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公开(公告)号:US09815852B2
公开(公告)日:2017-11-14
申请号:US15320870
申请日:2015-06-25
发明人: Hendrik Luesch , Jiyong Hong
IPC分类号: C07D513/14 , A61K31/429 , A61K45/06
CPC分类号: C07D513/14 , A61K31/429 , A61K45/06
摘要: The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders.
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公开(公告)号:US20160106720A1
公开(公告)日:2016-04-21
申请号:US14886917
申请日:2015-10-19
申请人: University of Florida Research Foundation, Inc. , Duke University , Korea Research Insitute of Chemical Technology
发明人: Hendrik Luesch , Jiyong Hong , Seong Hwan Kim
IPC分类号: A61K31/429 , A61K45/06
CPC分类号: A61K31/429 , A61K45/06 , C07D498/18 , A61K2300/00
摘要: The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as methods of modulating bone processes, and methods of treating bone-related disease, disorders, and symptoms thereof.
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公开(公告)号:US20160060299A1
公开(公告)日:2016-03-03
申请号:US14936323
申请日:2015-11-09
发明人: Hendrik Luesch
CPC分类号: C07K11/02 , A61K38/15 , A61K45/06 , C07D498/08 , C07D498/18 , C07D513/08 , C07D513/18
摘要: The instant invention describes macrocyclic compounds having therapeutic activity, and the mechanism and methods of treating disorders such as autoimmune diseases, inflammation, and cancer, tumors and cell proliferation related disorders.
摘要翻译: 本发明描述了具有治疗活性的大环化合物,以及治疗诸如自身免疫性疾病,炎症和癌症,肿瘤和细胞增殖相关病症等疾病的机制和方法。
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4.
公开(公告)号:US20150290264A1
公开(公告)日:2015-10-15
申请号:US14441744
申请日:2013-11-06
发明人: Hendrik Luesch , Valerie J. Paul , Rui Wang
IPC分类号: A61K36/05 , C07C235/76 , C07C59/76
CPC分类号: A61K36/05 , A61K9/0014 , A61K9/06 , A61K31/16 , A61K31/201 , A61K45/06 , A61K2236/00 , C07C59/76 , C07C235/76
摘要: The instant invention relates to seaweed extract compositions, processes for isolation, isolated active agents, and methods of treating disease, disorders and conditions in a subject, including, reactive oxygen species (ROS)-mediated diseases and diseases mediated through the activation of the Nrf2-ARE (antioxidant response element) pathway, including proliferative diseases and disorders, Alzheimer's disease, stroke, and certain diseases and disorders of aging and associated with aging and exposure, by use of the extracts, compounds, and compositions thereof.
摘要翻译: 本发明涉及海藻提取物组合物,分离方法,分离的活性剂,以及治疗受试者的疾病,病症和病症的方法,包括通过激活Nrf2介导的活性氧(ROS)介导的疾病和疾病 - 通过使用提取物,化合物及其组合物,包括增殖性疾病和病症,阿尔茨海默氏病,中风以及某些与衰老和老化和暴露相关的衰老和失调的疾病和障碍(抗氧化应答元件)途径。
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公开(公告)号:US10010569B2
公开(公告)日:2018-07-03
申请号:US14441744
申请日:2013-11-06
发明人: Hendrik Luesch , Valerie J. Paul , Rui Wang
IPC分类号: A61K36/00 , A61K36/05 , A61K45/06 , A61K31/16 , A61K31/201 , A61K9/00 , A61K9/06 , C07C59/76 , C07C235/76
CPC分类号: A61K36/05 , A61K9/0014 , A61K9/06 , A61K31/16 , A61K31/201 , A61K45/06 , A61K2236/00 , C07C59/76 , C07C235/76
摘要: The instant invention relates to seaweed extract compositions, processes for isolation, isolated active agents, and methods of treating disease, disorders and conditions in a subject, including, reactive oxygen species (ROS)-mediated diseases and diseases mediated through the activation of the Nrf2-ARE (antioxidant response element) pathway, including proliferative diseases and disorders, Alzheimer's disease, stroke, and certain diseases and disorders of aging and associated with aging and exposure, by use of the extracts, compounds, and compositions thereof.
