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    EXTRACORPOREAL AMBULATOR ASSIST LUNG
    1.
    发明申请
    EXTRACORPOREAL AMBULATOR ASSIST LUNG 审中-公开
    超声波助手辅助肺

    公开(公告)号：US20150314059A1

    公开(公告)日：2015-11-05

    申请号：US14647861

    申请日：2013-11-27

    申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  CARNEGIE MELLON UNIVERSITY

    发明人： William J. Federspiel ,  Brian Joseph Frankowski ,  James F. Antaki ,  Christian Andres Bermudez ,  Richard Garrett Jeffries ,  William R. Wagner

    IPC分类号： A61M1/36 ,  A61M1/32 ,  A61M1/10

    CPC分类号： A61M1/3667 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1015 ,  A61M1/1029 ,  A61M1/1036 ,  A61M1/1698 ,  A61M1/262 ,  A61M1/267 ,  A61M1/32 ,  A61M2205/7536 ,  A61M2206/20

    摘要： A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers may extend generally perpendicular to the direction of bulk flow of blood through the housing.

    摘要翻译： 用于肺辅助的体外系统包括壳体，与壳体流体连接的血流入口; 与所述壳体流体连接的血流出口; 多个中空透气纤维，其适于允许血液和中空透气纤维内部之间的气体扩散，多个中空透气纤维位于血流入口和血流出口之间，使得血液围绕 当从血流入口流到血流出口时，多个中空透气纤维; 与所述壳体流体连接并与所述多个中空透气纤维的入口流体连接的气体入口; 与所述壳体流体连接并与所述多个中空透气纤维的出口流体连接的气体出口; 以及至少一个移动元件以在与多个中空透气纤维接触的血流中产生速度场。 多个中空透气纤维可以大致垂直于血液通过壳体的大量流动方向延伸。

    REMOVAL OF CARBON DIOXIDE VIA DIALYSIS
    4.
    发明申请
    REMOVAL OF CARBON DIOXIDE VIA DIALYSIS 审中-公开
    通过透析去除二氧化碳

    公开(公告)号：US20150335807A1

    公开(公告)日：2015-11-26

    申请号：US14761321

    申请日：2014-01-18

    申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

    发明人： John Alston Kellum, JR. ,  Matthew Cove ,  William J. Federspiel

    IPC分类号： A61M1/16

    CPC分类号： A61M1/1654 ,  A61M1/1613 ,  A61M1/1694 ,  A61M1/1698 ,  A61M2230/202 ,  A61M2230/208 ,  B01D61/24 ,  B01D63/02 ,  B01D2311/13

    摘要： A method of reducing the concentration of carbon dioxide in blood plasma includes removing blood from a patient and treating or processing at least blood plasma of the blood by flowing the blood plasma on one side of at least one semi-permeable membrane and flowing a dialysate on the other side of the at least one semi-permeable membrane. The dialysate has a concentration of bicarbonate less than the concentration of bicarbonate in the blood plasma before treating the blood plasma and has a composition such that the blood plasma strong ion difference that results from treating the blood plasma in conjunction with an achieved reduction in blood plasma CO2 concentration results in a blood plasma pH that does not change by more than +/−0.5 during treatment.

    摘要翻译： 减少血浆中二氧化碳浓度的方法包括：从患者身上清除血液，并至少通过将至少一个半透膜的一侧上的血浆流动并使透析液流过，至少对血液进行血浆处理或加工 所述至少一个半透膜的另一侧。 在处理血浆之前，透析液的浓度比碳酸氢盐浓度低于血浆中的碳酸氢盐浓度，并且具有使血浆中的血浆强离子差异结合血浆等离子体的降低而得到的组成 CO 2浓度导致血浆pH在治疗期间不改变大于+/- 0.5。

    EXTRACORPOREAL AMBULATORY ASSIST LUNG
    5.
    发明申请
    EXTRACORPOREAL AMBULATORY ASSIST LUNG 有权

    公开(公告)号：US20210283324A1

    公开(公告)日：2021-09-16

    申请号：US17328049

    申请日：2021-05-24

    申请人： University of Pittsburgh- Of the Commonwealth System of Higher Education ,  Carnegie Mellon University ,  Mississippi State University

    发明人： Shalv Madhani ,  Brian Joseph Frankowski ,  William J. Federspiel ,  Gregory Burgreen ,  James F. Antaki

    IPC分类号： A61M1/36 ,  A61M1/16 ,  A61M60/82 ,  A61M60/113 ,  A61M60/419 ,  A61M60/818 ,  A61M60/824

    摘要： An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid connection with the pressurizing stator compartment via a flow channel within the housing, and a blood flow outlet in fluid connection with the fiber bundle compartment. An impeller is rotatably positioned within the pressurizing compartment for pressurizing blood entering the pressurizing stator compartment from the blood flow inlet. The system further includes a fiber bundle positioned within the fiber bundle compartment. The fiber bundle includes a plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers is adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers. The plurality of hollow gas permeable fibers is positioned such that blood flows around the plurality of hollow gas permeable fibers when flowing through the fiber bundle compartment. The plurality of hollow gas permeable fibers extend generally perpendicular to the direction of bulk flow of blood through the fiber bundle compartment from the flow channel to the blood flow outlet. The system further includes a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers and a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers.

    EXTRACORPOREAL AMBULATORY ASSIST LUNG
    7.
    发明申请
    EXTRACORPOREAL AMBULATORY ASSIST LUNG 审中-公开

    公开(公告)号：US20180353673A9

    公开(公告)日：2018-12-13

    申请号：US15738406

    申请日：2016-06-23

    申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education ,  Carnegie Mellon University ,  Mississippi State University

    发明人： Shalv Madhani ,  Brian Joseph Frankowski ,  William J. Federspiel ,  Gregory Burgreen ,  James F. Antaki

    IPC分类号： A61M1/36 ,  A61M1/10 ,  A61M1/16

    CPC分类号： A61M1/3667 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1015 ,  A61M1/1017 ,  A61M1/1036 ,  A61M1/1625 ,  A61M1/1698 ,  A61M1/3666 ,  A61M2205/7536

    摘要： An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid connection with the pressurizing stator compartment via a flow channel within the housing, and a blood flow outlet in fluid connection with the fiber bundle compartment. An impeller is rotatably positioned within the pressurizing compartment for pressurizing blood entering the pressurizing stator compartment from the blood flow inlet. The system further includes a fiber bundle positioned within the fiber bundle compartment. The fiber bundle includes a plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers is adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers. The plurality of hollow gas permeable fibers is positioned such that blood flows around the plurality of hollow gas permeable fibers when flowing through the fiber bundle compartment. The plurality of hollow gas permeable fibers extend generally perpendicular to the direction of bulk flow of blood through the fiber bundle compartment from the flow channel to the blood flow outlet. The system further includes a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers and a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers.