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1.发明公开公开(公告)号：US20240252598A1
公开(公告)日：2024-08-01
申请号：US18549539
申请日：2022-04-11
Applicant: University of Washington
Inventor： Quinton M. DOWLING , Neil P. KING , Daniel Brewster STETSON , Hannah VOLKMAN , Elizabeth Erin GRAY
CPC classification number: A61K38/45 , C12N9/1241 , C12Y207/07
Abstract: The disclosure provides constitutively active Cyclic GMP-AMP Synthase (cGAS) polypeptide mutants and. methods for their use as adjuvants.
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公开(公告)号：US20250092424A1
公开(公告)日：2025-03-20
申请号：US18884464
申请日：2024-09-13
Applicant: University of Washington
Inventor： Neil P. KING , Masaharu SOMIYA , Sydney FUNK
IPC: C12N15/88 , C07K14/705 , C12N15/85
Abstract: Nucleic acids and expression vectors, and host cells or vesicles containing them, are provided that encode polypeptides and fusion proteins capable of forming hetero-oligomeric complexes capable of inducing membrane or vesicle fusion, and their use as delivery vehicles.
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公开(公告)号：US20220144895A1
公开(公告)日：2022-05-12
申请号：US17602119
申请日：2020-04-20
Applicant: University of Washington
Inventor： Scott BOYKEN , David BAKER , Zibo CHEN , Alfredo Quijano RUBIO , Neil P. KING , Jason C. KLIMA , Carl WALKEY
IPC: C07K7/08
Abstract: Disclosed herein are polypeptides or polypeptide oligomers, including a buried hydrogen bond network that includes at least (1, 2, 3, 4, 5, 6, 7, 8, or 9) pH sensitive amino acids located (i) at an intra-chain interface between different: structural elements in one polypeptide, or (it) at an inter-chain interface between structural elements present in different chains of a polypeptide oligomer, wherein the polypeptide or polypeptide oligomer is stable above a given pH, and wherein the polypeptide or polypeptide oligomer undergoes a conformational transition when subjected to a pH at or below the given pH.
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公开(公告)号：US20160122392A1
公开(公告)日：2016-05-05
申请号：US14930792
申请日：2015-11-03
Applicant: UNIVERSITY OF WASHINGTON
Inventor： David BAKER , Jacob B. BALE , Neil P. KING , William H. SHEFFLER , Daniel ELLIS
CPC classification number: C07K14/00
Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.
Abstract translation: 合成纳米结构，可用于制备合成纳米结构的多肽以及使用这种合成纳米结构的方法在本文中公开。
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公开(公告)号：US20230159595A1
公开(公告)日：2023-05-25
申请号：US17934343
申请日：2022-09-22
Applicant: University of Washington
Inventor： David Baker , Jacob B. BALE , Neil P. KING , William H. SHEFFLER , Daniel ELLIS
IPC: C07K14/00
CPC classification number: C07K14/00
Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.
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Patent Agency Ranking
公开(公告)号：US20210380641A1
公开(公告)日：2021-12-09
申请号：US16762565
申请日：2018-11-09
Applicant: UNIVERSITY OF WASHINGTON
Inventor： Gabriel BUTTERFIELD , Marc Joseph LAJOIE , Neil P. KING , David BAKER , Daniel ELLIS
Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using synthetic nanostructures are disclosed herein.
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公开(公告)号：US20170218029A1
公开(公告)日：2017-08-03
申请号：US15490351
申请日：2017-04-18
Applicant: UNIVERSITY OF WASHINGTON
Inventor： David BAKER , Jacob B. BALE , Neil P. KING , William H. SHEFFLER , Daniel ELLIS
IPC: C07K14/00
CPC classification number: C07K14/00
Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.
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公开(公告)号：US20250127877A1
公开(公告)日：2025-04-24
申请号：US18723029
申请日：2023-01-05
Applicant: UNIVERSITY OF WASHINGTON , THE USA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventor： Neil P. KING , Daniel ELLIS , Anne DOSEY , Masaru KANEKIYO
IPC: A61K39/145 , A61K39/00 , A61P31/16 , C07K14/005 , C12N7/00
Abstract: Disclosed herein are polypeptides that include (a) a heptad motif domain comprising an amino acid sequence according to the genus (I-X1-X2-I-X3-X4-X5)n, wherein X1, X2, X3, X4, and X5 may independently be any amino acid other than proline, and wherein n can be 1-30; and (b) a second domain selected from the group consisting of (i) a polypeptide antigen, and (ii) a polypeptide component of a nanoparticle, nanoparticles including such polypeptides, and uses thereof.
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公开(公告)号：US20230090779A1
公开(公告)日：2023-03-23
申请号：US17904157
申请日：2021-03-04
Applicant: University of Washington , THE USA,AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventor： Neil P. KING , Daniel ELLIS , Masaru KANEKIYO , Julia LEDERHOFER , Barney S. GRAHAM
IPC: C12N9/24 , A61K39/145 , A61P31/16
Abstract: The disclosure provides non-naturally occurring mutant neuraminidase (NA) polypeptides that improve expression and or modifies the open/closed tetrameric conformational state of the NA polypeptide, and uses thereof.
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10.发明申请公开(公告)号：US20220169681A1
公开(公告)日：2022-06-02
申请号：US17523174
申请日：2021-11-10
Inventor： Neil P. KING , David BAKER , Brooke NICKERSON , Lance Joseph STEWART , Laurent PEREZ , Antonio LANZAVECCHIA , Jessica MARCANDALLI
IPC: C07K14/005 , A61P31/14 , A61K39/12 , B82Y5/00 , C12N7/00
Abstract: Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.
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