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公开(公告)号：US20210355175A1
公开(公告)日：2021-11-18
申请号：US17285033
申请日：2019-11-04
Applicant: UNIVERSITY OF WASHINGTON
Inventor： Zibo CHEN , Scott BOYKEN , Sherry BERMEO , Robert A. LANGAN , David BAKER
IPC: C07K14/435 , G01N33/53
Abstract: Disclosed herein are designed heterodimer proteins, monomeric polypeptides capable of forming heterodimer proteins, protein scaffolds including such polypeptides, and methods for using the heterodimer proteins and subunit polypeptides for designing logic gates.
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公开(公告)号：US20200239524A1
公开(公告)日：2020-07-30
申请号：US16796009
申请日：2020-02-20
Applicant: UNIVERSITY OF WASHINGTON
Inventor： Robert A. LANGAN , Scott BOYKEN , David BAKER , Walter NOVAK , Marc Joseph LAJOIE , Alfredo QUIJANO RUBIO
Abstract: Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (“off”) state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain, components of such protein switches, and their use.
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3.发明申请公开(公告)号：US20220273711A1
公开(公告)日：2022-09-01
申请号：US17609972
申请日：2020-05-18
Applicant: University of Washington
Inventor： Scott BOYKEN , Marc Joseph LAJOIE , Robert A. LANGAN , David BAKER , Jilliane Ruth BRUFFEY
Abstract: Disclosed am protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (“off”) state, until combined with a second designed polypeptide called die key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain only when the protein switch components are co-localized when bound to their targets, components of such protein switches, and their use.
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公开(公告)号：US20220185853A1
公开(公告)日：2022-06-16
申请号：US17603080
申请日：2020-04-15
Applicant: UNIVERSITY OF WASHINGTON
Inventor： Jooyoung PARK , Scott BOYKEN , Kathy WEI , Gustav OBERDORFER , David BAKER
Abstract: Disclosed herein are amantadine binding polypeptides, fusion proteins thereof, and uses of such polypeptides and fusion proteins.
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公开(公告)号：US20210363214A1
公开(公告)日：2021-11-25
申请号：US16976350
申请日：2019-02-28
Applicant: UNIVERSITY OF WASHINGTON
Inventor： Peilong LU , David BAKER , Scott BOYKEN , Zibo CHEN , Jorge FALLAS , George UEDA , William H. SHEFFLER
IPC: C07K14/705
Abstract: De novo designed multi-pass transmembrane polypeptides are described, that include 2 or more transmembrane domains that are each between 15 and 35 amino acids in length, include one or more polar residues, and include at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, or more hydrophobic amino acid residues.
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Patent Agency Ranking
公开(公告)号：US20220144895A1
公开(公告)日：2022-05-12
申请号：US17602119
申请日：2020-04-20
Applicant: University of Washington
Inventor： Scott BOYKEN , David BAKER , Zibo CHEN , Alfredo Quijano RUBIO , Neil P. KING , Jason C. KLIMA , Carl WALKEY
IPC: C07K7/08
Abstract: Disclosed herein are polypeptides or polypeptide oligomers, including a buried hydrogen bond network that includes at least (1, 2, 3, 4, 5, 6, 7, 8, or 9) pH sensitive amino acids located (i) at an intra-chain interface between different: structural elements in one polypeptide, or (it) at an inter-chain interface between structural elements present in different chains of a polypeptide oligomer, wherein the polypeptide or polypeptide oligomer is stable above a given pH, and wherein the polypeptide or polypeptide oligomer undergoes a conformational transition when subjected to a pH at or below the given pH.
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公开(公告)号：US20210115090A1
公开(公告)日：2021-04-22
申请号：US17077692
申请日：2020-10-22
Applicant: UNIVERSITY OF WASHINGTON
Inventor： Robert A. LANGAN , Scott BOYKEN , David BAKER , Walter NOVAK , Marc Joseph LAJOIE , Alfredo QUIJANO RUBIO
Abstract: Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (“off”) state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain, components of such protein switches, and their use.
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公开(公告)号：US20220098250A1
公开(公告)日：2022-03-31
申请号：US17502485
申请日：2021-10-15
Applicant: UNIVERSITY OF WASHINGTON
Inventor： Zibo CHEN , Scott BOYKEN , Sherry BERMEO , Robert A. LANGAN , David BAKER
IPC: C07K14/435 , G01N33/53
Abstract: Disclosed herein are designed heterodimer proteins, monomeric polypeptides capable of forming heterodimer proteins, protein scaffolds including such polypeptides, and methods for using the heterodimer proteins and subunit polypeptides for designing logic gates.
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公开(公告)号：US20220017579A1
公开(公告)日：2022-01-20
申请号：US17482713
申请日：2021-09-23
Applicant: UNIVERSITY OF WASHINGTON
Inventor： Zibo CHEN , Scott BOYKEN , Sherry BERMEO , Robert A. LANGAN , David BAKER
IPC: C07K14/435 , G01N33/53
Abstract: Disclosed herein are designed heterodimer proteins, monomeric polypeptides capable of forming heterodimer proteins, protein scaffolds including such polypeptides, and methods for using the heterodimer proteins and subunit polypeptides for designing logic gates.
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10.发明申请公开(公告)号：US20190112345A1
公开(公告)日：2019-04-18
申请号：US16088686
申请日：2017-03-31
Applicant: UNIVERSITY OF WASHINGTON
Inventor： David BAKER , Scott BOYKEN , Zibo CHEN , Chunfu XU , Sherry BERMEO , Robert LANGAN
IPC: C07K14/435 , C07K1/113 , C07K16/18 , C07K2/00 , C07K14/00
Abstract: Methods and apparatus for identifying and screening hydrogen bond networks are provided. A computing device can determine a search space for hydrogen bond networks related to one or more molecules, where the search space can include a plurality of energy terms related to a plurality of residues related to the hydrogen bond networks. The computing device can search the search space to identify one or more hydrogen bond networks based on the plurality of energy terms. The computing device can screen the identified hydrogen bond networks to identity one or more screened hydrogen bond networks based on scores for the identified hydrogen bond networks. An output can be generated that is related to the one or more screened hydrogen bond networks. Also provided are polypeptides that can form homo-oligomers with modular hydrogen bond network-mediated specificity.
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