17BETA-CYANO-19-ANDROST-4-ENE DERIVATIVE, ITS USE AND MEDICAMENTS COMPRISING THE DERIVATIVE
    2.
    发明申请
    17BETA-CYANO-19-ANDROST-4-ENE DERIVATIVE, ITS USE AND MEDICAMENTS COMPRISING THE DERIVATIVE 审中-公开
    17BETA-CYANO-19-ANDROST-4-ENE DERIVATIVE,其使用和药物包含衍生物

    公开(公告)号:US20100292184A1

    公开(公告)日:2010-11-18

    申请号:US12664099

    申请日:2008-06-12

    摘要: The 17β-cyano-19-androst-4-ene derivatives of the present invention possess gestagenic activity. They have the general chemical formula 1, in which Z is selected from the group comprising O, two hydrogen atoms, NOR and NNHSO2R, in which R is hydrogen or C1-C4-alkyl, R1, R2 are each independently hydrogen or methyl, or R1 and R2 together form methylene or are omitted with formation of a double bond between C1 and C2, R4 is hydrogen or halogen, furthermore either: R6a, R6b together form methylene or 1,2-ethanediyl or R6a is hydrogen and R6b is selected from the group comprising hydrogen, methyl and hydroxymethylene, and R7 is selected from the group comprising hydrogen, C1-C4-alkyl, C2-C3-alkenyl and cyclopropyl, or: R6a hydrogen and R6b and R7 together form methylene or are omitted with formation of a double bond between C6 and C7 or: R6a is methyl and R6b and R7 are omitted with formation of a double bond between C6 and C7, R15, R16 are hydrogen or together form methylene, R17 is selected from the group comprising hydrogen, C1-C4-alkyl and allyl, and moreover comprise their solvates, hydrates, stereoisomers, diastereomers, enantiomers and salts, with the proviso that particular compounds are excluded.

    摘要翻译: 本发明的17α-氰基-19-雄甾-4-烯衍生物具有孕激活作用。 它们具有一般化学式1,其中Z选自O,两个氢原子,NOR和NNHSO 2 R,其中R是氢或C 1 -C 4烷基,R 1,R 2各自独立地是氢或甲基,或 R1和R2一起形成亚甲基或被省略,在C1和C2之间形成双键,R4是氢或卤素,此外:R6a,R6b一起形成亚甲基或1,2-乙二基或R6a是氢,R6b选自 包括氢,甲基和羟基亚甲基的基团,并且R 7选自氢,C 1 -C 4 - 烷基,C 2 -C 3 - 烯基和环丙基,或者:R 6a氢和R 6b和R 7一起形成亚甲基或被形成 C6和C7之间的双键或:R6a是甲基,R6和C7之间形成双键,R6b和R7被省略,R15,R16是氢或一起形成亚甲基,R17选自氢,C1- C4-烷基和烯丙基,并且还包含它们的溶剂化物 es,水合物,立体异构体,非对映体,对映异构体和盐,条件是排除特定的化合物。