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公开(公告)号：US5705338A
公开(公告)日：1998-01-06
申请号：US434743
申请日：1995-05-04
IPC分类号： C12Q1/68 , G01N33/00 , G01N33/543 , G01N33/53 , G01N33/547
CPC分类号： C12Q1/6813 , C12Q1/6834 , G01N33/54306 , G01N2033/008
摘要： Novel non-competitive assay techniques have been developed which not only improve sensitivity, but also are convenient and less susceptible to interfering factors. They are compatible with existing instruments and can be run in one or more test tubes. The analyte is reacted with labeled specific binder, after which the mixture is reacted with (1) an insoluble material attached to an analyte derivative and (2) a solid phase carrying a binder. The solid phase is then separated, and the label attached to the solid phase is measured. Variations of the procedure include the use of a reversible bridge for attaching the insoluble material to the analyte mimic and the conduct of the assay in various porous media, such as paper, chromatographic and electrophoretic media, and dipsticks.
摘要翻译： 已经开发了新的非竞争性测定技术，其不仅提高灵敏度，而且方便且不易受干扰因素的影响。 它们与现有仪器兼容，可以在一个或多个试管中运行。 分析物与标记的特异性粘合剂反应，之后混合物与（1）与分析物衍生物连接的不溶性物质和（2）携带粘合剂的固相反应。 然后分离固相，测量附着于固相的标记。 方法的变化包括使用可逆桥接器将不溶性物质连接到分析物模拟物上，以及在各种多孔介质如纸张，色谱和电泳介质以及浸渍条中进行测定。
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公开(公告)号：US5312730A
公开(公告)日：1994-05-17
申请号：US889321
申请日：1992-05-27
IPC分类号： G01N33/543 , G01N33/547 , G01N33/92 , G01N33/541 , G01N33/544
CPC分类号： G01N33/54306 , G01N33/54333 , Y10S435/961 , Y10S435/968 , Y10S435/971 , Y10S436/829
摘要： This invention relates to methods that have been found useful in reducing non-specific binding in immunochemical assays, via methods that can be implemented much faster than those used by Ishikawa. The techniques include the use of a lipophilic bridge, such as a liposome, or the elution of the antigen-antibody complex from the solid phase by the use of an anti-idiotypic antibody or an antibody, or the use of a heterologous reversible bridge.
摘要翻译： 本发明涉及已经发现可用于减少免疫化学测定中的非特异性结合的方法，其方法可以比Ishikawa使用的方法快得多。 这些技术包括使用亲脂性桥，例如脂质体，或通过使用抗独特型抗体或抗体，从固相中洗脱抗原 - 抗体复合物，或使用异源可逆桥。
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公开(公告)号：US5817527A
公开(公告)日：1998-10-06
申请号：US554013
申请日：1995-11-06
IPC分类号： G01N33/547 , B01J20/281 , C07K1/22 , C07K17/00 , G01N30/88 , G01N33/543 , G01N33/546 , G01N33/552 , G01N33/553
CPC分类号： C07K17/00 , G01N33/543 , Y10S530/807 , Y10S530/811 , Y10S530/814 , Y10S530/815
摘要： A new method for immobilization of small molecules on solid supports via a macromolecular spacer has been developed. A protein or another macromolecule is first immobilized in an aqueous medium, and the solid support is than washed with an organic solvent. The small molecule is coupled in an organic medium, followed by organic medium washes. The new solid phases are useful for affinity purifications, immunoassays and other binding assays, and for selection of binders by panning procedures.
摘要翻译： 已经开发出通过大分子间隔物将小分子固定在固体载体上的新方法。 蛋白质或其他大分子首先固定在水性介质中，固体支持物用有机溶剂洗涤。 将小分子偶联在有机介质中，随后进行有机介质洗涤。 新的固相可用于亲和纯化，免疫测定和其它结合测定，以及通过淘选程序选择粘合剂。
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公开(公告)号：US5445936A
公开(公告)日：1995-08-29
申请号：US121806
申请日：1993-09-15
申请人： Uri Piran , William J. Riordan , Laurie A. Livshin
发明人： Uri Piran , William J. Riordan , Laurie A. Livshin
IPC分类号： C12Q1/68 , G01N33/00 , G01N33/543
CPC分类号： C12Q1/6813 , C12Q1/6834 , G01N33/54306 , G01N2033/008
摘要： A novel non-competitive immunoassay technique has been developed which not only improves sensitivity, but also is convenient and less susceptible to interfering factors. It is compatible with existing instruments and is an assay that can be run in one test tube. The analyte is reacted with labeled specific binder, after which the mixture is reacted with (1) an insoluble material attached to an analyte derivative and (2) a solid phase carrying a binder. The solid phase is then separated, and the label attached to the solid phase is measured.
