公开(公告)号：US20130129633A1

公开(公告)日：2013-05-23

申请号：US13729815

申请日：2012-12-28

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： PARVESH SHARMA ,  BRIJ M. MOUDGIL ,  GLENN A. WALTER ,  STEPHEN R. GROBMYER ,  SWADESHMUKUL SANTRA ,  HUABEI JIANG ,  SCOTT CHANG BROWN ,  EDWARD W. SCOTT ,  QIZHI ZHANG ,  NICLAS BENGTSSON

IPC: A61K49/22 ,  A61M31/00 ,  A61N5/10 ,  A61K41/00

CPC classification number: A61K49/222 ,  A61B5/0035 ,  A61B5/0059 ,  A61B5/0095 ,  A61B5/055 ,  A61B6/00 ,  A61K41/0052 ,  A61K49/0002 ,  A61K49/0093 ,  A61K49/0423 ,  A61K49/1806 ,  A61K49/1881 ,  A61M31/005 ,  A61N5/10 ,  B82Y5/00

Abstract: Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging.

Abstract translation: 多峰纳米颗粒是含有PAT造影剂和发光成像，X射线成像和/或MRI中的一种或多种的纳米颗粒。 多峰纳米颗粒可以具有包含在芯上具有金属涂层的氧化物的介电芯。 颗粒可以是金属斑点。 多模式纳米颗粒可用于治疗目的，例如肿瘤的消融或中子捕获以及用作成像的造影剂。

公开(公告)号：US20160039673A1

公开(公告)日：2016-02-11

申请号：US14766157

申请日：2014-02-06

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： KEVIN WILLIAM POWERS ,  JIAQING ZHOU ,  PARVESH SHARMA ,  SPYROS A. SVORONOS ,  BRIJ M. MOUDGIL ,  GARY WAYNE SCHEIFFELE ,  AJOY K. SAHA

IPC: C01B19/00 ,  C22B3/00 ,  H01B1/02 ,  B22F9/24 ,  B01J19/00 ,  C01B33/12

CPC classification number: C01B19/007 ,  B01J4/008 ,  B01J19/0033 ,  B01J19/004 ,  B01J2219/00054 ,  B01J2219/00162 ,  B01J2219/00186 ,  B22F9/24 ,  B82Y20/00 ,  C01B33/12 ,  C01P2002/72 ,  C01P2002/84 ,  C01P2004/04 ,  C01P2004/64 ,  C01P2004/80 ,  C22B11/04 ,  H01B1/02 ,  Y10S977/774

Abstract: A continuous reaction system (CRS) allows a method to prepare quantum dots (QDs) in a continuous manner with high precision. The CRS pumps a plurality of reagent fluids into one or more mixing sites to form a reaction fluid that is carried through a heating chamber at elevated pressures to carry out hydrothermal growth of the QDs. The pumps and heating chamber are controlled with a high precision by employing a detector downstream of the heating chamber to provide a signal that is dependent on the composition and size of the QDs. The signal is provided to a signal processor that provides a signal that control the flow rates and temperature parameters in the system. The QDs produced in this manner are consistent in size and composition and can be of a single semiconductor composition or can be core-shell QDs with a shell semiconductor formed on a core semiconductor.

Abstract translation: 连续反应体系（CRS）允许以高精度连续地制备量子点（QD）的方法。 CRS将多个试剂流体泵送到一个或多个混合位置以形成反应流体，该反应流体在升高的压力下通过加热室进行，以进行QD的水热生长。 泵和加热室通过在加热室下游采用探测器提供高精度的控制，以提供取决于量子点组成和尺寸的信号。 该信号被提供给提供控制系统中的流量和温度参数的信号的信号处理器。 以这种方式制造的量子点在尺寸和组成上是一致的，并且可以是单个半导体组成，或者可以是在芯半导体上形成壳壳半导体的芯壳量子点。