公开(公告)号：US20210324011A1

公开(公告)日：2021-10-21

申请号：US17285057

申请日：2019-10-24

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Hao SHEN ,  Jorge FALLAS ,  David BAKER

IPC: C07K14/00 ,  C07K1/00

Abstract: Disclosed herein are polypeptides having the amino acid sequence that is at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the full length of the amino acid sequence selected from the group consisting of SEQ ID NO: 1-33 and 36, wherein the polypeptides include at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% of the identified interface residues, and wherein the polypeptides are capable of end-to-end homo-polymerization, homo-polymers of the polypeptides, and related capping and anchor proteins to facilitate homo-polymer formation.

公开(公告)号：US20230233707A1

公开(公告)日：2023-07-27

申请号：US18000004

申请日：2021-06-07

Applicant: University of Washington

Inventor： George UEDA ,  James LAZAROVITS ,  Jorge FALLAS ,  David BAKER ,  Hannele RUOHOLA-BAKER ,  Robert DIVINE ,  Yan (Blair) Ting ZHAO ,  Julie MATHIEU ,  Neil KING ,  Marti TOOLEY

IPC: A61K47/69 ,  C07K14/515 ,  C07K16/28 ,  A61P11/00 ,  A61K47/68 ,  A61P35/00

CPC classification number: A61K47/6931 ,  C07K14/515 ,  C07K16/2878 ,  A61P11/00 ,  A61K47/6849 ,  A61P35/00 ,  C07K2319/30 ,  C07K2319/705 ,  C07K2317/75 ,  C07K2317/92

Abstract: Antibody particles are disclosed comprising polypeptides comprising an (Fc) binding domain, a helical polypeptide monomer, and an oligomer domain, and either Tie2 antibodies or dimers, or tumor necrosis factor receptor superfamily antibodies, and uses thereof.

公开(公告)号：US20220306697A1

公开(公告)日：2022-09-29

申请号：US17639442

申请日：2020-09-03

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Neil P KING ,  Brooke FIALA ,  George UEDA ,  Jorge FALLAS

IPC: C07K14/005 ,  A61K39/155 ,  A61P31/14

Abstract: Disclosed herein are nanostructures and their use, where the nanostructures include a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides selected from 153_dn5A, 153_dn5A.1 and I53_dn5A.2, or variants thereof; and a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides being 153 dn5B or a variant thereof, wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructure; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins, or antigenic fragments thereof.

公开(公告)号：US20210363214A1

公开(公告)日：2021-11-25

申请号：US16976350

申请日：2019-02-28

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Peilong LU ,  David BAKER ,  Scott BOYKEN ,  Zibo CHEN ,  Jorge FALLAS ,  George UEDA ,  William H. SHEFFLER

IPC: C07K14/705

Abstract: De novo designed multi-pass transmembrane polypeptides are described, that include 2 or more transmembrane domains that are each between 15 and 35 amino acids in length, include one or more polar residues, and include at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, or more hydrophobic amino acid residues.