-
公开(公告)号：US20110300144A1
公开(公告)日：2011-12-08
申请号：US13201702
申请日：2010-02-19
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Gerd Helftenbein , Korden Walter , Stefan Wöll , Gabriela-Elena Oprea
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Gerd Helftenbein , Korden Walter , Stefan Wöll , Gabriela-Elena Oprea
IPC分类号： A61K39/395 , C07H21/02 , C12N9/96 , C12N7/01 , C12N1/21 , C12N5/10 , C12N1/19 , C12N5/078 , C12Q1/68 , G01N33/574 , C07K16/30 , C07K14/705 , A61K39/00 , A61P35/00 , A61P35/04 , A61P37/04 , C07H21/04
CPC分类号： C12N15/113 , A61K31/7088
摘要： The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues such as ovarian tumor and lung tumor tissues and which represent targets for therapy or diagnosis of tumor diseases in a subject.
摘要翻译： 本发明涉及鉴定作为肿瘤组织如卵巢肿瘤和肺肿瘤组织的特征的核酸和氨基酸序列，其代表受试者中肿瘤疾病的治疗或诊断的靶标。
-
公开(公告)号：US09809815B2
公开(公告)日：2017-11-07
申请号：US13201702
申请日：2010-02-19
申请人： Ugur Sahin , Özlem Türeci , Michael Koslowski , Gerd Helftenbein , Korden Walter , Stefan Wöll , Gabriela-Elena Oprea
发明人： Ugur Sahin , Özlem Türeci , Michael Koslowski , Gerd Helftenbein , Korden Walter , Stefan Wöll , Gabriela-Elena Oprea
IPC分类号： G01N1/00 , G01N33/574 , C12N15/113 , A61K31/7088
CPC分类号： C12N15/113 , A61K31/7088
摘要： The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues such as ovarian tumor and lung tumor tissues and which represent targets for therapy or diagnosis of tumor diseases in a subject.
-
公开(公告)号：US20140127219A1
公开(公告)日：2014-05-08
申请号：US14117118
申请日：2012-04-20
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Wöll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan , Michael Weichel
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Wöll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan , Michael Weichel
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K39/39591 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDN6, including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLDN6的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如卵巢癌，肺癌，胃癌，乳腺癌，肝癌，胰腺癌，皮肤癌，恶性肿瘤 黑素瘤，头颈癌，肉瘤，胆管癌，膀胱癌，肾癌，结肠癌，胎盘绒毛膜癌，子宫颈癌，睾丸癌和子宫癌。
-
公开(公告)号：US20130183305A1
公开(公告)日：2013-07-18
申请号：US13808423
申请日：2011-07-04
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Maria Kreuzberg , Sylvia Luxen
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Maria Kreuzberg , Sylvia Luxen
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/28 , C07K16/3015 , C07K16/3023 , C07K16/3038 , C07K16/3046 , C07K16/3053 , C07K16/3069 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： The invention relates to the treatment and/or prevention of tumor diseases associated with cells expressing CLD-N6, in particular cancer and cancer metastasis using antibodies which bind to CLDN6. The present application demonstrates that the binding of antibodies to CLDN6 on the surface of tumor cells is sufficient to inhibit growth of the tumor and to prolong survival and extend the lifespan of tumor patients. Furthermore, binding of antibodies to CLDN6 is efficient in inhibiting growth of CLDN6 positive germ cell tumors such as teratocarcinomas or embryonal carcinomas, in particular germ cell tumors of the testis.
摘要翻译： 本发明涉及使用结合CLDN6的抗体治疗和/或预防与表达CLD-N6的细胞，特别是癌症和癌症转移相关的肿瘤疾病。 本申请表明抗体对CLDN6在肿瘤细胞表面的结合足以抑制肿瘤的生长并延长存活并延长肿瘤患者的寿命。 此外，抗体与CLDN6的结合在抑制CLDN6阳性生殖细胞肿瘤如畸胎癌或胚胎性癌，特别是睾丸生殖细胞肿瘤的生长中是有效的。
-
公开(公告)号：US09718886B2
公开(公告)日：2017-08-01
申请号：US13808423
申请日：2011-07-04
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Maria Kreuzberg , Sylvia Luxen
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Maria Kreuzberg , Sylvia Luxen
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/28 , C07K16/3015 , C07K16/3023 , C07K16/3038 , C07K16/3046 , C07K16/3053 , C07K16/3069 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： The invention relates to the treatment and/or prevention of tumor diseases associated with cells expressing CLDN6, in particular cancer and cancer metastasis using antibodies which bind to CLDN6. The present application demonstrates that the binding of antibodies to CLDN6 on the surface of tumor cells is sufficient to inhibit growth of the tumor and to prolong survival and extend the lifespan of tumor patients. Furthermore, binding of antibodies to CLDN6 is efficient in inhibiting growth of CLDN6 positive germ cell tumors such as teratocarcinomas or embryonal carcinomas, in particular germ cell tumors of the testis.
