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公开(公告)号：US12180477B2
公开(公告)日：2024-12-31
申请号：US17725102
申请日：2022-04-20
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Anastasia Khvorova , Bruno Miguel da Cruz Godinho , Matthew Hassler
IPC: C12N15/113
Abstract: Therapeutic oligonucleotides comprising pharmacokinetic (PK)-modifying anchors are provided. Methods for treating diseases or disorders comprising administering to a subject a therapeutic oligonucleotide comprising one or more PK-modifying anchors are provided.
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公开(公告)号：US11896669B2
公开(公告)日：2024-02-13
申请号：US17012787
申请日：2020-09-04
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Anastasia Khvorova , Matthew Hassler , Julia Alterman , Bruno Miguel da Cruz Godinho
IPC: A61K47/26 , C12N15/113 , C12N15/11 , A61K47/54 , A61K47/55 , A61K31/7084 , C07H3/08 , C07H21/04 , C07H99/00
CPC classification number: A61K47/26 , A61K31/7084 , A61K47/549 , A61K47/55 , A61K47/551 , C07H3/08 , C07H21/04 , C07H99/00 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/3513 , C12N2310/3515 , C12N2310/52
Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.
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公开(公告)号：US11492619B2
公开(公告)日：2022-11-08
申请号：US16746555
申请日：2020-01-17
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Anastasia Khvorova , Bruno Miguel Da Cruz Godinho , Matthew Hassler
IPC: C12N15/113
Abstract: Therapeutic oligonucleotides comprising pharmacokinetic (PK)-modifying anchors are provided. Methods for treating diseases or disorders comprising administering to a subject a therapeutic oligonucleotide comprising one or more PK-modifying anchors are provided.
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公开(公告)号：US20170369882A1
公开(公告)日：2017-12-28
申请号：US15691120
申请日：2017-08-30
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Anastasia Khvorova , Neil Aronin , Matthew Hassler , Julia Alterman
IPC: C12N15/113 , C12N15/11
CPC classification number: C12N15/113 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/343 , C12N2310/344 , C12N2310/346 , C12N2310/3515 , C12N2320/51 , C12N2320/53 , C12Y207/10001 , C12N2310/3521 , C12N2310/322 , C12N2310/3533
Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.
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公开(公告)号：US12173286B2
公开(公告)日：2024-12-24
申请号：US16927543
申请日：2020-07-13
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Anastasia Khvorova , Neil Aronin , Julia Alterman , Matthew Hassler
IPC: C12N15/113 , C12N15/11
Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.
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Patent Agency Ranking
公开(公告)号：US20240182904A1
公开(公告)日：2024-06-06
申请号：US18375235
申请日：2023-09-29
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Claudio Punzo , Anastasia Khvorova , Dimas Echeverria Moreno , Annabelle Biscans , Julia F. Alterman , Matthew Hassler , Shun-Yun Cheng , Jillian Caiazzi
IPC: C12N15/113 , A61K47/54 , A61P27/02 , C12N15/86
CPC classification number: C12N15/1137 , A61K47/549 , A61P27/02 , C12N15/86 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2750/14122 , C12N2750/14143
Abstract: Provided herein are oligonucleotides (e.g., siRNA) targeting S6K1. Also provided are methods of treating a disease associated with S6K1 expression.
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公开(公告)号：US11753638B2
公开(公告)日：2023-09-12
申请号：US16322212
申请日：2017-08-11
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Anastasia Khvorova , Mehran Nikan , Matthew Hassler , Maire Osborn , Reka Haraszti , Andrew Coles , Anton Turanov , Neil Aronin , Annabelle Biscans
IPC: A61K31/7088 , C12N15/113 , A61K47/54 , C07H21/02 , C07H21/04 , C07H21/00 , C12N15/11 , A61K47/55 , A61P1/16 , A61P9/00 , A61P13/12 , A61P1/00 , A61P5/00 , A61P11/00 , A61K9/00
CPC classification number: C12N15/113 , A61K9/0019 , A61K31/7088 , A61K47/54 , A61K47/543 , A61K47/549 , A61K47/551 , A61K47/554 , A61P1/00 , A61P1/16 , A61P5/00 , A61P9/00 , A61P11/00 , A61P13/12 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/111 , C12N2310/14 , C12N2310/312 , C12N2310/315 , C12N2310/346 , C12N2310/351 , C12N2310/3515 , C12N2320/32 , C12N2310/321 , C12N2310/3521 , C12N2310/322 , C12N2310/3533
Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution.
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公开(公告)号：US20220372476A1
公开(公告)日：2022-11-24
申请号：US17725102
申请日：2022-04-20
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Anastasia Khvorova , Bruno Miguel da Cruz Godinho , Matthew Hassler
IPC: C12N15/113
Abstract: Therapeutic oligonucleotides comprising pharmacokinetic (PK)-modifying anchors are provided. Methods for treating diseases or disorders comprising administering to a subject a therapeutic oligonucleotide comprising one or more PK-modifying anchors are provided.
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公开(公告)号：US20210139901A1
公开(公告)日：2021-05-13
申请号：US17071473
申请日：2020-10-15
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Anastasia Khvorova , Julia Alterman , Matthew Hassler
IPC: C12N15/113
Abstract: Provided are compositions and methods comprising two-tailed siRNAs (tt-siRNAs) that exhibit unprecedented cellular uptake and silencing. Also provided are methods of treating neurological and other diseases with the two-tailed siRNAs of the invention.
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公开(公告)号：US20210085793A1
公开(公告)日：2021-03-25
申请号：US17012787
申请日：2020-09-04
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Anastasia Khvorova , Matthew Hassler , Julia Alterman , Bruno Miguel da Cruz Godinho
IPC: A61K47/26 , C12N15/113 , C12N15/11 , A61K47/54 , A61K47/55 , A61K31/7084 , C07H3/08 , C07H21/04 , C07H99/00
Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.
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