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1.发明申请MOLECULAR TARGETS FOR THE PREVENTION AND/OR TREATMENT OF FIBROSIS, HYPERTROPHIC SCARS OR KELOIDS 有权用于预防和/或治疗纤维化，高血压或神经痛的分子靶标公开(公告)号：US20160168565A1
公开(公告)日：2016-06-16
申请号：US14909626
申请日：2014-07-30
申请人： Centre National de la Recherche Scientifique-CNRS CNRS , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE , URGO RECHERCHE INNOVATION ET DÉVELOPPEMENT , UNIVERSITÉ PARIS DIDEROT - PARIS 7 , ECOLE NORMALE SUPERIEURE
IPC分类号： C12N15/113 , A61K31/713 , A61K45/06
CPC分类号： C12N15/113 , A61K31/713 , A61K45/06 , A61K2300/00 , C07K14/4702 , C12N2310/14 , C12N2320/12 , C12N2320/30
摘要： The present invention relates to a therapeutic compound comprising: an agent that inhibits the activity of at least one gene selected from the group consisting of HIC1, FOXS1, CREB5, IRF7, POU2F2, STAT4, TCF4, and/or an agent that enhances the activity of at least one gene selected from the group consisting of MAF, MEOX2, SIX2.
摘要翻译： 本发明涉及一种治疗化合物，包括：抑制至少一种选自HIC1，FOXS1，CREB5，IRF7，POU2F2，STAT4，TCF4和/或增强活性的药物的活性的药剂 的至少一种选自MAF，MEOX2，SIX2的基因。
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公开(公告)号：US20170281628A1
公开(公告)日：2017-10-05
申请号：US14909669
申请日：2014-07-30
申请人： URGO RECHERCHE INNOVATION ET DÉVELOPPEMENT , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE- CNRS , UNIVERSITÉ PARIS DIDEROT - PARIS 7 , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE , ECOLE NORMALE SUPERIEURE
IPC分类号： A61K31/519 , C12N15/113 , A61L15/16 , A61K31/506 , A61K45/06 , A61K9/00 , A61K31/197
CPC分类号： A61K31/519 , A61K9/0014 , A61K31/197 , A61K31/506 , A61K45/06 , A61L15/16 , A61L2300/432 , C07K14/4702 , C12N15/113 , C12N2310/14
摘要： The present invention relates to a therapeutic compound comprising: an agent that inhibits the activity of at least one gene selected from the group consisting of MAF, MEOX2, SIX2 and homologues thereof having at least 50% identity with said genes and/or an agent that enhances the activity of at least one gene selected from the group consisting of CREBS, E2F1, EGR2, HIC1, IRF7, JUN, MYC, SRF, STAT4, TCF4, FOXS1, GLI1, SOX9 and homologues thereof having at least 50% identity with said gene for use in the treatment of wounds, preferably chronic wounds.
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公开(公告)号：US20150126447A1
公开(公告)日：2015-05-07
申请号：US14389420
申请日：2013-03-29
申请人： VIVATECH , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS , UNIVERSITE PARIS DIDEROT - PARIS 7 , ECOLE NORMALE SUPERIEURE
发明人： Claire Dugast Darzacq , Xavier Darzacq , Maite Noizet , Emilie Lagoutte , Hugues Roest Crollius , Marlene Gratigny , Marielle Bouschbacher
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178 , G01N33/6893 , G01N2800/20 , G01N2800/52
摘要： The present invention relates to a method and kit for the classification and prognosis of wounds of mammalian, in particular in human. The method defines a molecular signature that enables one to characterize a pathological wound healing such as chronic or non-healing wound.
摘要翻译： 本发明涉及哺乳动物，特别是人的伤口分类和预后的方法和试剂盒。 该方法定义了能够描述病理性伤口愈合的分子特征，例如慢性或非愈合伤口。
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4.发明授权公开(公告)号：US09840704B2
公开(公告)日：2017-12-12
申请号：US14909626
申请日：2014-07-30
申请人： Centre National de la Recherche Scientifique—CNRS , INSERM (Institut National de la Sante et de la Recherche Medicale) , URGO RECHERCHE INNOVATION ET DEVELOPPEMENT , Universite Paris Diderot-Paris 7 , Ecole Normale Superieure
IPC分类号： C12N15/11 , A61K31/715 , A61K48/00 , C07H21/02 , C07H21/04 , C12N15/113 , C07K14/47 , A61K45/06 , A61K31/713
CPC分类号： C12N15/113 , A61K31/713 , A61K45/06 , A61K2300/00 , C07K14/4702 , C12N2310/14 , C12N2320/12 , C12N2320/30
摘要： The present invention relates to a therapeutic compound comprising: an agent that inhibits the activity of at least one gene selected from the group consisting of HIC1, FOXS1, CREB5, IRF7, POU2F2, STAT4, TCF4, and/or an agent that enhances the activity of at least one gene selected from the group consisting of MAF, MEOX2, SIX2.
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5.发明申请METHOD AND KIT FOR THE CLASSIFICATION AND PROGNOSIS OF TISSUE OR ORGAN FIBROSIS IN A REPARATIVE OR REACTIVE PROCESS 审中-公开组织或组织纤维化在复原或反应过程中的分类和预防的方法和工具公开(公告)号：US20150087527A1
公开(公告)日：2015-03-26
申请号：US14389431
申请日：2013-03-29
申请人： VIVATECH , Centre National de la Recherche Scientifique- CNRS , Universite Paris Diderot- Paris 7 , Ecole Normale Superieure
发明人： Claire Dugast Darzacq , Xavier Darzacq , Maite Noizet , Emilie Lagoutte , Hugues Roest Crollius , Marlene Gratigny , Marielle Bouschbacher
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178 , G01N33/6893 , G01N2800/20 , G01N2800/52
摘要： The invention relates to methods of diagnosis or prognosis of a tissue or organ fibrosis (e.g., skin fibrosis, hypertrophic scar or a keloid) in a reparative or reactive process comprising the step of determining the levels of expression of genes encoding different molecular markers in a sample of a tissue or organ from a mammalian, wherein different genes markers are studied.
摘要翻译： 本发明涉及在修复或反应过程中组织或器官纤维化的诊断或预后的方法（例如，皮肤纤维化，肥大性瘢痕或瘢痕疙瘩），其包括确定编码不同分子标记物的基因的表达水平的步骤 来自哺乳动物的组织或器官的样品，其中研究不同的基因标记。
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