-
公开(公告)号：US09487584B2
公开(公告)日：2016-11-08
申请号：US13503461
申请日：2010-11-11
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Woll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Woll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/30 , C07K2317/14 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达紧密连接蛋白-6（CLDN6）的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如卵巢癌，肺癌，胃癌，乳腺癌，肝癌，胰腺癌 ，皮肤癌，恶性黑素瘤，头颈癌，肉瘤，胆管癌，膀胱癌，肾癌，结肠癌，胎盘绒毛膜癌，子宫颈癌，睾丸癌和子宫癌。
-
公开(公告)号：US09321842B2
公开(公告)日：2016-04-26
申请号：US14117118
申请日：2012-04-20
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Woll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan , Michael Weichel
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Woll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan , Michael Weichel
IPC分类号： C07K16/28 , C07K16/30 , A61K39/395 , A61K39/00
CPC分类号： C07K16/30 , A61K39/39591 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDN6, including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLDN6的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如卵巢癌，肺癌，胃癌，乳腺癌，肝癌，胰腺癌，皮肤癌，恶性肿瘤 黑素瘤，头颈癌，肉瘤，胆管癌，膀胱癌，肾癌，结肠癌，胎盘绒毛膜癌，子宫颈癌，睾丸癌和子宫癌。
-
公开(公告)号：US20120308478A1
公开(公告)日：2012-12-06
申请号：US13503461
申请日：2010-11-11
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Woll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Woll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/30 , C07K2317/14 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达紧密连接蛋白-6（CLDN6）的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如卵巢癌，肺癌，胃癌，乳腺癌，肝癌，胰腺癌 ，皮肤癌，恶性黑素瘤，头颈癌，肉瘤，胆管癌，膀胱癌，肾癌，结肠癌，胎盘绒毛膜癌，子宫颈癌，睾丸癌和子宫癌。
-
公开(公告)号：US20130071325A1
公开(公告)日：2013-03-21
申请号：US13636277
申请日：2011-03-10
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K39/39558 , A61K2039/505 , C07K16/462 , C07K16/464 , C07K2317/14 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C12N5/163 , C12N15/1138 , C12N2310/14
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, hepatocellular cancer, colon cancer, pancreatic cancer, esophageal cancer, head & neck cancer, kidney cancer, in particular renal cell carcinoma, prostate cancer, liver cancer, melanoma, sarcoma, myeloma, neuroblastoma, placental choriocarcinoma, cervical cancer, and thyroid cancer, and the metastatic forms thereof. In one embodiment, the tumor disease is metastatic cancer in the lung.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达GT468的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如乳腺癌，肺癌，胃癌，卵巢癌，肝细胞癌，结肠癌，胰腺癌，食管癌 癌症，头颈癌，肾癌，特别是肾细胞癌，前列腺癌，肝癌，黑素瘤，肉瘤，骨髓瘤，成神经细胞瘤，胎盘绒毛膜癌，子宫颈癌和甲状腺癌及其转移形式。 在一个实施方案中，肿瘤疾病是肺中的转移性癌症。
-
10.发明申请公开(公告)号：US20120070430A1
公开(公告)日：2012-03-22
申请号：US13266368
申请日：2010-04-22
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
IPC分类号： A61K39/395 , C07K16/18 , C07K14/47 , C12N5/10 , C12N1/21 , A61P35/00 , C07H21/00 , A61K39/00 , C12Q1/68 , G01N33/53 , A61K35/12 , C07H21/04 , C12N1/19
CPC分类号： G01N33/57484 , A61K31/7088
摘要： The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
摘要翻译： 本发明涉及其表达与癌症疾病相关的遗传产物。 本发明还涉及遗传产物表达或异常表达，特别是癌症疾病的疾病的治疗和诊断。
-
-
-
-
-
-
-
-
-
搜索结果
63 条记录 (耗时 0.04 秒)
