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35 条记录 (耗时 0.019 秒)

    RNA SEPARATION AND RELATED TECHNIQUES FOR DETERMINING VIRUSES SUCH AS CORONAVIRUSES
    2.
    发明公开
    RNA SEPARATION AND RELATED TECHNIQUES FOR DETERMINING VIRUSES SUCH AS CORONAVIRUSES 审中-公开

    公开(公告)号：US20230151443A1

    公开(公告)日：2023-05-18

    申请号：US17987973

    申请日：2022-11-16

    申请人： Analiza, Inc.

    发明人： Arnon Chait ,  Boris Y. Zaslavsky

    IPC分类号： C12Q1/70 ,  A61K9/51 ,  A61K39/215 ,  G01N33/52 ,  G01N33/569

    CPC分类号： C12Q1/701 ,  A61K9/51 ,  A61K39/215 ,  G01N33/523 ,  G01N33/56983 ,  G01N2333/165

    摘要： Certain aspects of the present disclosure generally relate to systems and methods for determining viruses such as coronaviruses. For instance, some aspects are directed to systems and methods for determining viruses using a partitioning system. Within the partitioning system, free RNA or other nucleic acids may preferentially partition into one phase, while intact viruses may be present in the other phase or in both phases. Accordingly, in some cases, free RNA or other nucleic acids may be preferentially removed, e.g., as compared to intact RNA or other nucleic acids present within a virus. In some cases, the phase containing intact viruses can be determined to determine the infectiousness, e.g., of a sample arising from a subject. This may be useful, for example, for distinguishing subjects who are capable of spreading an infection from those who are not infectious.

    RNA separation and related techniques for determining viruses such as coronaviruses
    3.
    发明授权
    RNA separation and related techniques for determining viruses such as coronaviruses 有权

    公开(公告)号：US11535902B2

    公开(公告)日：2022-12-27

    申请号：US17695994

    申请日：2022-03-16

    申请人： Analiza, Inc.

    发明人： Arnon Chait ,  Boris Y. Zaslavsky

    IPC分类号： C12N15/10 ,  C12N9/22 ,  C12N15/11 ,  C12N15/63 ,  C12Q1/6816 ,  C12Q1/70 ,  A61K9/51 ,  A61K39/215 ,  G01N33/52 ,  G01N33/569

    摘要： Certain aspects of the present disclosure generally relate to systems and methods for determining viruses such as coronaviruses. For instance, some aspects are directed to systems and methods for determining viruses using a partitioning system. Within the partitioning system, free RNA or other nucleic acids may preferentially partition into one phase, while intact viruses may be present in the other phase or in both phases. Accordingly, in some cases, free RNA or other nucleic acids may be preferentially removed, e.g., as compared to intact RNA or other nucleic acids present within a virus. In some cases, the phase containing intact viruses can be determined to determine the infectiousness, e.g., of a sample arising from a subject. This may be useful, for example, for distinguishing subjects who are capable of spreading an infection from those who are not infectious.

    METHODS AND DEVICES FOR DETERMINING A DISEASE STATE
    4.
    发明申请
    METHODS AND DEVICES FOR DETERMINING A DISEASE STATE 审中-公开

    公开(公告)号：US20170242017A1

    公开(公告)日：2017-08-24

    申请号：US15590215

    申请日：2017-05-09

    申请人： Analiza, Inc.

    发明人： Arnon Chait ,  Boris Y. Zaslavsky

    IPC分类号： G01N33/574 ,  G01N33/543

    CPC分类号： G01N33/57488 ,  G01N33/54366 ,  G01N33/57415 ,  G01N33/68 ,  G01N33/6893 ,  G01N2333/765 ,  G01N2800/085 ,  G01N2800/56

    摘要： The present invention, in some embodiments thereof, relates to methods and devices for determining a disease state in a patient. In some embodiments, human serum albumin may be analyzed for associated molecules, wherein the associated molecules are related to a disease such as cancer. Certain aspects of the invention are generally directed to devices and methods for determining a disease state as a function of the three-dimensional structure of a blood protein, human serum albumin (HSA) or its complex with other ligands, e.g., due to binding to disease-specific ligands. HSA interacts with biomolecules associated with a disease presence, and liganded HSA may differentially partition between aqueous phases of a predetermined partitioning system, wherein the partitioning behavior differs between HSA from healthy individuals and HSA from people harboring the predetermined disease, such as breast cancer.

