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公开(公告)号：US08168427B2
公开(公告)日：2012-05-01
申请号：US12094530
申请日：2006-11-24
申请人： Ugur Sahin , Ozlem Tureci , Dirk Usener , Stefan Fritz , Cristoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schroder , Philippe Thiel
发明人： Ugur Sahin , Ozlem Tureci , Dirk Usener , Stefan Fritz , Cristoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schroder , Philippe Thiel
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6807 , A61K47/6809 , A61K47/6813 , A61K47/6821 , A61K47/6823 , A61K47/6829 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K51/1063 , A61K2039/505 , C07K16/28 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLD18的细胞相关疾病的治疗剂的抗体，包括肿瘤相关疾病如胃癌，食管癌，胰腺癌，肺癌，卵巢癌，结肠癌，肝癌，头部 - 癌症和胆囊癌。
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公开(公告)号：US20090169547A1
公开(公告)日：2009-07-02
申请号：US12094530
申请日：2006-11-24
申请人： Ugur Sahin , Ozlem Tureci , Dirk Usener , Stefan Fritz , Cristoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schroder , Philippe Thiel
发明人： Ugur Sahin , Ozlem Tureci , Dirk Usener , Stefan Fritz , Cristoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schroder , Philippe Thiel
IPC分类号： A61K39/395 , C07K16/30 , C12N5/16 , A61P35/00
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6807 , A61K47/6809 , A61K47/6813 , A61K47/6821 , A61K47/6823 , A61K47/6829 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K51/1063 , A61K2039/505 , C07K16/28 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLD18的细胞相关疾病的治疗剂的抗体，包括肿瘤相关疾病如胃癌，食管癌，胰腺癌，肺癌，卵巢癌，结肠癌，肝癌，头部 - 癌症和胆囊癌。
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公开(公告)号：US09212228B2
公开(公告)日：2015-12-15
申请号：US13425538
申请日：2012-03-21
申请人： Ugur Sahin , Ozlem Tureci , Dirk Usener , Stefan Fritz , Christoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schroder , Phillippe Thiel
发明人： Ugur Sahin , Ozlem Tureci , Dirk Usener , Stefan Fritz , Christoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schroder , Phillippe Thiel
IPC分类号： C07K16/00 , A61K39/395 , C07K16/30 , A61K47/48 , A61K51/10
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6807 , A61K47/6809 , A61K47/6813 , A61K47/6821 , A61K47/6823 , A61K47/6829 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K51/1063 , A61K2039/505 , C07K16/28 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLD18的细胞相关疾病的治疗剂的抗体，包括肿瘤相关疾病如胃癌，食管癌，胰腺癌，肺癌，卵巢癌，结肠癌，肝癌，头部 - 癌症和胆囊癌。
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公开(公告)号：US08425902B2
公开(公告)日：2013-04-23
申请号：US12601488
申请日：2008-05-27
申请人： Ugur Sahin , Ozlem Tureci , Gunda Brandenburg , Dirk Usener
发明人： Ugur Sahin , Ozlem Tureci , Gunda Brandenburg , Dirk Usener
IPC分类号： A61K39/395
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/30 , C07K16/3046 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, cancer of the gallbladder, and the metastases thereof.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLD18的细胞相关疾病的治疗剂的抗体，包括肿瘤相关疾病如胃癌，食管癌，胰腺癌，肺癌，卵巢癌，结肠癌，肝癌，头部 - 癌症，胆囊癌及其转移灶。
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5.发明申请公开(公告)号：US20100166779A1
公开(公告)日：2010-07-01
申请号：US12601488
申请日：2008-05-27
申请人： Ugur Sahin , Ozlem Tureci , Gunda Brandenburg , Dirk Usener
发明人： Ugur Sahin , Ozlem Tureci , Gunda Brandenburg , Dirk Usener
IPC分类号： A61K39/395 , C07K16/00 , C07K16/30 , C12N5/00 , A61P35/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/30 , C07K16/3046 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD1 8, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, cancer of the gallbladder, and the metastases thereof.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLD18的细胞相关疾病的治疗剂的抗体，包括肿瘤相关疾病如胃癌，食管癌，胰腺癌，肺癌，卵巢癌，结肠癌，肝癌， 头颈癌，胆囊癌及其转移灶。
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6.发明申请公开(公告)号：US20080193454A1
公开(公告)日：2008-08-14
申请号：US11596106
申请日：2005-05-11
申请人： Ozlem Tureci , Ugur Sahin , Sandra Schneider , Gerd Helftenbein , Volker Schluter , Dirk Usener , Philippe Thiel
发明人： Ozlem Tureci , Ugur Sahin , Sandra Schneider , Gerd Helftenbein , Volker Schluter , Dirk Usener , Philippe Thiel
IPC分类号： A61K39/395 , C12N15/11 , C12Q1/68 , C12Q1/02 , C12N5/06 , A61K31/70 , A61P43/00 , C07K14/00 , A61K35/12 , G01N33/574 , C07K16/18
CPC分类号： A61K39/39558 , A61K39/395 , A61K45/06 , C07K14/4748 , C07K16/28 , C07K16/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/53
摘要： The invention relates to the identification of gene products that are the result of tumor-associated expression and the nucleic acids encoding the same. The invention also relates to the therapy and diagnosis of diseases wherein these gene products are the result of an aberrant tumor-associated expression. The invention also relates to the proteins, polypeptides and peptides that are the result of tumor-associated expression and to the nucleic acids encoding the same.