摘要翻译： 已经开发了一种新型的非竞争性免疫测定技术，不仅提高了灵敏度，而且方便，不易受干扰因素的影响。 它与现有仪器兼容，是可以在一个试管中运行的测定法。 分析物与标记的特异性粘合剂反应，之后混合物与（1）与分析物衍生物连接的不溶性物质和（2）携带粘合剂的固相反应。 然后分离固相，测量附着于固相的标记。
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公开(公告)号：US4298335A
公开(公告)日：1981-11-03
申请号：US70164
申请日：1979-08-27
IPC分类号： F23N5/12
CPC分类号： F23N5/123 , F23N2023/26 , F23N2023/28 , F23N2027/38 , F23N2029/12 , F23N2035/12
摘要： A fuel burner control system including a valve for controlling the flow of fuel to a burner, a resistive heater element for igniting fuel, a power supply for supplying current to the heater element, a flame sensing circuit comprising an ac source for supplying ac voltage to the heater element, and a detector for producing an output signal only in response to the flow through the heating element of current rectified by the flame, a valve control circuit for maintaining the valve open in response to the output signal, and a coupling circuit interconnecting the heating element with both the power supply and the sensing circuit and adapted to prevent the flow of current therebetween. By utilizing a coupling circuit that prevents the flow of current between the power supply and the flame sensing circuit, the resistive heater element can be efficiently and alternately used both as a fuel igniting mechanism and as an electrode for deriving current rectified by flame at the burner.
摘要翻译： 一种燃料燃烧器控制系统，包括用于控制燃烧器的燃料流的阀，用于点燃燃料的电阻加热器元件，用于向加热元件供应电流的电源;火焰感测电路，包括用于将交流电压提供给 所述加热器元件和用于仅响应于通过所述加热元件流过由所述火焰整流的电流而产生输出信号的检测器，用于响应于所述输出信号保持所述阀打开的阀控制电路，以及将所述输出信号互连的耦合电路 所述加热元件具有电源和感测电路，并且适于防止其间的电流流动。 通过利用防止电源和火焰检测电路之间的电流流动的耦合电路，电阻加热器元件可以被有效地并且交替地用作燃料点火机构，并且作为用于导出在燃烧器处由火焰整流的电流的电极 。
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公开(公告)号：US4140474A
公开(公告)日：1979-02-20
申请号：US815105
申请日：1977-07-13
IPC分类号： F23N5/20
CPC分类号： F23N5/203 , F23N2023/26 , F23N2027/04 , F23N2027/36
摘要： A burner control system including a valve for controlling the flow of fuel to a burner, a flame sensor for producing a flame signal in response to the presence of flame at the burner, a start-up circuit for producing a start-up signal, a control circuit for opening the valve to establish fuel flow in response to either the flame or start-up signal, and a timing capacitor first delays the generation of the start-up signal while charging during a predetermined purge period after energization of the start-up circuit and then terminates the start-up signal while discharging during a predetermined ignition period. A monostable electronic switch produces the start-up signal in response to the charge level on the timing capacitor and a valve initiator for opening the valve is powered by energy discharged by the timing capacitor during the ignition period.
摘要翻译： 一种燃烧器控制系统，包括用于控制到燃烧器的燃料流的阀，响应于在燃烧器处存在火焰产生火焰信号的火焰传感器，用于产生启动信号的启动电路， 控制电路，用于响应于火焰或启动信号来打开阀门以建立燃料流量，并且定时电容器首先在启动通电之后的预定清除时段期间在充电期间延迟产生启动信号 然后在预定的点火期间内放电时终止启动信号。 单稳态电子开关响应于定时电容器上的充电水平产生启动信号，并且用于打开阀的阀启动器由在点火期间由定时电容器放电的能量供电。
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公开(公告)号：US4459097A
公开(公告)日：1984-07-10
申请号：US286528
申请日：1981-07-24
IPC分类号： F23N5/12
CPC分类号： F23N5/123
摘要： A fuel burner control system including a valve for controlling the flow of fuel to a burner, a resistive heater element for igniting fuel, a power supply for supplying current to the heater element, a flame sensing circuit comprising an ac source for supplying ac voltage to the heater element, and a detector for producing an output signal only in response to the flow through the heating element of current rectified by the flame, a valve control circuit for maintaining the valve open in response to the output signal, and a coupling circuit interconnecting the heating element with both the power supply and the sensing circuit and adapted to prevent the flow of current therebetween. By utilizing a coupling circuit that prevents the flow of current between the power supply and the flame sensing circuit, the resistive heater element can be efficiently and alternately used both as a fuel igniting mechanism and as an electrode for deriving current rectified by flame at the burner.