    DEVICES AND METHODS FOR DETERMINING AND/OR ISOLATING CELLS SUCH AS CIRCULATING CANCER OR FETAL CELLS
    5.
    发明申请
    DEVICES AND METHODS FOR DETERMINING AND/OR ISOLATING CELLS SUCH AS CIRCULATING CANCER OR FETAL CELLS 有权

    公开(公告)号：US20150160196A1

    公开(公告)日：2015-06-11

    申请号：US14225512

    申请日：2014-03-26

    申请人： Analiza, Inc.

    发明人： Pavel Idelevich ,  Arnon Chait ,  Alan Bauer

    IPC分类号： G01N33/50 ,  G01N33/574

    CPC分类号： G01N33/5094 ,  G01N33/5005 ,  G01N33/5091 ,  G01N33/57492 ,  G01N2333/70514 ,  G01N2333/70517

    摘要： The present invention generally relates to devices and methods for determining and/or isolating cells. One aspect is generally directed to methods and devices for detecting, identifying, counting, and/or potentially sorting cells of interest in blood or other biological sample. In some embodiments, blood samples (or other biological fluids) may be treated with signaling entities, such as pH-sensitive entities, that change color or otherwise produce a signal in suitable internal environments. For example, certain cells, such as cancer or fetal cells, may have differences in intracellular pH compared to other cells, which can be detected using pH-sensitive entities. In certain embodiments, the cells may be sorted based on such signaling entities; for example, illumination of cells in a suitable machine for sorting cells (e.g., using fluorescent light) may allow determination of the cells, which may also be recovered or isolated for further manipulation in some cases.

    Devices and methods for determining and/or isolating cells such as circulating cancer or fetal cells
    7.
    发明授权
    Devices and methods for determining and/or isolating cells such as circulating cancer or fetal cells 有权

    公开(公告)号：US10928405B2

    公开(公告)日：2021-02-23

    申请号：US16208671

    申请日：2018-12-04

    申请人： Analiza, Inc.

    发明人： Pavel Idelevich ,  Arnon Chait ,  Alan Bauer ,  Paul David Jackson

    IPC分类号： G01N33/84 ,  G01N33/569 ,  G01N33/574 ,  G01N33/50 ,  C12Q1/6806

    摘要： Some embodiments of the present invention generally relate to devices and methods for determining and/or isolating cells. For example, one aspect is generally directed to methods and devices for detecting, identifying, counting, and/or potentially sorting cells of interest in blood or other biological sample. In some embodiments, blood samples (or other biological fluids) may be treated with signaling entities, such as pH-sensitive entities, that change color or otherwise produce a signal in suitable internal environments. For example, certain cells, such as cancer or fetal cells, may have differences in intracellular pH compared to other cells, which can be detected using pH-sensitive entities. In certain embodiments, the cells may be sorted based on such signaling entities; for example, illumination of cells in a suitable machine for sorting cells (e.g., using fluorescent light) may allow determination of the cells, which may also be recovered or isolated for further manipulation in some cases.

    Methods and devices for determining a disease state
    8.
    发明授权
    Methods and devices for determining a disease state 有权

    公开(公告)号：US09678076B2

    公开(公告)日：2017-06-13

    申请号：US14312907

    申请日：2014-06-24

    申请人： Analiza, Inc.

    发明人： Arnon Chait ,  Boris Y. Zaslavsky

    IPC分类号： G01N33/574 ,  G01N33/68

    CPC分类号： G01N33/57488 ,  G01N33/54366 ,  G01N33/57415 ,  G01N33/68 ,  G01N33/6893 ,  G01N2333/765 ,  G01N2800/085 ,  G01N2800/56

    摘要： The present invention, in some embodiments thereof, relates to methods and devices for determining a disease state in a patient. In some embodiments, human serum albumin may be analyzed for associated molecules, wherein the associated molecules are related to a disease such as cancer. Certain aspects of the invention are generally directed to devices and methods for determining a disease state as a function of the three-dimensional structure of a blood protein, human serum albumin (HSA) or its complex with other ligands, e.g., due to binding to disease-specific ligands. HSA interacts with biomolecules associated with a disease presence, and liganded HSA may differentially partition between aqueous phases of a predetermined partitioning system, wherein the partitioning behavior differs between HSA from healthy individuals and HSA from people harboring the predetermined disease, such as breast cancer.

