公开(公告)号：US20240131239A1

公开(公告)日：2024-04-25

申请号：US18400507

申请日：2023-12-29

申请人： University of Massachusetts ,  Analiza, Inc. ,  Medical University of Graz

发明人： Yossi Chait ,  Joseph Horowitz ,  Christopher V. Hollot ,  Hamed Samandari ,  Michael J. Germain ,  Daniel Schneditz

IPC分类号： A61M1/16 ,  A61B5/00 ,  A61B5/02 ,  A61B5/0275 ,  A61B5/145 ,  A61M1/26 ,  A61M1/36

CPC分类号： A61M1/1613 ,  A61B5/02028 ,  A61B5/0275 ,  A61B5/14535 ,  A61B5/6866 ,  A61M1/267 ,  A61M1/361 ,  A61M2205/3389 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2230/20 ,  A61M2230/207

摘要： Absolute blood volume in dialysis patients is a useful patient attribute to know for dialysis treatment, diagnosis, adjustments, etc. In some cases, it is difficult or impossible to directly determine absolute blood volume. Estimating absolute blood volume may be used to overcome the inability to directly determine the absolute blood volume. Estimating absolute blood volume may include obtaining a series of measurements of hemoconcentration of a patient over a time period, and estimating parameters for a physiological model based on the series of measurements. The absolute blood volume of the patient may be determined using the physiological model.

公开(公告)号：US11896748B2

公开(公告)日：2024-02-13

申请号：US16617904

申请日：2018-06-01

申请人： University of Massachusetts ,  Analiza, Inc. ,  Medical University of Graz

发明人： Yossi Chait ,  Joseph Horowitz ,  Christopher V. Hollot ,  Hamed Samandari ,  Michael J. Germain ,  Daniel Schneditz

IPC分类号： A61M1/16 ,  A61B5/02 ,  A61B5/145 ,  A61M1/36 ,  A61M1/26 ,  A61B5/0275 ,  A61B5/00

CPC分类号： A61M1/1613 ,  A61B5/02028 ,  A61B5/0275 ,  A61B5/14535 ,  A61B5/6866 ,  A61M1/267 ,  A61M1/361 ,  A61M2205/3389 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2230/20 ,  A61M2230/207

摘要： Absolute blood volume in dialysis patients is a useful patient attribute to know for dialysis treatment, diagnosis, adjustments, etc. In some cases, it is difficult or impossible to directly determine absolute blood volume. Estimating absolute blood volume may be used to overcome the inability to directly determine the absolute blood volume. Estimating absolute blood volume may include obtaining a series of measurements of hemoconcentration of a patient over a time period, and estimating parameters for a physiological model based on the series of measurements. The absolute blood volume of the patient may be determined using the physiological model.

公开(公告)号：US20150220700A1

公开(公告)日：2015-08-06

申请号：US14427775

申请日：2013-09-12

申请人： University of Massachusetts ,  Analiza, Inc.

发明人： Yossi Chait ,  Michael J. Germain ,  Christopher V. Hollot ,  Joseph Horowitz ,  William Charles Vogt

IPC分类号： G06F19/00 ,  A61M5/172 ,  A61M5/158 ,  A61K38/18

CPC分类号： G16H20/10 ,  A61K38/1816 ,  A61M5/158 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3303 ,  A61M2230/20 ,  G06F19/00 ,  G06F19/3456 ,  G16H50/50

摘要： The present invention is generally directed to methods and devices for determining dosing for a medical agent. In some embodiments, a mathematical algorithm is employed for computing erythropoiesis-stimulating agents dosing for treating anemia in a subject, e.g., a human subject. Any suitable dosing may be used, e.g., intravenous, subcutaneous, or oral dosing. In some cases, dosing for a wide range of subject types and health conditions can be achieved using the devices and methods disclosed herein.

摘要翻译： 本发明一般涉及用于确定药物剂量的方法和装置。 在一些实施方案中，使用数学算法来计算用于治疗受试者例如人受试者的贫血的促红细胞生成刺激剂。 可以使用任何合适的剂量，例如静脉内，皮下或口服给药。 在一些情况下，可以使用本文公开的装置和方法来实现广泛的受试者类型和健康状况的给药。

公开(公告)号：US20190013090A1

公开(公告)日：2019-01-10

申请号：US16032990

申请日：2018-07-11

申请人： University of Massachusetts ,  Analiza, Inc.

发明人： Yossi Chait ,  Michael J. Germain ,  Christopher V. Hollot ,  Joseph Horowitz ,  William Charles Vogt

IPC分类号： G16H20/10 ,  A61K38/18 ,  A61M5/158 ,  G06F19/00 ,  G16H50/50 ,  A61M5/172

摘要： The present invention is generally directed to methods and devices for determining dosing for a medical agent. In some embodiments, a mathematical algorithm is employed for computing erythropoiesis-stimulating agents dosing for treating anemia in a subject, e.g., a human subject. Any suitable dosing may be used, e.g., intravenous, subcutaneous, or oral dosing. In some cases, dosing for a wide range of subject types and health conditions can be achieved using the devices and methods disclosed herein.

公开(公告)号：US10049187B2

公开(公告)日：2018-08-14

申请号：US14427775

申请日：2013-09-12

申请人： University of Massachusetts ,  Analiza, Inc.

发明人： Yossi Chait ,  Michael J. Germain ,  Christopher V. Hollot ,  Joseph Horowitz ,  William Charles Vogt

IPC分类号： G01N33/48 ,  G06F19/00 ,  A61K38/18 ,  A61M5/158 ,  A61M5/172 ,  G16H50/50 ,  G06G7/58

摘要： The present invention is generally directed to methods and devices for determining dosing for a medical agent. In some embodiments, a mathematical algorithm is employed for computing erythropoiesis-stimulating agents dosing for treating anemia in a subject, e.g., a human subject. Any suitable dosing may be used, e.g., intravenous, subcutaneous, or oral dosing. In some cases, dosing for a wide range of subject types and health conditions can be achieved using the devices and methods disclosed herein.