摘要翻译： 一种燃料燃烧器控制系统，包括用于控制燃烧器的燃料流的阀，用于点燃燃料的电阻加热器元件，用于向加热元件供应电流的电源;火焰感测电路，包括用于将交流电压提供给 所述加热器元件和用于仅响应于通过所述加热元件流过由所述火焰整流的电流而产生输出信号的检测器，用于响应于所述输出信号保持所述阀打开的阀控制电路，以及将所述输出信号互连的耦合电路 所述加热元件具有电源和感测电路，并且适于防止其间的电流流动。 通过利用防止电源和火焰感测电路之间的电流流动的耦合电路，电阻加热器元件可以被有效地并且交替地用作燃料点火机构，并且作为用于导出在燃烧器处由火焰整流的电流的电极 。
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公开(公告)号：US3987346A
公开(公告)日：1976-10-19
申请号：US528224
申请日：1974-11-29
申请人： William J. Riordan
发明人： William J. Riordan
CPC分类号： F23N5/203 , F23N2023/26 , F23N2027/04 , F23N2033/06
摘要： Disclosed herein is a fuel burner control system with a purge timer having a current responsive control relay that is energized into an active state only by a given minimum input current level but can be maintained in that active state by a substantially lesser input current level. After connection to an electrical supply an activating circuit supplies the given input current level to the control relay only after a predetermined purge time period established by an electrical timer, after which a hold circuit supplies the lesser input current level maintaining the relay in its active state. A blower dissipates any residual fuel vapor in the vicinity of the burner during the purge period and only after its conclusion is fuel flow initiated and ignition attempted in response to contact closures effected in the relay's active state. In a preferred embodiment of the invention, the purge timer comprises an energy storage capacitor which is charged from the supply during the purge period after which a threshold device dumps the energy stored in the capacitor to produce the current level required to move the control relay into its active state.
摘要翻译： 这里公开了一种燃料喷射器控制系统，其具有清洗定时器，其具有电流响应控制继电器，该电流响应控制继电器仅通过给定的最小输入电流电平被激励成活动状态，但是可以通过基本较小的输入电流电平保持在该激活状态。 在连接到电源之后，启动电路仅在由电定时器建立的预定清洗时间段之后才将控制继电器提供给控制继电器，之后保持电路提供较小的输入电流电平，以使继电器保持在其激活状态 。 鼓风机在净化期间在燃烧器附近消散任何残留的燃料蒸汽，只有在其结束之后，燃料流开始并且响应于在继电器的活动状态下实现的接触闭合而尝试着火。 在本发明的优选实施例中，净化计时器包括储能电容器，其在净化期间从电源充电，之后阈值装置将存储在电容器中的能量转储成电流，以将控制继电器移动到 其活跃状态。
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公开(公告)号：US4521180A
公开(公告)日：1985-06-04
申请号：US619771
申请日：1984-06-11
申请人： Carl W. Walter , William J. Riordan
发明人： Carl W. Walter , William J. Riordan
CPC分类号： F23N5/123 , F23N2027/36 , F23N2035/14
摘要： A laboratory gas burner and control apparatus including a burner assembly made from electrically conductive material and adapted for positioning on a counter. Defined by the burner is an inlet for connection to a gas source and an outlet for feeding gas to a flame. An electrically operated valve controls the flow of gas to the burner outlet and an igniter is energizable by a power supply to ignite gas emanating from the burner outlet. Associated with the igniter is an activation circuit that produces either ignition periods during which the igniter is energized by the supply or non-ignition periods during which the igniter is deenergized. Initiation of each ignition period requires manipulation of a manual activation mechanism. Once ignited, the presence of flame at the burner outlet is detected by a flame sensing mechanism. A valve control circuit maintains the supply valve open only during either ignition periods or periods during which flame is detected by the sensing mechanism.
摘要翻译： 一种实验室气体燃烧器和控制装置，包括由导电材料制成并适于定位在柜台上的燃烧器组件。 由燃烧器定义的是用于连接到气体源的入口和用于将气体供给到火焰的出口。 电动阀控制到燃烧器出口的气体流动，并且点火器由电源供电以点燃从燃烧器出口发出的气体。 与点火器相关联的是激活电路，其产生点火周期，在此期间，点火器由点火器断电的供电或非点火时段激励。 启动每个点火期需要操纵手动启动机构。 一旦点燃，燃烧器出口处的火焰的存在通过火焰感测机构来检测。 阀控制电路仅在点火周期或感测机构检测到火焰期间保持供气阀打开。
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公开(公告)号：US4455589A
公开(公告)日：1984-06-19
申请号：US395863
申请日：1982-07-06
CPC分类号： F23N5/123 , F23N2027/38 , F23N2029/12 , F23N5/12
摘要： An electrical control system including a source of electrical power and an electrical load coupled together by a power switch having alternate circuit open and circuit closed conditions. A closure means activates the power switch to a circuit closed condition to produce power transmission between the source and the load in response to a closure signal produced by a condition responsive control circuit. Connected in series with the power switch is a protective switch also activated from a circuit open to a circuit closed condition in response to the closure signal. A sensing circuit produces a fault signal in response to a closed condition of the power switch and a simultaneous circuit open condition of the protective switch.
摘要翻译： 一种电气控制系统，包括电源和通过具有交替电路断开和电路关闭状态的电源开关耦合在一起的电负载。 闭合装置响应于由条件响应控制电路产生的闭合信号，将电源开关激活到电路闭合状态以在源极和负载之间产生电力传输。 与电源开关串联的是一个保护开关，也从电路开启到电路闭合状态，响应闭合信号。 感测电路响应于电源开关的闭合状态和保护开关的同时电路断开状态产生故障信号。
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