摘要翻译： 本发明涉及作为肿瘤相关表达的结果的基因产物的鉴定和编码其的核酸。 本发明还涉及其中这些基因产物是异常肿瘤相关表达的结果的疾病的治疗和诊断。 本发明还涉及作为肿瘤相关表达的结果的蛋白质，多肽和肽以及编码其的核酸。
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公开(公告)号：US20140017254A1
公开(公告)日：2014-01-16
申请号：US13946302
申请日：2013-07-19
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Dirk Usener
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Dirk Usener
IPC分类号： C07K14/47
CPC分类号： A61K39/0011 , A61K45/06 , A61K2039/5256 , A61K2039/54 , A61K2039/57 , A61K2039/572 , C07K14/4748 , C07K16/2803 , C07K16/30 , C07K2317/34 , C12Q1/6886 , C12Q2600/158 , G01N33/574
摘要： The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
摘要翻译： 本发明涉及其表达与癌症疾病相关的遗传产物。 本发明还涉及遗传产物表达或异常表达，特别是癌症疾病的疾病的治疗和诊断。
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8.发明授权Tumor vaccination involving a humoral immune response against self-proteins 有权涉及针对自身蛋白质的体液免疫应答的肿瘤接种公开(公告)号：US08840902B2
公开(公告)日：2014-09-23
申请号：US13634696
申请日：2011-03-09
申请人： Thorsten Klamp , Ugur Sahin , Ozlem Tureci , Michael Koslowski , Thomas Hiller , Jens Schumacher
发明人： Thorsten Klamp , Ugur Sahin , Ozlem Tureci , Michael Koslowski , Thomas Hiller , Jens Schumacher
CPC分类号： C07K14/4748 , A61K39/0011 , A61K2039/5156 , A61K2039/523 , A61K2039/5258 , A61K2039/53 , A61K2039/57 , A61K2039/575 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N7/00 , C12N2730/10123 , C12N2730/10134 , C12N2730/10143 , C12N2730/10171
摘要： The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.
摘要翻译： 本发明涉及使用包含全部或部分乙型肝炎病毒核心抗原蛋白的嵌合蛋白和包含衍生自肿瘤相关抗原的细胞外部分的表位的氨基酸序列的肿瘤免疫治疗，特别是肿瘤免疫治疗。 特别地，本发明提供了包含所述嵌合蛋白的病毒样颗粒，其可用于在受试者内针对肿瘤相关抗原，特别是针对在其表面上携带所述肿瘤相关抗原的细胞引起体液免疫应答，其中 肿瘤相关抗原是所述受试者的自身蛋白质。
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9.发明申请公开(公告)号：US20140186338A1
公开(公告)日：2014-07-03
申请号：US14043109
申请日：2013-10-01
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
CPC分类号： C07K16/3076 , A61K47/549 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K2317/30 , C07K2317/34 , G01N33/57484
摘要： The present technology relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for the expressed products. An embodiment of the present technology also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic acids coding for the polypeptides, peptides and proteins.
摘要翻译： 本技术涉及与肿瘤相关表达的遗传产物的鉴定和用于表达产物的编码核酸。 本技术的一个实施方案还涉及其中遗传产物与肿瘤相关表达的肿瘤，蛋白质，多肽和肽异常表达的疾病的治疗和诊断，以及编码多肽的核酸 ，肽和蛋白质。
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10.发明授权公开(公告)号：US08586047B2
公开(公告)日：2013-11-19
申请号：US12423153
申请日：2009-04-14
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00 , C12P21/08
CPC分类号： C07K16/3076 , A61K47/48569 , A61K47/549 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K2317/30 , C07K2317/34 , G01N33/57484
摘要： The present technology relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for the expressed products. An embodiment of the present technology also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic acids coding for the polypeptides, peptides and proteins.
摘要翻译： 本技术涉及与肿瘤相关表达的遗传产物的鉴定和用于表达产物的编码核酸。 本技术的一个实施方案还涉及其中遗传产物与肿瘤相关表达的肿瘤，蛋白质，多肽和肽异常表达的疾病的治疗和诊断，以及编码多肽的核酸 ，肽和蛋白质。
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