE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  ECOLE PRATIQUE DES HAUTES ETUDES

发明人： Nadine Nassif ,  Frederic Gobeaux ,  Marie-Madeleine Giraud-Guille ,  Gervaise Mosser

IPC分类号： A61L27/46 ,  A61L27/24

CPC分类号： A61L27/46 ,  A61L2430/02 ,  C08L89/06

摘要： A method for preparing a synthetic material having an organic phase and a mineral phase which consists in preparing an initial acidic aqueous solution of collagen which is a precursor for the organic phase (I), and at least one aqueous solution of precursors for the mineral phase (II), and in precipitating the collagen by increasing the pH to a value of at least 7. The method includes the concentration of collagen in the acidic aqueous solution is at least 75 mg/ml and remains constant during said increase in pH. The mineral phase precursors have at least one calcium salt and at least one phosphate salt. The precipitation of the mineral phase (II) is carried out by bringing the mineral phase precursor solution into contact with the organic phase (I), the bringing into contact being carried out before or after the precipitation of the organic phase (I).

摘要翻译： 一种制备具有有机相和无机相的合成材料的方法，其包括制备作为有机相（I）的前体的初始酸性水溶液，和至少一种矿物相的前体水溶液 （II），并且通过将pH增加至至少7来沉淀胶原蛋白。该方法包括在酸性水溶液中的胶原浓度为至少75mg / ml，并且在所述增加pH期间保持恒定。 矿物相前体具有至少一种钙盐和至少一种磷酸盐。 矿物相（II）的沉淀是通过使矿物相前体溶液与有机相（I）接触进行的，在有机相（I）的沉淀之前或之后进行接触。