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6.
公开(公告)号:US20160051604A1
公开(公告)日:2016-02-25
申请号:US14846544
申请日:2014-03-14
CPC分类号: A61K36/05 , A61K31/11 , A61K36/02 , A61K2236/33
摘要: The instant invention relates to seaweed extract compositions, processes for isolation, isolated active agents, and methods of treating disease, disorders and conditions in a subject, including, reactive oxygen species (ROS)-mediated diseases and diseases mediated through the activation of the Nrf2-ARE (antioxidant response element) pathway, including proliferative diseases and disorders, Alzheimer's disease, stroke, and certain diseases and disorders of aging and associated with aging and exposure, by use of the extracts, compounds, and compositions thereof.
摘要翻译: 本发明涉及海藻提取物组合物,分离方法,分离的活性剂,以及治疗受试者的疾病,病症和病症的方法,包括通过激活Nrf2介导的活性氧(ROS)介导的疾病和疾病 - 通过使用提取物,化合物及其组合物,包括增殖性疾病和病症,阿尔茨海默氏病,中风以及某些与衰老和老化和暴露相关的衰老和失调的疾病和障碍(抗氧化应答元件)途径。
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公开(公告)号:US20140031400A1
公开(公告)日:2014-01-30
申请号:US13747044
申请日:2013-01-22
发明人: Hendrik Luesch , Taori Kanchan , Valerie J. Paul
IPC分类号: C07D513/14 , A61K45/06 , A61K31/429
CPC分类号: C07D513/14 , A61K31/429 , A61K38/00 , A61K45/06 , C07D513/18
摘要: The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders, or affect cell differentiation, dedifferentiation or transdifferentiation.
摘要翻译: 本发明描述了具有治疗活性的大环化合物,以及治疗疾病如癌症,肿瘤和细胞增殖相关病症或影响细胞分化,去分化或转分化的方法。
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公开(公告)号:US09730970B2
公开(公告)日:2017-08-15
申请号:US14846544
申请日:2014-03-14
CPC分类号: A61K36/05 , A61K31/11 , A61K36/02 , A61K2236/33
摘要: The instant invention relates to seaweed extract compositions, processes for isolation, isolated active agents, and methods of treating disease, disorders and conditions in a subject, including, reactive oxygen species (ROS)-mediated diseases and diseases mediated through the activation of the Nrf2-ARE (antioxidant response element) pathway, including proliferative diseases and disorders, Alzheimer's disease, stroke, and certain diseases and disorders of aging and associated with aging and exposure, by use of the extracts, compounds, and compositions thereof.
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公开(公告)号:US20170197988A1
公开(公告)日:2017-07-13
申请号:US15320870
申请日:2015-06-25
发明人: Hendrik Luesch , Jiyong Hong
IPC分类号: C07D513/14 , A61K45/06 , A61K31/429
CPC分类号: C07D513/14 , A61K31/429 , A61K45/06
摘要: The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders.
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公开(公告)号:US09492434B2
公开(公告)日:2016-11-15
申请号:US14363730
申请日:2012-12-07
发明人: Hendrik Luesch , Brian Keith Law
IPC分类号: A61K31/426 , A61K31/573 , A61K31/429 , A61K45/06 , C07D513/16
CPC分类号: A61K31/429 , A61K31/426 , A61K31/573 , A61K45/06 , C07D513/16 , A61K2300/00
摘要: The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as methods of modulating cellular proliferation processes, and methods of treating disease, disorders, and symptoms thereof.
摘要翻译: 本发明描述了具有治疗活性的大环化合物和治疗疾病如调节细胞增殖过程的方法的方法,以及治疗疾病,病症和症状的方法。
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