    Devices and methods for determining and/or isolating cells such as circulating cancer or fetal cells
    9.
    发明授权
    Devices and methods for determining and/or isolating cells such as circulating cancer or fetal cells 有权
    用于确定和/或分离细胞如循环癌症或胎儿细胞的装置和方法

    公开(公告)号：US09063127B1

    公开(公告)日：2015-06-23

    申请号：US14312875

    申请日：2014-06-24

    申请人： Analiza, Inc.

    发明人： Pavel Idelevich ,  Arnon Chait ,  Alan Bauer

    IPC分类号： G01N33/50

    CPC分类号： G01N33/5094 ,  G01N33/5005 ,  G01N33/5091 ,  G01N33/57492 ,  G01N2333/70514 ,  G01N2333/70517

    摘要： The present invention generally relates to devices and methods for determining and/or isolating cells. One aspect is generally directed to methods and devices for detecting, identifying, counting, and/or potentially sorting cells of interest in blood or other biological sample. In some embodiments, blood samples (or other biological fluids) may be treated with signaling entities, such as pH-sensitive entities, that change color or otherwise produce a signal in suitable internal environments. For example, certain cells, such as cancer or fetal cells, may have differences in intracellular pH compared to other cells, which can be detected using pH-sensitive entities. In certain embodiments, the cells may be sorted based on such signaling entities; for example, illumination of cells in a suitable machine for sorting cells (e.g., using fluorescent light) may allow determination of the cells, which may also be recovered or isolated for further manipulation in some cases.

    摘要翻译： 本发明一般涉及用于确定和/或分离细胞的装置和方法。 一方面通常涉及用于检测，识别，计数和/或潜在地分选血液或其他生物样品中感兴趣的细胞的方法和装置。 在一些实施方案中，血液样品（或其他生物流体）可以用信号实体（例如pH敏感实体）来处理，其在适当的内部环境中改变颜色或以其它方式产生信号。 例如，某些细胞，如癌症或胎儿细胞，与其他细胞相比，细胞内的pH可能有差异，其可以使用pH敏感的实体来检测。 在某些实施方案中，可以基于这种信令实体对细胞进行分类; 例如，在用于分选细胞的合适的机器中照射细胞（例如，使用荧光）可以允许确定细胞，其在一些情况下也可以被回收或分离用于进一步的操作。

    SYSTEMS AND METHODS FOR DETERMINING VIRUSES SUCH AS CORONAVIRUSES
    10.
    发明公开
    SYSTEMS AND METHODS FOR DETERMINING VIRUSES SUCH AS CORONAVIRUSES 审中-公开

    公开(公告)号：US20240241123A1

    公开(公告)日：2024-07-18

    申请号：US18618944

    申请日：2024-03-27

    申请人： Analiza, Inc.

    发明人： Arnon Chait ,  Boris Y. Zaslavsky

    IPC分类号： G01N33/569 ,  C12Q1/6888 ,  C12Q1/70 ,  G01N33/49

    CPC分类号： G01N33/56983 ,  C12Q1/6888 ,  C12Q1/70 ,  G01N33/491 ,  G01N2333/11 ,  G01N2333/165

    摘要： Certain aspects of the present disclosure generally relate to systems and methods for determining viruses. For instance, some aspects are directed to systems and methods for determining viruses using a partitioning system. Within the partitioning system, the virus may partition into one or more phases. In some cases, a virus-binding moiety facilitates partitioning of the virus. The phases may be assayed to determine the virus based on, e.g., quantitative or qualitative assessments of the distribution of virus-binding and/or signaling moieties. The virus-binding moiety may be attached to particles that may form a complex around a virus. The complex may be detectable without a signaling moiety (e.g., as a color change) in some embodiments. In some cases, more than one virus may be determined. For example, a virus-binding moiety may substantially alter the partitioning behavior of one virus or complex, relative to another, by being selective for the first virus.