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公开(公告)号：US20190284242A1
公开(公告)日：2019-09-19
申请号：US16427493
申请日：2019-05-31
Applicant: UNIVERSITY OF WASHINGTON
Inventor： David BAKER , Jacob B. BALE , Neil P. KING , William H. SHEFFLER , Daniel ELLIS
IPC: C07K14/00
Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.
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公开(公告)号：US20250127877A1
公开(公告)日：2025-04-24
申请号：US18723029
申请日：2023-01-05
Applicant: UNIVERSITY OF WASHINGTON , THE USA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventor： Neil P. KING , Daniel ELLIS , Anne DOSEY , Masaru KANEKIYO
IPC: A61K39/145 , A61K39/00 , A61P31/16 , C07K14/005 , C12N7/00
Abstract: Disclosed herein are polypeptides that include (a) a heptad motif domain comprising an amino acid sequence according to the genus (I-X1-X2-I-X3-X4-X5)n, wherein X1, X2, X3, X4, and X5 may independently be any amino acid other than proline, and wherein n can be 1-30; and (b) a second domain selected from the group consisting of (i) a polypeptide antigen, and (ii) a polypeptide component of a nanoparticle, nanoparticles including such polypeptides, and uses thereof.
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公开(公告)号：US20230090779A1
公开(公告)日：2023-03-23
申请号：US17904157
申请日：2021-03-04
Applicant: University of Washington , THE USA,AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventor： Neil P. KING , Daniel ELLIS , Masaru KANEKIYO , Julia LEDERHOFER , Barney S. GRAHAM
IPC: C12N9/24 , A61K39/145 , A61P31/16
Abstract: The disclosure provides non-naturally occurring mutant neuraminidase (NA) polypeptides that improve expression and or modifies the open/closed tetrameric conformational state of the NA polypeptide, and uses thereof.
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公开(公告)号：US20250002907A1
公开(公告)日：2025-01-02
申请号：US18884675
申请日：2024-09-13
Applicant: University of Washington , Fred Hutchinson Cancer Center
Inventor： Daniel ELLIS , Neil KING , Jesse BLOOM , Tyler STARR , Allison GREANEY
IPC: C12N15/11 , A61K39/215 , C07K14/165 , C12N15/64 , C12Q1/6811
Abstract: Provided herein are compositions and methods comprising mutated coronavirus “S” spike proteins or receptor binding domains thereof that have an increased expression level, yield and stability compared to its corresponding native or wild-type coronavirus spike protein under the same expression, culture or storage conditions. These mutated spike proteins can be used for generating a protein-based vaccine against one or more coronaviruses.
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Patent Agency Ranking
公开(公告)号：US20220325279A1
公开(公告)日：2022-10-13
申请号：US17563271
申请日：2021-12-28
Inventor： Daniel ELLIS , Neil KING , Jesse BLOOM , Tyler STARR , Allison GREANEY
IPC: C12N15/11 , C12Q1/6811 , C12N15/64
Abstract: Provided herein are compositions and methods comprising mutated coronavirus “S” spike proteins or receptor binding domains thereof that have an increased expression level, yield and stability compared to its corresponding native or wild-type coronavirus spike protein under the same expression, culture or storage conditions. These mutated spike proteins can be used for generating a protein-based vaccine against one or more coronaviruses.
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公开(公告)号：US20160122392A1
公开(公告)日：2016-05-05
申请号：US14930792
申请日：2015-11-03
Applicant: UNIVERSITY OF WASHINGTON
Inventor： David BAKER , Jacob B. BALE , Neil P. KING , William H. SHEFFLER , Daniel ELLIS
CPC classification number: C07K14/00
Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.
Abstract translation: 合成纳米结构，可用于制备合成纳米结构的多肽以及使用这种合成纳米结构的方法在本文中公开。
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公开(公告)号：US20230159595A1
公开(公告)日：2023-05-25
申请号：US17934343
申请日：2022-09-22
Applicant: University of Washington
Inventor： David Baker , Jacob B. BALE , Neil P. KING , William H. SHEFFLER , Daniel ELLIS
IPC: C07K14/00
CPC classification number: C07K14/00
Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.
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公开(公告)号：US20210380641A1
公开(公告)日：2021-12-09
申请号：US16762565
申请日：2018-11-09
Applicant: UNIVERSITY OF WASHINGTON
Inventor： Gabriel BUTTERFIELD , Marc Joseph LAJOIE , Neil P. KING , David BAKER , Daniel ELLIS
Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using synthetic nanostructures are disclosed herein.
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公开(公告)号：US20170218029A1
公开(公告)日：2017-08-03
申请号：US15490351
申请日：2017-04-18
Applicant: UNIVERSITY OF WASHINGTON
Inventor： David BAKER , Jacob B. BALE , Neil P. KING , William H. SHEFFLER , Daniel ELLIS
IPC: C07K14/00
CPC classification number: C07K14/00
Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.
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